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Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy

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Chinese Chemical Letters 2024年第10期35卷 374-378页

作者： lin li Bingjun Sun Jin Sun lin Chen Zhonggui He Department of Pharmacy Women and Children's Hospital of Chongqing Medical University/Chongqing Health Center for Women and Children Department of Pharmaceutics Wuya College of Innovation Shenyang Pharmaceutical University

Chemotherapy has been recommended as the standard protocol for triple-negative breast cancer （TNBC）at the advanced ***,the current treatment is unsatisfactory due to inefficient drug accumulation and rapid ***,rational design of advanced drug delivery systems that can induce multiple cell death pathways is a promising strategy to combat *** is a powerful non-apoptotic cell death modality,showing potential in tumor ***,we propose a binary prodrug nanoassemblies that combines chemotherapy with ferroptosis for TNBC *** this system,paclitaxel is linked with paracetamol （ferroptosis activator） by a disulfide linkage to construct self-assembly ***,2-distearoyl-sn-glycerol-3-phosphoethanolamine-N-methyl（polyethylene glycol）-2000-tyrosine (DSPE-PEG2k-tyrosine) is applied for large neutral amino acid transporter 1 （LAT1） targeting,which is highly expressed in *** prodrug nanoassemblies exhibit good stability and a glutathione （GSH）-responsive release ***,the LAT1-targeted nanoassemblies show stronger cytotoxicity,higher cellular uptake,and more obvious ferroptosis activation than non-decorated *** a TNBC mice model,the prodrug nanoassemblies demonstrate strong anti-tumor *** application of ferroptosis-assisting chemotherapy may provide a promising strategy for TNBC therapy.

关键词： Ferroptosis LAT1 Paclitaxel Prodrug nanoassemblies Triple-negative breast cancer

Effects of proton pump inhibitors on inflammatory bowel disease:An updated review

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World Journal of Gastroenterology 2024年第21期30卷 2751-2762页

作者： Yu liang Zhen Meng Xue-li Ding Man Jiang Department of Pharmacy The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Intervention The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina Department of Gastroenterology The Affiliated Hospital of Qingdao UniversityQingdao 266003Shandong ProvinceChina

Inflammatory bowel disease(IBD)is believed to be caused by various factors,including abnormalities in disease susceptibility genes,environmental factors,immune factors,and intestinal *** pump inhibitors(PPIs)are the primary drugs used to treat acid-related *** are also commonly prescribed to patients with *** studies have suggested a potential association between the use of certain medications,such as PPIs,and the occurrence and progression of *** this review,we summarize the potential impact of PPIs on IBD and analyze the underlying *** findings may provide insights for conducting further investigations into the effects of PPIs on IBD and serve as an important reminder for physicians to exercise caution when prescribing PPIs to patients with IBD.

关键词： Drug safety Proton pump inhibitor Inflammatory bowel disease Ulcerative colitis Crohn’s disease

我国运动与精神卫生领域研究热点及前沿趋势的科学知识图谱分析

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四川体育科学 2024年第2期43卷 47-51,146页

作者：寇月李海中国民用航空飞行学院体育部四川广汉618307 中国民用航空飞行学院民航安全工程学院四川广汉618307

目的为拓展运动干预精神卫生问题的创新性探索提供前景预测和有益参考。方法以中国知网数据库(CNKI)为检索对象,以“运动”“精神卫生”为主题词,检索到1993年4月—2022年9月收录的相关文献212篇,筛选来源类别为核心期刊后得到114篇代... 详细信息

目的为拓展运动干预精神卫生问题的创新性探索提供前景预测和有益参考。方法以中国知网数据库(CNKI)为检索对象,以“运动”“精神卫生”为主题词,检索到1993年4月—2022年9月收录的相关文献212篇,筛选来源类别为核心期刊后得到114篇代表性文献,利用科学知识图谱工具VOSviewer进行科学计量分析。结果2020年至今发文量开始呈稳定增长趋势,推测精神卫生问题的关注度上升与新冠疫情对行业冲击和生活压力的影响因素相关;发文机构集中在经济发达地区的北京、上海、宁波、广州等省市,以中小学、科学研究院居多,高校在整体研究机构中的占比较低;研究热点聚焦在精神卫生、青少年学生体育锻炼行为、干预性研究、健康促进和健康教育研究等方面;文章多数发表在以学校卫生、行为医学为主题的刊物;研究方法多以干预性实验和比较分析为主。结论正视国内运动干预精神卫生问题研究发展中的区域不平衡性,积极探索与优势地区科研单位建立长效交流的协作机制,促进垮校际、垮区域的学科交叉与融合,推动知识信息与研究成果的互通共享。未来在精神卫生不同的社会群体、问题的变化趋势及相应的治疗干预措施等方面,围绕具有集体性、竞赛性、趣味性特点的中等强度团体性运动项目制定运动处方,通过长期规律性的、高质量的运动手段干预,降低精神卫生症状的发生率。

