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Long Non-coding RNA PCED1B Antisense RNA 1 Promotes Cell Proliferation and Invasion in Hepatocellular Carcinoma by Regulating the MicroRNA-34a/CD44 Axis

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Current Medical Science 2024年第3期44卷 503-511页

作者： Jian-gang BI Qi li Yu-sheng GUO li-ping liU Shi-yun BAO ping XU Department of Hepatobiliary and Pancreatic Surgery Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China Department of Endocrinology Shenzhen People's HospitalThe Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and TechnologyShenzhen 518020China

Objective This study aimed to examine the role of long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1)in the development of hepatocellular carcinoma(HCC).Methods A total of 62 pairs of HCC tissues and adjacent non-tumor tissues were obtained from 62 HCC *** interactions of PCED1B-AS1 and microRNA-34a(miR-34a)were detected by dual luciferase activity assay and RNA pull-down *** RNA expression levels of PCED1B-AS1,miR-34a and CD44 were detected by RT-qPCR,and the protein expression level of CD44 was determined by Western *** cell proliferation was detected by cell proliferation assay,and the cell invasion and migration by transwell invasion *** HCC tumor growth after PCED1B-AS1 was downregulated was determined by in vivo animal *** PCED1B-AS1 was highly expressed in HCC tissues,which was associated with poor survival of HCC ***,PCED1B-AS1 interacted with miR-34a in HCC cells,but they did not regulate the expression of each ***,PCED1B-AS1 increased the expression level of CD44,which was targeted by *** cell proliferation and invasion assay revealed that miR-34a inhibited the proliferation and invasion of HCC in vitro,while CD44 exhibited the opposite ***,PCED1B-AS1 suppressed the role of ***,the knockdown of PCED1B-AS1 repressed the HCC tumor growth in nude mice in *** PCED1B-AS1 may play an oncogenic role by regulating the miR-34a/CD44 axis in HCC.

关键词： long non-coding RNA PCED1B antisense RNA 1(PCED1B-AS1) hepatocellular carcinoma microRNA-34a(miR-34a) CD44 proliferation invasion

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Media Power Measuring via Emotional Contagion

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Journal of Social Computing 2024年第1期5卷 15-35页

作者： Xue lin Hong Huang Zongya li hai Jin National Engineering Research Center for Big Data Technology and System Services Computing Technology and System LabCluster and Grid Computing LabSchool of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China School of Journalism Huazhong University of Science and TechnologyWuhan 430074China

Media power,the impact that media have on public opinion and perspectives,plays a significant role in maintaining internal stability,exerting external influence,and shaping international dynamics for nations/***,prior research has primarily concentrated on news content and reporting time,resulting in limitations in evaluating media *** more accurately assess media power,we use news content,news reporting time,and news emotion simultaneously to explore the emotional contagion between *** use emotional contagion to measure the mutual influence between media and regard the media with greater impact as having stronger media *** propose a framework called Measuring Media Power via Emotional Contagion(MMPEC)to capture emotional contagion among media,enabling a more accurate assessment of media power at the media and national/regional *** also interprets experimental results through correlation and causality analyses,ensuring *** analyses confirm the higher accuracy of MMPEC compared to other baseline models,as demonstrated in the context of COVID-19-related news,yielding compelling and interesting insights.

关键词： explainability media power emotional contagion

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Construction of a small peptide library related to inhibitor OM99-2 and its structure-activity relationship to β-secretase

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Acta Pharmacologica Sinica 2006年第12期27卷 1586-1593页

作者： Bin HU Bing XIONG Bei-ying QIU Xin li hai-ping YU Kun XIAO Xin WANG Jia li Jing-kang SHEN~2 State Key Laboratory of Drug Research and National Center for Drug Screening,Shanghai Institute of Materia Medica,Shanghai Institutes for Biological Sciences,Chinese Academy of Sciences,Shanghai 201203,China State Key Laboratory of Drug Research and National Center for Drug Screening Shanghai Institute of Materia Medica Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Shanghai China

