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Nonlinear constitutive behavior of ferroelectric materials

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Science China(Physics,Mechanics & Astronomy) 2008年第9期51卷 1339-1356页

作者： li haijun liU Feng WANG TzuChiang LNM Institute of MechanicsChinese Academy of SciencesBeijing 100190China

The ferroelectric specimen is considered as an aggregation of many randomly oriented domains. According to this mechanism,a multi-domain mechanical model is developed in this paper. Each domain is represented by one element. The applied stress and electric field are taken to be the stress and electric field in the formula of the driving force of domain switching for each element in the specimen. It means that the macroscopic switching criterion is used for calculating the volume fraction of domain switching for each element. By using the hardening relation between the driving force of domain switching and the volume fraction of domain switching calibrated,the volume fraction of domain switching for each element is calculated. Substituting the stress and electric field and the volume fraction of domain switching into the constitutive equation of ferroelectric material,one can easily get the strain and electric displacement for each element. The macroscopic behavior of the ferroelectric specimen is then directly calculated by volume averaging. Mean-while,the nonlinear finite element analysis for the ferroelectric specimen is carried out. In the finite element simulation,the volume fraction of domain switching for each element is calculated by using the same method mentioned above. The in-teraction between different elements is taken into account in the finite element simulation and the local stress and electric field for each element is obtained. The macroscopic behavior of the specimen is then calculated by volume averaging. The computation results involve the electric butterfly shaped curves of axial strain versus the axial electric field and the hysteresis loops of electric displacement versus the electric field for ferroelectric specimens under the uniaxial coupled stress and electric field loading. The present theoretical prediction agrees reasonably with the experimental results.

关键词： volume fraction of domain switching multi-domain mechanical model finite element method (FEM) domain switching

Assessment of the Capability of ENSEMBLES Hindcasts in Predicting Spring Climate in China

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Journal of Meteorological Research 2019年第2期33卷 307-322页

作者： Yitong liN Haiming XU Jing MA haijun li Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science &Technology

Using the hindcasts provided by the Ensemble-Based Predictions of Climate Changes and Their Impacts(ENSEMBLES) project for the period of 1980–2005, the forecast capability of spring climate in China is assessed mainly from the aspects of precipitation, 2-m air temperature, and atmospheric circulations. The ENSEMBELS can reproduce the climatology and dominant empirical orthogonal function(EOF) modes of precipitation and 2-m air temperature, with some differences arising from different initialization months. The multi-model ensemble(MME) forecast of interannual variability is of good performance in some regions such as eastern China with February *** spatial patterns of the MME interannual and inter-member spreads for precipitation and 2-m air temperature are consistent with those of the observed interannual spread, indicating that internal dynamic processes have major impacts on the interannual anomaly of spring climate in China. We have identified two coupled modes between intermember anomalies of the 850-hPa vorticity in spring and sea surface temperature(SST) both in spring and at a lead of 2 months, of which the first mode shows a significant impact on the spring climate in China, with an anomalous anticyclone located over Northwest Pacific and positive precipitation and southwesterly anomalies in eastern *** results also suggest that the SST at a lead of two months may be a predictor for the spring climate in eastern China. A better representation of the ocean–atmosphere interaction over the tropical Pacific, Northwest Pacific, and Indian Ocean can improve the forecast skill of the spring climate in eastern China.

关键词： ENSEMBLES seasonal forecast spring climate coupled atmosphere-ocean mode

HCV immune evasion and regulatory T cell activation: cause or consequence?

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Cellular & Molecular Immunology 2018年第5期15卷 536-538页

作者： haijun li Tianyang li Ian Nicholas Crispe Zhengkun Tu Institute of Translational Medicine the First HospitalJilin UniversityChangchunChina Department of Pathology University of WashingtonSeattleWashingtonUSA Institute of liver diseases the First HospitalJilin UniversityChangchunChina

Hepatitis C virus(HCV)infection remains a major public health problem given that an estimated 71 million people are currently infected and 1.75 million are newly infected every *** to 85%of HCV infections become persistent and may eventually lead to chronic liver diseases,including cirrhosis and hepatocellular carcinoma.1 Immune responses play a crucial role in virus control and liver injury;however,the underlying mechanism is not completely *** chronically infected with HCV generally exhibit a weak peripheral blood T cell response against HCV,which could explain viral *** cells that play a key role in dominant immune tolerance,regulatory T(T-reg)cells suppress inflammatory responses and prevent the development of autoimmune diseases.

