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Congenital dysplasia involving both medial and inferior recti: clinical features and surgical outcomes

International Journal of Ophthalmology(English edition) 2021年第10期14卷 1628-1632页

作者： li-cheng fu Bin-Bin Zhu Jian-Hua Yan State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM: To investigate the clinical features and surgical outcomes of congenital dysplasia involving both inferior recti(IR) and medial recti(MR) ***: A retrospective review was conducted including cases of simultaneous congenital dysplasia of IR and MR that were diagnosed and surgically treated at the Zhongshan Ophthalmic Center, Sun Yat-sen University, China, from July 2009 to November 2019. Ocular motility, ocular alignment at distance(6 m) and near(33 cm) by prism alternating cover test and stereoacuity were assessed in all patients before and after surgery. RESULTS: A total of five patients(four males and one female;three with right eye and two with left eye congenital dysplasia) were included in this review. The patients ranged in age from 10 to 42 y(21±13.4 y). The main clinical findings were hypertropia and exotropia of the affected eye, along with motility limitations in adduction and depression. Lateral rectus(LR) recession/transposition combined with IR resection was performed in one case. Two scheduled surgeries were performed in four cases, with one involving superior rectus recession and IR resection and the others LR recession and MR resection. Mean±SD pre-surgical exotropia of 51.0±31.11 prism diopter(PD) and hypertropia of 29.20±7.12 PD in the primary position were decreased to 3.6±12.90 and 3.2±10.09 PD, respectively, at two years after surgery, with a success rate of 60% and an undercorrection rate of 40%. CONCLUSION: The main clinical features associated with simultaneous MR/IR congenital dysplasia are hypertropia and exotropia of the affected eye along with motility limitations in adduction and depression. Scheduled two-stage surgeries achieved a success rate of 60%.

关键词： medial rectus inferior rectus paralytic strabismus strabismus surgery dysplasia of extraocular muscle

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Aquaporin-1 down regulation associated with inhibiting cell viability and inducing apoptosis of human lens epithelial cells

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International Journal of Ophthalmology(English edition) 2016年第1期9卷 15-20页

作者： Hong-Hua Zheng Guo-Xing Xu Jian Guo li-cheng fu Yao Yao fujian Institute of Ophthalmology the First Affiliated Hospital of Fujian Medical University

AIM：To investigate the role of Aquaporin-1（AQP-1）in lens epithelial cells（LECs）and its potential target ***-1 is specifically expressed in LECs of eyes and is significant for lens homeostasis and transparency ***,AQP-1 expression in LECs was investigated to evaluate its influence on cell survival in association with its potential role in cataract formation.·M ETHODS：LECs were transfected with lentivirus carrying AQP-1 small interfering RNA（si RNA）.Real-time polymerase chain reaction（PCR）and Western blotting were conducted to detect AQP-1 expression in LECs from different ***,cell counting kit-8（CCK-8）assay and flow cytometry were performed to measure LEC proliferation and apoptosis,respectively.·RESULTS：AQP-1 expression was significantly reduced in LECs,both at m RNA and protein levels（〈0.05）,after si RNA *** cell viability was detected by CCK-8 assay in LECs with si RNA interference,compared to control cells（〈0.05）.The apoptosis rate significantly increased in cells after si RNA interference（〈0.05）.·CONCLUSION：The decreased cell viability following AQP-1 down regulation is largely due to its induction of apoptosis of ***-1 reduction might lead to changes of physiological functions in LECs,which might be associated with the occurrence and development of cataracts.

关键词： Aquaporin-1 small interfering RNA lensepithelial cells proliferation apoptosis cell counting kit-8 flow cytometry

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Discussion on heat source mechanism and geothermal system of Qinghai Gonghe-Guide Basin

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Journal of Groundwater Science and Engineering 2015年第1期3卷 86-97页

作者： Wang Bin li Bai-xiang li fu-cheng National Key Laboratory of Hydrogeology and Geothermal Geology of Qinghai Province Qinghai Institute of Hydrogeological Engineering Geological and Environmental Geological Survey Second Institute of Geological and Mineral Exploration Gansu Bureau of Geology and Mineral Resources

The Qinghai Gonghe-Guide Basin together with the alternatively distributed mountainous region shows characteristics that the conductive geothermal resource of the basin has high geothermal gradient, the granite occurs in the bottom of borehole for geothermal exploration, and the convective hot springs in the basin-edge uplift fracture are in zonal distribution and with high-temperature geothermal water. There are still some divergences about the heat source mechanism of the basin. In this paper, queries to the view of mantle-derived heat source have been put forward, coming up with geochemical evidences to prove that the radiogenic heat of granite is the heat source within the mantle. Additionally, temperature curve is drawn based on the geothermal boring and geochemical geothermometer has been adopted for an estimation of the temperature and depth of the geothermal reservoir, it has been found that the surrounding mountains belong to the medium-temperature geothermal system while the area within the basin belongs to the high-temperature geothermal system with the temperature of borehole bottom reaching up to 175-180 ℃. In this paper, discussions on the problems existing in the calculation of geothermal gradient and the differences generated by the geothermal system have been carried out.

关键词： Heat source mechanism Mantle-derived heat source Radiogenic heat of granite Estimation of temperature and depth of geothermal reservoir Geothermal system

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Sustained AMP-activated protein kinase activation attenuates the activity of brain-derived neurotrophic factor/tyrosine kinase receptor B signaling in mice exposed to chronic stress

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Chinese Medical Journal 2021年第15期134卷 1874-1876页

作者： li-Tao Yi Shuang-Shuang Wang Jie cheng Min Chen Ji-Xiao Zhu cheng-fu li Shu-Qi Dong Qing liu Department of Chemical and Pharmaceutical Engineering College of Chemical EngineeringHuaqiao UniversityXiamenFujian 361021China fujian Provincial Key Laboratory of Biochemical Technology Huaqiao UniversityXiamenFujian 361021China Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine Jiangxi University of Traditional Chinese MedicineNanchang 330004JiangxiChina Xiamen Hospital of Traditional Chinese Medicine XiamenFujian 361009China

To the Editor:Major depressive disorder is one of the most leading causes of disability *** molecular pathophysiology of depression is complicated and has already attracted intensive and considerable attentionj11 Nowadays,the neurotrophic hypothesis of depression suggests that brain-derived neurotrophic factor(BDNF)/tyrosine kinase receptor B(TrkB)receptor binding activates the downstream signaling pathways to culminate in cell *** process is essential for neurogenesis and synaptogenesis,which are involved in the effects of antidepressants.

关键词： activation stress hypothesis

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Advancements and Challenges in Organic–Inorganic Composite Solid Electrolytes for All‑Solid‑State lithium Batteries

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Nano-Micro Letters 2025年第1期17卷 46-97页

作者： Xueyan Zhang Shichao cheng Chuankai fu Geping Yin liguang Wang Yongmin Wu Hua Huo State Key Laboratory of Space Power‑Sources School of Chemistry and Chemical EngineeringHarbin Institute of TechnologyHarbin 150001People’s Republic of China College of Chemical and Biological Engineering Zhejiang UniversityHangzhou 310058People’s Republic of China State Key Laboratory of Space Power-Sources 2965 Dongchuan RoadMinhang DistrictShanghai 200240People’s Republic of China

To address the limitations of contemporary lithium-ion batteries,particularly their low energy density and safety concerns,all-solid-state lithium batteries equipped with solid-state electrolytes have been identified as an up-and-coming *** the various SEs,organic–inorganic composite solid electrolytes(OICSEs)that combine the advantages of both polymer and inorganic materials demonstrate promising potential for large-scale ***,OICSEs still face many challenges in practical applications,such as low ionic conductivity and poor interfacial stability,which severely limit their *** review provides a comprehensive overview of recent research advancements in ***,the influence of inorganic fillers on the main functional parameters of OICSEs,including ionic conductivity,li+transfer number,mechanical strength,electrochemical stability,electronic conductivity,and thermal stability are systematically *** lithium-ion conduction mechanism of OICSE is thoroughly analyzed and concluded from the microscopic ***,the classic inorganic filler types,including both inert and active fillers,are categorized with special emphasis on the relationship between inorganic filler structure design and the electrochemical performance of ***,the advanced characterization techniques relevant to OICSEs are summarized,and the challenges and perspectives on the future development of OICSEs are also highlighted for constructing superior ASSLBs.

关键词： Composite solid electrolytes Inorganic filler Interfacial stability li-ion conduction mechanism Characterization techniques

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构建明智简约的添附制度新体系

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河北法学 2005年第8期23卷 26-30页

作者：李富成中国人民大学法学院北京100872

从古罗马法以来,添附制度即被寄予维护价值与鼓励创造价值的社会经济使命。这一添附制度传统在试图解决特定问题的同时,另外产生了更多问题。在我国制定物权法之际,有必要检讨传统的添附观念,根据奥卡姆剃刀原理的启示,建构一个明智简... 详细信息

从古罗马法以来,添附制度即被寄予维护价值与鼓励创造价值的社会经济使命。这一添附制度传统在试图解决特定问题的同时,另外产生了更多问题。在我国制定物权法之际,有必要检讨传统的添附观念,根据奥卡姆剃刀原理的启示,建构一个明智简约的添附制度新体系。

关键词：简约明智奥卡姆剃刀古罗马法社会经济创造价值物权法传统检讨

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Quantum public-key crypto via EPR pairs

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Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun fu Hong-Wei li Jian-Hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

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我国育儿假的法理分析与制度构建

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华侨大学学报（哲学社会科学版） 2022年第5期 104-118页

作者：李富成西南政法大学经济法学院重庆401120

我国育儿假面临中央立法缺乏可操作性和地方立法规范性不足的问题,亟需在厘清基本法理的基础上构建专门性的育儿假立法。在法理层面,育儿假以工作—家庭平衡、性别平等及社会连带理论作为理论基础,其具有权利属性,各主体间的权利义务参... 详细信息

我国育儿假面临中央立法缺乏可操作性和地方立法规范性不足的问题,亟需在厘清基本法理的基础上构建专门性的育儿假立法。在法理层面,育儿假以工作—家庭平衡、性别平等及社会连带理论作为理论基础,其具有权利属性,各主体间的权利义务参照劳动合同中止理论予以构造。出于落实积极人口生育政策、推动生育假期制度完善的需要以及地方立法难以保障育儿假有效实施的现状,我国有必要对育儿假进行统一的专门立法。宪法提供立法基础、地方立法实践的探索以及域外的有益经验也进一步证成了立法的可行性。在立法层面,我国育儿假的立法模式应实现从短期的单独立法向长期的体系化立法的转变;在具体规则上,应同步构建育儿假的请假和销假等程序规则和育儿假的覆盖范围、休假条件、休假期限、休假方式、经济补偿等实体规则。

关键词：育儿假生育假期性别平等生育保险

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A Hybrid Approach for Pavement Crack Detection Using Mask R-CNN and Vision Transformer Model

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Computers, Materials & Continua 2025年第1期82卷 561-577页

作者： Shorouq Alshawabkeh li Wu Daojun Dong Yao cheng liping li Faculty of Engineering China University of GeosciencesWuhan430074China

Detecting pavement cracks is critical for road safety and infrastructure *** methods,relying on manual inspection and basic image processing,are time-consuming and prone to *** deep-learning(DL)methods automate crack detection,but many still struggle with variable crack patterns and environmental *** study aims to address these limitations by introducing the Masker Transformer,a novel hybrid deep learning model that integrates the precise localization capabilities of Mask Region-based Convolutional Neural Network(Mask R-CNN)with the global contextual awareness of Vision Transformer(ViT).The research focuses on leveraging the strengths of both architectures to enhance segmentation accuracy and adaptability across different pavement *** evaluated the performance of theMaskerTransformer against other state-of-theartmodels such asU-Net,TransformerU-Net(TransUNet),U-NetTransformer(UNETr),SwinU-NetTransformer(Swin-UNETr),You Only Look Once version 8(YoloV8),and Mask R-CNN using two benchmark datasets:Crack500 and *** findings reveal that the MaskerTransformer significantly outperforms the existing models,achieving the highest Dice SimilarityCoefficient(DSC),precision,recall,and F1-Score across both ***,the model attained a DSC of 80.04%on Crack500 and 91.37%on DeepCrack,demonstrating superior segmentation accuracy and *** high precision and recall rates further substantiate its effectiveness in real-world applications,suggesting that the Masker Transformer can serve as a robust tool for automated pavement crack detection,potentially replacing more traditional methods.

关键词： Pavement crack segmentation transportation deep learning vision transformer Mask R-CNN image segmentation

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Tailoring light–Matter Interactions in Overcoupled Resonator for Biomolecule Recognition and Detection

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Nano-Micro Letters 2025年第1期17卷 262-280页

作者： Dongxiao li Hong Zhou Zhihao Ren cheng Xu chengkuo Lee Department of Electrical and Computer Engineering National University of SingaporeSingapore 117583Singapore Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingapore 117608Singapore

Plasmonic nanoantennas provide unique opportunities for precise control of light–matter coupling in surface-enhanced infrared absorption(SEIRA)spectroscopy,but most of the resonant systems realized so far suffer from the obstacles of low sensitivity,narrow bandwidth,and asymmetric Fano resonance ***,we demonstrated an overcoupled resonator with a high plasmon-molecule coupling coefficient(μ)(OC-Hμresonator)by precisely controlling the radiation loss channel,the resonator-oscillator coupling channel,and the frequency detuning *** observed a strong dependence of the sensing performance on the coupling state,and demonstrated that OC-Hμresonator has excellent sensing properties of ultra-sensitive(7.25%nm^(−1)),ultra-broadband(3–10μm),and immune asymmetric Fano *** characteristics represent a breakthrough in SEIRA technology and lay the foundation for specific recognition of biomolecules,trace detection,and protein secondary structure analysis using a single array(array size is 100×100μm^(2)).In addition,with the assistance of machine learning,mixture classification,concentration prediction and spectral reconstruction were achieved with the highest accuracy of 100%.Finally,we demonstrated the potential of OC-Hμresonator for SARS-CoV-2 *** findings will promote the wider application of SEIRA technology,while providing new ideas for other enhanced spectroscopy technologies,quantum photonics and studying light–matter interactions.

关键词： Plasmonic nanoantennas light-matter interaction Surface-enhanced infrared absorption Overcoupled Biosensing

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