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Predictive value of antiplatelet resistance on early stent thrombosis in patients with acute coronary syndrome

Chinese Medical Journal 2013年第4期126卷 626-633页

作者： li Lei li hai-yan QIAO Rui YU hai-yi ZENG Hui GAO Wei ZHANG Jie Department of Cardiology Department of Laboratory Medicine Peking University Third Hospital Beijing 100191 China Key Laboratory of Cardiovascular Molecular Biology and Regulatory Peptides Ministry of Health Key Laboratory of Molecular Cardiovascular Sciences Ministry of Education Beijing 100191 China

Background Despite outstanding antiplatelet properties of aspirin and clopidogrel, some patients taking these drugs continue to suffer complications. Antiplatelet resistance appears to be a new prognostic factor in acute coronary syndrome patients for clinical events associated with stent thrombosis （ST）. However, there is no optimal method to identify it and assess its correlation to clinical outcomes. This study sought to evaluate the predictive value of antiplatelet resistance assessed by whole blood impedance aggregometry for the risk of early ST in patients with acute coronary syndrome who underwent coronary stenting. Methods Platelet responses to aspirin and clopidogrel in 86 patients with acute coronary syndrome were measured by whole blood impedance aggregometry. Spontaneous platelet aggregation was defined as antiplatelet resistance identified by the increased electrical impedance. The clinical endpoint was early stent thrombosis during 30-day follow-up after coronary stenting. Results The prevalence of aspirin resistance, clopidogrel resistance and dual resistance of combined clopidogrel and aspirin resistance were 19.8%, 12.8% and 5.8% respectively. Diabetes, female and higher platelet counts were more frequently detected in clopidogrel-resistant and dual-resistant patients. During 30-day follow-up, the patients with clopidogrel resistance and dual resistance had higher incidence of early stent thrombosis （18.2% vs. 1.3%, 40.0% vs. 1.2%, P 〈0.05）. Binary Logistic Regression analysis indicated that dual resistance remained an independent predicator for early stent thrombosis （odds ratio 34.064, 95% CI 1.919-604.656, P=-0.016）. Conclusions Antiplatelet resistance assessed by whole blood impedance aggregometry is paralleled to clinical events, and dual antiplatelet resistance is an independent predicator for early stent thrombosis in patients with acute coronary syndrome. As a physiological assessment of platelet reactivity, whole blood impedance aggregometr

关键词： antiplatelet resistance electrical impedance aggregation method acute coronary syndrome stent thrombosis

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临床医学科技成果评价指标体系的实证研究

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中华医院管理杂志 2011年第8期27卷 610-612页

作者：李海燕徐顽强董小艳曹蓓华中科技大学公共管理学院武汉430074 南方医科大学科技处

目的以某省科技成果评审为例，对前期所建立的临床科技成果评价指标体系进行验证。方法制定各评价指标的详细评分准则，由5位专家对某省2010年度20份科技成果申报材料进行模拟评分。采用加权求和法计算各评审项目的总得分，考核指标体... 详细信息

目的以某省科技成果评审为例，对前期所建立的临床科技成果评价指标体系进行验证。方法制定各评价指标的详细评分准则，由5位专家对某省2010年度20份科技成果申报材料进行模拟评分。采用加权求和法计算各评审项目的总得分，考核指标体系的信度和效度。结果指标体系的克朗巴赫a系数为0．91。各实测指标评分与总得分以及所属一级指标之间普遍存在高度相关。专家重新评分结果与原有评审结果有一定相关性（rs=0．71，P〈0．001），但尚存在某些差异。结论结合调查数据开展实证分析，反映该评价指标体系及评分准则简便易行，有很好的信度和效度，可推广应用于临床科技成果评价工作。

关键词：科技成果临床医学实证

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Overexpression of vacuolar proton pump ATPase(V-H^+-ATPase) subunits B, C and H confers tolerance to salt and saline-alkali stresses in transgenic alfalfa(Medicago sativa L.)

