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Yixin Ningshen Tablet Alleviates Comorbidity of Myocardial Infarction and Depression by Enhancing Myocardial Energy Metabolism and Increasing Availability of Monoamine Neurotransmitter

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Chinese Journal of Integrative Medicine 2022年第7期28卷 586-593页

作者： JIANG Bing WU Ruo-ming li hai-dong li Kun li Hui DANG Wen-zhen FENG Gui-ze BAO Wei-lian YE Guan SHEN Xiao-yan Department of Pharmacology School of PharmacyFudan UniversityShanghai 200120China Department of Pharmacology of Chinese Materia Medica School of Traditional Chinese MedicineGuangdong Pharmaceutical UniversityGuangzhou 510006China Central Research Institute Shanghai Pharmaceuticals Holding Co.Ltd.Shanghai 200120China

Objective: To investigate the therapeutic effect of Yixin Ningshen Tablet(YXNS) on comorbidity of myocardial infarction(MI) and depression in rats and explore the underlying mechanism. Methods: The Sprague-Dawley rats were randomly divided into 5 groups with 7 rats in each group according to their weights,including control, model, fluoxetine(FLXT, 10 mg/kg), low-dose YXNS(LYXNS, 100 mg/kg), and high-dose YXNS(HYXNS, 300 mg/kg) groups. All rats were pretreated with corresponding drugs for 12 weeks. The rat model of MI and depression was constructed by ligation of left anterior descending coronary artery and chronic mild stress stimulation. The echocardiography, sucrose preference test, open field test, and forced swim test were performed. Myocardial infarction(MI) area and myocardial apoptosis was also detected. Serum levels of interleukin(IL)-6, IL-1β, tumor necrosis factor-α(TNF-α), 5-hydroxytryptamine(5-HT), adrenocorticotrophic hormone(ACTH), corticosterone(CORT), and norepinephrine(NE) were determined by enzyme linked immunosorbent assay. The proteins of adenosine 5’-monophosphate-activated protein kinase(AMPK), p-AMPK,peroxisome proliferator-activated receptor gamma coactivator-1α(PGC-1α), and nuclear respiratory factor 1(NRF1) in heart were detected by Western blot analysis. The expression levels of TNF-α, IL-6, indoleamine 2,3-dioxygenase(IDO1), kynurenine 3-monooxygenase(KMO), and kynureninase(KYNU) in hippocampus were detected by real-time quantitative polymerase chain reaction. Results: Compared with the model group,the cardiac function of rats treated with YXNS significantly improved(P<0.01). Meanwhile, YXNS effectively reduced MI size and cardiomyocytes apoptosis of rats(P<0.01 or P<0.05), promoted AMPK phosphorylation,and increased PGC-1α protein expression(P<0.01 or P<0.05). HYXNS significantly increased locomotor activity of rats, decreased the levels of TNF-α, IL-6 and IL-1β, and increased the serum levels of 5-HT, NE, ACTH,and CORT(all P<0.05). More

关键词： Yixin Ningshen Tablet depression cardiovascular disorders inflammatory factor monoamine neurotransmitter kynurenine pathway Chinese medicine

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球磨机制粉系统的线性自抗扰控制

工程科学学报 2015年第4期37卷 509-516页

作者：董君伊孙立李东海清华大学热能工程系电力系统国家重点实验室北京100084

球磨机制粉系统具有大惯性、大时滞和强耦合等特点,很难建立精确的数学模型.本文分析了球磨机制粉系统的动态特性,并为其设计分散线性自抗扰控制方案.该方案综合分散控制和线性自抗扰控制器的优点,结构简单,不依赖于对象精确模型,可以... 详细信息

球磨机制粉系统具有大惯性、大时滞和强耦合等特点,很难建立精确的数学模型.本文分析了球磨机制粉系统的动态特性,并为其设计分散线性自抗扰控制方案.该方案综合分散控制和线性自抗扰控制器的优点,结构简单,不依赖于对象精确模型,可以对被控对象中存在的耦合、干扰和不确定性等进行估计并补偿.根据实际现场要求,对球磨机制粉系统进行设定值跟踪实验、输入扰动实验和性能鲁棒性实验,并比较所设计方案与PID方案的控制性能.结果表明,分散线性自抗扰控制具有更强的解耦能力和抗干扰能力,且性能鲁棒性更优.

关键词：球磨机制粉干扰抑制线性控制系统解耦鲁棒性

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基于马尔科夫链蒙特卡罗的时延估计算法

物理学报 2014年第13期63卷 59-65页

作者：李晶赵拥军李冬海解放军信息工程大学导航与空天目标工程学院郑州450001

针对无源雷达中时延估计辐射源信号未知的情况,构建了一种新的时延最大似然估计模型.根据模型特点利用快速傅里叶变换(FFT)的计算方法实现时延估计.为了提高估计的精度,采用马尔科夫链蒙特卡罗(MCMC)抽样的方法估计时延值.该方法不需峰... 详细信息

针对无源雷达中时延估计辐射源信号未知的情况,构建了一种新的时延最大似然估计模型.根据模型特点利用快速傅里叶变换(FFT)的计算方法实现时延估计.为了提高估计的精度,采用马尔科夫链蒙特卡罗(MCMC)抽样的方法估计时延值.该方法不需峰值检测,可直接给出时延估计结果.并推导了该模型下的时延估计的克拉美罗界(CRLB).仿真实验表明,MCMC算法可适用于窄带和宽带信号的时延估计;在样本相同的条件下,MCMC算法估计精度高于重要性采样(IS)算法和基于峰值检测的ML算法,计算复杂度低于IS算法,且MCMC算法可直接估计采样间隔非整数倍的时延.

关键词：时延估计最大似然马尔科夫蒙特卡罗计算复杂度

一类热工过程分布参数模型的PID控制仿真研究

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系统仿真学报 2008年第9期20卷 2382-2386页

作者：陈星李东海清华大学热能动力仿真与控制研究所热科学与动力工程教育部重点实验室北京100084

分布参数系统普遍存在于热工过程中,PID是普遍采用的控制方法,因此有必要研究分布参数对象的PID控制问题。一般的PID控制器设计方法需要将分布参数模型简化为集总参数模型并降阶,这样就引入了模型误差;基于遗传算法的PID控制器优化设计... 详细信息

分布参数系统普遍存在于热工过程中,PID是普遍采用的控制方法,因此有必要研究分布参数对象的PID控制问题。一般的PID控制器设计方法需要将分布参数模型简化为集总参数模型并降阶,这样就引入了模型误差;基于遗传算法的PID控制器优化设计方法(GAOPT)不受模型限制,可以直接基于分布参数模型进行控制器设计。利用GAOPT方法设计了一类分布参数模型的PID控制器。仿真结果表明,GAOPT方法比常规方法可以获得在超调量、调节时间、ITAE和性能鲁棒性等指标上都较优的控制效果;同时,基于分布参数模型的控制器比基于近似模型的控制器的控制效果有明显改善。

关键词： PID控制分布参数系统遗传算法 Monte-Carlo方法

Surgical Treatment of Complete Transposition of the Great Arteries in Newborn

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Chinese Medical Journal 2016年第19期129卷 2381-2383页

作者： Qing-Yu Wu dong-hai li Hui Xue Zhong-Hua Xu Hong-Yin li Ming-Kui Zhang First Hospital of Tsinghua University Medical Center Tsinghua University Beijing 100016 China

INTRODUCTION Complete transposition of the great arteries （TGAs）is a common cyanotic congenital heart defect,with an incidence rate of 0.02%,accounting for 5-7% of congenital heart diseases.[1] After birth,infants with TGA largely rely on ventricular septal defect （VSD）,atrial septal defect （ASD）,and patent ductus arteriosus （PDA）to sustain *** systemic-pulmonary shunt and surgical correction,these infants will probably die on the day after birth.

