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The miR172a–SNB module orchestrates both induced and adult-plant resistance to multiple diseases via MYB30-mediated lignin accumulation in rice

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Molecular Plant 2025年第1期18卷 59-75页

作者： He wang Zhe-Xu wang hong-yuan Tian yu-Long Zeng Hao Xue Wan-Ting Mao Lu-yue Zhang Jun-Ni Chen Xiang Lu Yong Zhu Guo-Bang li Zhi-Xue zhao Ji-Wei Zhang Yan-Yan Huang jing Fan Pei-Zhou Xu Xiao-qiong Chen Wei-tao li Xian-Jun Wu Wen-ming wang Yan li State Key Laboratory of Crop Gene Exploration and Utilization in Southwest China Sichuan Agricultural UniversityChengdu 611130China Rice Research Institute and Key Lab for Major Crop Diseases Sichuan Agricultural UniversityChengduChina

Plants mount induced resistance and adult-plant resistance against different pathogens throughout the whole growth *** production faces threats from multiple major diseases,including rice blast,sheath blight,and bacterial leaf ***,we report that the miR172a–SNB–MYB30 module regulates both induced and adult-plant resistance to these three major diseases via lignification in ***,pathogen infections induce the expression of miR172a,which downregulates the transcription factor SNB to release its suppression of MYB30,leading to an increase in lignin biosynthesis and disease resistance throughout the whole growth ***,expression levels of miR172a and MYB30 gradually increase and are consistently correlated with lignin contents and disease resistance during rice development,reaching a peak at full maturity,whereas SNB RNA levels are negatively correlated with lignin contents and disease resistance,indicating the involvement of the miR172a–SNB–MYB30 module in adult-plant *** functional domain of SNB protein and its binding sites in the MYB30 promoter are highly conserved among more than 4000 rice accessions,while abnormal expression of miR172a,SNB,or MYB30 compromises yield traits,suggesting artificial selection of the miR172a–SNB–MYB30 module during rice *** together,these results reveal a novel role for a conserved miRNA-regulated module that contributes significantly to induced and adult-plant resistance against multiple pathogens by increasing lignin accumulation,deepening our understanding of broad-spectrum resistance and adult-plant resistance.

关键词： miR172a SNB MYB30 lignin induced resistance adult-plant resistance

Impact of main vessel calcification on procedural and clinical outcomes of bifurcation lesion undergoing provisional single-stenting intervention: a multicenter, prospective, observational study

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Journal of Geriatric Cardiology 2019年第2期16卷 156-163页

作者： jing BAI Yan yuE hong-qi FENG Shu-Xin HAO liang PENG ming ZHANG Shaheena Nazneen li-Feng liU Zhe TANG Xiao-lin yu yu-tao XIE Fu-Xiang SHAN ming-Zhi SHEN Jiang-tao wang Xue-Hua WAN yun-dai CHEN yu wang Department of Cardiology Chinese PLA General HospitalBeijingChina People's Hospital of rongcheng Shandong eChina Clifford Hospital GuangdongChina Hengshui Cardiovescular Hospital HebeiChina Fuwai Central China Cardiovascular Hospital HenanChina Lab Aid Cardiac Hospital DhanmondiDhaka.Bangladesh Heart Center Beijing Chaoyang HospitalCapital Medical UniversityBeijingChina Emergency and Critical Care Center Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijingChina People's Hospital of Xinjiang Uygur Autonomous Region XinjiangChina The People's Hospital in Jimusar XinjiangChina Hainan Branch of Chinese PLA General Hospital HainanChina

