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Strenulagus(Mammalia: Lagomorpha) from the Middle Eocene Irdin Manha Formation of the Erlian Basin, Nei Mongol, China

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Acta Geologica Sinica(English Edition) 2015年第1期89卷 12-26页

作者： Lucja FOSTOWICZ-FREliK li chuankui li Qian MENG Jin WANG Yuanqing Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of Sciences Institute of Paleobiology Polish Academy of Sciences Division of Paleontology American Museum of Natural History

New material of Strenulagus solaris, a stem lagomorph, from the lower part of the Middle Eocene Irdin Manha Formation at the Irdin Manha and Huheboerhe localities, Erlian Basin, Nei Mongol, China includes remains of isolated cheek teeth, fragmentary upper incisors （dI2） and postcranial elements, reported from the species for the first time. The tarsal bones display advanced features, such as a wide calcaneofibular articulation surface and, along with an increase in hypsodonty, the new data document the early stage of lagomorph evolution in the Middle Eocene of the Erlian Basin. This finding is stratigraphically well constrained and probably predates that of the type material of S. solaris from the Khaychin Formation, Bugin-Tsav Basin, Mongolia.

关键词： Vertebrate paleontology stem lagomorphs morphology Paleogene Land Mammal Ages,Inner Mongolia

A new family of primitive mammal from the Mesozoic of western liaoning,China

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Chinese Science Bulletin 2001年第9期46卷 782-786页

作者： Jinling li Yuan Wang Yuanqing Wang chuankui li Chinese Acad Sci Inst Vertebrate Paleontol & Paleoanthropol Beijing 100044 Peoples R China

A fairly well-preserved specimen of a new primitive mammal, Repenomamus robustus gen. et sp. nov., has been described from the Yixian Formation (Lower Cretaceous), western liaoning, China. This animal has several derived characteristics, such as well-developed den-tary/squamosal articulation, reduced number of tooth, differentiation of premolars and molars in postcanine teeth, presence of a dorsal process of the premaxilla that is not in contact with the nasal, closed medial wall of the orbit, and presence of fingerlike promontorium on the petrosal. It also retains some primitive reptile-like features. It is the most primitive taxon among the three mammals known from the Jehol Biota, and also represents the largest mammal of Mesozoic age over the world.

关键词： primitive mammal Early Cretaceous western liaoning.

沉默MPZL1调控β-catenin对A549/Tax细胞干性及耐药性的影响

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安徽医科大学学报 2024年第1期59卷 99-105页

作者：臧超戈巧李超洪海宁李伟苏君黎传奎陈力维王安生蚌埠医学院第一附属医院胸外科蚌埠233004 蚌埠医学院研究生院蚌埠233030 蚌埠医学院附属第三人民医院胸外科蚌埠233000

目的探讨髓磷脂蛋白零样蛋白1(MPZL1)沉默后是否通过调控β-catenin表达对A549/Tax耐药性和细胞干性产生影响。方法采用不同浓度阿霉素和紫杉醇处理A549和A549紫杉醇耐药性(A549/Tax)细胞,观察两种细胞的耐药性差异。实时荧光定量聚合... 详细信息

目的探讨髓磷脂蛋白零样蛋白1(MPZL1)沉默后是否通过调控β-catenin表达对A549/Tax耐药性和细胞干性产生影响。方法采用不同浓度阿霉素和紫杉醇处理A549和A549紫杉醇耐药性(A549/Tax)细胞,观察两种细胞的耐药性差异。实时荧光定量聚合酶链式反应(qRT-PCR)和Western blot检测A549和A549/Tax细胞中MPZL1的表达量差异。对A549/Tax细胞沉默或者过表达MPZL1,进一步将细胞分为对照(control)组、短发卡RNA阴性对照(sh-NC)组、MPZL1沉默(sh-MPZL1)组、过表达阴性对照(OE-NC)组、MPZL1过表达(OE-MPZL1)组,运用细胞计数试剂盒8(CCK-8)和平板克隆实验分别检测MPZL1的表达变化对A549/Tax细胞增殖和克隆形成能力的影响。Western blot检测Wnt/β-catenin抑制剂XAV939和激活剂CHIR-99201处理细胞后,不同蛋白的表达变化。结果A549/Tax细胞对阿霉素和紫杉醇的半数抑制浓度(IC 50)较A549细胞明显增加(P<0.01)。MPZL1在A549/Tax中呈更高的表达趋势。MPZL1敲除后A549/Tax对阿霉素和紫杉醇的IC 50分别为2.731 mg/ml和4.939μg/ml,较阴性对照组的4.541 mg/ml和13.55μg/ml降低(P<0.01)。CCK-8和克隆形成实验结果显示,MPZL1敲除抑制肺癌A549/Tax细胞的增殖活力和克隆形成能力(P<0.05);Western blot结果显示,与阴性对照组相比,MPZL1、肿瘤干性相关蛋白(CD44和CD133)、多药耐药蛋白1(MDR1)、肺耐药相关蛋白(LRP)和β-catenin在sh-MPZL1中的表达水平明显减少(P<0.01)。此外,XAV939可抑制MPZL1、CD44、CD133、MDR1、LRP和β-catenin的表达。CHIR-99201处理细胞后部分逆转敲除MPZL1对上述蛋白的抑制作用。结论MPZL1在肺癌A549/Tax细胞中高表达。敲除MPZL1可抑制肿瘤干性和细胞增殖,增强肺癌A549/Tax细胞对阿霉素和紫杉醇的敏感性。

关键词： MPZL1 肿瘤干性 A549/Tax肺癌细胞多药耐药紫杉醇

A new species of Gobiconodon(Triconodonta, Mammalia) and its implication for the age of Jehol Biota

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Chinese Science Bulletin 2003年第11期48卷 1129-1134页

作者： li chuankui WANG Yuanqing HU Yaoming MENG Jin Institute of Vertebrate Paleontology and Paleoanthropology Chinese Academy of SciencesAmerican Museum of Natural History Beijing 100044 ChinaBeijing 100044China American Museum of Natural History New York NY 10024 USA Biology Program (Ecology Evolutionary Biology and Behavior) Graduate School and City College City University of New York NY 10016 USANew York NY 10024 USA

A new species of Gobiconodon is found from the Yixian Formation of western liaoning, China. The new taxa, G. zofiae sp. nov., has a confluent opening for branches Ⅱ and Ⅲ of the trigeminal nerve on the anterior lamina of the petrosal. G. zofiae sp. nov. is similar to Repenomamus in having an ossified Meckels cartilage connecting the lower jaws and ear region. The new species, with enlarged I1/I1, posteriorly located infraorbital foramen and four mental foramina, distinctly differs from the other species of Gobiconodon. The new material indicates that Gobiconodon has four, not five, upper molariforms. The presence of Gobiconodon in Jehol Biota makes it possible to correlate Jehol Biota with faunas in eastern Asia and North America, and suggests the age of the Yixian Formation to be Early Cretaceous.

关键词：辽宁白垩纪骨化石中生代哺乳动物头盖骨

The Shanghuang Mammalian Fauna, Middle Eocene of Jiangsu:History of Discovery and Significance

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古脊椎动物学报(中英文） 1996年第3期 209-214页

作者： Qi Tao K. Christopher Beard Wang Banyue Mary R. Dawson Guo Jianwei li chuankui(Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences Beijing 100044)(Section of Vertebrate Paleontology, Carnegie Museam of Natural Histo

A Paleogene mammalian fauna, here named the Shanghuang fauna, was discov ered near the village of Shanghuang, close to liyang City, Jiangsu Province, China (Fig.1). At present, rouglily sixty species of fossil mammals have been recognied in the Shanghuang fauna. Many of these mammal taxa are new to science, and others represent new occurrences for the Eocene of China. Particularly well represented in the Shanghuang fauna are micromammals (including marsupials, insectivores, rodents,lagomorphs, primates, and bats) that have seldom if ever been found in other Eocene Asian localities. Biostratigraphic correlations suggest that the Shanghuang fauna repre sents the Irdinmanhan and early Sharamurunian Land Mammal Ages and is likely to be about 45 million years old. Ongoing study of the Shanghuang manunal fauna promlses to shed new insight into the phylogeny and historical biogeography of numer ous higherlevel mammalian taxa. Here, we provide a history of field activities at Shanghuang and an overview of mammalian diversity at Shanghuang.