关键词： Newborn Switch Operation Transposition of the Great Arteries

Surgical Treatment of Double Outlet Right Ventricle Complicated by Pulmonary Hypertension

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Chinese Medical Journal 2017年第4期130卷 409-413页

作者： Qing-Yu Wu dong-hai li Hong-Yin li Ming-Kui Zhang Zhong-Hua Xu Hui Xue Department of Cardiology The First Hospital of Tsinghua University Medical Center Tsinghua University Beijing 100016 China

Background： Double outlet right ventricle （DORV） is a group of complex congenital heart abnormalities. Preoperative pulmonary hypertension （PH） is considered an important risk factor for early death during the surgical treatment of DORV. The aim of this study was to report our experience on surgical treatment of DORV complicated by PH. Methods： From June 2004 to November 2016, 61 patients （36 males and 25 females） aged 2 weeks to 26 years （median： 0.67 years and interquartile range： 0.42-1.67 years） with DORV （two great arteries overriding at least 50%） complicated by PH underwent surgical treatment in our center. All patients were categorized according to surgical age and lesion type, respectively. Pulmonary artery systolic pressure （PASP）, pulmonary artery diastolic pressure （PADP）, and mean pulmonary artery pressure （mPAP） were measured directly before cardiopulmonary bypass （CPB） was established and after CPB was removed. An intracardiac channel procedure was performed in 37 patients, arterial switch procedure in 19 patients, Rastelli procedure in three patient, Senning procedure in one patients, and Mustard procedure in one patient. The Student＇s t-test and Chi-squared test were performed to evaluate clinical outcomes of the surgical timing and operation choice. Results： Fifty-five patients had uneventful recovery. PASP fell from 55.3 ± 11.2 mmHg to 34.7±11.6 mmHg （t = 14.05, P 〈 0.001）, PADP fell from 29.7 ± 12.5 mmHgto 18.6± 7.9 mmHg （t = 7.39,P〈 0.001）, and mPAP fell from 40.3 ± 10.6 mmHgto25.7 ± 8.3 mmHg （t= 11.85, P 〈 0.001）. Six （9.8%） patients died owing to complications including low cardiac output syndrome in two patients, respiratory failure in two, pulmonary hemorrhage in one, and sudden death in one patient. Pulmonary artery pressure （PAP） dropped significantly in infant and child patients. Mortality of both infants （13.9%） and adults （33.3%） was high. Conclusions： PAP of patients with DORV complicated by PH can be expected to fall significantly aft

关键词： Congenital Heart Disease Double Outlet Right Ventricle Pulmonary Hypertension

基于灰色关联理论和距离协同模型的区域协同发展评价方法及实证

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系统工程理论与实践 2014年第7期34卷 1749-1755页

作者：李海东王帅刘阳中国科学技术大学管理学院合肥230026

对区域协同发展程度进行评价是有效促进区域协同发展的前提和指导.在分析现有研究现状,总结了定量研究两类思想的基础上,论文结合TOPSIS思想和灰色关联理论对距离协同模型进行改进,构建了新的区域协同发展程度评价方法.该方法引入理想... 详细信息

对区域协同发展程度进行评价是有效促进区域协同发展的前提和指导.在分析现有研究现状,总结了定量研究两类思想的基础上,论文结合TOPSIS思想和灰色关联理论对距离协同模型进行改进,构建了新的区域协同发展程度评价方法.该方法引入理想规划值,运用相对距离比来衡量区域系统发展度;运用各个子系统间的灰色关联度来确定子系统间的拉动因子,进而得出理想发展度和协同度,弥补了距离协同模型的两处不足.利用此方法对皖江城市带的协同发展进行了实证分析,实证结果表明皖江城市带的整体协同发展度呈上升趋势,但程度较低,发展度远远低于协同度;经济子系统对其它子系统有显著拉动作用,同时是皖江区域发展中的瓶颈因素;承接产业转移对皖江区域的协同发展有显著促进作用.

关键词：协同发展灰色关联理论距离协同模型皖江城市带

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li hai Zhu dong Wang Jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong li Hui-Min Xing hai-dong Qian Qiao Gao Sheng-Lan Xu Hua Ma Zai-Long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles