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Genome-wide analysis of Panonychus citrimicro RNAs witha focus on potential insecticidal activity of 4 micro RNAs toeggs and nymphs

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Insect Science 2024年第2期31卷 354-370页

作者： Chuan-Zhen li Yu-Hang liu Deng Pan Meng-Hao Xia Qiang Zhang Yu-Chuang li Guo-Rui Yuan Jin-Jun Wang Wei Dou Key Laboratory of Entomology and Pest Control Engineering College of Plant ProtectionAcademy of Agricultural SciencesSouthwestUniversityChongqingChina Key Laboratory of Agricultural Biosafety and Green Production of Upper Yangtze River(Ministry of Education) Academy of Agricultural SciencesSouthwest UniversityChongqingChina

Panonychus citriMcGregor(Acari:Tetranychidae),a destructive citrus pest,causes considerable annual economic losses due to its short lifespan and rapid ***(miRNA)-induced RNA interference is a promising approachfor pest control because of endogenous regulation of pest growth and *** for miRNAs with potential insecticidal activity ***,genome-wide analysis ofmiRNAs at different developmental stages was conducted,resulting in the identificationof 136 miRNAs,including 73 known and 63 novel miRNAs.A total of 17 isomiRNAsand 12 duplicated miRNAs were ***-1 and miR-252-5p were identified asreference miRNAs *** *** on differential expressionanalysis,treatments with miR-let-7a and miR-315 mimics and the miR-let-7a antagomirsignificantly reduced the egg hatch rate and resulted in abnormal egg ***-expression or downregulation of miR-34-5p and miR-305-5p through feeding significantlydecreased the adult eclosion rate and caused molting *** 4 miRNAs,miR-let-7a,miR-315,miR-34-5p,and miR-305-5p,had important regulatory functions and insectici-dal properties in egg hatching and adult *** general,these data advance our un-derstanding of miRNAs in mite biology,which can assist future studies on insect-specificmiRNA-based green pest control technology.

关键词： growth and development microRNAs Panonychus citri referencemiRNAs regulation small RNA libraries

Elevated levels of KLF12 impair trophoblast syncytialization via GCM1 downregulation

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Reproductive and Developmental Medicine 2024年第3期8卷 131-137页

作者： Qing-Qing Shi Xing Wu Nan-Nan Kang Ji-Dong Zhou Xin Zhen Ze-Wu li Gui-Jun Yan hai-Xiang Sun Jing-Yu liu Yang liu Reproductive Medicine Center Nanjing Drum Tower Hospital Clinical College of Nanjing Medical UniversityNanjing 210000China Center for Reproductive Medicine and Obstetrics and Gynecology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjing 210000China Center for Molecular Reproductive Medicine Nanjing UniversityNanjing 210000China Department of Obstetrics and Gynecology Nanjing Drum Tower HospitalNanjing University Medical SchoolNanjing 210000China Center for Reproductive Medicine Affiliated Hospital of Jining Medical UniversityJining 272000China Reproductive Medicine Center Nanjing Drum Tower HospitalState Key Laboratory of Pharmaceutical BiotechnologyNanjing UniversityNanjing 210000China

Objective:Placental dysfunction is a major contributor to miscarriages in *** observed elevated expression of Kruppel-like factor 12(KLF12)in placental villi of women who experienced miscarriage compared to that in women with healthy *** study aimed to elucidate the role of KLF12 in maintaining a successful ***:To investigate the role of KLF12 in placentation,we employed a model of forskolin-induced syncytialization in BeWo ***:Our findings revealed that KLF12 expression is downregulated during normal ***,we observed that abnormally high KLF12 levels directly suppressed glial cells missing-1(GCM1)*** suppression of GCM1 expression subsequently impaired BeWo cell ***,we observed placental deformities in KLF12-overexpressing mouse ***(s):This study demonstrated that elevated levels of KLF12 disrupt trophoblast syncytialization by downregulating GCM1 *** findings suggest that KLF12 may be a novel candidate gene contributing to unexplained miscarriages.

