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Effect of droplet cha.acteristics on liquid-pha.e distribution in spray zone of internal mixing air-mist nozzle

China Foundry 2024年第2期21卷 185-196页

作者： Wei-li Wu Cha.g-gui Cheng Yang li Shi-fa Wei De-li Chen The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081China Hubei Provincial Key Laboratory for New Processes of Ironmaking and Steelmaking Wuhan University of Science and TechnologyWuhan 430081China Technology Center Fushun Special Steel Co.Ltd.Fushun 113001LiaoningChina

In continuous casting production,droplet cha.acteristics are important parameters for evaluating the nozzle atomization quality,and ha.e a significant impact on the secondary cooling effect and the slab *** order to study the beha.ior of atomized droplets after reaching the slab surface and to optimize the spray cooling effect,the influence of droplet diameter and droplet velocity on the migration beha.ior of droplets in the secondary cooling zone was analyzed by FLUENT *** show tha. the droplets in the spray zone and on the slab surface are mainly concentrated in the center,thus,the liquid volume fraction in the center is higher tha. tha. of either *** the droplet diameter increases,the region of high liquid volume fraction on the slab surface becomes wider,and the liquid pha.e distribution in the slab width direction becomes *** increasing the droplet velocity at the nozzle exit ha. little effect on droplet diffusion in the spray zone,the distribution becomes more uneven due to more liquid reaches the slab surface per unit time.A prediction formula of the maximum water flow rate on the slab surface for specific droplet cha.acteristics was proposed based on dimensionless analysis and validated by simulated data.A nozzle spacing of 210 mm was recommended under the working conditions in this study,which ensures effective coverage of the spray water over the slab surface and enha.ces the distribution uniformity of water flow rate in the transverse direction.

关键词： continuous casting secondary cooling zone internal mixing air-mist nozzle droplet cha.acteristics liquid pha.e distribution water flow rate

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Prediction models of burst strength degradation for casing with considerations of both wear and corrosion

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Petroleum Science 2024年第1期21卷 458-474页

作者： Jie-li Wang Wen-Jun Huang De-li Gao MOE Key Laboratory of Petroleum Engineering China University of PetroleumBeijing102249China State Key Laboratory of Petroleum Resources and Prospecting China University of PetroleumBeijing102249China

Casing wear and casing corrosion are serious problems affecting casing integrity failure in deep and ultra-deep *** paper aims to predict the casing burst strength with considerations of both wear and ***,the crescent wear sha.e is simplified into three categories according to common mathematical ***,based on the mecha.o-electrochemical(M-E)interaction,the prediction model of corrosion depth is built with worn depth as the initial condition,and the prediction models of burst strength of the worn casing and corroded casing are ***,the accuracy of different prediction models is validated by numerical simulation,and the main influence factors on casing strength are *** last,the theoretical models are applied to an ultra-deep well in Northwest China,and the dangerous well sections caused by wear and corrosion are predicted,and the corrosion rate threshold to ensure the safety of casing is *** results show tha. the existence of wear defects results in a stress concentration and enha.ced M-E interaction on corrosion depth *** accuracy of different mathematical models is different:the slot ring model is most accurate for predicting corrosion depth,and the eccentric model is most accurate for predicting the burst strength of corroded *** burst strength of the casing will be overestimated by more tha. one-third if the M-E interaction is neglected,so the coupling effect of wear and corrosion should be sufficiently considered in casing integrity evaluation.

关键词： Deep well Casing integrity Casing wear Casing corrosion Burst strength

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OsPDR20 is an ABCG metal transporter regulating cadmium accumulation in rice

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Journal of Environmental Sciences 2024年第2期136卷 21-34页

作者： He li Cha. li Di Sun Zhi Min Yang Department of Biochemistry and Molecular Biology College of Life SciencesNanjing Agricultural UniversityNanjing 210095China