Background Few data on the combined effects of bifurcation and calcification on coronary artery disease(CAD)patients undergoing percutaneous coronary intervention(PCI)are *** study evaluated the impact of main vessel(MV)calcification on the procedural and long-term outcomes in patients with CAD who underwent provisional single stent *** This is a multicenter,prospective,observational *** with bifurcation lesions were enrolled at 10 PCI centers in China from January 2015 to December *** ultrasound or optical coherence tomography was performed in all patients to evaluate the MV *** were treated with provisional single stent strategy using drug eluting stents and followed-up at 1 month,6 months and 12 months after discharge by telephone contact or outpatient *** coronary imaging was performed within one *** compared the procedural success rates in MV and in side branch(SB),and target lesion failure(TLF),defined as a composite of cardiac death,non-fatal myocardial infarction,definite or possible stent thrombosis and target lesion revascularization between patients with and without MV *** A total of 185 subjects were enrolled according to the inclusion and exclusion criteria of this *** calcification was detected in 119(64.3%,calcification group)and not found in 66(35.7%,non-calcification group)*** angiographic success rate of MV was 95.8%in the calcification group and 97.0%in the non-calcification group(P=0.91);the angiographic success rate of SB was 32.8%in the calcification group and 53.0%in the non-calcification group(P<0.05).During the one-year follow-up period,TLF occurred in 14(11.8%)patients in the calcification group and in 13(19.7%)in the non-calcification group{P=0.31).Multivariate regression analysis showed the same result(HR=1.23,95%CI:0.76-1.52,P=0.47).Calcification on group had higher recurrent angina than non-calcification group(13.51%vs.17.65%,P

关键词： Bifurcation lesion Coronary artery disease Coronary calcification Percutaneous coronary intervention

Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease in China(RWE-PCSK study)

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Journal of Geriatric Cardiology 2021年第4期18卷 261-270页

作者： yu-qi liU Dan-Dan li Meng CHAI hong-liang CONG Xiao-qiang CONG Jun dai rong-Pin DU ming GAO Jin-Cheng GUO Yan-qing GUO Xiao-Jian hong rong-Chong HUANG Feng-Shun JIA Jia-yu li qing li Jia-Mei liU Xin-Ping liU yu-Guo liU hong-Gang NIE Bing SHAO Xiao-yu SHEN Hai-qing SONG Yi-Jun SONG li-Jun wang Shuo wang Dong-Mei WU jing XIA Zhi-Yong YANG hong-Ying yu Hui ZHANG Tie-Mei ZHANG Ji-Yi zhao liang-Chen zhao ming-qi ZHENG yun-dai CHEN Department of Cardiology Chinese PLA General HospitalBeijingChina Department of Cardiology Beijing Anzhen HospitalCapital Medical UniversityBeijing Institute of Heart Lung and Blood Vessel DiseaseBeijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic DiseaseClinical Center for Coronary Heart DiseaseCapital Medical UniversityBeijingChina Department of Cardiology Tianjin Chest HospitalTianjinChina Department of Cardiology the First Hospital of Jilin UniversityChangchunChina Department of Cardiology Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Department of Cardiology Hebei People’s HospitalShijiazhuangChina Department of Cardiology Kailuan General HospitalHebei Union UniversityTangshanChina Department of Cardiology Beijing Luhe HospitalCapital Medical UniversityBeijingChina Department of Cardiology Shanxi Cardiovascular HospitalTaiyuanChina Department of Cardiology the Fourth Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology Beijing Friendship HospitalCapital Medical UniversityBeijingChina Department of Cardiology Tangshan Worker’s HospitalTangshanChina Department of Cardiology China-Japan Friendship Hospital Affiliated Jilin UniversityChangchunChina Department of Cardiology Handan Central HospitalHebeiChina Heart Center Beijing Key Laboratory of HypertensionBeijing Chao-Yang HospitalCapital Medical UniversityBeijingChina Department of Cardiology the First Affiliated Hospital of Dalian Medical UniversityLiaoningChina Department of Cardiology the Second Affiliated Hospital of Harbin Medical UniversityHarbinChina Department of Cardiology the Second Affiliated Hospital of Shenyang Medical CollegeShenyangChina Department of Cardiology the Second Hospital of Shanxi Medical UniversityTaiyuanChina Department of Neurology Xuanwu Hospital Capital Medical UniversityBeijingChina Department of Neurology Tianjin Medical University Gen