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Journal of Integrative Agriculture 2016年第10期15卷 2279-2289页

作者： WANG Fa-wei WANG Chao SUN Yao WANG Nan li Xiao-wei DONG Yuan-yuan YAO Na liU Xiu-ming CHEN Huan CHEN Xi-feng WANG Zhen-min li hai-yan College of life Sciences Jilin Agricultural University/Engineering Research Center of Bioreactor and Pharmaceutical Development Ministry of Education Jilin Technology Innovation Center for Soybean Region Jilin Agricultural University

The vacuolar proton pump ATPase（V-H^＋-ATPase）, which is a multi-subunit membrane protein complex, plays a major role in the activation of ion and nutrient transport and has been suggested to be involved in several physiological processes, such as cell expansion and salt tolerance. In this study, three genes encoding V-H^＋-ATPase subunits B（Sc VHA-B, Gen Bank： JF826506）, C（Sc VHA-C, Gen Bank： JF826507） and H（Sc VHA-H, Gen Bank： JF826508） were isolated from the halophyte Suaeda corniculata. The transcript levels of Sc VHA-B, Sc VHA-C and Sc VHA-H were increased by salt, drought and saline-alkali treatments. V-H^＋-ATPase activity was also examined under salt, drought and saline-alkali stresses. The results showed that V-H^＋-ATPase activity was correlated with salt, drought and saline-alkali stress. Furthermore, V-H^＋-ATPase subunits B, C and H（Sc VHA-B, Sc VHA-C and Sc VHA-H） from S. corniculata were introduced separately into the alfalfa genome. The transgenic alfalfa was verified by Southern and Northern blot analysis. During salt and saline-alkali stresses, transgenic lines carrying the B, C and H subunits had higher germination rates than the wild type（WT）. More free proline, higher superoxide dismutase（SOD） activity and lower malondialdehyde（MDA） levels were detected in the transgenic plants under salt and saline-alkali treatments. Moreover, the Sc VHA-B transgenic lines showed greater tolerance to salt and saline-alkali stresses than the WT. These results suggest that overexpression of Sc VHA-B, Sc VHA-C and Sc VHA-H improves tolerance to salt and saline-alkali stresses in transgenic alfalfa.

关键词： vacuolar proton pump salt tolerance saline-alkali tolerance alfalfa

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Preparation of Electrospun CdSe-Quantum-Dots-Doped Porous Films

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Journal of Donghua University(English Edition) 2014年第5期31卷 609-616页

作者： GAO Bing SHEN Chao YUAN Shuang-long ZHANG Jian-guang yanG Yun-xia MO Xiu-mei li hai-yan CHEN Guo-rong Key Laboratory for Ultrafine Materials of Ministry of Education School of Materials Science and Engineering East ChinaUniversity of Science and Technology Shanghai 20023 7 China College of Chemistry Chemical Engineering and Biotechnology Donghua University Shanghai 201620 China Med-X Research Institute School of Biomedical Engineering Shanghai Jiaotong University Shanghai 200030 China

Electrospun porous films doped with the green-synthesized CdSe quantum dots were synthesized. Glycerol was chosen to prepare the quantum dots （ QDs）, with the highest quantum yield of 78.28%. Polycaprolactone （PCL） was electrospun with CdSe QDs to avoid the QDs＇ toxicity and improve the QDs＇ cytocompatibility. The electrospun QDs-doped films preserve the original QDs＇ fluorescence. Pores can be detected from the SEM of the films, predicting the possibility of loading drugs in the cancer therapy. The cell proliferation assay shows excellent cytocompatibility of the eletrospun CdSe-QDs-doped films. The present eletrospun CdSe- QDs-doped porous films are cytocompatibale, highly-fluorescent and ootential to load drugs in cancer therapy.

关键词： CdSe-quantum dots (QDs ) electrospun films polycaprolactone (PCL) photoluminescence (PL) cytocompatibility cell proliferation assay

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Effects of Outdoor Temperature on Blood Pressure in a Prospective Cohort of Northwest China

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Biomedical and Environmental Sciences 2021年第2期34卷 89-100页

作者： ZHENG Shan WANG Min Zhen CHENG Zhi Yuan KANG Feng NIE Yong Hong MI Xiu Ying li hai yan JIN Lan ZHANG Ya Wei BAI Ya Na Institute of Epidemiology and Statistics School of Public HealthLanzhou UniversityLanzhou 73000GansuChina Department of Epidemiology School of Public HealthBrown UniversityProvidenceRhode Island 02903USA Workers'Hospital of Jinchuan Group Co. Ltd.Jinchang 737103GansuChina Jinchang Center for Disease Prevention and Control Jinchang 737100GansuChina Jinchang Meteorological Service Jinchang737100GansuChina Department of Surgery Yale School of MedicineNew Haven 06511USA Department of Environmental Health Sciences Yale School of Public HealthNew Haven 06511US

Objective The relationship between outdoor temperature and blood pressure(BP) has been inconclusive. We analyzed data from a prospective cohort study in northwestern China to investigate the effect of outdoor temperature on BP and effect modification by *** A total of 32,710 individuals who participated in both the baseline survey and the first follow-up in 2011–2015 were included in the study. A linear mixed-effect model and generalized additive mixed model(GAMM) were applied to estimate the association between outdoor temperature and BP after adjusting for confounding *** The mean differences in systolic blood pressure(SBP) and diastolic blood pressure(DBP)between summer and winter were 3.5 mm Hg and 2.75 mm Hg, respectively. After adjusting for individual characteristics, meteorological factors and air pollutants, a significant increase in SBP and DBP was observed for lag 06 day and lag 04 day, a 0.28 mm Hg(95% CI: 0.27–0.30) per 1 °C decrease in average temperature for SBP and a 0.16 mm Hg(95% CI: 0.15–0.17) per 1 °C decrease in average temperature for DBP, respectively. The effects of the average temperature on both SBP and DBP were stronger in summer than in other seasons. The effects of the average temperature on BP were also greater if individuals were older, male, overweight or obese, a smoker or drinker, or had cardiovascular diseases(CVDs), hypertension, and *** This study demonstrated a significant negative association between outdoor temperature and BP in a high-altitude environment of northwest China. Moreover, BP showed a significant seasonal variation. The association between BP and temperature differed by season and individuals' demographic characteristics(age, gender, BMI), unhealthy behaviors(smoking and alcohol consumption), and chronic disease status(CVDs, hypertension, and diabetes).

关键词： Outdoor temperature Season Blood pressure Jinchang cohort

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Effects of insulin-like growth factor binding protein-related protein 1 in mice with hepatic fibrosis induced by thioacetamide

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Chinese Medical Journal 2010年第18期123卷 2521-2526页

作者： liU li-xin ZHANG hai-yan ZHANG Qian-qian GUO Xiao-hong Experimental Center of Science and Research of the First Teaching Hospital of Shanxi Medical University Institute of liver Disease and Key Laboratory of Cell Physiology Provincial Department of the Ministry of Education of Shanxi Medical University Taiyuan Shanxi 030001 China

Background Insulin-like growth factor binding protein-related protein 1 （IGFBPrP1） can activate hepatic stellate cells and increase extracellular matrix （ECM） in vitro. However, the effects of IGFBPrP1 in mice with hepatic fibrosis, and the mechanisms of these effects, are currently unknown. We aim to address these issues in this study. Methods Intraperitoneal injection of thioacetamide （TAA） is a classic method for establishing a mouse model of hepatic fibrosis. Using this model, we administered anti-IGFBPrP1 antibody, again via intraperitoneal injection. The morphological changes of liver fibrosis were observed with both HE and Masson stainning. The immunohistochemical assays and Western blotting were used to measure changes in IGFBPrP1, a-smooth muscle actin （a-SMA） and ECM in liver tissues, and the expression of transforming growth factor-β1 （TGF-β1） and Smad3. Data were statistically analyzed using one-way analysis of variance （ANOVA）, the SNK-q test for inter-group differences. Results The Masson staining analysis showed that compared with normal control group, content of collagen fiber in TAA5w group was significantly increased （P 〈0.01）, and it was significantly decreased in TAA5w/alGFBPrP1 group compared with in TAA5w group （P 〈0.01）. The expression of hepatic IGFBPrP1, a-SMA, TGF-β1, Smad3, collagen 1 and fibronectin （FN） was significantly up-regulated in the TAA5w group （P 〈0.01）. Anti-IGFBPrP1 treatment reversed these changes （P 〈0.01）. Conclusions IGFBPrP1 plays an important role in the development of hepatic fibrosis. Anti-IGFBPrP1 prevents fibrosis in mice by suppressing the activation of hepatic stellate cells, inhibiting the synthesis of major components of the ECM （namely, collagen I and FN）. The mechanism for this suppression of fibrosis is associated with the TGF-β1/Smad3 signaling pathways.