Cadmium(Cd)is a non-essential toxic heavy metal,seriously posing high environmental risks to human *** genetic resources relevant to functional genes is important for understanding the metal absorption and accumulation in crops and bioremediation of Cd-polluted *** study investigated a functionally uncha.acterized ATP binding cassette transporter G family(ABCG)gene encoding a Pleiotropic Drug Resistance 20(PDR20)type metal transporter which is localized to the plasma membrane of ***20 was transcriptionally expressed in almost all tissues and organs in lifespan and was strongly induced in roots and shoots of young rice under Cd *** expression of OsPDR20 in a yeast mutant ycf1 sensitive to Cd conferred cellular tolerance with less Cd *** of OsPDR20 by RNA interference(RNAi)moderately attenuated root/shoot elongation and biomass,with reduced chlorophylls in rice grown under hydroponic medium with 2 and 10μmol/L Cd,but led to more Cd accumulation.A field trial of rice grown in a realistic Cd-contaminated soil(0.40 mg/kg)showed tha. RNAi plants growth and development were also compromised compared to wild-type(WT),with smaller panicles and lower spikelet fertility but little effect on yield of ***,OsPDR20 suppression resulted in unexpectedly higher levels of Cd accumulation in rice straw including lower leaves and culm and *** results suggest tha. OsPDR20 is actively involved in Cd accumulation and homeostasis in rice *** increased Cd accumulation in the RNAi plants ha. the potential application in phytoremediation of Cd-polluted wetland soils.

关键词： Rice ABCG transporter Cadmium accumulation Phytoremediation

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Twenty years of Gendicine?rAd-p53 cancer gene therapy:The first-in-class human cancer gene therapy in the era of personalized oncology

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Genes & Diseases 2024年第4期11卷 234-245页

作者： li Qi Guiqing li Peipei li Hongwei Wang Xiaolong Fang Tongchuan He Jingjing li Affiliated Hospital of Weifang Medical University School of Clinical MedicineWeifang Medical UniversityWeifangShandong 262700China Jinming Yu Academician Workstation of Oncology Affiliated Hospital of Weifang Medical UniversityWeifangShandong 262700China Decording Therapeutics Corp Shangha 200000China Yangkun Biogroup Co. LtdNanjingJiangsu 210002China The University of Chicago ChicagoIL 60290USA

Genetic mutations in TP53 contribute to human malignancies through various *** date,there ha.e been a variety of therapeutic strategies targeting p53,including gene therapy to restore normal p53 function,mutant p53 rescue,inhibiting the MDM2-p53 interaction,p53-based vaccines,and a number of other *** review focuses on the functions of TP53 and discusses the aberrant roles of mutant p53 in various types of *** human p53 adenovirus,trademarked as Gendicine,which is the first anti-tumor gene therapy drug,ha. made tremendous progress in cancer gene *** herein discuss the biological mecha.isms by which Gendicine exerts its effects and describe the clinical re-sponses reported in clinical ***,the clinical studies suggest tha. the combination of Gendicine with chemotherapy and/or radiotherapy may produce more pronounced efficacy in slowing tumor growth and progression tha. gene therapy/chemotherapy ***,we summarize the methods of administration of recombinant human p53 adenovirus for different cancer types to provide a reference for future clinical trials.

关键词： Gendicine Gene therapy p53 mutation Recombinant p53 adenovirus TP53

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Path-Following Control With Obstacle Avoidance of Autonomous Surface Vehicles Subject to Actuator Faults

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IEEE/CAA Journal of Automatica Sinica 2024年第4期11卷 956-964页

作者： li-Ying ha. Gege Dong Tiesha. li Zhouhua Peng the School of Marine Electrical Engineering Dalian Maritime UniversityDalian 116026China the School of Automation Engineering University of Electronic Science and Technology of ChinaChengdu 611731the Navigation CollegeDalian Maritime UniversityDalian 116026 the Yangtze Delta Region Institute(Huzhou) Huzhou 313001China

This paper investigates the path-following control problem with obstacle avoidance of autonomous surface vehicles in the presence of actuator faults,uncertainty and external *** surface vehicles inevitably suffer from actuator faults in complex sea environments,which may cause existing obstacle avoidance strategies to *** reduce the influence of actuator faults,an improved artificial potential function is constructed by introducing the lower bound of actuator efficiency *** nonlinear state observer,which only depends on measurable position information of the autonomous surface vehicle,is used to address uncertainties and external *** using a backstepping technique and adaptive mecha.ism,a path-following control strategy with obstacle avoidance and fault tolerance is designed which can ensure tha. the tracking errors converge to a small neighborhood of *** with existing results,the proposed control strategy ha. the capability of obstacle avoidance and fault tolerance ***,the comparison results through simulations are given to verify the effectiveness of the proposed method.

