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Science China chemistry 2005年第5期48卷 424-430页

作者： li di1, sun chunyan1,{2., li jinghong1,2.& chen shaowei3 1. state key laboratory of electroanalytical chemistry, changchun institute of applied chemistry, chinese academy of sciences, changchun 13002., China 2. Department of chemistry, Tsinghua University, Beijing 100084, China 3. Department of chemistry, University of California, Santa Cruz, Santa Cruz, CA 95064, USA state {1. {2. of {2. chemistry changchun institute of applied chemistry Chinese Academy of Sciences Changchun China Department of chemistry Tsinghua University Beijing China Department of chemistry University of California Santa Cruz Santa Cruz USA

Electron transfer through the self-assembled monolayers (SAMs) on gold nanopar-ticles is investigated by using the monolayer protected gold nanoclusters (MPCs) as elec-tron-transfer mediators. 3-Mercaptopropionic acid (MPA) and 1.-meraptoundecanoic acid (MUA) MPCs were employed to catalyze the redox reaction between potassium ferricyanide and sodium thiosulfate. The catalytic mechanism was proposed that the MPCs act as diffusing elec-tron-mediators and electron transfers to and from the MPCs surface. Therefore the electron transfer rate through the capping layers would be proportional to the MPCs catalyzed reaction rate, which was monitored by the UV absorbance of ferricyanide. The calculated apparent rate constant was orders of magnitude smaller than that of the maximum of tunneling current, which was attributed to the splited energy level of the nanoscale particles.

关键词： electron transfer, three-dimensional self-assembled monolayers, redox reaction, electron transfer mediator, surface effect.

Ultrasonic vibration enabled under-liquid forming of metallic glasses

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Science Bulletin 2024年第2期69卷 163-166页

作者： Xin li Luyao li Sajad Sohrabi Jia'nan Fu Zhen li Zhe chen Rongce sun Yu Zhang Jinbiao huang Heting Zhang Jian Zhu Xiangyan chen Kaikai Song Jiang Ma School of Mechanical Electrical&Information EngineeringShandong UniversityWeihai 264209China state {1. {2. of Radio Frequency Heterogeneous Integration College of Mechatronics and Control EngineeringShenzhen UniversityShenzhen 518060China Department of Mechanics and Aerospace Engineering Southern University of Science and TechnologyShenzhen 518055China Shenzhen Research institute of Shandong University Shenzhen 518057China

Advancements in forming technology offer significant advantages for the manufacturing industry,including enhanced efficiency,energy conservation,and improved material uti{1.zation[1..However,traditional additive manufacturing[2.,thermoplastic forming[3],and laser cutting[4]encounter challenges when applied in under-{1.quid environments,mainly due to difficulties in temperature control and heat source provision.

关键词： glasses liquid metallic

Structural transition,electric transport,and electronic structures in the compressed trilayer nickelate La_(4)Ni_(3)O_(1.)

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Science China(Physics,Mechanics & Astronomy) 2024年第11期67卷 9-15页

作者： Jingyuan li Cui-Qun {1. Chaoxin {2. Yifeng Han Mengwu Huo Xing {2. Peiyue Ma Zhengyang Qiu Junfeng {1. Xunwu Hu Lan {1. Tao Xie Bing Shen Hualei sun Dao-Xin Yao Meng Wang Center for Neutron Science and Technology Guangdong Provincial Key Laboratory of Magnetoelectric Physics and DevicesSchool of PhysicsSun Yat-sen UniversityGuangzhou 510275China Center for Materials of the Universe School of Molecular SciencesArizona State UniversityTempe 85287USA School of sciences Sun Yat-sen UniversityShenzhen 518107China

Atomic structure and electronic band structure are fundamental properties for understanding the mechanism of superconductivity. Motivated by the discovery of pressure-induced high-temperature superconductivity at 80 K in the bilayer Ruddlesden-Popper nickelate La_(3)Ni_(2.O_(7), the atomic structure and electronic band structure of the trilayer nickelate La_(4)Ni_(3)O_({2.) under pressure up to 44.3 GPa are investigated. A structural transition from the monoclinic P2.({2./a space group to the tetragonal I4/mmm around {2..6-{2..4 GPa is identified, accompanied by a drop of resistance below 7 K. Density functional theory calculations suggest that the bonding state of Ni 3d_(z^(2.) orbital rises and crosses the Fermi level at high pressures, which may give rise to possible superconductivity observed in resistance under pressure in La_(4)Ni_(3)O_({2.). The trilayer nickelate La_(4)Ni_(3)O_({2.) shows some similarities with the bilayer La_(3)Ni_(2.O_(7) and has unique properties, providing a new platform to investigate the underlying mechanism of superconductivity in nickelates.

