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Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： jing Wang Bing Zhang Lanfang li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang liu Youming Lu Xinyan li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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FUBP3 mediates the amyloid-β-induced neuronal NLRP3 expression

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Neural Regeneration Research 2025年第7期20卷 2068-2083页

作者： jing Yao Yuan li Xi liu Wenping liang Yu li liyong Wu Zhe Wang Weihong Song The National Clinical Research Center for Geriatric Disease Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Neurology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan ProvinceChina Department of Neurosurgery Xuanwu HospitalCapital Medical UniversityBeijingChina Department of Pediatrics The Second Affiliated Hospital and Yuying Children’s HospitalKey Laboratory of Alzheimer’s Disease of Zhejiang ProvinceInstitute of AgingWenzhou Medical UniversityWenzhouZhejiang ProvinceChina Oujiang Laboratory(Zhejiang Laboratory for Regenerative Medicine Visionand Brain Health)WenzhouZhejiang ProvinceChina

Alzheimer's disease is characterized by deposition of amyloid-β,which forms extracellular neuritic plaques,and accumulation of hyperphosphorylated tau,which aggregates to form intraneuronal neurofibrillary tangles,in the *** NLRP3 inflammasome may play a role in the transition from amyloid-βdeposition to tau phosphorylation and *** NLRP3 is primarily found in brain microglia,and tau is predominantly located in neurons,it has been suggested that NLRP3 expressed by microglia indirectly triggers tau phosphorylation by upregulating the expression of pro-inflammatory ***,we found that neurons also express NLRP3 in vitro and in vivo,and that neuronal NLRP3 regulates tau *** biochemical methods,we mapped the minimal NLRP3 promoter and identified FUBP3 as a transcription factor regulating NLRP3 expression in *** primary neurons and the neuroblastoma cell line Neuro2A,FUBP3 is required for endogenous NLRP3 expression and tau phosphorylation only when amyloid-βis *** the brains of aged wild-type mice and a mouse model of Alzheimer's disease,FUBP3 expression was markedly increased in cortical *** analysis suggested that FUBP3 plays a role in neuron-mediated immune *** also found that FUBP3 trimmed the 5′end of DNA fragments that it bound,implying that FUBP3 functions in stress-induced *** findings suggest that neuronal NLRP3 may be more directly involved in the amyloid-β-to–phospho-tau transition than microglial NLRP3,and that amyloid-βfundamentally alters the regulatory mechanism of NLRP3 expression in *** that FUBP3 was only expressed at low levels in young wild-type mice and was strongly upregulated in the brains of aged mice and Alzheimer's disease mice,FUBP3 could be a safe therapeutic target for preventing Alzheimer's disease progression.

关键词： 5′end trimming Alzheimer's disease amyloid-beta amyloid-β-dependent transcription FUBP3 inflammasome inflammation neuron NLRP3 tau transcription factor

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我所亲历的水利建设及涌潮研究--林炳尧访谈录(下篇)

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浙江水利科技 2020年第2期48卷 75-79页

作者：李海静(访谈整理) 浙江水利水电学院水文化研究所浙江杭州310018

1964年,林炳尧被分配到长江流域规划办公室工作,参与了这一时期即将开展的长江三峡工程前期勘探工作。期间,与国内多位知名水利专家相识相交于此。访谈录分为上、下2篇。下篇讲述林炳尧来到杭州,从事钱塘江河口治理和涌潮研究工作的经... 详细信息

1964年,林炳尧被分配到长江流域规划办公室工作,参与了这一时期即将开展的长江三峡工程前期勘探工作。期间,与国内多位知名水利专家相识相交于此。访谈录分为上、下2篇。下篇讲述林炳尧来到杭州,从事钱塘江河口治理和涌潮研究工作的经历和研究心得。

关键词：林炳尧钱塘江涌潮研究

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硅、UVB及镉胁迫对玉米种子萌发的影响

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种子 2010年第12期29卷 106-107页

作者：郭彦杨洪双李海静聊城大学生命科学学院山东聊城252059

以郑单958玉米种子为材料,采用水培法,用2.5 mmol/L硅酸钠、5 mg/L氯化镉、3 h UVB单独或复合处理种子,每天定时测发芽率,处理7天后,测根长、芽长及鲜重。结果表明：24 h以前各处理均表现为促进作用,作用效果依次为Cd〉UVB〉Si。在24-4... 详细信息

以郑单958玉米种子为材料,采用水培法,用2.5 mmol/L硅酸钠、5 mg/L氯化镉、3 h UVB单独或复合处理种子,每天定时测发芽率,处理7天后,测根长、芽长及鲜重。结果表明：24 h以前各处理均表现为促进作用,作用效果依次为Cd〉UVB〉Si。在24-48 h之间每个处理的发芽率都表现出直线上升的趋势。在52 h以后各组的发芽率基本上趋向稳定并达到最大值。硅酸钠与氯化镉共同作用时对玉米种子的发芽率促进作用最明显,而硅酸钠与UVB的抑制作用最明显。Cd及其Si、Cd共同作用对玉米幼苗的根长、芽长、鲜重都有抑制作用。

关键词：玉米 UVB 根长芽长鲜重

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基于Ergun方程的微灌砂颗粒形状系数测定方法研究

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节水灌溉 2020年第12期 1-5页

作者：李景海翟国亮刘清霞李国强安阳工学院土木与建筑工程学院河南安阳455000 中国农业科学院农田灌溉研究所河南新乡453002 安阳市第一中学河南安阳455000

形状系数表征石英砂颗粒与理想球体的差异程度,是影响砂滤层过滤水头损失和孔隙率的重要参数。为了对砂颗粒的形状特征进行准确描述,本文采用体积和砂颗粒相同的圆球外表面积与砂颗粒外表面积之比作为砂颗粒的形状系数,以粒径范围分别为... 详细信息

形状系数表征石英砂颗粒与理想球体的差异程度,是影响砂滤层过滤水头损失和孔隙率的重要参数。为了对砂颗粒的形状特征进行准确描述,本文采用体积和砂颗粒相同的圆球外表面积与砂颗粒外表面积之比作为砂颗粒的形状系数,以粒径范围分别为1.18~1.4 mm和1.4~1.7 mm,厚度为400 mm的2种石英砂滤层为研究对象。首先,通过开展清水过滤试验,测量了滤层过滤速度及相应压降,采用注水法测量了滤层孔隙率,根据砂颗粒平均质量,计算了砂颗粒等体积当量直径。然后,根据多孔介质中液相动量方程,结合砂滤层过滤特征,对Ergun方程进行了推导,从理论上说明了Ergun方程对砂滤层的适用性。最后,根据Ergun方程,得出了砂颗粒等比外表面积当量直径,为了消除湍流对测量结果的影响,采用湍流强度对计算结果进行修正,最终得到2种滤层砂颗粒形状系数分别为0.821和0.798,最大相对误差仅为2.44,说明计算方法可行。计算结果表明,由于砂颗粒表面流动滞缓边界层的存在,随过滤速度的增加,等比外表面积当量直径计算结果呈减小趋势。同时,随过滤速度的增加,湍流稳定性逐渐增强,湍流强度则随之减小。为保证形状系数计算结果的准确性,清水过滤试验时,过滤速度的选取,应以湍流强度不低于10为控制范围。研究结论为砂滤料的选型和加工提供了技术参考。

关键词：微灌砂过滤器石英砂滤层阻力压降形状系数过滤速度多孔介质 Ergun方程

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马铃薯全粉食品研究进展

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食品工业科技 2019年第20期40卷 363-367页

作者：赵晶时东杰屈岩峰王红梅李景海黑龙江东方学院黑龙江哈尔滨150066 黑龙江省佳明佳营养食品股份有限公司黑龙江哈尔滨150078

当前国家对马铃薯主粮化和居民营养健康高度重视,使得马铃薯全粉及其食品成为广大学者的研究热点。本文以马铃薯全粉及其加工的食品为综述对象,在广泛调研文献特别是马铃薯全粉食品研究的最新成果基础上,对马铃薯全粉食品的研究进行了... 详细信息

当前国家对马铃薯主粮化和居民营养健康高度重视,使得马铃薯全粉及其食品成为广大学者的研究热点。本文以马铃薯全粉及其加工的食品为综述对象,在广泛调研文献特别是马铃薯全粉食品研究的最新成果基础上,对马铃薯全粉食品的研究进行了分析总结,阐述了马铃薯全粉的营养价值、功能特性、国内加工研究现状和马铃薯全粉食品的研究现状,并对马铃薯全粉食品发展方向进行了展望。为我国早日实现马铃薯主粮化和“健康中国2030”规划提供参考。

关键词：食品马铃薯全粉主粮化

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Highly conductive and stable iodine doped argyrodite electrolyte for all-solid-state lithium batteries

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Journal of Energy Chemistry 2025年第1期100卷 50-58页

作者： Gaozhan liu jing Zhang jing Yang jinghui Chen Xingyue Xiao Xiayin Yao Ningbo Institute of Materials Technology and Engineering Chinese Academy of Sciences Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences

lithium argyrodites with high ionic conductivity and low cost are considered as one of the most prospective solid electrolytes for all-solid-state lithium ***,the poor chemical stability and compatibility with lithium metal limit their ***,li5.4PS4.4Cl1.4I0.2solid electrolyte with high ionic conductivity of 11.49 m S cm-1and improved chemical stability is synthesized by iodine *** ultra-thin li5.4PS4.4Cl1.4I0.2membrane with thickness of 10μm can be obtained by wet coating process,exhibiting a high ionic conductivity of 2.09 mS cm-1and low areal resistance of 1.17Ω***,iodine doping could in-situ form liI at the lithium/electrolyte interface and improve the critical current density of li5.4PS4.4Cl1.6from 0.8 to 1.35 mA *** resultant liCoO2/li5.4PS4.4Cl1.4I0.2/li battery shows excellent cycling stability at 1 C,with a reversible specific capacity of 110.1 mA h g-1and a retention of 80.5% after 1000 *** addition,the assembled liCoO2/li5.4PS4.4Cl1.4I0.2membrane/li pouch cell delivers an initial discharge capacity of 110.4 mA h g-1and 80.5% capacity retention after 100 cycles.

关键词： Argyrodite electrolytes Iodine doping Ionic conductivity Stability All-solid-state lithium battery

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抑制氮氧化物排放的无烟燃煤技术及其在窑炉改造中的应用

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过程工程学报 2001年第1期1卷 95-98页

作者：徐有宁宋文立白蕴如张建国林伟刚李静海中国科学院化工冶金研究所多相反应开放实验室北京100080

抑制NO排放的无烟燃煤技术能够同时降低NO和烟黑的排放, 提高燃烧效率. 本文介绍了该技术用于窑炉改造的实例，并对改造前后的污染物排放结果进行了讨论.

关键词：窑炉氮氧化物一氧化碳烟黑污染控制无烟燃煤技术

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超声辅助酶法制备海参性腺ACE抑制肽及其模拟体内消化稳定性的研究

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食品研究与开发 2021年第16期42卷 83-91页

作者：李文欣李海静张立娟孙方达黑龙江八一农垦大学黑龙江大庆163711 东北农业大学食品学院黑龙江哈尔滨150030 天津市食品研究所有限公司天津301609

该研究利用超声波技术(0~500 W,0~35 min)辅助中性蛋白酶(0.5%~5%,1 h~6 h,1 500 U/g~7 500 U/g)水解海参性腺制备血管紧张素转化酶(angiotensin convert enzyme,ACE)抑制肽,再经过模拟体内消化试验分析海参性腺ACE抑制肽的消化稳定性... 详细信息

该研究利用超声波技术(0~500 W,0~35 min)辅助中性蛋白酶(0.5%~5%,1 h~6 h,1 500 U/g~7 500 U/g)水解海参性腺制备血管紧张素转化酶(angiotensin convert enzyme,ACE)抑制肽,再经过模拟体内消化试验分析海参性腺ACE抑制肽的消化稳定性。试验结果表明:随着超声功率、超声时间、底物浓度、酶解时间和酶添加量的增加,ACE抑制率先增加后降低。随超声功率、超声时间和底物浓度的增加,水解度具有相同的变化趋势;随着酶解时间和加酶量的增加,水解度逐渐上升后趋于平稳。根据水解度和ACE抑制率得出可以高效制备海参性腺ACE抑制肽的超声预处理和酶解反应条件:超声预处理功率200 W,时间15 min,底物浓度2%,酶添加量4 500 U/g,酶解时间2 h,海参性腺酶解液的水解度和ACE抑制率均较高,分别为7.81%和73.81%。此条件下制备的海参性腺ACE抑制肽经超滤后进行胃肠模拟消化试验,消化前后海参性腺ACE抑制肽的活性无显著性差异(P>0.05),表明其在体内能够表现出良好的稳定性,具有稳定的降血压功效。

关键词：超声波酶解海参性腺 ACE抑制肽消化稳定性

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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： Wen Gao jing-Wen li Hui Ye Xue-Zhi Zhang Jian-Xiang liu Hong Cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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