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化工冶金 2000年第2期21卷 133-138页

作者：韩龙宋文立李静海中国科学院化工冶金研究所多相反应开放实验室北京100080

建立了循环流化床轴向“Ｓ”型分布过渡段高度的计算模型，实现了仅由操作条件和物料性质计算过渡段长度及对应的空隙率分布．与几种体系实验值的比较表明，模型计算结果与实际吻合较好．

关键词：循环流化床 EMMS模型轴向过渡段空隙率分布

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论重复投资的标准界定与促进产业竞争

特区经济 2005年第7期 326-327页

作者：李景海暨南大学经济学院

一、我国经济的投资现状和面临的问题建国初期,我国国民经济投资单纯在积累和消费的比例上做文章,长期实行高积累、低消费、低效益甚至不顾简单再生产的维持(对老企业长期不留折旧、不更新设备),只顾铺新摊子,搞外延式重复建设扩大规模... 详细信息

一、我国经济的投资现状和面临的问题建国初期,我国国民经济投资单纯在积累和消费的比例上做文章,长期实行高积累、低消费、低效益甚至不顾简单再生产的维持(对老企业长期不留折旧、不更新设备),只顾铺新摊子,搞外延式重复建设扩大规模的恶性循环.

关键词：重复投资标准产业竞争中国产业结构技术创新资源配置

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农业部继续落实惠民工程奶牛良种补贴1亿元

中国畜牧杂志 2007年第12期43卷 15-16页

作者：李海晶《中国畜牧杂志》记者

奶牛良种问题成为制约我国奶业快速发展的主要因素之一。为加快我国的良种改良速度,中央1号文件明确提出:“从2005年起实施奶牛良种繁育项目补贴”。在刚刚结束的“2007年奶牛良种补贴项目管理培训班”上,代表们就奶牛良种补贴项目实施... 详细信息

奶牛良种问题成为制约我国奶业快速发展的主要因素之一。为加快我国的良种改良速度,中央1号文件明确提出:“从2005年起实施奶牛良种繁育项目补贴”。在刚刚结束的“2007年奶牛良种补贴项目管理培训班”上,代表们就奶牛良种补贴项目实施2年来所取得的成绩和面临的问题进行交流。从本期开始,有关奶牛良种补贴项目内容,我们将对其做连续报道。

关键词：良种覆盖率奶牛改良财政补贴农业部畜牧业结构工程持续健康发展生产效率

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li hai Zhu Dong Wang jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong jing-jing Hu Yan Yu Xiao-li li Xiao-Ting Sun li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia Yang Qian-Ru He Fei Ding hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

从“防”到“治”——国民政府时期钱塘江防治理念的发展

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上海交通大学学报（哲学社会科学版） 2017年第5期25卷 81-89页

作者：李海静石云里中国科学技术大学科技史与科技考古系安徽合肥230026 中国水利博物馆浙江杭州310025

对于钱塘江的涌潮和江道变迁灾害,清代之前人们所奉行的一直是以"防"为主的理念,导致了海塘的修筑。伴随西方治水理念和治水技术的传入,国民政府时期,工程技术专家提出以"治"代"防",通过实施江道整治实现治本的目的。由此,钱塘江防治理... 详细信息

对于钱塘江的涌潮和江道变迁灾害,清代之前人们所奉行的一直是以"防"为主的理念,导致了海塘的修筑。伴随西方治水理念和治水技术的传入,国民政府时期,工程技术专家提出以"治"代"防",通过实施江道整治实现治本的目的。由此,钱塘江防治理念从"防"转为"治"。本文通过梳理史料,阐述了国民政府时期钱塘江防治理念的演变发展过程,探析不同时期防治理念的内容及其产生的影响。

关键词：国民政府时期钱塘江防治工程防治理念

Increase in the variability of terrestrial carbon uptake in response to enhanced future ENSO modulation

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 32-38页

作者： Younong li li Dan jing Peng Qidong Yang Fuqiang Yang Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric Environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El Niño-Southern Oscillation(ENSO)is a major driver of climate change in middle and low latitudes and thus strongly influences the terrestrial carbon cycle through land-air *** the ENSO modulation and carbon flux variability are projected to increase in the future,but their connection still needs further *** investigate the impact of future ENSO modulation on carbon flux variability,this study used 10 CMIP6 earth system models to analyze ENSO modulation and carbon flux variability in middle and low latitudes,and their relationship,under different scenarios simulated by CMIP6 *** results show a high consistency in the simulations,with both ENSO modulation and carbon flux variability showing an increasing trend in the *** higher the emissions scenario,especially SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** flux variability in the middle and low latitudes under SSP2-4.5 increases by 30.9%compared to historical levels during 1951-2000,while under SSP5-8.5 it increases by 58.2%.Further analysis suggests that ENSO influences mid-and low-latitude carbon flux variability primarily through *** occurrence may potentially be attributed to the increased responsiveness of gross primary productivity towards regional temperature fluctuations,combined with the intensified influence of ENSO on land surface temperatures.

关键词： Carbon variability ENSO modulation CMIP6 models

高渗盐水制作角膜上皮瓣的准分子激光角膜上皮瓣下磨镶术治疗近视的疗效观察

维普期刊数据库评论

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中华眼科杂志 2007年第1期43卷 23-26页

作者：李艳雷玉琳李镜海山东省立医院眼科济南250021 山东大学医学院山东大学齐鲁医院眼科

目的探讨5％高渗盐水制作角膜上皮瓣的准分子激光上皮下角膜磨镶术（LASEK）手术治疗中、低度近视的疗效。方法收集2005年1至11月在我院眼科行LASEK手术的中低度近视患者48例（96只眼），分为两组。第一组22例（44只眼），术中使用20％... 详细信息

目的探讨5％高渗盐水制作角膜上皮瓣的准分子激光上皮下角膜磨镶术（LASEK）手术治疗中、低度近视的疗效。方法收集2005年1至11月在我院眼科行LASEK手术的中低度近视患者48例（96只眼），分为两组。第一组22例（44只眼），术中使用20％乙醇（A-LASEK）制作上皮瓣；第二组26例（52只眼），术中采用5％高渗盐水（HS-LASEK）制作上皮瓣。观察角膜上皮修复时间及术后裸眼视力、屈光度数及角膜上皮下雾状混浊，随访时间为6个月。结果所有患者术中、术后均无严重并发症发生。术后A-LASEK患者上皮修复时间平均为（4．52±0．21）d，HS-LASEK患者为（3．84±0．39）d，两组比较差异有统计学意义（P＜0．05）。摘除角膜接触镜后两组患者视力较术前明显提高，术后3d视力达到0．8者A-LASEK组为12只眼（27．3％）。***组为25眼（48．1％），其差异有统计学意义（P＜0．05）。术后1个月A-LASEK患者有13只眼（29．5％）出现角膜上皮下雾状混浊，HS-LASEK患者有15只眼（28．8％）出现角膜上皮下雾状混浊。但均低于0．5级。不影响患者视力，至术后3个月角膜上皮下雾状混浊发生率均为10％，两组间比较差异无统计学意义（P＞0．05）。术后1d A-LASEK患者12只眼（27．3％）有明显的疼痛；HS-LASEK患者仅有6只眼（11．5％）有明显的疼痛，两组问比较差异有统计学意义（P＜0．05）。结论使用高渗盐水的LASEK手术治疗中、低度近视安全、有效。在减轻术后疼痛及角膜上皮下雾状混浊方面优于乙醇制作上皮瓣的LASEK。

关键词：角膜切削术上皮下激光盐水高渗近视

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气固两相流介尺度LBM-DEM模型

计算力学学报 2015年第5期32卷 685-692页

作者：王利民邱小平李静海中国科学院过程工程研究所多相复杂系统国家重点实验室北京100190 中国科学院大学北京100049

LBM-DEM耦合方法通常是指一种颗粒流体系统直接数值模拟算法,即是一种不引入经验曳力模型的计算方法,颗粒尺寸通常比计算网格的长度大一个量级,颗粒的受力通过表面的粘性力与压力积分获得,其优点是能描述每个颗粒周围的详细流场,产生详... 详细信息

LBM-DEM耦合方法通常是指一种颗粒流体系统直接数值模拟算法,即是一种不引入经验曳力模型的计算方法,颗粒尺寸通常比计算网格的长度大一个量级,颗粒的受力通过表面的粘性力与压力积分获得,其优点是能描述每个颗粒周围的详细流场,产生详细的颗粒-流体相互作用的动力学信息,可以探索颗粒流体界面的流动、传递和反应的详细信息及两相相互作用的本构关系,但其缺点是计算量巨大,无法应用于真实流化床过程模拟。本文针对气固流化床中的流体以及固体颗粒间的多相流体力学行为,建立了一种稠密气固两相流的介尺度LBMDEM模型,即LBM-DEM耦合的离散颗粒模型,实现在颗粒尺度上流化床的快速离散模拟。该耦合模型采用格子玻尔兹曼方法(LBM)描述气相的流动和传递行为,离散单元法(DEM)用于描述颗粒相的运动,并利用能量最小多尺度(EMMS)曳力解决气固耦合不成熟问题,以提高其模拟精度。通过经典快速流态化的模拟,验证了介尺度LBM-DEM耦合模型的有效性。模拟结果表明介尺度LBM-DEM模型是一种探索实验室规模气固系统的有力手段。

关键词：介尺度离散颗粒模型格子玻尔兹曼方法离散单元法 EMMS 曳力

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产业集聚经验研究进展及展望

经济问题探索 2010年第11期 130-136页

作者：李景海陈雪梅南方医科大学广州510515 暨南大学经济学系广州510632

理论形成和推进需要经验研究的证实。经验研究对象的多样性带来困难和挑战。本文指出了产业集聚经验研究的主要理论来源及面对的困难和挑战,通过回顾国内外对产业集聚经验研究的成果,归纳了经验研究的三条主线,并提出了未来需要进一步... 详细信息

理论形成和推进需要经验研究的证实。经验研究对象的多样性带来困难和挑战。本文指出了产业集聚经验研究的主要理论来源及面对的困难和挑战,通过回顾国内外对产业集聚经验研究的成果,归纳了经验研究的三条主线,并提出了未来需要进一步研究的方向。

关键词：产业集聚经验研究市场潜力技术溢出收入差距