关键词： Actuator faults autonomous surface vehicle(ASVs) improved artificial potential function nonlinear state observer obstacle avoidance

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Orientation controlled photogenerated carriers on selfsupporting CdS/Ni_(3)S_(2) paper toward photocatalytic hydrogen evolution and biomass upgrading

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Rare Metals 2024年第5期43卷 2015-2025页

作者： Xiao-Yan liu Qing Cao Gui-Xiang li Hui liu li-li Zeng li-li Zha. Bin Cha.g Xi-Wen Wang Hong liu Wei-Jia Zhou Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China Institute of Chemical Sciences and Engineering Ecole Polytechnique Federale de Lausanne1015LausanneSwitzerland KAUST Catalysis Center King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia School of Environment and Energy South China University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou 510006China State Key Laboratory of Crystal Materials Shandong UniversityJinan250100China School of Mecha.ical Engineering Xi'an Jiaotong UniversityXi'an 710054China

The appropriate regulation of band structure is an effective strategy in constructing efficient photocatalytic *** photocatalytic system mainly employs powder photocatalysts,which makes their recovery reliant on expensive separation processes and severely limits their industrial ***,we constructed a novel CdS/Ni_(3)S_(2)heterostructure using free-standing and flexible nickel fiber paper as the *** regulated energy band structure achieves effective electron–hole *** as-synthesized flexible photocatalyst exhibits considerable photocatalytic activity toward the H_(2)evolution reaction under visible-light irradiation,with an H_(2)production rate of5.63μmol·cm^(-2)·h^(-1)(14.1 mmol·g^(-1)cat·h^(-1)according to the catalyst loading content).Additionally,the otherwisewasted excited holes simultaneously drive organic transformations to yield value-added organic products,thus markedly improving the photocatalytic H_(2)evolution *** a photocatalytic system is scaled up further,where a self-supported 20 cm×25 cm sample achieves a cha.pion H_(2)production rate of 60-80μmol·h^(-1)under practical sun *** newly developed self-supported photocatalyst produces opportunities for practical solar H2production with biomass upgrading.

关键词： Self-supporting photocatalyst CdS/Ni_(3)S_(2) heterojunction Hydrogen evolution Biomass upgrading Large-scaleapplication

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Application of GNSS-PPP on Dynamic Deformation Monitoring of Offshore Platforms

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China Ocean Engineering 2024年第2期38卷 352-361页

作者： YU li-na XIONG Kuan GAO Xi-feng li Zhi FAN li-long Zha.G Kai Institute of Ocean Energy and Intelligent Construction Tianjin University of TechnologyTianjin 300384China China Railway Construction Bridge Engineering Bureau Group Co.LTD Tianjin 300300China School of Civil Engineering Tianjin UniversityTianjin 300072China Department of Land Surveying and Geo-Informatics The Hong Kong Polytechnic UniversityHong KongChina State Key Laboratory of Precision Blasting Jianghan UniversityWuhan 430056China

The real-time dynamic deformation monitoring of offshore platforms under environmental excitation is crucial to their safe *** Global Navigation Satellite System-Precise Point Positioning(GNSS-PPP)ha. been considered for this purpose,its monitoring accuracy is relatively ***,the influence of background noise on the dynamic monitoring accuracy of GNSS-PPP remains ***,it is imperative to further validate the feasibility of GNSS-PPP for deformation monitoring of offshore *** address these concerns,vibration table tests with different amplitudes and frequencies are *** results demonstrate tha. GNSS-PPP can effectively monitor horizontal vibration displacement as low as±30 mm,which is consistent with ***,the spectral cha.acteristic of background noise in GNSS-PPP is similar to tha. of GNSS-RTK(Real Time Kinematic).Building on this observation,an improved Complete Ensemble Empirical Mode Decomposition with Adaptive Noise(CEEMDAN)ha. been proposed to de-noise the data and enha.ce the dynamic monitoring accuracy of *** monitoring application research is also undertaken,successfully extracting and analyzing the dynamic deformation of an offshore platform structure under environmental excitation using GNSS-PPP monitoring in conjunction with improved CEEMDAN *** comparing the de-noised dynamic deformation trajectories of the offshore platform during different periods,it is observed tha. the platform exhibits reversible alternating vibration responses under environmental excitation,with more pronounced displacement deformation in the direction of load *** research results confirm the feasibility and potential of GNSS-PPP for dynamic deformation monitoring of offshore platforms.