BACKGROUND The efficacy and safety of proprotein convertase subtilisin/kexin type 9(PCSK-9) inhibitors were confirmed by several clinical trials, but its effectiveness in routine clinical practice in China has not been evaluated. This study aims to describe the real world effectiveness of PCSK-9 inhibitors combined with statins compared with statins-based therapy among patients with very high risk of atherosclerotic cardiovascular disease(ASCVD).METHODS This is a multi-center observational study, enrolled patients from 32 hospitals who underwent percutaneous coronary intervention(PCI) from January to June in 2019. There are 453 patients treated with PCSK-9 inhibitors combined with statins in PCSK-9 inhibitor group and 2,610 patients treated with statins-based lipid lowering therapies in statins-based group. The lipid control rate and incidence of major adverse cardiovascular events(MACE) over six months were compared between two groups.A propensity score-matched(PSM) analysis was used to balance two groups on confounding factors. Survival analysis using Kaplan-Meier methods was applied for *** In a total of 3,063 patients, 89.91% of patients had received moderate or high-intensity statins-based therapy before PCI, but only 9.47% of patients had low-density lipoprotein cholesterol(LDL-C) levels below 1.4 mmol/L at baseline. In the PSM selected patients, LDL-C level was reduced by 42.57% in PCSK-9 inhibitor group and 30.81%(P < 0.001) in statins-based group after six months. The proportion of LDL-C ≤ 1.0 mmol/L increased from 5.29% to 29.26% in PCSK-9 inhibitor group and 0.23% to 6.11% in statins-based group, and the proportion of LDL-C ≤ 1.4 mmol/L increased from 10.36% to 47.69% in PCSK-9 inhibitor group and 2.99% to 18.43% in statins-based group(P < 0.001 for both). There was no significant difference between PCSK-9 inhibitor and statins-based treatment in reducing the risk of MACE(hazard ratio = 2.52, 95% CI: 0.49-12.97, P = 0.250).CONCLUSIONS In the real

关键词： LDL RWE-PCSK study Real world effectiveness of PCSK-9 inhibitors combined with statins versus statins-based therapy among patients with very high r

Dramatic Changes of Matrix Metalloproteinases-7 and Lysozyme in the Ulcerative Colitis of Mice Induced by Dextran Sulfate Sodium

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Journal of Integrative Agriculture 2014年第4期13卷 858-869页

作者： KANG jing-jing zhao De-ming TENG Ke-dao JIAO Xi-lan wang Ping-li SUN Zhe NI Pei-pei wang Zhi-feng ZHANG Rui YANG yu-rong liANG hong-de Pathology Laboratory College of Animal Husbandry and Veterinary Science Henan Agricultural University College of Animal Medicine China Agricultural University

Ulcerative colitis （UC） is a lifelong illness with profound emotional and social impacts, and could cause serious damage to large intestine, especially in colon. However, the pathogenesis of UC remained unclear. The present study attempts to find out the role of matrix metalloproteinases-7 （MMP-7） and lysozyme in the pathogenesis of UC through a mice model induced by dextran sulfate sodium （DSS）. The UC model was evaluated both by disease activity index （dai） and the intestinal histopathology. The results show that there is a high correlation between the dai score and the pathological changes of colon. Interleukin-6 （IL-6） serum levels and large intestinal fluids levels in UC mice are always higher than that of the control groups, which might be associated with the degree of the inflammation damage in the colon. The change tendency of the MMP-7 mRNA and protein expressions are both up-regulated firstly and then down-regulated from 1 to 5 d in the colon, but only the MMP-7 protein is up-regulated at 7 d again. The up-regulated MMP-7 levels in the early stage of UC may play a protective role through the activated defensins, while the down-regulated levels in the mid-later stage of UC may be connected with the severe lesions in the colon. However, the up-regulated MMP-7 levels in the later stage of UC in the colon may also contribute to the tissue repair or be served as a marker to CRC （colorectal cancer）. The distribution of lysozyme protein indicates that there may be Paneth-like cells in the colon. Both the changes of MMP-7 and lysozyme in the small intestine may play a protective role for the safe environment of the whole gut, especially to the colon of UC.

关键词： matrix metalloproteinases-7 lysozyme interleukin-6 ulcerative colitis dextran sulfate sodium

电磁连铸颗粒增强铝基复合材料圆坯及其摩擦性能

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材料工程 2005年第12期33卷 53-56页

作者：王宏明李桂荣赵玉涛戴起勋江苏大学材料科学与工程学院江苏镇江212013

Al-Zr(CO3)2体系原位反应合成法制备(Al2O3+Al3Zr)p/Al颗粒增强铝基复合材料圆坯,在合成及半连铸过程中施加低频电磁搅拌来改善增强相颗粒在铝基体内的分布状态,同时在结晶器初始凝固区域施加高频电磁场实现软接触连铸,以改善铸坯的表... 详细信息

Al-Zr(CO3)2体系原位反应合成法制备(Al2O3+Al3Zr)p/Al颗粒增强铝基复合材料圆坯,在合成及半连铸过程中施加低频电磁搅拌来改善增强相颗粒在铝基体内的分布状态,同时在结晶器初始凝固区域施加高频电磁场实现软接触连铸,以改善铸坯的表面质量。扫描电镜(SEM)分析显示:施加电磁搅拌后复合材料的凝固组织致密,颗粒增强相的体积分数增加,且颗粒细化、分布更趋于均匀。干滑动摩擦磨损实验表明:施加电磁搅拌后,复合材料的耐磨性能提高。磨损表面的SEM分析显示粘着磨损比不施加电磁搅拌时明显减少,摩擦磨损机制以磨粒磨损为主。施加的高频磁场使得单纯使用低频电磁搅拌产生的表面粗糙现象消失,铸坯表面质量显著提高。

关键词：电磁连铸颗粒增强铝基复合材料

Al-Zr-O-B体系原位合成颗粒增强铝基复合材料及其性能

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中国有色金属学报 2005年第4期15卷 572-577页

作者：李桂荣戴起勋赵玉涛王宏明朱延山江苏大学材料科学与工程学院镇江212013

研究了采用Al2Zr(CO3)22KBF4组元通过熔体反应法原位合成颗粒增强铝基复合材料。X射线衍射(XRD)和扫描电镜(SEM)分析表明:内生增强相颗粒为ZrAl3、ZrB2和Al2O3,粒度为3～4μm,且在基体中弥散分布。复合材料的力学性能和干滑动磨损特性... 详细信息

研究了采用Al2Zr(CO3)22KBF4组元通过熔体反应法原位合成颗粒增强铝基复合材料。X射线衍射(XRD)和扫描电镜(SEM)分析表明:内生增强相颗粒为ZrAl3、ZrB2和Al2O3,粒度为3～4μm,且在基体中弥散分布。复合材料的力学性能和干滑动磨损特性研究表明:在反应物加入量为0～20%(质量百分数)范围内时,复合材料的抗拉强度和屈服强度较纯铝基体明显提高,当反应物加入量为20%时,抗拉强度为15013MPa,屈服强度为11317MPa。当反应物加入量为5%时延伸率最佳为33%,属塑性断裂。复合材料的耐磨性较铝基体显著提高,当反应物加入量为10%时耐磨性最好。铝基体的磨损机制是粘着磨损,而(ZrAl3+ZrB2+Al2O3)p/Al复合材料的磨损机制是磨粒磨损。

关键词： Al-Zr-O-B体系复合材料原位合成抗拉强度磨粒磨损

低频交变电磁场对(Al_2O_3+Al_3Zr)_p/Al复合材料凝固组织和干滑动磨损性能影响

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铸造 2005年第7期54卷 689-691页

作者：李桂荣王宏明赵玉涛戴起勋李家旺江苏大学材料科学与工程学院江苏镇江212013

在低频交变电磁场条件下,研究了Al-Zr(CO3)2组元通过熔体反应法原位合成的Al2O3、Al3Zr颗粒增强铝基复合材料,结果表明:外加低频交变电磁场能够有效地改善反应动力学条件,对固液两相反应的传质和扩散起到了很好的促进怍用,凝固组织中增... 详细信息

在低频交变电磁场条件下,研究了Al-Zr(CO3)2组元通过熔体反应法原位合成的Al2O3、Al3Zr颗粒增强铝基复合材料,结果表明:外加低频交变电磁场能够有效地改善反应动力学条件,对固液两相反应的传质和扩散起到了很好的促进怍用,凝固组织中增强相颗粒在铝基体中的体积分数增加,分布弥散均匀。复合材料干滑动磨损机制是磨粒磨损, 磨损量31.7mg,比未加电磁场时的磨损量下降了46.1%,耐磨性提高。