关键词： Jiangsu Middle Eocene Shanghuang Mammalian Fauna

人参皂苷Rg3通过TGF-β1/ERK信号通路调控原位荷瘤人肺癌裸鼠的淋巴管生成的机制

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中国比较医学杂志 2019年第11期29卷 34-40页

作者：陶涛汪国文李其才黎传奎蚌埠医学院第一附属医院

目的探究人参皂苷Rg3(GS-Rg3)通过转化生长因子-β1(TGF-β1)/细胞外调节蛋白激酶(ERK)信号通路调控原位荷瘤人肺癌裸鼠淋巴管生成的机制。方法 60只裸鼠随机分为3组,即模型组、GS-Rg3组和ERK抑制剂(SCH772984)组。GS-Rg3组和SCH77298... 详细信息

目的探究人参皂苷Rg3(GS-Rg3)通过转化生长因子-β1(TGF-β1)/细胞外调节蛋白激酶(ERK)信号通路调控原位荷瘤人肺癌裸鼠淋巴管生成的机制。方法 60只裸鼠随机分为3组,即模型组、GS-Rg3组和ERK抑制剂(SCH772984)组。GS-Rg3组和SCH772984组建立人肺癌裸鼠原位移植模型,GS-Rg3组小鼠使用GSRg3灌胃,SCH772984组小鼠腹腔注射ERK抑制剂SCH772984。观察各组小鼠建模和淋巴转移情况。并分析各组肿瘤组织中淋巴管生成情况、TGF-β1/ERK信号通路以及血管内皮生长因子(VEGF)表达情况。结果 HE染色病理学检查证实肺癌以及肺癌淋巴转移。GS-Rg3组和SCH772984组小鼠出现淋巴转移的比例、肿瘤体积和肿瘤质量均显著低于模型组,GS-Rg3组和SCH772984组无显著差异。使用podoplanin蛋白标记淋巴管,GS-Rg3组和SCH772984组podoplanin蛋白表达水平和淋巴管相对密度显著低于模型组,GS-Rg3组和SCH772984组无显著差异。GS-Rg3和SCH772984可以显著抑制TGF-β1/ERK通路的激活。GS-Rg3组和SCH772984组的VEGF-C、VEGF-3表达水平较模型组低,GS-Rg3组和SCH772984组无显著差异。结论 GS-Rg3可以通过下调TGF-β1/ERK信号通路的转导水平抑制VEGF-C、VEGF-3蛋白的表达,从而抑制淋巴管的生成降低肺癌的淋巴转移率,其作用水平与SCH772984相似。

关键词：肺癌人参皂苷Rg3 转化生长因子-β1/细胞外调节蛋白激酶淋巴管生成血管内皮生长因子裸鼠

多媒体联合视频讲解教学方法在肺癌根治术带教学习中的应用效果

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长治医学院学报 2022年第2期36卷 141-144页

作者：黎传奎蚌埠医学院第一附属医院胸外科 233000

目的:探讨多媒体联合视频讲解教学应用于肺癌根治术带教学习中的效果。方法:将胸外科实习的72例本科临床实习生作为研究对象,使用简单随机法将其分为观察组与对照组,每组各36例,2组实习生均接受肺癌根治术治疗教学;对照组实习生接受常... 详细信息

目的:探讨多媒体联合视频讲解教学应用于肺癌根治术带教学习中的效果。方法:将胸外科实习的72例本科临床实习生作为研究对象,使用简单随机法将其分为观察组与对照组,每组各36例,2组实习生均接受肺癌根治术治疗教学;对照组实习生接受常规教学联合多媒体教学,观察组实习生在对照组基础上增加视频讲解教学。对比2组实习生带教学习情况的差异。结果:观察组综合成绩考核中理论考核[(96.33±16.35)vs(83.26±17.33)分]、临床技能[(89.26±9.67)vs(76.52±11.25)分]、病例分析[(93.22±12.64)vs(84.35±11.37)分]、病历书写[(84.57±11.32)vs(73.64±10.67)分]及诊疗思维评分[(87.62±12.51)vs(69.74±13.44)分]均高于对照组(P<0.05);观察组问诊能力考核中病情观察评估能力[(84.66±10.36)vs(72.51±11.24)分]、应变处理能力[(79.36±9.73)vs(67.44±8.64)分]以及医患沟通能力成绩[(82.35±7.48)vs(76.52±8.67)分]均高于对照组(P<0.05);教学方式认可度比较,观察组赞成在教学中使用该教学方式(91.67%vs 80.56%)、认为该教学方式有效(94.44%vs 86.11%)、认为教学方式有利于手术操作及治疗知识的掌握(80.56%vs 66.67%)、认为该教学法能够有效提高手术操作及临床治疗水平(75.00%vs 58.33%)、认为该教学法能够提高自己实际工作中解决问题的能力(75.00%vs 61.11%)、认为该教学法能够促使自己主动学习(77.78%vs 52.78%)等6个方面占比均高于对照组(P<0.05)。结论:多媒体教学联合视频讲解教学在肺癌根治术带教学习中,有利于提高实习生的理论水平及实践能力,有利于提高学生的认可程度。

关键词：多媒体教学视频讲解教学肺癌根治术应用效果

Effect of lattice distortion on spin admixture and quantum transport in organic devices with spin–orbit coupling

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Chinese Physics B 2024年第7期33卷 519-527页

作者：王莹李丹孙新英张惠晴马晗李慧欣任俊峰王传奎胡贵超 School of Physics and Electronics Shandong Normal UniversityJinan 250358China

With an extended Su–Schrieffer–Heeger model and Green's function method, the spin–orbit coupling(SOC) effects on spin admixture of electronic states and quantum transport in organic devices are investigated. The role of lattice distortion induced by the strong electron–lattice interaction in organics is clarified in contrast with a uniform chain. The results demonstrate an enhanced SOC effect on the spin admixture of frontier eigenstates by the lattice distortion at a larger SOC,which is explained by the perturbation theory. The quantum transport under the SOC is calculated for both nonmagnetic and ferromagnetic electrodes. A more notable SOC effect on total transmission and current is observed for ferromagnetic electrodes, where spin filtering induced by spin-flipped transmission and suppression of magnetoresistance are *** the spin admixture, a stronger SOC effect on transmission exists for the uniform chain rather than the organic lattices with distortion. The reason is attributed to the modified spin-polarized conducting states in the electrodes by lattice configuration, and hence the spin-flip transmission, instead of the spin admixture of eigenstates. This work is helpful to understand the SOC effect in organic spin valves in the presence of lattice distortion.

关键词： organic spintronics spin–orbit coupling spin admixture quantum transport

基于SEER数据库的肺大细胞神经内分泌癌预后影响因素分析

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淮海医药 2023年第6期41卷 551-555,559页

作者：杨逸凡黎传奎李其才王祖义蚌埠医学院第一附属医院胸外科安徽蚌埠233000

目的:基于美国监测、流行病学和结果数据库(SEER)中的数据,分析影响肺大细胞神经内分泌癌(pLCNEC)预后相关因素。方法:筛选SEER中2013年1月—2015年12月病理诊断为pLCNEC患者的临床资料,通过Log-rank检验比较患者总体生存期(OS)、肿瘤... 详细信息

目的:基于美国监测、流行病学和结果数据库(SEER)中的数据,分析影响肺大细胞神经内分泌癌(pLCNEC)预后相关因素。方法:筛选SEER中2013年1月—2015年12月病理诊断为pLCNEC患者的临床资料,通过Log-rank检验比较患者总体生存期(OS)、肿瘤特异性生存期(CSS)在不同性别、年龄、肿瘤位置、肿瘤分期、治疗方案等方面的差异,采用乘积极限法(Kaplan-meier)计算累积生存率并绘制生存曲线,采用Cox比例风险回归模型进行多因素分析,探索其预后相关影响因素。结果:本研究共纳入pLCNEC患者429例,1、3、5年累积生存率分别为52.80%、27.60%、18.80%。单因素及多因素分析显示,pLCNEC患者OS情况:在不同性别、肿瘤TNM分期、T分期、N分期、M分期、治疗方案方面比较差异有统计学意义(P<0.05),女性(HR=1.298,P<0.05)、淋巴结转移(N1 HR=1.634、N2 HR=1.654、N3 HR=2.094、P均<0.001)、远处转移(M1 HR=1.832,P<0.001)是OS的独立危险因素,治疗方案(仅化疗HR=0.401、仅放疗HR=0.762、仅手术HR=0.251、化疗+放疗HR=0.271、化疗+手术HR=0.156、放疗+手术HR=0.359、放疗+化疗+手术HR=0.320,P均<0.001)是OS的独立保护性因素。pLCNEC患者CSS情况:在肿瘤不同TNM分期、T分期、N分期、M分期、治疗方案方面比较差异有统计学意义(P<0.05),淋巴结转移(N1 HR=1.755、N2 HR=1.881、N3 HR=2.331,P均<0.001)、远处转移(M1 HR=2.217,P<0.001)是CSS的独立危险因素,治疗方案(仅化疗HR=0.438、仅放疗HR=0.921、仅手术HR=0.205、化疗+放疗HR=0.296、化疗+手术HR=0.158、放疗+手术HR=0.491、放疗+化疗+手术HR=0.354,P均<0.001)是CSS的独立保护性因素。结论:pLCNEC患者预后较差,女性、淋巴结转移、远处转移是影响患者预后的独立危险因素,以手术为主的综合治疗(手术、手术联合化疗、手术联合放疗)是影响患者预后的独立保护性因素。

关键词：肺肿瘤大细胞神经内分泌癌预后影响因素