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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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A Damage Control Model for Reinforced Concrete Pier Columns Based on Pre-Damage Tests under Cyclic Reverse Loading

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Structural Durability & Health Monitoring 2025年第2期19卷 327-346页

作者： zhao-Jun zhang Jing-Shui zhen Bo-Cheng li de-Cheng Cai Yang-Yang Du Wen-Wei Wang Offshore Oil Engineering Co. Ltd.Tianjin300461China department of Bridge Engineering School of TransportationSoutheast UniversityNanjing21189China

To mitigate the challenges in managing the damage level of reinforced concrete(RC)pier columns subjected to cyclic reverse loading,this study conducted a series of cyclic reverse tests on RC pier *** analyzing the outcomes of destructive testing on various specimens and fine-tuning the results with the aid of the iMK(ibarra Medina Krawinkler)recovery model,the energy dissipation capacity coefficient of the pier columns were able to be ***,utilizing the calibrated damage model parameters,the damage index for each specimen were *** on the obtained damage levels,three distinct pre-damage conditions were designed for the pier columns:minor damage,moderate damage,and severe *** study then predicted the variations in hysteresis curves and damage indices under cyclic loading *** experimental findings reveal that the displacement at the top of the pier columns can serve as a reliable indicator for controlling the damage level of pier columns ***,the calibrated damage index model exhibits proficiency in accurately predicting the damage level of RC pier columns under cyclic loading.

关键词： Reinforced concrete pier cyclic reverse load pre-damage damage index displacement control

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Moment Redistribution Effect of the Continuous Glass Fiber Reinforced Polymer-Concrete Composite Slabs Based on Static Loading Experiment

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Structural Durability & Health Monitoring 2025年第1期19卷 105-123页

作者： zhao-Jun zhang Wen-Wei Wang Jing-Shui zhen Bo-Cheng li de-Cheng Cai Yang-Yang Du Hui Huang Offshore Oil Engineering Co.Ltd. Tianjin300461China department of Bridge Engineering School of TransportationSoutheast UniversityNanjing211189China

This study aimed to investigate the moment redistribution in continuous glass fiber reinforced polymer(GFRP)-concrete composite slabs caused by concrete cracking and steel bar yielding in the negative bending moment *** experimental bending moment redistribution test was conducted on continuous GFRP-concrete composite slabs,and a calculation method based on the conjugate beam method was *** composite slabs were formed by combining GFRP profiles with a concrete layer and supported on steel beams to create two-span continuous composite slab *** methods,epoxy resin bonding,and stud connection,were used to connect the composite slabs with the steel *** experimental findings showed that the specimen connected with epoxy resin exhibited two moments redistribution phenomena during the loading process:concrete cracking and steel bar yielding at the internal *** contrast,the composite slab connected with steel beams by studs exhibited only one-moment redistribution phenomenon throughout the loading *** the concrete at the internal support cracked,the bending moment decreased in the internal support section and increased in the midspan *** the steel bars yielded,the bending moment further decreased in the internal support section and increased in the mid-span *** GFRP profiles do not experience cracking,there was no significant decrease in the bending moment of the mid-span *** test specimens experienced compressive failure of concrete at the mid-span *** results showed good agreement between the calculated and experimental values of bending moments in the mid-span section and internal support *** proposed model can effectively predict the moment redistribution behavior of continuous GFRP-concrete composite slabs.

关键词： Moment redistribution GFRP-concrete composite slabs bending moment experimental study analysis model

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Ti^(3+)/Ti^(4+)and Co^(2+)/Co^(3+)redox couples in Ce-doped Co-Ce/TiO2 for enhancing photothermocatalytic toluene oxidation

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Journal of Environmental Sciences 2025年第3期149卷 164-176页

作者： Guanghui li Xiaolan li Xinhui Hao Qiang li Meng zhang Hongpeng Jia Xiamen Key Laboratory of Materials for Gaseous Pollutant Control Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China Key Laboratory of Urban Pollutant Conversion Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China CAS Center for Excellence in Regional Atmospheric Environment Institute of Urban EnvironmentChinese Academy of SciencesXiamen 361021China University of Chinese Academy of Sciences Beijing 100049China

Cerium and cobalt loaded Co-Ce/TiO_(2)catalyst prepared by impregnation method was investigated for photothermal catalytic toluene *** on catalyst characterizations(XPS,EPR and H2-TPR),redox cycle between Co and TiO_(2)(Co^(2+)+Ti^(4+)↔Co^(3+)+Ti^(3+))results in the formation of Co^(3+),Ti^(3+)and oxygen vacancies,which play important roles in toluene catalytic oxidation *** introduction of Ce brings in the dual redox cycles(Co^(2+)+Ti^(4+)↔Co^(3+)+Ti^(3+),Co^(2+)+Ce4+↔Co^(3+)+Ce3+),further promoting the elevation of reaction sites *** full spectrum irradiation with light intensity of 580mW/cm^(2),Co-Ce/TiO_(2)catalyst achieved 96%of toluene conversion and 73%of CO_(2)yield,obviously higher than Co/P25 and Co/TiO_(2).Co-Ce/TiO_(2)efficiently maintains 10-hour stability test under water vapor conditions and exhibits better photothermal catalytic performance than counterparts under different wavelengths *** catalytic reaction displays improved activities compared with thermal catalysis,which is attributed to the promotional effect of light including photocatalysis and light activation of reactive oxygen species.