关键词：低频电磁场原位合成干滑动磨损

Stepped-up development of accelerator mass spectrometry method for the detection of ^(60)Fe with the HI-13 tandem accelerator

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Nuclear Science and Techniques 2024年第4期35卷 136-143页

作者： Yang Zhang sheng-Quan Yan ming He qing-Zhang zhao Wen-Hui Zhang Chao-Xin Kan Jian-ming Zhou Kang-Ning li Xiao-Fei wang Jian-Cheng liu zhao-Hua Peng Zhuo liang Ai-ling li Jian Zheng qi-Wen Fan yun-Ju li You-Bao wang Zhi-hong li Yang-Ping Shen Ding Nan Wei Nan yu-qiang Zhang Jia-Ying-Hao li Jun-Wen Tian Jiang-lin Hou Chang-Xin Guo Zhi-Cheng Zhang ming-Hao Zhu yu-Wen Chen yu-Chen Jiang tao Tian Jin-Long Ma Yi-Hui liu jing-yu Dong Run-Long liu Mei-yue-Nan Ma Yong-Shou Chen Wei-Ping liu Bing Guo China Institute of Atomic Energy P.O.Box 275(10)Beijing 102413China College of Science Southern University of Science and TechnologyShenzhen 518055China School of Physics Xi’an Jiaotong UniversityXi’an 710049China

The Moon provides a unique environment for investigating nearby astrophysical events such as *** samples retain valuable information from these events,via detectable long-lived“fingerprint”radionuclides such as^(60)*** this work,we stepped up the development of an accelerator mass spectrometry(AMS)method for detecting^(60)Fe using the HI-13tandem accelerator at the China Institute of Atomic Energy(CIAE).Since interferences could not be sufficiently removed solely with the existing magnetic systems of the tandem accelerator and the following Q3D magnetic spectrograph,a Wien filter with a maximum voltage of±60 kV and a maximum magnetic field of 0.3 T was installed after the accelerator magnetic systems to lower the detection background for the low abundance nuclide^(60)Fe.A 1μm thick Si_(3)N_(4) foil was installed in front of the Q3D as an energy *** particle detection,a multi-anode gas ionization chamber was mounted at the center of the focal plane of the ***,an^(60)Fe sample with an abundance of 1.125×10^(-10)was used to test the new AMS *** results indicate that^(60)Fe can be clearly distinguished from the isobar^(60)*** sensitivity was assessed to be better than 4.3×10^(-14)based on blank sample measurements lasting 5.8 h,and the sensitivity could,in principle,be expected to be approximately 2.5×10^(-15)when the data were accumulated for 100 h,which is feasible for future lunar sample measurements because the main contaminants were sufficiently separated.

关键词： Accelerator mass spectrometry Wien filter Isobar separation Supernovae Chang'e-5 lunar samples

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电磁软接触连铸高频磁场的数值模拟

中国有色金属学报 2008年第3期18卷 529-534页

作者：夏小江王宏明戴起勋李桂荣赵玉涛江苏大学材料学院镇江212013

以经典电磁场理论为依据，利用有限元软件ANSYS建立了电磁软接触连铸高频磁场计算的数学物理模型。用小线圈法实测了线圈内磁感应强度的分布，并将实测值与计算值进行比较，验证了模型的有效性。通过计算，分析了割缝结晶器内磁感应强... 详细信息

以经典电磁场理论为依据，利用有限元软件ANSYS建立了电磁软接触连铸高频磁场计算的数学物理模型。用小线圈法实测了线圈内磁感应强度的分布，并将实测值与计算值进行比较，验证了模型的有效性。通过计算，分析了割缝结晶器内磁感应强度分布的不均匀性以及感应线圈匝间距对结晶器内磁感应强度分布的影响。结果表明：切缝对结晶器中半径小于25mm范围的影响很小，使接近结晶器壁处圆周上磁感应强度分布的不均匀性较大；减小线圈匝间距可以提高结晶器内磁感应强度，线圈匝间距以5～10mm为宜。

关键词：电磁软接触连铸高频电磁场数值模拟