关键词：精神卫生 VOSviewer 研究热点前沿主题

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BIO-inspired intelligent navigation: from methodology, system theory, to behavioural science

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Science China(Information Sciences) 2024年第9期67卷 333-335页

作者： Wenshuo li Xin liU Pengwei HU Jian YANG Xiang YU Lei GUO Hangzhou Innovation Institute of Beihang University School of Automation Science and Electrical Engineering Beihang University School of Instrumentation and Optoelectronic Engineering Beihang University

It is crucial for unmanned systems to determine their motion information accurately, reliably, and in real time. This function is accomplished by the autonomous navigation module of the unmanned systems. By analogy to the animals,the autonomous navigation module can be regarded as the“sensory nerve center” of an unmanned system.

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Effect of changing the proportion of C16:0 and cis-9 C18:1 in fat supplements on rumen fermentation, glucose and lipid metabolism, antioxidation capacity, and visceral fatty acid profile in finishing Angus bulls

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ANIMAL NUTRITION 2024年第3期18卷 39-48页

作者： Bai, haixin Wang, Lubo Lambo, Modinat Tolani li, Yang Zhang, Yonggen Northeast Agr Univ Coll Anim Sci & Technol Harbin 150030 Peoples R China

This study evaluated the effects of different proportions of palmitic (C16:0) and oleic (cis-9 C18:1) acids in fat supplements on rumen fermentation, glucose (GLU) and lipid metabolism, antioxidant function, and visceral fat fatty acid (FA) composition in Angus bulls. The design of the experiment was a randomized block design with 3 treatments of 10 animals each. A total of 30 finishing Angus bulls (21 +/- 0.5 months) with an initial body weight of 626 +/- 69 kg were blocked by weight into 10 blocks, with 3 bulls per block. The bulls in each block were randomly assigned to one of three experimental diets: (1) control diet without additional fat (CON), (2) CON + 2.5% palmitic calcium salt (PA; 90% C16:0), (3) CON + 2.5% mixed FA calcium salts (MA; 60% C16:0 + 30% cis-9 C18:1). Both fat supplements increased C18:0 and cis9 C18:1 in visceral fat (P liver FA transport protein 5 (FATP5; P lin concentration (P liver, the content of the C16:0 in visceral fat (P = 0.004), and weight gain (P = 0.032), and up-regulated the expression of liver diacylglycerol acyltransferase 2 (DGAT2; P liver, insulin resistance, and reduced antioxidant function. These adverse effects were alleviated by partially replacing C16:0 with cis-9 C18:1.

关键词： Palmitic acid Oleic acid lipid metabolism lipotoxicity Finishing bull SUBCUTANEOUS ADIPOSE-TISSUE OLEIC-ACID INSUliN-RESISTANCE MILK-PRODUCTION DAIRY-COWS PRODUCTION RESPONSES STEARIC-ACID PALM OIL BODY-FAT liVER

Organic ferroelastic enantiomers with high Tc and large dielectric switching ratio triggered by order-disorder and displacive phase transition

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Chinese Chemical Letters 2024年第10期35卷 254-258页

作者： Zhaohong Chen Mengzhen li Jinfei Lan Shengqian Hu Xiaogang Chen Ordered Matter Science Research Center Nanchang University

Molecular-based ferroelastics with dielectric switching properties are highly desirable for their applications on microelectronic dielectric switches,sensors,data storage,and so ***,the current reports mostly focus on organic-inorganic hybrids containing toxic heavy metal atoms,and the relatively low phase transition temperature limits their *** this paper,low-toxic organic salt ferroelastic enantiomers （R/S）-4-fluoro-1-azabicyclo[3.2.1]octonium chloride[（R/S）-F-321]were designed and synthesized under the introducing chirality *** undergo a 432F422-type ferroelastic phase transition with a high Curie temperature （Tc） of 470 K,simultaneously exhibiting excellent dielectric switching *** addition to the ordered-disordered movement of cations,the significant displacement of anions is also responsible for such high Tcand large dielectric switching ratios,which is very rare in molecular-based switching *** work enriches the development of molecular ferroelastic switching materials and gives inspiration for the exploration of environmentally friendly high Tcorganic salt ferroelastics with prominent switching performances.

关键词： Dielectric switching Enantiomers Ferroelastic Organic salt Phase transition

基于响应灵敏度方法的螺栓连接结构参数识别及实验

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中山大学学报（自然科学版）（中英文） 2024年第1期63卷 121-127页

作者：廖华松陈海汪利杨达豪吕中荣中山大学航空航天学院广东深圳518107

本文提出一种基于响应灵敏度的Bouc-Wen滞回模型辨识方法,从率无关角度揭示了螺栓连接所带来的接触摩擦能量耗散特性。首先,将参数识别问题简化成可以使用梯度算法求解的非线性最小二乘问题,并对Bouc-Wen模型进行了响应灵敏度分析。接着... 详细信息

本文提出一种基于响应灵敏度的Bouc-Wen滞回模型辨识方法,从率无关角度揭示了螺栓连接所带来的接触摩擦能量耗散特性。首先,将参数识别问题简化成可以使用梯度算法求解的非线性最小二乘问题,并对Bouc-Wen模型进行了响应灵敏度分析。接着,通过有限元仿真研究螺栓连接结构滞回响应,利用响应灵敏度方法识别了Bouc-Wen模型参数,验证了所提方法的有效性。最后,基于准静态实验研究,开展螺栓连接结构模型修正,并用于预估其他荷载下的滞回曲线。研究表明,Bouc-Wen模型不仅可以避免传统Iwan模型由于离散成Jenkins单元所带来的强非线性、刚性方程等问题,而且能够有效地表征螺栓连接结构滞回响应。

关键词：螺栓连接参数识别灵敏度分析滞回 Bouc-Wen模型

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Effects of simulated gut pH environment on bacterial composition and pheromone production of Dendroctonus valens

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Insect Science 2024年第1期31卷 225-235页

作者： Qingjie Cao Yu Zhao Tuuli-Marjaana Koski Huiping li Jianghua Sun College of Forestry Hebei Agricultural UniversityBaodingHebei ProvinceChina State Key Laboratory of Integrated Management of Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijingChina College of life Science/Hebei Basic Science Center for Biotic Interactions Institute of Life Science and Green DevelopmentHebei UniversityBaodingHebei ProvinceChina

Bark beetles are an economically and ecologically important insect group,with aggregation behavior and thus host colonization success depends on pheromone-mediated *** some species,such as the major invasive forest pest in China,red turpentine beetle(Dendroctonus valens),gut microbiota participates in pheromone production by converting tree monoterpenes into pheromone ***,how variation in gut microenvironment,such as pH,affects the gut microbial composition,and consequently pheromone production,is *** this study,we fed wild caught *** with 3 different pH media(main host diet with natural pH of 4.7;a mildly acidic diet with pH 6 mimicking the beetle gut pH;and highly acidic diet with pH 4),and measured their effects on the gut pH,bacterial community and production of the main aggregation and anti-aggregation pheromone(verbenone).We further tested the verbenone production capacity of 2 gut bacterial isolates in different pH environments(pH 6 and 4).Compared to natural state or main host diet,feeding on less acidic diet(pH 6)diluted the acidity of the gut,whereas feeding on highly acidic diet(pH 4)enhanced *** changes in gut pH reduced the abundance of dominant bacterial genera,resulting in decreased verbenone ***,the highest pheromone conversion rate of the bacterial isolates was observed in pH mimicking the acidity in beetle *** together,these results indicate that changes in gut pH can affect gut microbiota composition and pheromone production,and may therefore have the potential to affect host colonization behavior.

关键词： Dendroctonus valens gut bacteria gut pH verbenone

Base editor-mediated large-scale screening of functional mutations in bacteria for industrial phenotypes

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Science China(life Sciences) 2024年第5期67卷 1051-1060页

作者： Yaomeng Yuan Xihao liao Shuang li Xin-Hui Xing Chong Zhang MOE Key Laboratory for Industrial Biocatalysis Institute of Biochemical EngineeringDepartment of Chemical EngineeringTsinghua UniversityBeijing 100084China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolShenzhen 518055China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 440300China Center for Synthetic and Systems Biology Tsinghua UniversityBeijing 100084China

Base editing,the targeted introduction of point mutations into cellular DNA,holds promise for improving genome-scale functional genome screening to single-nucleotide *** efforts in prokaryotes,however,remain confined to loss-of-function screens using the premature stop codons-mediated gene inactivation library,which falls far short of fully releasing the potential of base ***,we developed a base editor-mediated functional single nucleotide variant screening pipeline in Escherichia *** constructed a library with 31,123 sgRNAs targeting 462 stress response-related genes in ***,and screened for adaptive mutations under isobutanol and furfural selective *** by the screening results,we successfully identified several known and novel functional *** pipeline might be expanded to the optimization of other phenotypes or the strain engineering in other microorganisms.

关键词： base editor high-throughput large-scale screening Escherichia coli functional mutation

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