关键词： La_(4)Ni_(3)O_(1.) high pressure synchrotron X-ray diffraction structural transition DFT calculations

Nasal vaccination of triple-RBD scaffold protein with flagellin elicits long-term protection against SARS-CoV-2.variants inclu{2.ng JN.1

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2312-2323页

作者： Xian li Mengxin Xu Jingyi Yang li Zhou lin liu Min li Shasha Wang Mei-Qin liu Zhixiang huang Zhen Zhang Shuning liu Yunqi Hu Haofeng lin Bowen liu Ying sun Qingguo Wu Zheng-li Shi Ke Lan Yu {12. Huimin Yan Yao-Qing {12. Wuhan institute of Virology Chinese Academy of SciencesWuhanChina Vaccine and Immunology Research Center Translational Medical Research InstituteShanghai Public Health Clinical CenterFudan UniversityShanghaiChina University of chinese academy of sciences BeijingChina School of Public Health(Shenzhen) Shenzhen Campus of Sun Yat-sen UniversityShenzhenGuangdongChina state {1. {2. of Virology Modern Virology Research CenterCollege of Life SciencesWuhan UniversityWuhanChina Aerosol Bio-Tech(Suzhou)Co. LTDSuzhouJiangsuChina National Medical Products Administration {1. {2. for Quality Monitoring and Evaluation of Vaccines and Biological Products Sun Yat-sen UniversityGuanzhouChina

Developing a mucosal vaccine against SARS-CoV-2.is critical for combatting the ***,we investigated long-term immune responses and protection against SARS-CoV-2.for the intranasal vaccination of a triple receptor-binding domain(RBD)scaffold protein(3R-NC)adjuvanted with a flagel{1.n protein(KFD)(3R-NC+KFdi.n).In mice,the vaccination e{1.cited RBD-specific broad-neutra{1.zing antibody responses in both serum and mucosal sites sustained at high level over a *** long-lasting humoral immunity was correlated with the presence of long-{1.ved RBD-specific IgG-and IgA-producing plasma cells,alongside the Th1. and Tfh1.-biased T-cell responses driven by the KFD *** upon these prec{1.nical findings,an open labeled c{1.nical trial was conducted in individuals who had been primed with the inactivated SARS-CoV-2.IAV)*** a favorable safety profile,the 3R-NC+KFdi.n boost e{1.cited enduring broad-neutra{1.zing IgG in plasma and IgA in sa{1.vary *** meet the challenge of frequently emerged variants,we further designed an updated triple-RBD scaffold protein with mutated RBD combinations,which can induce adaptable antibody responses to neutra{1.ze the newly emerging variants,including *** findings high{1.ght the potential of the KFD-adjuvanted triple-RBD scaffold protein is a promising prototype for the development of a mucosal vaccine against SARS-CoV-2.infection.

关键词： vaccination vaccine sustained

Efficacy and safety of anlotinib combined with the STUPP regimen in patients with newly diagnosed g{1.oblastoma: a multicenter, single-arm, phase Ⅱ trial

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Cancer Biology & Medicine 2024年第5期21卷 433-444页

作者： Shuzhen Lai Peijing li Xiaohui liu Guihong liu Tieming Xie Xing Zhang Xiaoxuan Wang Jing huang Yiqiang Tang Zhigang liu Guoping Shen Chaoming li Fangxiao Lu Lei Wang Fagui Jiang Caixing sun Yuanyuan chen Ming chen Department of Radiation Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000China Department of Radiation Oncology Yuebei People’s Hospital Affiliated to the Medical College of Shantou UniversityShaoguan 512026China Chinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology The Second Clinical Medical College of Zhejiang Chinese Medical UniversityHangzhou 311403China Department of Radiation Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221004China Chinese Academy of SciencesHangzhou 310022China state {1. {2. of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.LtdNanjing 210000China Department of Radiation Oncology The Affiliated Huai’an First People’s Hospital of Nanjing Medical UniversityHuai’an 223399China Department of Radiation Oncology Jiangxi Cancer Hospital of Nanchang UniversityNanchang 330029China Department of Radiotherapy Dongguan Institute of Clinical Cancer ResearchDongguan Key Laboratory of Precision Diagnosis and Treatment for TumorsAffiliated Dongguan HospitalSouthern Medical UniversityDongguan 523059China The Cancer Center The Fifth Affiliated Hospital of Sun Yat-Sen UniversityZhuhai 519000China Department of Radiation Oncology The First Affiliated Hospital of Sun Yat-Sen UniversityGuangzhou 510080China Department of Oncology Maoming People’s HospitalMaoming 525000China Department of Radiation Oncology Kecheng District People’s HospitalQuzhou 324003China Chinese Academy of SciencesHangzhou 310022China Department of Radiation Oncology State Key Laboratory of Oncology in South ChinaSun Yat-sen University Cancer CenterGuangzhou 510060China United laboratory of Frontier Ra{1.otherapy Technology of {2. Yat-sen University&chinese {2. of sciences Ion Me{1.cal Technology Co. LtdGuangzhou 510060China

Objective:Glioblastomas are highly vascularized malignant *** determined the efficacy and safety of the anti-angiogenic multi-kinase inhibitor,anlotinib,for a newly {2.agnosed ***:This multicenter,single-arm trial(NCT041.9674)enrolled 33 treatment-naïve patients with histologically proven glioblastomas between March 2.1. and November *** underwent treatment with the standard STUPP regimen[fractionated focal irra{2.ation in daily fractions of 1.8-2.Gy given 5 d/w×6 w(total=54-60 Gy)]or ra{2.otherapy plus continuous daily temozolomide(TMZ)(75 mg/m^(2.of body surface area/d,7 d/w from the first to the last day of ra{2.otherapy),followed by 6 cycles of adjuvant TMZ(1.0-2.0 mg/m^(2.×5 d during each 2.-d cycle)plus anlotinib(8 mg/d on d 1.1. of each 3-w cycle for 2.cycles during concomitant chemora{2.otherapy,8 maximal cycles as adjuvant therapy,followed by maintenance at 8 mg/*** primary endpoint was progression-free survival(PFS).Secondary endpoints included overall survival(OS)and adverse events(AEs).Results:Thirty-three patients received the planned *** me{2.an PFS was 1..9 months(95%CI,9.9-1..7 months)and the 1.-month PFS rate was 48.5%.The me{2.an OS was 1..4 months(95%CI,1..5-2.3}1.months)and the 1.-month OS rate was 81.8%.The most common AEs included hypertriglyceridemia[58%(n=1.)],hypoalbuminemia[46%(n=1.)],and hypercholesterolemia[46%(n=1.)]during concurrent chemora{2.otherapy and leukopenia[73%(n=2.)],hypertriglyceridemia[67%(n=2.)],and neutropenia[52.(n=1.)]during adjuvant *** patients {2.scontinued treatment due to ***1.HR,5.6;95%CI,1.3-2..7;P=0.02.3}and RP1.1.alterations(HR,1..1.95%CI,2.2.57.2.P=0.004)were associated with a significantly shorter ***:Anlotinib plus the STUPP regimen has promising anti-tumor activity against glioblastoma and manageable ***1.and RP1.1.alterations might be novel pre{2.ctive biomarkers of the response to anlotinib.

关键词： Glioblastoma anti-angiogenesis multi-kinase inhibitor anlotinib temozolomide progression-free survival

Id2.epigenetically controls CD8^(+)T-cell exhaustion by disrupting the assembly of the Tcf3-LSD1.complex

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Cellular & Molecular Immunology 2024年第3期21卷 292-308页

作者： Yiming li Mingwei Han Haolin Wei Wan {2. Zhinan chen Tianjiao Zhang Meirui Qian lin Jing Gang Nan Xiuxuan sun Shuhui Dai Kun Wang Jianli Jiang Ping Zhu liang chen Department of Cell Biology of National Translational Science Center for Molecular Medicine and Department of C{1.nical Immunology of Xijing Hospital Fourth Military Medical UniversityXi’anShaanxi 710032China state {1. {2. of New Targets discovery and Drug Development for Major diseases GanzhouJiangxi341000Xi’anShaanxi 710032China School of Medicine Shanghai UniversityShanghai 200444China

CD8^(+)T-cell exhaustion is a state of dysfunction that promotes tumor progression and is marked by the generation of Slamf6^(+)progenitor exhausted(Tex^(prog))and Tim-^(3+)terminally exhausted(Tex^(term))*** of DNA bin{1.ng protein 2.Id2.has been shown to play important roles in T-cell development and CD8^(+)T-cell ***,the role of Id2.in CD8^(+)T-cell exhaustion is ***,we found that Id2.transcriptionally and epigenetically regulates the generation of Texprog cells and their conversion to Texterm *** deletion of Id2.dampens CD8^(+)T-cell-me{1.ated immune responses and the maintenance of stem-like CD8^(+)T-cell subpopulations,suppresses PD-1.blockade and increases tumor ***,through its HLH domain,Id2.binds and {1.srupts the assembly of the Tcf3-Tal1.transcriptional regulatory complex,and thus modulates chromatin accessibility at the Slamf6 promoter by preventing the interaction of Tcf3 with the histone lysine demethylase ***,Id2.increases the abundance of the permissive H3K4me2.mark on the Tcf3-occupied E-boxes in the Slamf6 promoter,modulates chromatin accessibility at the Slamf6 promoter and epigenetically regulates the generation of Slamf6+Texprog *** LSD1.inhibitor GSK2.79552.can rescue the Id2.knockout phenotype in tumor-bearing *** of LSD1.increases the abundance of Slamf6^(+)Tim-3^(−)Tex^(prog) cells in tumors and the expression level of Tcf1.in Id2.deleted CD8+T *** study demonstrates that Id2.me{1.ated transcriptional and epigenetic mo{1.fication drives hierarchical CD8^(+)T-cell exhaustion,and the mechanistic insights gained may have implications for therapeutic intervention with tumor immune evasion.

关键词： Id2 T-cell exhaustion Epigenetic modification Immune evasion

Sintilimab(anti-PD-1.antibody)plus chidamide(histone deacetylase inhibitor)in relapsed or refractory extranodal natural killer T-cell lymphoma(SCENT):a phase Ⅰb/Ⅱ study

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Signal Transduction and Targeted Therapy 2024年第6期9卷 2765-2773页

作者： Yan Gao Haixia He Xueping li liling Zhang Wei Xu Ru Feng Wenyu li Yin Xiao Xinxiu liu Yu chen Xiaoxiao Wang Bing Bai Huijing Wu Qingqing Cai Zhiming li Jibin li Suxia lin Yanxia He liqin Ping cheng {2. Jiaying Mao Xiujin chen Baitian Zhao Huiqiang {2. state {1. {2. of Oncology in South China&Collaborative Innovation Center of Cancer Medicine Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhouChina Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhouChina Department of Radiation Oncology Sun Yat-sen Memorial HospitalSun Yat-sen UniversityGuangzhouChina Department of Hematology Sun Yat-sen University Cancer CenterGuangzhouChina Cancer Center Union Hospital affiliated to Tongji Medical College of Huazhong University of Science and TechnologyWuhanChina Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingChina Department of Hematology Nanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Lymphoma Guangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of pathology Guangdong General HospitalGuangdong Academy of Medical SciencesGuangzhouChina Department of Medical Oncology Hubei Cancer CenterWuhanChina Department of Clinical Research Sun Yat-sen University Cancer CenterGuanzhouChina Department of Pathology Sun Yat-sen University Cancer CenterGuangzhouChina

Anti-PD-1.antibodies are a favorable treatment for relapsed or refractory extranodal natural killer T cell lymphoma(RR-ENKTL),however,the complete response(CR)rate and the duration of response(DOR)need to be *** phase 1./2.study investigated the safety and efficacy of sinti{1.mab,a fully human anti-PD-1.antibody,plus chidamide,an oral subtype-selective histone deacetylase inhibitor in 38 patients with *** objective response rate(ORR)of combination treatment was 80%.Patients received escalating doses of chidamide,administered concomitantly with fixed-dose sinti{1.mab in 2.0}days cycles up to 1. *** dose-{1.miting events were observed,RP2. of chidamide was 30 mg twice a ***-nine patients were enrolled in phase *** the intention-to-treat population(n=37),overall response rate was 59.5% with a complete remission rate of 48.6%.The median DOR,progression-free survival(PFS),and overall survival(OS)were 2..3,2..2.and 32.9 months,*** most common grade 3 or higher treatment-emergent adverse events(AEs)were neutropenia(2..9%)and thrombocytopenia(1..5%),immune-related AEs were reported in 1.(47.3%)*** biomarker assessment suggested that a combination of dynamic plasma ctDNA and EBV-DNA played a vital prognostic ***3 mutation shows an unfavorable *** outcome of anticipate ORR was not achieved,sinti{1.mab plus chidamide was shown to have a manageable safety profile and yielded encouraging CR rate and DOR in RR-ENKTL for the first *** is a promising therapeutic option for this population.

关键词： killer lymphoma doses

Synergistic induction of mitotic pyroptosis and tumor remission by inhibiting proteasome and WEE family kinases

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Signal Transduction and Targeted Therapy 2024年第8期9卷 3467-3482页

作者： Zhan-li {1. {1. Xie Wei Zeng Rui-Qi {2. Jin-E Yang Jin-Yu liu Ya-Jing {1. Shi-Mei Z{2. MOE key {1. of Gene Function and Regulation Guangdong Province Key Laboratory of Pharmaceutical Functional GenesSchool of Life SciencesState Key Laboratory of Oncology in Southern ChinaSun Yat-sen UniversityGuangzhouPR China key {1. of {2.ver disease of Guangdong Province The Third Affiliated HospitalSun Yat-sen UniversityGuangzhou 510630PR China

Mitotic catastrophe(MC),which occurs under dysregulated mitosis,represents a fascinating tactic to specifically eradicate tumor *** pyroptosis can be a death form of MC remains ***-mediated protein degradation is crucial for ***(BTZ),which inhibits the 2.S catalytic particle of proteasome,is approved to treat multiple myeloma and mantle cell lymphoma,but not so{2.d tumors due to primary *** date,whether and how proteasome inhibitor affected the fates of cells in M-phase remains ***,we show that BTZ treatment,or silencing of PSMC5,a subunit of 1.S regulatory particle of proteasome,causes G2.and M-phase arrest,multi-polar spindle formation,and consequent caspase-3/GSDME-mediated pyroptosis in M-phase(designated as mitotic pyroptosis).Further investigations reveal that inhibitor of WEE1.PKMYT1.PD01.62.5),but not inhibitor of ATR,CHK1.or CHK2.abrogates the BTZ-induced G2.phase arrest,thus exacerbates the BTZ-induced mitotic arrest and *** BTZ and PD01.62.5 treatment(named BP-Combo)selectively kills various types of so{2.d tumor cells,and significantly lessens the IC50 of both BTZ and PD01.62.5 compared to BTZ or PD01.62.5 *** using various mouse models show that BP-Combo has much stronger inhibition on tumor growth and metastasis than BTZ or PD01.62.5 monotreatment,and no obvious toxicity is observed in BP-Combo-treated *** findings disclose the effect of proteasome inhibitors in inducing pyroptosis in M-phase,characterize pyroptosis as a new death form of mitotic catastrophe,and identify dual inhibition of proteasome and WEE family kinases as a promising anti-cancer strategy to selectively kill so{2.d tumor cells.

关键词： proteasome inhibiting catastrophe

CRL2.(APPBP2.-mediated TSPYL2.degradation counteracts human mesenchymal stem cell senescence

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Science China(life {1.) 2024年第3期67卷 460-474页

作者： Daoyuan huang Qian Zhao Kuan Yang Jinghui Lei Ying Jing Hongyu {1. {2. Zhang Shuai Ma Shuhui sun Yusheng Cai Guibin Wang Jing Qu Weiqi Zhang Si Wang Guang-Hui {1.u Advanced Innovation Centerfor Human Brain Protection National Clinical Research Centerfor Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China state {1. {2. of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational MedicineCenter International Centerfor Aging and CancerBejing Municipal GeriatricMedical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China state {1. {2. of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of chinese academy of sciences Beijing 100049China Beijing institute for Stem Cell and Regenerative Me{1.cine Beijing100101China CAS key {1. of Genomic and Precision Me{2.cine Bejing Institute of Genomics and China National Center for BioinformationChinese Academy of SciencesBeijing 100101China institute for Stem Cell and Regeneration CASBeijing 100101China The Fifth People's Hospital of Chongqing Chongqing 400062China Sino-Danish Cllege University of Chinese Academy of SciencesBeijing101408China National laboratory of Biomacromolecules CAS Center for Excelence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing100101China state {1. {2. of Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijing 102206China

Cullin-RING E3 ubiquitin ligases(CRLs),the largest family of multi-subunit E3 ubiquitin ligases in eukaryotic cells,represent core cellular machinery for executing protein degradation and maintaining ***,we asked what roles Cullin proteins play in human mesenchymal stem cell(hMSC)homeostasis and *** this end,we conducted a comparative aging phenotype analysis by individually knocking down Cullin members in three senescence models:replicative senescent hMSCs,Hutchinson-Gilford Progeria Syndrome hMSCs,and Werner syndrome *** all family members,we found that CUL2.deficiency rendered hMSCs the most susceptible to *** investigate CUL2.specific underlying mechanisms,we then applied CRISPR/Cas9-mediated gene editing technology to generate CUL2.deficient human embryonic stem cells(hESCs).When we differentiated these into h MSCs,we found that CUL2.deletion markedly accelerates hMSC ***,we identified that CUL2.targets and promotes ubiquitin proteasome-mediated degradation of TSPYL2.a known negative regulator of proliferation)through the substrate receptor protein APPBP2.which in turn downregulates one of the canonical aging marker-P2.13}(waf1.cip1.,and thereby delays *** work provides important insights into how CRL2.(APPBP2.-mediated TSPYL2.degradation counteracts hMSC senescence,providing a molecular basis for directing intervention strategies against aging and aging-related diseases.

关键词： Cullins stem cell senescence aging proteostasis ubiquitination APPBP2 TSPYL2

Treatment outcomes for different subgroups of nasopharyngeal carcinoma patients treated with intensity-modulated radiation therapy

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chinese Journal of Cancer 2011年第8期30卷 565-573页

作者： Sheng-Fa Su 1.2.3,Fei Han 1.2.Chong Zhao 1.2.Ying huang 1.2.Chun-Yan {1. 1.2.Wei-Wei Xiao 1.2.Jia-Xin li 1.2.and Tai-Xiang Lu 1.2.1.{12. key laboratory of Oncology in South China,Guangzhou,Guangdong 51.060,P.R.China 2.Department of Radiation Oncology,sun Yat-sen University Cancer Center,Guangzhou,Guangdong 51.060,P.R.China 3 Department of Oncology,Guiyang Medical College Hospital,Tumor Hospital of Guizhou,Guiyang,Guizhou 550003,P.R.China. state {1. {2. of Oncology in South China Guangzhou Guangdong 510060 P. R. China.

Although many studies have investigated intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma (NPC),sample sizes in the reported studies are usually small and different in outcomes in different T and N subgroups are seldom ***,we evaluated the outcomes of NPC patients treated with IMRT and further explored treatment strategy to improve such *** collected clinical data of 865 NPC patients treated with IMRT alone or in combination with chemotherapy,and classified all cases into the following prognostic categories according to different TNM stages:early stage group (T1.2.0-1.0),advanced local disease group (T3-4N0-1.0),advanced nodal disease group (T1.2.2.3M0),and advanced locoregional disease group (T3-4N2.3M0).The 5-year overall survival (OS),local relapse-free survival (LRFS),and distant metastases-free survival (DMFS) were 83.0%,90.4%,and 84.0%,*** early disease group had the lowest treatment failure rate,with a 5-year OS of 95.6%.The advanced local disease group and advanced nodal disease group had similar failure pattern and treatment outcomes as well as similar hazard ratios for death (4.2.0 and 4.62.,respectively).The advanced locoregional disease group had the highest incidence of relapse and death,with a 5-year DMFS and OS of 62.3% and 62.2.,respectively,and a hazard ratio for death of *** with IMRT alone,IMRT in combination with chemotherapy provided no significant benefit to locoregionally advanced *** results suggest that the decision of treatment strategy for NPC patients should consider combinations of T and N stages,and that IMRT alone for early stage NPC patients can produce satisfactory ***,for advanced local,nodal,and locoregional disease groups,a combination of chemotherapy and radiotherapy is recommended.

关键词：放射治疗强度调制鼻咽癌患者调控样本大小临床资料结合治疗