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ZD 7288,an HCN channel blocker,attenuates chronic visceral pain in irritable bowel syndrome-like rats

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World Journal of Gastroenterology 2014年第8期20卷 2091-2097页

作者： Yu Chen Chun lin Ying Tang Ai-Qin Chen Cui-Ying liu da-li lu Laboratory for Pain Research Key Laboratory of Brain Aging and Neurodegenerative DiseasesCenter for Neuroscience ResearchDepartment of Physiology and PathophysiologyFujian Medical University

AIM: To investigate the effects of ZD 7288, a hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blocker, on rats with chronic visceral pain.

关键词： Abdominal withdrawal reflex Electromyography Hyperpolarization-activated cyclic nucleotide-gated channel Visceral hypersensitivity ZD 7288 Irritable bowel syndrome

Prevalence of dental caries among preschool children in Shanghe County of Shandong Province and relevant prevention and treatment strategies

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Chinese Medical Journal 2008年第22期121卷 2246-2249页

作者： SHANG Xiao-hong li da-lu HUANG Yi CHEN Hui SUN Ruo-peng Department of Pediatrics Jinan Central Hospital Affiliated to Shandong University Jinan Shandong 250013 China Department of Oral and Maxillofacial Surgery Stomatological Hospital of Jinan Jinan Shandong 250001 China Department of Stomatology Maternity and Children's Hospital of Jinan Jinan Shandong 250001 China Department of Operative Dentistry and Endodontics Stomatological Hospital of Jinan Jinan Shandong 250001 China Department of Pediatrics Qilu Hospital of Shandong University Jinan Shandong 250012 China

Background Decayed teeth are harmful to children＇s growth and development and can severely jeopardize their health. This study was set out to investigate and analyze the prevalence of dental caries in preschool children in Shanghe County in Shandong Province, China, and provide new insights into potential prevention and treatment strategies. Methods Based on the random sampling method, we performed dental examinations of children aged 2 to 6 years in kindergartens of Shanghe County. The prevalence of caries, the average number of decayed teeth per capita as well as the constituent rates of decayed, missing and filled teeth were determined retrospectively. SPSS software was used for data analysis. Results Dental caries were found in 1088 out of 2052 children from 56 kindergartens. The total number of decayed teeth was 4487 with a prevalence of 53.02%. The average number of decayed teeth per capita was 2.187, and the filling rate was 0.29%. There was no statistical difference in the prevalence of caries between boys and girls though there were significant differences between different age groups. The prevalence of decayed teeth as well as the mean number of decayed teeth infected per capita increased with age. In addition, urban children had a higher prevalence than those from rural areas （P 〈0.01）. Conclusions The prevalence of decayed caries among kindergarten children in Shanghe County was high, suggesting that more emphasis should be put on improving oral health education with priority given to prevention. Further efforts should be made to increase the decayed caries filling rate.

关键词： decayed, missing and filled teeth dental caries oral health preschool child prevalence," preventive dentistry

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基于循环神经网络的动态等值模型辨识

高电压技术 2008年第5期34卷 1001-1004页

作者：陈涵邓长虹李大路武汉大学电气工程学院武汉430072

为了在系统稳定计算分析中简化和减小计算难度,用动态等值作为一种建模方法提出了一种基于循环神经网络的电力系统动态等值法并结合串并联辨识结构将其用于等值后模型的辨识。这种方法不需要预先建立确定的动态模型,仅靠边界节点的测量... 详细信息

为了在系统稳定计算分析中简化和减小计算难度,用动态等值作为一种建模方法提出了一种基于循环神经网络的电力系统动态等值法并结合串并联辨识结构将其用于等值后模型的辨识。这种方法不需要预先建立确定的动态模型,仅靠边界节点的测量数据。循环神经网络的权值和结构决定了被等值外部模型的参数和结构。对IEEE的39节点进行的仿真结果表明了该方法能够捕捉原始系统的动态特性,有较高的精确性。