关键词： KLF12 GCM1 Syncytialization Miscarriage

Nd:Bi_(2)WO_(6)/ZnS纳米复合材料的制备及其光学性能研究

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化学研究与应用 2024年第8期36卷 1902-1907页

作者：谢瑞士李园利刘海峰西南科技大学材料与化学学院分析测试测中心四川绵阳621010

采用简易的化学溶液法结合采用外延生长技术制备Nd:Bi_(2)WO_(6)/ZnS掺杂纳米复合材料。详细地研究了Nd:Bi_(2)WO_(6)/ZnS纳米复合材料的结构、光谱性质和光学性能。通过掺杂的策略,调控了Bi_(2)WO_(6)/ZnS复合结构的光学带隙调控,优化... 详细信息

采用简易的化学溶液法结合采用外延生长技术制备Nd:Bi_(2)WO_(6)/ZnS掺杂纳米复合材料。详细地研究了Nd:Bi_(2)WO_(6)/ZnS纳米复合材料的结构、光谱性质和光学性能。通过掺杂的策略,调控了Bi_(2)WO_(6)/ZnS复合结构的光学带隙调控,优化了样品对可见光的利用。当掺杂浓度为5 at%时,样品的禁带宽度最小,对可见光的吸收能力最强,此时产物的光致发光性能最低。

关键词：纳米复合材料化学合成晶体结构光学性能

Nomogram model including LATS2 expression was constructed to predict the prognosis of advanced gastric cancer after surgery

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World Journal of Gastrointestinal Surgery 2024年第2期16卷 518-528页

作者： Nan Sun Bi-Bo Tan Yong li Department of Blood Transfusion The Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hubei ProvinceChina Third Department of General Surgery the Fourth Hospital of Hebei Medical UniversityShijiazhuang 050011Hebei ProvinceChina

BACKGROUND Gastric cancer is a leading cause of cancer-related deaths *** assessments are typically based on the tumor-node-metastasis(TNM)staging system,which does not account for the molecular heterogeneity of this ***2,a tumor suppressor gene involved in the Hippo signaling pathway,has been identified as a potential prognostic biomarker in gastric *** To construct and validate a nomogram model that includes LATS2 expression to predict the survival prognosis of advanced gastric cancer patients following ra-dical surgery,and compare its predictive performance with traditional TNM *** A retrospective analysis of 245 advanced gastric cancer patients from the Fourth Hospital of Hebei Medical University was *** patients were divided into a training group(171 patients)and a validation group(74 patients)to deve-lop and test our prognostic *** performance of the model was determined using C-indices,receiver operating characteristic curves,calibration plots,and decision *** The model demonstrated a high predictive accuracy with C-indices of 0.829 in the training set and 0.862 in the validation *** under the curve values for three-year and five-year survival prediction were significantly robust,suggesting an excellent discrimination *** plots confirmed the high concordance between the predictions and actual survival *** We developed a nomogram model incorporating LATS2 expression,which significantly outperformed conven-tional TNM staging in predicting the prognosis of advanced gastric cancer patients *** model may serve as a valuable tool for individualized patient management,allowing for more accurate stratification and im-proved clinical *** validation in larger patient cohorts will be necessary to establish its generaliza-bility and clinical utility.

关键词： Gastric cancer LATS2 Column line graph Prognosis Advanced gastric cancer survival Molecular biomarkers Predictive analytics in oncology Survival analysis

Reveal more mechanisms of precondition mesenchymal stem cells inhibiting inflammation

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World Journal of Stem Cells 2024年第4期16卷 459-461页

作者： Yi li Qian-Qian Chen En-Qiang linghu Department of Gastroenterology First Medical Center of Chinese PLA General HospitalBeijing 100853China Department of Gastroenterology and Hepatology First Medical Center of Chinese PLA General HospitalBeijing 100853China

Hypoxia can get more ability to inhibit *** how it impact on survival time of mesenchymal stem cells(MSCs)is confusing and how preconditioned MSCs inhibiting inflammation are partially *** issues decided the value of ... 详细信息

关键词： Mesenchymal stem cell Hypoxia-inducible factor 1α Hypoxia Inflammation Macrophage

Polarization-entangled photon pairs with factorable spectra engineered by using an uneven four-stage nonlinear interferometer

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Chinese Optics Letters 2024年第5期22卷 106-110页

作者：崔亮陈浩然李嘉敏李小英 College of Precision Instrument and Opto-Electronics Engineering Key Laboratory of Opto-Electronics Information TechnologyMinistry of EducationTianjin UniversityTianjin 300072China School of Physics Taiyuan University of TechnologyTaiyuan 030000China

We report the generation of polarization-entangled photon pairs in the 1550 nm band by pumping an uneven nonlinear interferometer loop with two orthogonally polarized counterpropagating pump *** uneven nonlinear interferometer,providing a more ideal interference pattern due to the elimination of secondary maxima,consists of four pieces of dispersion-shifted fibers sandwiched with three pieces of standard single-mode fibers,and the lengths of the nonlinear fibers follow the binomial *** mode number of the photon pairs deduced from the measured joint spectrum is∼*** collection efficiency of the photon pairs is found to be∼94%(after background noise correction).The directly measured visibility of two-photon interference of the polarization-entangled photon pairs is∼92%,while no interference is observed in the direct detection of either the signal or idler photons.

关键词： polarization-entangled photon pairs nonlinear interferometer quantum state engineering optical fiber

Automatic detection of breast lesions in automated 3D breast ultrasound with cross-organ transfer learning

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虚拟现实与智能硬件（中英文） 2024年第3期6卷 239-251页

作者： lingyun BAO Zhengrui HUANG Zehui liN Yue SUN Hui CHEN You li Zhang li Xiaochen YUAN lin XU Tao TAN Affiliated Hangzhou First People's Hospital School of MedicineWestlake UniversityHangzhou 330100China Faculty of Applied Sciences Macao Polytechnic UniversityMacao 999078China Pathology Department Changsha First HospitalChangsha 410073China Radiology Department Changsha First HospitalChangsha 410073China College of Aerospace Science and Engineering National University of Defense TechnologyChangsha 410073China Hunan Provincial Key Laboratory of Image Measurement and Vision Navigation Changsha 410073China School of Information Science and Technology Shanghaitech UniversityShanghai 201210China

Background Deep convolutional neural networks have garnered considerable attention in numerous machine learning applications,particularly in visual recognition tasks such as image and video *** is a growing interest in applying this technology to diverse applications in medical image *** three dimensional Breast Ultrasound is a vital tool for detecting breast cancer,and computer-assisted diagnosis software,developed based on deep learning,can effectively assist radiologists in ***,the network model is prone to overfitting during training,owing to challenges such as insufficient training *** study attempts to solve the problem caused by small datasets and improve model detection *** We propose a breast cancer detection framework based on deep learning(a transfer learning method based on cross-organ cancer detection)and a contrastive learning method based on breast imaging reporting and data systems(BI-RADS).Results When using cross organ transfer learning and BIRADS based contrastive learning,the average sensitivity of the model increased by a maximum of 16.05%.Conclusion Our experiments have demonstrated that the parameters and experiences of cross-organ cancer detection can be mutually referenced,and contrastive learning method based on BI-RADS can improve the detection performance of the model.

关键词： Breast ultrasound Automated 3D breast ultrasound Breast cancers Deep learning Transfer learning Convolutional neural networks Computer-aided diagnosis Cross organ learning

Clinical and molecular significance of homologous recombination deficiency positive non-small cell lung cancer in Chinese population:An integrated genomic and transcriptional analysis

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Chinese Journal of Cancer Research 2024年第3期36卷 282-297页

作者： Yifei Wang Yidan Ma Lei He Jun Du Xiaoguang li Peng Jiao Xiaonan Wu Xiaomao Xu Wei Zhou li Yang Jing Di Changbin Zhu liming Xu Tianlin Sun lin li Dongge liu Zheng Wang Department of Pathology Department of Minimally Invasive Tumor Therapies Center Department of Thoracic Surgery Department of Oncology Department of Respiratory and Critical Care Medicine Beijing HospitalNational Center of GerontologyInstitute of Geriatric MedicineChinese Academy of Medical SciencesBeijing 100730China Amoy Diagnostics Co. Ltd.Xiamen 361027China