关键词： Photothermal catalysis Redox cycle Oxygen vacancy VOCs Titanium dioxide

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Fluorine-functionalized zirconium-organic cages for efficient photocatalytic oxidation of thioanisole

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Chinese Chemical Letters 2025年第1期36卷 632-636页

作者： Jia-Ru li Ning li li-ling He Jun He School of Chemical Engineering and light industry Guangdong University of TechnologyGuangzhou 510006China School of Chemistry South China Normal UniversityGuangzhou 510006China

zirconium-based metal-organic cages(zr-MOCs)typically exhibit high stability,but their structural and application reports are scarce due to stringent crystallization *** have successfully fluorinated the classical zr-MOCs(zrT-3)for the first time,obtaining the fluorinated MOCs(zrT-3-F).Notably,zrT-3-F not only inherits the high stability of its parent structure,but also acts as a catalyst for the effective oxidation of benzyl thioether for the first *** reaction can reach a conversion rate of 99%in 6 h,and the selectivity reaches 95%,which far exceeds the non-fluorinated *** work proves that the specific functionalization of the classical zr-MOCs can further expand their application potential,such as catalysis.

关键词： Ultraviolet light Fluorine zirconium-based metal-organic cages Sulfide oxidation Multiphase photocatalysis

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Prediction of velocity and pressure of gas-liquid flow using spectrum-based physics-informed neural networks

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Applied Mathematics and Mechanics(English Edition) 2025年第2期46卷 341-356页

作者： Nanxi DiNG Hengzhen FENG H.z. LOU Shenghua FU Chenglong li zihao zHANG Wenlong MA zhengqian zHANG School of Mechanical Engineering Beijing Institute of Technology University of Southern California Xi'an institute of Electromechanical information Technology

This research introduces a spectrum-based physics-informed neural network (SP-PiNN) model to significantly improve the accuracy of calculation of two-phase flow parameters, surpassing existing methods that have limitations in global and continuous data sampling. SP-PiNNs address the challenges of traditional methods in terms of continuous sampling by integrating the spectral analysis and pressure correction into the Navier-Stokes (N-S) equations, enhancing the predictive accuracy especially in critical regions like gas-phase boundaries and velocity peaks. The novel introduction of a pressure-correction module within SP-PiNNs mitigates prediction errors, achieving a substantial reduction to 1‰compared with the conventional physics-informed neural network (PiNN) approaches. Experimental applications validate the model’s ability to accurately and rapidly predict flow parameters with different sampling time intervals,with the computation time of predicting unsampled data less than 0.01 s. Such advancements signify a 100-fold improvement over traditional DNS calculations, underscoring the model’s potential in the real-time calculation and analysis of multiphase flow dynamics.

关键词： physics-informed neural network (PiNN) spectral method two-phase flow parameter prediction O359

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High-throughput screening of CO_(2) cycloaddition MOF catalyst with an explainable machine learning model

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Green Energy & Environment 2025年第1期10卷 132-138页

作者： Xuefeng Bai Yi li Yabo Xie Qiancheng Chen Xin zhang Jian-Rong li Beijing Key Laboratory for Green Catalysis and Separation and department of Chemical Engineering College of Materials Science&EngineeringBeijing University of TechnologyBeijing100124China

The high porosity and tunable chemical functionality of metal-organic frameworks(MOFs)make it a promising catalyst design ***-throughput screening of catalytic performance is feasible since the large MOF structure database is *** this study,we report a machine learning model for high-throughput screening of MOF catalysts for the CO_(2) cycloaddition *** descriptors for model training were judiciously chosen according to the reaction mechanism,which leads to high accuracy up to 97%for the 75%quantile of the training set as the classification *** feature contribution was further evaluated with SHAP and PDP analysis to provide a certain physical understanding.12,415 hypothetical MOF structures and 100 reported MOFs were evaluated under 100℃ and 1 bar within one day using the model,and 239 potentially efficient catalysts were *** them,MOF-76(Y)achieved the top performance experimentally among reported MOFs,in good agreement with the prediction.