关键词：辨识电力系统动态等值循环神经网络串并联辨识结构动态特性

Micro-strain regulation strategy to stabilize perovskite lattice based on the categories and impact of strain on perovskite solar cells

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Journal of Energy Chemistry 2025年第1期100卷 578-604页

作者： Caixia li Wenwu liu Shiji da lingbin Kong Fen Ran State Key Laboratory of Advanced Processing and Recycling of Nonferrous Metals Lanzhou University of Technology School of Materials Science and Engineering Lanzhou University of Technology

Photovoltaic metal halide perovskite solar cells(PSCs) convert light to electricity more efficiently than crystalline silicon cells, and the cost of materials used to make them is lower than that of silicon *** efficiency is not a core issue affecting the application of perovskite solar cells in special *** present, stability is the major technical encounters that hinders its further commercial development. Microstrain in PSCs is currently a significant factor responsible for the device's instability. Strain-induced ion migration is widely believed to accelerate perovskite degradation even when external stimuli are ***, it is imperative to study strain to enhance the stability of PSCs. This paper reviews recent developments to understand strain's origin and effect mechanisms on performance of PSCs, including ion migration,failure behavior, defect formation, and its effect on photoelectric properties, stability, and ***, several well-known strain management strategies are systematically introduced based on the strain effect mechanism and strain engineering on the film, providing more clues for further preparation with increased stability. The manipulation of external physical strain applied from films to entire devices has been extensively studied. Furthermore, recommendations for future research directions and chemical approaches have been provided. It is emphasized that strain engineering plays a crucial role in improving the efficiency and longevity of PSCs. Tensile strain causes rapid degradation, while moderate compressive strain and external strain control could improve properties and stability. Efforts should focus on controlling compressive strain to mitigate residual tensile strain and introducing it in a controlled manner. Future research endeavors may focus on exploring these pathways to improve the efficiency and lifespan of PSCs.

关键词： Halide perovskite solar cells Strain origins Strain effects Strain management

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可变遗忘因子递推最小二乘法对时变参数测量

高电压技术 2008年第7期34卷 1474-1477页

作者：陈涵刘会金李大路代静武汉大学电气工程学院武汉430072 国网武汉高压研究院武汉430074

针对传统的递推最小二乘法对于非平稳环境下的突变和时变信号的跟踪能力不够,常常无法检测到信号特征参数的问题,提出了在指数加权递推最小二乘法中引入可变的加权遗忘因子λ,对电力系统时变信号的幅值、相位、频率进行测量的方法。加... 详细信息

针对传统的递推最小二乘法对于非平稳环境下的突变和时变信号的跟踪能力不够,常常无法检测到信号特征参数的问题,提出了在指数加权递推最小二乘法中引入可变的加权遗忘因子λ,对电力系统时变信号的幅值、相位、频率进行测量的方法。加权λ对算法的收敛速度和跟踪能力有很大影响,如能很好的调节λ,既可确保对时变参数的快速跟踪能力,又能具备小的参数估计误差。仿真结果表明:与传统的递推最小二乘法相比,该方法测量精度和收敛速度更优越,即使在低信噪比环境下,也能较精确的测出时变参数值。

关键词：递推最小二乘法可变遗忘因子幅值相位频率电力系统

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城市公共设施设计的地域文化重构

包装工程 2018年第10期39卷 280-282页

作者：孙大力陆津大庆师范学院美术与设计学院大庆163712

目的探究地域文化在设计中的重要性及其价值重构。方法从文化的含义入手,探索城市建设中文化内涵的重要价值,结合城市公共设施的定义及其主要功能体现,分析城市公共设施中地域文化的相互关联,最后调动社会力量,收集历史素材;结合城市实... 详细信息