关键词： infected diseases consequence

Phosphorylation of Ago2 is required for its role in DNA double-strand break repair

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Journal of Genetics and Genomics 2021年第4期48卷 333-340页

作者： Xiaolu Hu Yan li Tianfang Zhang lin li She Chen Xiaohong Wu haijun li Binjie Qi Zuobing Chen Department of Rehabilitation Medicine The First Affiliated HospitalCollege of MedicineZhejiang UniversityHangzhou 310000China Center for Plant Biology School of Life SciencesTsinghua UniversityBeijing 100084China Tsinghua-Peking Center for life Sciences Beijing 100084China National Institute of Biological Sciences Zhongguancun Life Science ParkBeijing 102206China

Repair of DNA double-strand break(DSB)is critical for the maintenance of genome integrity.A class of DSB-induced small RNAs(di RNAs)has been shown to play an important role in DSB *** humans,di RNAs are associated with Ago2 and guide the recruitment of Rad51 to DSB sites to facilitate repair by homologous recombination(HR).Ago2 activity has been reported to be regulated by phosphorylation under normal and hypoxic ***,the role of Ago2 phosphorylation in DNA damage repair is ***,we show that S672,S828,T830,and S831 of human Ago2 are phosphorylated in response to ionizing radiation(IR).S672 A mutation of Ago2 leads to significant reduction in Rad51 foci formation and HR *** further show that defective association of Ago2 S672 A variant with DSB sites,instead of defects in di RNA and Rad51 binding,may account for decreased Rad51 foci formation and HR *** study reveals a novel regulatory mechanism for the function of Ago2 in DNA repair.

关键词： Ago2 diRNA DNA repair Phosphorylation Small RNA

Histological Study of the liver Pigmentation of Chinese Fire-bellied Newt (Cynops orientalis) During Activity and Hibernation Periods

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Asian Herpetological Research 2012年第4期3卷 322-326页

作者： Zhaohui XIE haijun li Boying li linna CHENG Anfang ZHAO Cunshuan XU Department of Bioengineering Henan University of Urban Construction College of life Sciences and Key Laboratory for Cell Differentiation Regulation Henan Normal University

The pigmentation in the liver of Chinese fire-bellied newt(Cynops orientalis) was described during two periods of the annual cycle(summer activity and winter hibernation). A large number of melanin granules were gathered into clusters and distributed unevenly inside the pigment cells. liver pigmentation(melanin content) was found unstable,varying during the annual cycle. During the hibernation period,pigmentation accumulation was shown to increase in the liver of the Chinese fire-bellied newt. Hepatocytes during the active period are approximately 14.64% larger than those in the hibernation period,while the nucleus is approximately 7.43% bigger during the active period when compared with that during the hibernation period. These findings indicate that variation in pigment distribution and hepatocyte morphology in Chinese fire-bellied newt liver may be an ecologically adaptive strategy to the adverse physiological conditions during hibernation.

关键词： Chinese fire-bellied newt histology pigment cell hepatocyte seasonal variation

Effects of lighting mode on the growth performance,cortisol level and oxidative stress of juvenile Chinese three-keeled pond turtle(Chinemys Reevesii)

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International Journal of Agricultural and Biological Engineering 2023年第4期16卷 58-62页

作者： haijun li Jianlin Guo Jian Zhao Zhangying Ye Mingdong Ji Songming Zhu College of Biosystems Engineering and Food Science Zhejiang UniversityHangzhou 310058China、Key Laboratory of Equipment and Informatization in Environment Controlled AgricultureMinistry of Agriculture and Rural AffairsChina Key Laboratory of Healthy Freshwater Aquaculture Ministry of Agriculture and Rural Affairs、Key Laboratory of Fish Health and Nutrition of Zhejiang Province、Zhejiang Institute of Freshwater FisheriesHuzhou 313001ZhejiangChina Ocean Research Institute Zhejiang UniversityZhoushan 316021ZhejiangChina School of Engineering Huzhou UniversityHuzhou 313000ZhejiangChina

To improve the light environment and welfare of the turtle cultured indoors,the effects of lighting mode on growth performance,cortisol level,and oxidative stress of juvenile Chinese three-keeled pond turtle,Chinemys reevesii,were investigated in this *** experimental turtles with an initial weight of 5.61±0.09 g were reared in tanks under four different lighting modes:three groups with light(lighting the basking area and water area,LBW;lighting the water area only,LW;lighting the basking area only,LB)and control group(no light,NL).The experiment was conducted for more than six months,with each group having three *** 203 d of the experiment,the turtle in the LW group exhibited higher weight gain rate(WGR)and a specific growth rate(SGR,%/d)compared to other ***,results showed that the final body weight of the turtle exposed to LW was higher than that exposed to other *** the physiological level,serum cortisol level in turtles exposed to LW was significantly lower than that in other *** oxidative stress,the level of catalase(CAT)in turtles exposed to LW and LB was significantly lower than that exposed to LBW and *** malonaldehyde(MDA)activity in turtles exposed to LW was significantly lower than other *** on the growth performance and health status,it is suggested that lighting the water area only is the optimal lighting mode for the juvenile threekeeled pond turtle cultured indoors.

关键词： Chinese three-keeled pond turtle lighting mode growth stress response oxidative stress

Hepatitis C virus core protein triggers expansion and activation of CD4＋CD25＋ regulatory T cells in chronic hepatitis C patients

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Cellular & Molecular Immunology 2015年第6期12卷 743-749页

作者： Naicui Zhai Xiumei Chi Tianyang li Hongxiao Song haijun li Xia Jin Ian Nicholas Crispe lishan Su Junqi Niu Zhengkun Tu Institute of Translational Medicine The First Hospital Jilin University Changchun China Department of Hepatology The First Hospital Jilin University Changchun China Institute Pasteur of Shanghai Chinese Academy of Sciences Shanghai China Department of Pathology University of Washington Seattle WA USA lineberger Comprehensive Cancer Center School of Medicine University of North Carolina at Chapel Hill Chapel Hill NC USA

CD4＋CD25＋FoxP3 ＋ regulatory T ceils （Tregs） are increased in patients with chronic hepatitis C, which may contribute to the sustained suppression of hepatitis C virus （HCV）-specific T-cell responses and viral persistence in HCV-infected individuals. We postulated that HCV core protein （HCVc） directly contributes to the expansion of Tregs in HCV-infected patients, and we provide evidence to support this hypothesis in the report. Peripheral blood mononuclear cells （PBMCs） and sera were collected from 87 treatment-naive chronic HCV-infected patients, CD4＋CD25＋ Tregs were measured by flow cytometry, and HCV RNA and HCVc levels were detected using qPCR and enzyme-linked immunosorbent assay （EliSA）, respectively. CD4＋, CD8＋, CD4＋CD25＋ and CD4＋CD25- T cells were purified from healthy donors and cultured with recombinant HCVc and Toll-like receptor （TLR） ligands. Flow cytometry was used to analyze cell proliferation, and EliSA was performed to measure cytokine production. In the 87 chronic HCV-infected patients, HCVc showed a significant correlation with HCV RNA and CD4＋CD25＋Tregs. Mechanistic studies showed that HCVc, together with anti-CD3 antibody, augmented CD4＋CD25＋ Treg proliferation, but inhibited CD4＋CD25- T-cell proliferation and IFN-γ production, in a dose-dependent and Treg-dependent manner. Moreover, unlike the TLR3 ligand （poly hC） and the TLR4 ligand （lipopolysaccharide, LPS）, the TLR2 ligand （lipoteichoic acid, LTA） and HCVc both inhibited TCR-induced CD4＋ T-cell proliferation and IFN-γ secretion in a Treg-dependent manner. These data indicate that HCVc, like other TLR2 ligands, triggers CD4＋CD25＋ Treg activation and expansion to inhibit host immune responses, which may play a critical role in viral persistence in HCV-infected patients.

关键词： CD4+CD25+ regulatory T cells HCV core Toll-like receptor

Surgical outcomes of mini-open Wiltse approach and conventional open approach in patients with single-segment thoracolumbar fractures without neurologic injury

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The Journal of Biomedical Research 2015年第1期29卷 76-82页

作者： haijun li Lei Yang Hao Xie lipeng Yu Haifeng Wei Xiaojian Cao Department of Orthopaedics the First Affiliated Hospital of Nanjing Medical University Department of Orthopaedics the Second Affiliated Hospital of Nanjing Medical University Department of Radiology Taizhou People's Hospital affiliated to Nantong University

This study aimed to introduce a novel mini-open pedicle screw fixation technique via Wiltse approach, and com- pared it with the traditional posterior open method. A total of 72 cases of single-segment thoracolumbar fractures without neurologic injury underwent pedicle screw fixation via two different approaches. Among them, 37 patients were treated using posterior open surgery, and 35 patients received mini-open operation via Wiltse approach. Crew placement accuracy rate, operative time, blood loss, postoperative drainage, postoperative hospitalization time, radiation exposure time, postoperative improvement in R value, Cobb＇s angle and visual analog scale （VAS） scores of the two methods were compared. There were no significant differences in the accuracy rate of pedicle screw placement, radiation exposure and postoperative R value and Cobb＇s angle improvement between the two groups. However, the mini-open method had obvious advantages over the conventional open method in operative time, blood loss, postoperative drainage, postoperative hospitalization time, and postoperative improvement in VAS. The mini-open pedicle screw technique could be applied in treatment of single-segment thoracolumbar fracture without neurologic injury and had advantages of less tissue trauma, short operative and rehabilitative time on the premise of guaranteed accuracy rate and no increased radiation exposure.

关键词： thoracolumbar fracture pedicle screw Mini-open Wiltse approach minimally invasive

DULCE IT DECORUMEST PROPATRIA MORI IS AN OLD liE

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西藏大学学报（社会科学版） 1993年第3期8卷 87-88页

作者： li haijun

这是一首描写第二次世界大战时期,人们,特别是士兵厌战的诗篇。诗人通过亲眼目睹战争,将战争的残酷及人们对战争的极端厌恶在这首诗中描写得淋漓尽致。本文作者通过对这首诗从内容,写作技巧作详细的分析与欣赏。

关键词：战争恐惧血与火