Aim:To develop probes for detecting the binding specificity between β-secretaseand substrate,and provide reliable biological activity data for further researchingencircling substrate-based ***:To prepare the inhibitors,thehydroxyethylene(HE)segment including P1and P1′ was synthesized after multi-step reactions;the combination of all segments was then completed through solidphase *** human β-secretase ectodomain(amino acid resi-dues 1-460)was expressed as a secreted protein with a C-terminal His tag in insectcells using baculovirus infection,and all compounds were evaluated in thisβ-secretase enzyme *** order to understand the interaction in detail,the theoretical methods,namely molecular dynamics(MD)simulation and mo-lecular mechanics-generalized-born surface area(MM-GBSA)analysis,were per-formed on the complex of β-secretase and OM99-2 to obtain the geometrical andenergetical ***:We designed and constructed a positional scan-ning combinatorial library including 16 compounds;all members of the librarywere synthesized based on HE dipeptide ***-activity relationshipstudies at the P4-P1and P1′-P4′ positions led to the discoveries of P and P’sidesbinding specificity and potent inhibitors 14,18,and *** binding free energyon the whole system and every residue were compared to the biological ***:The removal of P4′ yielded inhibitor 22(A3*B2)with highpotency;further truncation of P3′ gave inhibitor 18(A3*B1)with equal activity,implying that the right side of the inhibitors play a less important role and could beeasily simplified,while change on the P side may cause substantial results.

关键词： β-secretase hydroxyethylene OM99-2 Alzheimer’s disease structure-activity relationship

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Numerical analysis of hydraulic fracture propagation in deep shale reservoir with different injection strategies

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第9期16卷 3558-3574页

作者： Yingjie Xia Mingyu Yao Tianjiao li hai Yang Chun'an Tang School of Civil Engineering Dalian University of TechnologyDalian116024China Deep Underground Engineering Research Center Dalian University of TechnologyDalian116024China CNPC Chuanqing Drilling Engineering Company limited Chengdu610051China

Deep shale reservoirs are characterized by elevated breakdown pressures,diminished fracture complexity,and reduced modified volumes compared to medium and shallow ***,it is urgent to investigate particular injection strategies that can optimize breakdown pressure and fracturing efficiency to address the increasing demands for deep shale reservoir *** this study,the efficiency of various stimulation strategies,including multi-cluster simultaneous fracturing,modified alternating fracturing,alternating shut-in fracturing,and cyclic alternating fracturing,was ***,the sensitivity of factors such as the cycle index,shut-in time,cluster spacing,and horizontal permeability was ***,the flow distribution effect within the wellbore was *** results indicate that relative to multi-cluster simultaneous fracturing,modified alternating fracturing exhibits reduced susceptibility to the stress shadow effect,which results in earlier breakdown,extended hydraulic fracture lengths,and more consistent propagation despite an increase in breakdown *** alternating shut-in fracturing benefits the increase of fracture length,which is closely related to the shut-in ***,cyclic alternating fracturing markedly lowers breakdown pressure and contributes to uniform fracture propagation,in which the cycle count plays an important *** alternating fracturing demonstrates insensitivity to variations in cluster spacing,whereas horizontal permeability is a critical factor affecting fracture *** wellbore effect restrains the accumulation of pressure and flow near the perforation,delaying the initiation of hydraulic *** simulation results can provide valuable numerical insights for optimizing injection strategies for deep shale hydraulic fracturing.

关键词： Fracture propagation Numerical simulation Hydraulic fracturing Rock failure process analysis(RFPA) Injection strategy

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论当代西方国家的宪法变迁

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当代法学 2006年第1期20卷 133-138页

作者：李海平深圳大学法学院广东深圳518060

西方国家从20世纪80年代开始所推行的行政改革导致这些国家的宪法在未经修改的情况下发生了巨大变迁。在民主制度方面,代议民主制转变为代议制民主、行政民主、社会民主并存的多重民主制。在人权制度方面,人权的核心内容由生存权演变为... 详细信息

西方国家从20世纪80年代开始所推行的行政改革导致这些国家的宪法在未经修改的情况下发生了巨大变迁。在民主制度方面,代议民主制转变为代议制民主、行政民主、社会民主并存的多重民主制。在人权制度方面,人权的核心内容由生存权演变为发展权,人权的义务主体从国家扩展到自治的社团。在权力制衡制度方面,国家层面的权力制衡转变为国家层面的权力制衡和国家与社会之间的权力制衡相结合的双重权力制衡机制。

关键词：宪法变迁多重民主制发展权双重权力制衡机制

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Synthesis of crystalline g-C_(3)N_(4) with rock/molten salts for efficient photocatalysis and piezocatalysis

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Green Energy & Environment 2024年第5期9卷 890-898页

作者： Tingting Xu Jung Hur ping Niu Shulan Wang Sangwook Lee Sang-Eun Chun li li Department of Chemistry College of ScienceNortheastern UniversityShenyang110819China State Key Laboratory of Rolling and Automation Northeastern UniversityShenyang110819China School of Metallurgy Northeastern UniversityShenyang110819China School of Materials Science and Engineering Kyungpook National UniversityDaegu41566Republic of Korea School of Industrial Technology Advances Kyungpook National UniversityDaegu41566Republic of Korea

Graphitic carbon nitride(g-C_(3)N_(4))is emerging as a promising visible-light photocatalyst while the low crystallinity with sluggish charge separation/migration dynamics signiﬁcantly restricts its practical ***,synthesizing highly crystalline g-C_(3)N_(4) with sufﬁcient surface activities still remains ***,different from using alkali molten salts which is commonly reported,we propose an approach for synthesis of highly crystalline g-C_(3)N_(4) with FeCl3/KCl rock/molten mixed *** rock salt can serve as the structure-directing template while molten salt provides the required liquid medium for ***,the synthesized photocatalyst showed further enhanced crystallinity and improved surface area along with high p/p*excitation compared with crystalline C_(3)N_(4) prepared from conventional molten-salt *** catalytically advantageous features lead to its superior photocatalytic and piezocatalytic activities with a high reactivity for overall water splitting that is not commonly reported for C_(3)N_(4).This work provides an effective strategy for structural optimization of organic semiconductor based materials and may inspire new ideas for the design of advanced photocatalysts.

关键词： High crystallinity Carbon nitride Photocatalysis Piezocatalysis Overall water splitting

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具有两个加性输入时滞系统的状态反馈控制

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数学的实践与认识 2020年第8期50卷 199-207页

作者：李海萍河北科技大学理学院河北石家庄050018

主要考虑了具有两个加性输入时滞的网络化控制系统的状态反馈控制问题.首先考虑具有两个加性时滞的系统稳定性,构造适当的Lyapunov泛函,不需要所有的矩阵正定,只需其整体正定.其次在估计Lyapunov泛函沿系统的导数时,针对时滞范围的不同... 详细信息

主要考虑了具有两个加性输入时滞的网络化控制系统的状态反馈控制问题.首先考虑具有两个加性时滞的系统稳定性,构造适当的Lyapunov泛函,不需要所有的矩阵正定,只需其整体正定.其次在估计Lyapunov泛函沿系统的导数时,针对时滞范围的不同,引入了不同的松弛矩阵,得出系统保守性较小的稳定条件.在此基础上,研究了系统状态反馈控制,最后得出闭环系统渐近稳定的充分条件,并给出控制器的设计方法.