Objective:The clinical significance of homologous recombination deficiency(HRD)in breast cancer,ovarian cancer,and prostate cancer has been established,but the value of HRD in non-small cell lung cancer(NSCLC)has not been fully *** study aimed to systematically analyze the HRD status of untreated NSCLC and its relationship with patient prognosis to further guide clinical ***:A total of 355 treatment-naïve NSCLC patients were retrospectively *** status was assessed using the AmoyDx Genomic Scar Score(GSS),with a score of≥50 considered ***,transcriptomic,tumor microenvironmental characteristics and prognosis between HRD-positive and HRDnegative patients were ***:Of the patients,25.1%(89/355)were *** to HRD-negative patients,HRDpositive patients had more somatic pathogenic homologous recombination repair(HRR)mutations,higher tumor mutation burden(TMB)(Plifications in PI3K pathway and cell cycle genes,MET and MYC in epidermal growth factor receptor(EGFR)/anaplastic lymphoma kinase(ALK)mutant NSCLC,and more PIK3CA and AURKA in EGFR/ALK wild-type ***-positive NSCLC displayed higher tumor proliferation and immunosuppression ***-negative NSCLC showed activated signatures of major histocompatibility complex(MHC)-II,interferon(IFN)-γand effector memory CD8+T ***-positive patients had a worse prognosis and shorter progressionfree survival(PFS)to targeted therapy(first-and third-generation EGFR-TKIs)(P=0.042).Additionally,HRDpositive,EGFR/ALK wild-type patients showed a numerically lower response to platinum-free immunotherapy ***:Unique genomic and transcriptional characteristics were found in HRD-positive *** prognosis and poor response to EGFR-TKIs and immunotherapy were observed in HRD-positive *** study highlights potential actionable alterations in HRD

关键词： Non-small cell lung cancer homologous recombination deficiency genetic alterations transcriptional analysis tumor microenvironment prognosis

Electro-assisted photocatalytic reduction of CO_(2) in ambient air using Ag/TNTAs at the gas-solid interface

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Materials Reports(Energy) 2024年第2期4卷 71-82页

作者： Feng Yue Zhaoya Fan Cong li Yang Meng Shuo Zhang Mengke Shi Minghua Wang Mario Berrettoni Jun li Hongzhong Zhang Henan Collaborative Innovation Center of Environmental Pollution Control and Ecological Restoration Zhengzhou University of Light IndustryZhengzhou450001PR China Henan Institute of Advanced Technology Zhengzhou UniversityZhengzhou450052PR China Department of Chemistry University of CamerinoCamerino62032MacerataItaly

The direct conversion of atmospheric CO_(2) into fuel via photocatalysis exhibits significant practical application value in advancing the carbon *** this study,we established an electro-assisted photocatalytic system with dual compartments and interfaces,and coated Ag nanoparticles on the titanium nanotube arrays(TNTAs)by polydopamine *** the absence of sacrificial agent and alkali absorption liquid conditions,the stable,efficient and highly selective conversion of CO_(2) to CO at the gas-solid interface in ambient air was realized by photoelectric ***,with the assistance of potential,the CO formation rates reached 194.9μmol h^(−1) m^(−2) and 103.9μmol h^(−1) m^(−2) under ultraviolet and visible light irradiation,respectively;the corresponding CO_(2) conversion rates in ambient air were 30%and 16%,*** excellent catalytic effect is mainly attributed to the formation of P–N heterojunction during the catalytic process and the surface plasmon resonance ***,the introduction of solid agar electrolytes effectively inhibits the hydrogen evolution reaction and improves the electron utilization *** system promotes the development of photocatalytic technology for practical applications and provides new insights and support for the carbon cycle.

关键词： Electro-assisted photocatalytic Gas-solid interface Ambient air P–N heterojunction Practical applications