关键词： GNSS-PPP offshore platform dynamic deformation monitoring improved CEEMDAN de-noising

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Stimulation and imaging of neural cells via photonic nanojets

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Photonics Research 2024年第8期12卷 1604-1609页

作者： HENG li XIXI CHEN TIANli WU ZHIYONG GONG JINGHUI GUO XIAOSONG BAI JIAWEI li YAO Zha.G YUCha. li BAOJUN li Guangdong Provincial Key Laboratory of Nanophotonic Manipulation Institute of NanophotonicsCollege of Physics&Optoelectronic EngineeringJinan UniversityGuangzhou 511443China School of Medicine The Chinese University of Hong KongShenzhen 518172China InnerMedical Co. Ltd.Shenzhen 518055China

Various neuromodulation techniques ha.e been developed to modulate the peak activity of neurons,thereby regulating brain function and alleviating neurological ***,neuronal stimulation and imaging ha.e significantly contributed to the understanding and treatment of these ***,we propose utilizing photonic nanojets for optical stimulation and imaging of neural *** application of resin microspheres as microlenses enha.ces fluorescence imaging of neural lysosomes,mitochondria,and actin filaments by generating photonic ***,optical tweezers can precisely manipulate the microlenses to locate specific targets within the cell for real-time stimulation and *** focusing capabilities of these microlenses enable subcellular-level spatial precision in stimulation,allowing highly accurate targeting of neural cells while minimizing off-target ***,fluorescent signals during neural cell stimulation can be detected in real-time using these *** proposed method facilitates investigation into intercellular signal transmission among neural cells,providing new insights into the underlying mecha.isms of neuronal cell activities at a subcellular level.

关键词： stimulation neural utilizing

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Unconventional Fluorescent and Multi-responsive Polyethyleneimine with LCST and UCST Beha.ior:Synthesis,Cha.acterization and Biological Applications

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Chinese Journal of Polymer Science 2024年第6期42卷 826-837页

作者： Feng-Ming Yin li-li Wu Shu-Sheng li Xiao-Na Pan Xiao-li Zhu Xu-Bao Jiang Xiang Zheng Kong College of Chemistry and Chemical Engineering University of JinanJinan250022China Sha.dong Institute for Product Quality Inspection Jinan250102China College of Chemical Engineering Tianjin UniversityTianjin300072China

Non-aromatic fluorescent and multi-responsive materials,exhibiting inherent fluorescence emission and controlled pha.e cha.ge,ha.e garnered significant attention in recent ***,the underlying interaction between their fluorescent properties and pha.e transition remains *** this study,we synthesized a series of catalyst-free aza-Micha.l addition-based polyethyleneimine(RFPEI)materials by reacting polyethyleneimine(PEI)with N-isopropyl acrylamide(NIPAM).The resulting RFPEI was comprehensively cha.acterized,and demonstrated dual-pha.e transition beha.ior(LCST and UCST)in water,which could be finely tuned by adjusting its composition or external factors such as ***,upon UV irradiation(365 nm),RFPEI exhibited strong fluorescence *** further investigated the effects of NIPAM grafting percentage to PEI,polymer concentration,and pH on the LCST/UCST and fluorescent properties of RFPEI aqueous ***,we showcased the great potential of RFPEI as a versatile tool for physiological cell imaging,trace detection,and controlled release of *** study presents a novel class of stimuli-responsive fluorescent materials with promising applications in the field of biomedicine.

关键词： Polyethyleneimine Multi-responsiveness Intrinsic fluorescence emission Cell imaging Controlled drug release

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Optimal pivot path of the simplex method for linear programming based on reinforcement learning

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Science China Mathematics 2024年第6期67卷 1263-1286页

作者： Anqi li Tiande Guo Congying ha. Bonan li ha.ran li School of Mathematical Sciences University of Chinese Academy of SciencesBeijing100049China

Based on the existing pivot rules,the simplex method for linear programming is not polynomial in the worst ***,the optimal pivot of the simplex method is *** this paper,we propose the optimal rule to find all the shortest pivot paths of the simplex method for linear programming problems based on Monte Carlo tree ***,we first propose the SimplexPseudoTree to transfer the simplex method into tree search mode while avoiding repeated basis ***,we propose four reinforcement learning models with two actions and two rewards to make the Monte Carlo tree search suitable for the simplex ***,we set a new action selection criterion to ameliorate the inaccurate evaluation in the initial *** is proved tha. when the number of vertices in the feasible region is C_(n)^(m),our method can generate all the shortest pivot paths,which is the polynomial of the number of *** addition,we experimentally validate tha. the proposed schedule can avoid unnecessary search and provide the optimal pivot ***,this method can provide the best pivot labels for all kinds of supervised learning methods to solve linear programming problems.

关键词： simplex method linear programming pivot rules reinforcement learning

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