关键词： Metal-organic frameworks High-throughput screening Machine learning Explainable model CO_(2)cycloaddition

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Epigenetic regulation of the inflammatory response in stroke

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Neural Regeneration Research 2025年第11期20卷 3045-3062页

作者： Jingyi liang Fei Yang zixiao li Qian li School of Basic Medical Sciences Capital Medical UniversityBeijingChina department of Neurobiology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Laboratory for Clinical Medicine Beijing Key Laboratory of Neural Regeneration and RepairCapital Medical UniversityBeijingChina department of Neurology Beijing Tiantan HospitalCapital Medical UniversityBeijingChina China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina National Center for Healthcare Quality Management in Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Chinese institute for Brain Research BeijingChina Research Unit of Artificial intelligence in Cerebrovascular Disease Chinese Academy of Medical SciencesBeijingChina Beijing Engineering Research Center of Digital Healthcare for Neurological Diseases BeijingChina department of Biochemistry and Molecular Biology School of Basic Medical SciencesCapital Medical UniversityBeijingChina Beijing Key Laboratory of Cancer invasion and Metastasis Research Capital Medical UniversityBeijingChina

Stroke is classified as ischemic or hemorrhagic,and there are few effective treatments for either *** mechanisms play a critical role in secondary brain injury following a stroke,which manifests as cytokine release,blood–brain barrier disruption,neuronal cell death,and ultimately behavioral *** the inflammatory response has been shown to mitigate this cascade of events in experimental stroke ***,in clinical trials of anti-inflammatory agents,longterm immunosuppression has not demonstrated significant clinical benefits for *** may be attributable to the dichotomous roles of inflammation in both tissue injury and repair,as well as the complex pathophysiologic inflammatory processes in *** acute harmful inflammatory responses or inducing a phenotypic shift from a pro-inflammatory to an anti-inflammatory state at specific time points after a stroke are alternative and promising therapeutic *** agents that can modulate inflammation requires a detailed understanding of the inflammatory processes of ***,epigenetic reprogramming plays a crucial role in modulating post-stroke inflammation and can potentially be exploited for stroke *** this review,we summarize current findings on the epigenetic regulation of the inflammatory response in stroke,focusing on key signaling pathways including nuclear factor-kappa B,Janus kinase/signal transducer and activator of transcription,and mitogen-activated protein kinase as well as inflammasome *** also discuss promising molecular targets for stroke *** evidence to date indicates that therapeutic targeting of the epigenetic regulation of inflammation can shift the balance from inflammation-induced tissue injury to repair following stroke,leading to improved post-stroke outcomes.

关键词： DNA methylation histone modification intracerebral hemorrhage ischemic stroke neuroinflammation neuroprotection non-coding RNA RNA methylation subarachnoid hemorrhage treatment

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Alpha-decay properties of nuclei around neutron magic numbers

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Nuclear Science and Techniques 2025年第1期36卷 140-149页

作者： Ming li Chu-Xin Chen Lan-Fang Xiao Yi zhang Song Luo Xiao-Hua li School of Nuclear Science and Technology University of South ChinaHengyang 421001China PET‑CT Center Chenzhou First People’s HospitalChenzhou 423000China Hengyang Ecological Environment Monitor Center Hengyang 421001China China Certification and inspection Group Hefei 230000China National Exemplary Base for international Science and Technology Collaboration of Nuclear Energy and Nuclear Safety University of South ChinaHengyang 421001China Cooperative innovation Center for Nuclear Fuel Cycle Technology and Equipment University of South ChinaHengyang 421001China Key Laboratory of Low Dimensional Quantum Structures and Quantum Control Hunan Normal UniversityChangsha 410081China

By combining experimental α-decay energies and half-lives, the α-particle preformation factor for nuclei around neutron magic numbers N of 126, 152, and 162 were extracted using the two-potential approach. The nuclei around the shell closure were more tightly bound than adjacent nuclei. Additionally, based on the WS4 mass model (Wang et al., Phys. Lett.B 734, 215 (2014)), we extended the two-potential approach to predict the α-decay half-lives of nuclei around N values of178 and 184 with z of 119 and 120. We believe that our findings will serve as guidelines for future experimental studies.

关键词： adecay Preformation factor Neutron magic number Heavy and superheavy nuclei

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Experimental and Numerical Study of Bonding Capacity of interface between Ultra-High Performance Concrete and Steel Tube

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Structural Durability & Health Monitoring 2025年第2期19卷 285-305页

作者： Ruikun Xu Jiu li Wenjie li Wei zhang China Communications Third Highway Engineering Bureau Co. Ltd.Fuzhou350300China College of Civil Engineering Fujian University of TechnologyFuzhou350118China

This study investigates the bond performance at the interfacial region shared by Ultra-High Performance Concrete(UHPC)and steel tubes through push-out *** study examines how changes in steel fiber volumetric ratio and thickness of steel tube influence the bond strength *** results show that as the enhancement of the steel tube wall thickness,the ultimate bond strength at the interface improves significantly,whereas the initial bond strength exhibits only slight *** influence of steel fiber volumetric ratio presents a nonlinear trend,with initial bond strength decreasing at low fiber content and increasing significantly as fiber content ***,finite element(FE)simulations were applied to replicate the experimental conditions,and the outcomes showed strong correlation with the experimental data,confirming the exactitude of the FE model in predicting the bond behavior at the UHPC-Steel *** findings provide valuable insights for optimizing the design of UHPC-Filled steel tubes in high-performance structure.

关键词： Ultra-high performance concrete filled steel tube(UHPCFST) push-out test bonding capacity cohesive zone model

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