关键词：时滞系统状态反馈控制加性时滞

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Ultrafast investigation of room temperature valley polarization in“optical bilayer”WS_(2)

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Science China(Technological Sciences) 2024年第1期67卷 91-97页

作者： ZHAO LeYi WANG hai liU TianYu li FangFei ZHOU Qiang WANG haiYu Synergetic Extreme Condition High-Pressure Science Center State Key Laboratory of Superhard MaterialsCollege of PhysicsJilin UniversityChangchun 130012China State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China

Monolayer transition metal dichalcogenides(TMDCs)have become a promising platform in valleytronics due to possessing the regulatable valley degrees of ***,as a result of the rapid intervalley scattering,it is difficult to measure the PL valley polarization of monolayer TMDCs at room temperature,which limits their application in valleytronics ***,we report a room temperature photoluminescence(PL)valley polarization up to 3.73%in an“optical bilayer”WS_(2)formed by transferring monolayer WS_(2)onto flat Ag ***,in the transient absorption(TA)measurements,a remarkably long valley depolarization lifetime is ***,we demonstrate the valley properties of such“optical bilayer”WS_(2)resemble actual bilayer WS_(2),in which the robust valley polarization can be attributed to the phonons depletion effect and the blocked interlayer hopping *** peculiar valley features in“optical bilayer”WS_(2)provide a particularly simple method to enhance valley control at room temperature.

关键词： valleytronics optical bilayer transient absorption tungsten disulfide

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A survey on dynamic graph processing on GPUs: concepts, terminologies and systems

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Frontiers of Computer Science 2024年第4期18卷 1-23页

作者： Hongru GAO Xiaofei liAO Zhiyuan SHAO Kexin li Jiajie CHEN hai JIN National Engineering Research Center for Big Data Technology and System/Services Computing Technology and System Lab/Cluster and Grid Computing Lab School of Computer Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074China Zhejiang Lab Hangzhou 311121China

Graphs that are used to model real-world entities with vertices and relationships among entities with edges,have proven to be a powerful tool for describing real-world problems in *** most real-world scenarios,entities and their relationships are subject to constant *** that record such changes are called dynamic *** recent years,the widespread application scenarios of dynamic graphs have stimulated extensive research on dynamic graph processing systems that continuously ingest graph updates and produce up-to-date graph analytics *** the scale of dynamic graphs becomes larger,higher performance requirements are demanded to dynamic graph processing *** the massive parallel processing power and high memory bandwidth,GPUs become mainstream vehicles to accelerate dynamic graph processing ***-based dynamic graph processing systems mainly address two challenges:maintaining the graph data when updates occur(i.e.,graph updating)and producing analytics results in time(i.e.,graph computing).In this paper,we survey GPU-based dynamic graph processing systems and review their methods on addressing both graph updating and graph *** comprehensively discuss existing dynamic graph processing systems on GPUs,we first introduce the terminologies of dynamic graph processing and then develop a taxonomy to describe the methods employed for graph updating and graph *** addition,we discuss the challenges and future research directions of dynamic graph processing on GPUs.

关键词： dynamic graphs graph processing graph algorithms GPUs

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Nonlinear characteristics of torsional stiffness of a coilable mast with triangular section

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Chinese Journal of Aeronautics 2024年第10期37卷 313-324页

作者： Yu liU liang SUN hai HUANG Shenyan CHEN Weipeng li Xurui ZHAO School of Astronautics Beihang UniversityBeijing 100191China Institute of Remote Sensing Satellite China Academy of Space TechnologyBeijing 100094China

With numerous applications coilable masts in high-precision astronomical observations,such as X-ray source observations,it is important to investigate mast *** date,there have been many studies on the bending stiffness of coilable masts,but few studies on their torsional stiffness,especially regarding the nonlinear characteristics of torsional stiffness of coilable masts under large torsional *** this paper,a nonlinear analysis method is presented to examine the torsional stiffness of coilable masts with triangular *** on the second-order bending buckling hypothesis of battens under large torsion deformation,the nonlinear relationship between torsional torque and torsional angle is obtained by analyzing torsional deformation and force of coilable *** method is used to analyze the torsional stiffness nonlinearity of a certain type of coilable mast which will be used in a practical application in the future and the results are verified by simulation and *** comparison results show that the error is within the acceptable range,which proves the effectiveness of the proposed method.

关键词： Coilable mast Torsion testing Torsional stiffness nonlinearity Torsional deformation Torsion simulation

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