关键词： insulin-like growth factor binding protein-related protein 1 hepatic fibrosis extracellular matrix Smad3 protein transforming growth factor beta 1

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石英尾砂对濠河中、下游沉积物磁学性质的影响及其环境意义

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地球物理学报 2011年第10期54卷 2620-2630页

作者：李勇李海燕刘慧安徽科技学院理学院安徽凤阳233100 中国地质大学(北京)地质过程与矿产资源国家重点实验室北京100083

为监测石英尾砂对濠河沉积物的影响,采用环境磁学方法进行研究.在濠河中、下游采集了三条典型沉积物剖面,通过详细的岩石磁学参数与SiO_2质量分数(w(SiO_2))测量,结果表明濠河中、下游沉积物中的主要磁性矿物是磁铁矿.三条典型沉积物剖... 详细信息

为监测石英尾砂对濠河沉积物的影响,采用环境磁学方法进行研究.在濠河中、下游采集了三条典型沉积物剖面,通过详细的岩石磁学参数与SiO_2质量分数(w(SiO_2))测量,结果表明濠河中、下游沉积物中的主要磁性矿物是磁铁矿.三条典型沉积物剖面在纵向上按磁性参数曲线的变化特征均可分成四个磁性层,第二、第三、第四层沉积物受石英尾砂稀释作用的影响显著,W(SiO_2)的平均值高达80%,这三层沉积物的磁学性质由石英尾砂控制.濠河中、下游沉积物的磁性参数(χ、SIRM和χ_(ARM))随w(SiO_2)增加而减少,两者存在负相关关系(-0.88≤R≤-0.81),表明磁性参数可用于分析石英尾砂对濠河沉积物的影响.同时,沉积物磁性参数的变化也能指示沉积环境的变化.

关键词：石英尾砂沉积物环境磁学濠河

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石英尾砂对濠河上游沉积物污染的磁学响应

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吉林大学学报（地球科学版） 2011年第4期41卷 1204-1211页

作者：李勇李海燕刘慧安徽科技学院理学院安徽凤阳233100 中国地质大学地质过程与矿产资源国家重点实验室北京100083

濠河上游沉积物和石英尾砂磁学参数及SiO2质量分数（w（SiO2））分析结果表明,沉积物中w（SiO2）高达80%以上,说明沉积物已被石英尾砂严重污染。磁测结果显示,沉积物与石英尾砂的磁学特征基本相同,这2类样品中的主要磁性矿物是磁铁矿,... 详细信息

濠河上游沉积物和石英尾砂磁学参数及SiO2质量分数（w（SiO2））分析结果表明,沉积物中w（SiO2）高达80%以上,说明沉积物已被石英尾砂严重污染。磁测结果显示,沉积物与石英尾砂的磁学特征基本相同,这2类样品中的主要磁性矿物是磁铁矿,含量较低,磁性矿物粒径较宽,主要为0.1-5μm;这主要是大量石英尾砂进入濠河后,在其稀释作用下,沉积物磁性减弱,使磁性矿物的粒径变粗。沉积物中w（SiO2）与磁学参数（χ、SIRM和χARM）存在负相关关系（-0.83≤R≤-0.61）,表明磁学参数能反映石英尾砂对沉积物的污染程度,其值越低说明石英尾砂对濠河污染越严重。

关键词：石英尾砂濠河沉积物环境磁学污染

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Intravitreal bevacizumab combined with/without triamcinolone acetonide in single injection for treatment of diabetic macular edema

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Chinese Medical Journal 2011年第3期124卷 352-358页

作者： WANG Yu-sheng li Xiao WANG hai-yan ZHANG Zi-feng li Man-hong SU Xiao-na Department of Ophthalmology the Eye Institute of People's Liberation Army Xijing Hospital Fourth Military Medical University Xi'an Shannxi 710032 China

Background Diabetic macular edema （DME） is a common manifestation of diabetic retinopathy （DR） that forms the main cause of central visual impairment. This study aimed to compare the efficacy and safety of a single intravitreal injection of bevacizumab alone versus bevacizumab combined with triamcinolone acetonide in eyes with diabetic macular edema （DME）.Methods A total of 40 eyes in 40 Chinese patients （22 male and 18 female） diagnosed with diabetic macular edema were enrolled in this prospective, randomized, consecutive study. Among them, 21 patients in group 1 were treated with intravitreal injection of bevacizumab （1.25 mg/0.05 ml）, and the other 19 patients in group 2 accepted intravitreal bavacizumab （1.25 mg/0.05 ml） combined with triamcinolone acetonide （2 mg/0.05 ml）. All patients were examined at baseline and followed up at 4, 6 and 12 weeks after the injection. Changes in mean best correct visual acuity （BCVA）using ETDRS chart, central retina thickness （CRT） measured by optical coherence tomography （OCT）, and intraocular pressure （IOP） were focused *** In group 1, mean BCVA improved from （41.76±15.59） letters （baseline） to （56.24±18.56）letters, （52.5712.31）letters and （48.41±17.90） letters at 4, 6 and 12 weeks post-injection, respectively （P=0.004, P=0.011 and P=0.026,respectively）. Mean CRT decreased from （525.76±184.10）μm（baseline） to （270.33±202.67） μm, （303.12±168.43） μm and（402.26±196.21）μm, respectively （P=0.009, P=0.016 and P=0.030, respectively）. In group 2, mean BCVA improved from （39.89±12.27） letters （baseline） to （55.31±19.27） letters, （51.25±13.48） letters and （46.97±16.23） letters at 4, 6 and 12 weeks after injection, respectively （P=0.003, P=0.010 and P=0.027, respectively）. Mean CRT decreased from （554.50±169.05）μm（baseline） to （292.76±196.05）μm, （323.46±164.05） μm and （426.38±169.05） μm, respectively （P=0.009, P=0.014 and P=0.028, respectively）. However, there was no significant difference between these two groups with regard to m

关键词： bevacizumab triamcinolone acetonide diabetic macular edema

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低渗透储层成岩储集相及储集空间演化模式

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中国石油大学学报（自然科学版） 2007年第5期31卷 1-6页

作者：李海燕彭仕宓中国石油大学资源与信息学院北京102249

以砂西油田古近系下干柴沟组下段(E13)为例,综合应用取心井的岩石铸体薄片、图像分析、扫描电镜、电子探针能谱、阴极发光、粘土矿物X衍射分析、镜质体反射率等实验测试资料,对E13储层的成岩作用、成岩演化序列和成岩阶段划分方法进行... 详细信息

以砂西油田古近系下干柴沟组下段(E13)为例,综合应用取心井的岩石铸体薄片、图像分析、扫描电镜、电子探针能谱、阴极发光、粘土矿物X衍射分析、镜质体反射率等实验测试资料,对E13储层的成岩作用、成岩演化序列和成岩阶段划分方法进行了研究,分析了低渗透储层成岩作用对储集物性的影响,详细阐述了低渗透储层中各类成岩储集相的特征及其形成机制,并探讨了其储集空间类型及演化模式。研究结果表明,本区储层砂岩较低渗透率的主要成因是成岩期各种自生矿物的充填和胶结作用。根据成岩作用及其特有的储集空间组合,可将E13储层划分为4种成岩储集相类型,即不稳定组分中强溶解次生孔隙成岩储集相(A相)、中等胶结中强压实残余粒间孔成岩储集相(B相)、碳酸盐强胶结成岩储集相(C相)和早期硬石膏强胶结成岩储集相(D相),其中A类储集相的储集性能最好,D类最差,为差储层或非储层。

关键词：砂西油田古近系下干柴沟组成岩作用成岩储集相储集空间演化

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