目的探究地域文化在设计中的重要性及其价值重构。方法从文化的含义入手,探索城市建设中文化内涵的重要价值,结合城市公共设施的定义及其主要功能体现,分析城市公共设施中地域文化的相互关联,最后调动社会力量,收集历史素材;结合城市实际,再生造型符号元素;重视文化认同,提升居民生活幸福感,并结合不同地域的代表性城市的公共设施在地域文化重构中的具体策略进行实例论证,得出城市文化的构建策略与延伸方向。结论城市公共设施是城市文化的物质载体,在其中融入地域文化元素,实现文化价值重构,能表现城市地域特色,提升城市的文化属性,让人们产生认同感、归属感和幸福感。

关键词：城市公共设施重构文化价值

OSA变性淀粉的乳化特性及其对纳米乳液构建影响的研究

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食品工业科技 2017年第1期38卷 59-64页

作者：李达鸿李璐解新安李雁华南农业大学食品学院广东广州510642

研究生物大分子辛烯基琥珀酸淀粉(OSA)的乳化特性,并以其为乳化剂构建负载番茄红素的稳定纳米乳液体系。研究结果表明:溶解温度70℃,淀粉浓度为30%(w/w)时,OSA变性淀粉的乳化性能最佳。以其为乳化剂,当油相(中链甘油三酯,MCT)中番茄红... 详细信息

研究生物大分子辛烯基琥珀酸淀粉(OSA)的乳化特性,并以其为乳化剂构建负载番茄红素的稳定纳米乳液体系。研究结果表明:溶解温度70℃,淀粉浓度为30%(w/w)时,OSA变性淀粉的乳化性能最佳。以其为乳化剂,当油相(中链甘油三酯,MCT)中番茄红素的质量浓度为0.1%(w/w),油水比1∶9时,通过高压均质得到的纳米乳液粒径120 nm,番茄红素负载率63%,经过一个月的储藏后,乳液粒径增加到160 nm,增长幅度小于34%,性状稳定,没有油相析出,表明OSA变性淀粉适合作为构建安全稳定纳米乳液的乳化剂。

关键词： OSA变性淀粉乳化特性纳米乳液稳定性

Synergistic effect of bonding heterogeneity and phonon localization in introducing excellent thermoelectric properties in layered heteroanionic NdZnSbO material

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Journal of Energy Chemistry 2025年第1期100卷 259-272页

作者： da Wan Shuwei Tang Shulin Bai Xiaodong li Peng Ai Wanrong Guo Tuo Zheng College of Materials Science and Engineering Liaoning Technical University Faculty of Chemistry Northeast Normal University

Layered rare-earth metal oxides, harnessing the dual properties of oxides and two-dimensional layered materials, exhibit remarkable thermal stability and quantum confinement effects. Therefore, this work adopts the first-principles calculation combined with the Boltzmann transport theory to predict the thermoelectric properties of NdZnSbO compound. The coexistence of weak interlayer van der Waals interactions, robust intralayer ionic bonding, and partial covalent bonding leads to remarkable bonding heterogeneity, which engenders pronounced phonon scattering and imposes constraints on thermal transport along the out-of-plane direction. The weakened chemical bonds induced by the antibonding states, together with the rattling-like behavior of the Zn atom, culminate in the profound anharmonicity in the layered NdZnSbO compound. The weakening bond and heavy element contribute to the softness of phonon modes, which significantly diminishes the phonon group velocity. The redistribution-dominated four-phonon scattering process spans a large optical gap, which effectively reduces the lattice thermal conductivity. The NdZnSbO compound exhibits direct semiconductor characteristic with a bandgap of 0.73 e V by adopting the Heyd-Scuseria-Ernzerhof(HSE06) functional in combination with spin–orbit coupling(SOC) effect. The multi-valley feature of NdZnSbO compound augur favorably for band degeneracy, thus amplifying the power factor. Consequently, an optimal figure-of-merit(ZT) of 3.40 at 900 K is achieved for the n-type NdZnSbO compound. The present study delves deeply insights into the origins for the low thermal conductivity of NdZnSbO compound and proposes an optimization scheme to enhance overall thermoelectric performance.

关键词： Bond strength (chemical)

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang Bing Zhang Lanfang li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang liu Youming lu Xinyan li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury