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Formation and evolution of supercritical geofluid

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Science China Earth Sciences 2025年第1期68卷 39-51页

作者： Huaiwei NI yilin XIAO Xiaolin XIONG Xiandong liU Chunxiao GAO yi-Xiang CHEN Yunguo li Wan-Cai li Xuan GUO Yang-Yang WANG Dong-Bo TAN li ZHANG State Key Laboratory of lithospheric and Environmental Coevolution University of Science and Technology of China Deep Space Exploration Laboratory/School of Earth and Space Sciences University of Science and Technology of China Guangzhou Institute of Geochemistry Chinese Academy of Sciences School of Earth Sciences and Engineering Nanjing University State Key Lab of Superhard Materials Jilin University

In this work, we provide a comprehensive review on the formation, evolution, properties, and effects of supercritical geofluid. In Earth's interior, enhanced miscibility between H2O and silicate by the addition of special components or by the increase of pressure and temperature gives rise to supercritical geofluid with a significant amount of both H2O and silicate *** formation of supercritical geofluid in magmatic-hydrothermal systems, typified by pegmatite system, is governed by meltfluid critical curve. The formation of supercritical geofluid in metamorphic systems, typified by subducted slab, is governed by the second critical end point. Experimental results suggest that the presence of boron and fluorine in pegmatite system makes it possible to form supercritical geofluid at crustal depths, but the release of supercritical geofluid from subducted slab is withheld until almost 100 km depth. A major presence of both H2O and depolymerized structural units（monomers, dimers, etc.） endows supercritical geofluid with unique physical properties including low density, low elastic moduli, low viscosity, high diffusivity,and high electrical conductivity. Supercritical geofluid can effectively mobilize a variety of elements even including high field strength elements and heavy rare earth elements. The chemical signatures of supercritical geofluid can be inherited by metasomatized mantle and mantle-derived melts, and this could give an explanation of the oxidation of arc magmas. Phase separation of supercritical geofluid through the mechanism of spinodal decomposition leads to formation of a melt network. Multiphase fluid inclusions recovered from subduction zone rocks and pegmatites are possible relics of supercritical geofluid. Supercritical geofluid can cause electrical anomaly and low seismic velocity near the top of subducted slab, and can be linked with intermediate-focus earthquakes. Supercritical geofluid may have played a crucial role in the formation of pe

关键词： Supercritical geofluid Miscibility Subduction zone Pegmatite

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联合检测血清CA125、CA199、CA153和CA724对卵巢癌的诊断价值

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中国妇幼保健 2012年第2期27卷 271-273页

作者：李宜川芦琨赵炎商丘医学高等专科学校生物化学教研室河南商丘476000 河南省商丘市妇幼保健院

目的:探讨肿瘤标志物CA125、CA199、CA153和CA724联合检测对卵巢癌的诊断价值。方法:采用电化学发光法测定45例卵巢癌患者、38例卵巢良性肿瘤患者和41例健康妇女血清中的CA125、CA199、CA153和CA724水平。结果:卵巢癌患者血清CA125、CA... 详细信息

目的:探讨肿瘤标志物CA125、CA199、CA153和CA724联合检测对卵巢癌的诊断价值。方法:采用电化学发光法测定45例卵巢癌患者、38例卵巢良性肿瘤患者和41例健康妇女血清中的CA125、CA199、CA153和CA724水平。结果:卵巢癌患者血清CA125、CA199和CA153水平显著高于正常对照组(P<0.05);卵巢癌患者血清CA125、CA199和CA153阳性率分别为66.6%、31.1%和42.2%,均显著高于正常对照组(P<0.05);联合检测CA125、CA199、CA153和CA724诊断卵巢癌的阳性率为86.6%,诊断卵巢良性肿瘤的阳性率为34.2%,均显著高于正常对照组(P<0.05),且显著高于单一肿瘤标志物检测的阳性率;联合检测的敏感性(86.6%)和准确性(91.5%)均高于单项检测结果。结论:联合检测CA125、CA199、CA153和CA724对卵巢恶性肿瘤的诊断和鉴别具有重要意义。

关键词：卵巢癌CA125 CA199 CA153 CA724联合

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基于多模态特征融合嵌入的相似广告检索方法

计算机学报 2022年第7期45卷 1500-1516页

作者：冯奕周晓松李传艺王挺葛季栋胡雨成张小鹏骆斌南京大学计算机软件新技术国家重点实验室南京210046 南京大学软件学院南京210093 深圳市腾讯计算机系统有限公司广东深圳518000

随着互联网人工智能技术的飞速发展,学习用户特征并精准投放广告能够显著提升广告的点击率(Click-Through-Rate,CTR)与转化率(Conversion Rate,CVR).人群智能定向是解决广告投放问题中极其重要的一环,其业界主流方法是使用转化用户和非... 详细信息

随着互联网人工智能技术的飞速发展,学习用户特征并精准投放广告能够显著提升广告的点击率(Click-Through-Rate,CTR)与转化率(Conversion Rate,CVR).人群智能定向是解决广告投放问题中极其重要的一环,其业界主流方法是使用转化用户和非转化用户训练基于用户特征的判断其是否会成为转化用户的分类模型.这个分类器的优劣依赖广告的实际转化人群规模,规模越大,越能准确判断.但在实际应用中通常面临某些广告转化人群不足的问题,本文利用在学术与工业场景占据重要研究地位的基于内容的检索技术来扩充相似广告集合,从而扩充对应转化人群.现有的单模态检索方案只关注于单个模态的特征(文本/图像),忽视了不同模态间的内在共有联系,使得挖掘出的广告特征不全且包含大量噪声,最终导致相似广告的检索结果质量不高,从而导致相似转化人群的扩充质量低下.而近年来兴起的跨模态检索方案主要关注以文搜图或以图搜文,并且没有考虑到通用目标检测器并不适用于特定领域图像数据这一事实.为解决这些问题,本文提出一种以广告分类为基本训练目标的多模态商品广告特征融合建模方法,以提升相似广告检索的效果.具体来说,本文使用Transformer模型提取文本语义特征,使用目标检测YOLO模型挖掘图像中细粒度的视觉特征,并结合文本注意力机制识别图像中与商品相关的目标,以降低无关目标给广告特征带来的噪声影响.同时,本文提出了一种多模态融合注意力机制,以高效融合广告文本和图像特征.该模型命名为ToTYEmb(Text oriented Transformer-Yolo fusion Embedding).另外,本文还提出了一种算法框架,将相似广告扩充、转化人群扩充加入到现有的人群智能定向工作流中.实验结果表明,较多个基线模型,本文方案有效提升了相似商品广告的检索质量,避免了很多由单模态信息带来的错误.同时离线人群定向更新实验表明本文提出的利用相似广告扩充转化人群确实能在很大程度上优化现有的人群智能定向算法.

关键词：多模态特征融合相似广告检索 Transformer 注意力机制

融合信息检索和深度模型特征的软件缺陷定位方法

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软件学报 2024年第7期35卷 3245-3264页

作者：申宗汶牛菲菲李传艺陈翔李奇葛季栋骆斌计算机软件新技术国家重点实验室(南京大学) 江苏南京210023 南通大学信息科学技术学院江苏南通226019

构建自动化的缺陷定位方法能够加快程序员利用缺陷报告定位到复杂软件系统缺陷代码的过程.早期相关研究人员将缺陷定位视为检索任务,通过分析缺陷报告和相关代码构造缺陷特征,并结合信息检索的方法实现缺陷定位.随着深度学习的发展,利... 详细信息

构建自动化的缺陷定位方法能够加快程序员利用缺陷报告定位到复杂软件系统缺陷代码的过程.早期相关研究人员将缺陷定位视为检索任务,通过分析缺陷报告和相关代码构造缺陷特征,并结合信息检索的方法实现缺陷定位.随着深度学习的发展,利用深度模型特征的缺陷定位方法也取得了一定效果.然而,由于深度模型训练的时间成本和耗费资源相对较高,现有基于深度模型的缺陷定位研究方法存在实验搜索空间和真实情况不符的情况.这些研究方法在测试时并没有将项目下的所有代码作为搜索空间,而仅仅搜索了与已有缺陷相关的代码,例如DNNLOC方法、DeepLocator方法、DreamLoc方法.这种做法和现实中程序员进行缺陷定位的搜索场景是不一致的.致力于模拟缺陷定位的真实场景,提出了一种融合信息检索和深度模型特征的TosLoc方法进行缺陷定位.TosLoc方法首先通过信息检索的方式检索真实项目的所有源代码,确保已有特征的充分利用;再利用深度模型挖掘源代码和缺陷报告的语义,获取最终定位结果.通过两阶段的检索,TosLoc方法能够对单个项目的所有代码实现快速缺陷定位.通过在4个常用的真实Java项目上进行实验,TosLoc方法能够在检索速度和准确性上超越已有基准方法.与最优基准方法DreamLoc相比,TosLoc方法在消耗DreamLoc方法35%的检索时间下,平均MRR值比DreamLoc方法提高了2.5%,平均MAP值提高了6.0%.

关键词：缺陷定位缺陷报告信息检索深度学习检索空间

新时代高职院校思想政治工作者的教育责任担当

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教育理论与实践 2019年第36期39卷 37-39页

作者：李传义丁增锋连云港职业技术学院思政部

高职院校思想政治工作者自我的责任担当是新时代矛盾变化的外在要求,体现了马克思主义信仰责任的内在追求和教育者教育责任的社会需求,也是教育者个体自我价值的展现。高职院校思想政治工作者开展责任担当教育的路径是:强化新时代意识,... 详细信息

高职院校思想政治工作者自我的责任担当是新时代矛盾变化的外在要求,体现了马克思主义信仰责任的内在追求和教育者教育责任的社会需求,也是教育者个体自我价值的展现。高职院校思想政治工作者开展责任担当教育的路径是:强化新时代意识,呼唤高职大学生直面问题的责任担当;弘扬新时代榜样,引领高职大学生树立责任担当的正确价值取向;重塑社会责任主体意识,以劳动尊严观教育引领高职生成为未来社会合格劳动者;注重理论与实践的结合,让高职生在积极政治认同中乐于为社会奉献;以文化人,使大学生在文化自信教育中形成新时代合格人格。

关键词：高职院校思想政治工作者责任担当

Longitudinal assessment of peripheral organ metabolism and the gut microbiota in an APP/PS1 transgenic mouse model of Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2982-2997页

作者： Hongli li Jianhua Huang Di Zhao Lemei Zhu Zheyu Zhang Min yi Weijun Peng Department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina National Clinical Research Center for Metabolic Diseases ChangshaHunan ProvinceChina Hunan Academy of Chinese Medicine ChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina

Alzheimer’s disease not only affects the brain,but also induces metabolic dysfunction in peripheral organs and alters the gut *** aim of this study was to investigate systemic changes that occur in Alzheimer’s disease,in particular the association between changes in peripheral organ metabolism,changes in gut microbial composition,and Alzheimer’s disease *** do this,we analyzed peripheral organ metabolism and the gut microbiota in amyloid precursor protein-presenilin 1(APP/PS1)transgenic and control mice at 3,6,9,and 12 months of ***-month-old APP/PS1 mice exhibited cognitive impairment,Alzheimer’s disease-related brain changes,distinctive metabolic disturbances in peripheral organs and fecal samples(as detected by untargeted metabolomics sequencing),and substantial changes in gut microbial composition compared with younger APP/PS1 ***,a strong correlation emerged between the gut microbiota and kidney metabolism in APP/PS1 *** findings suggest that alterations in peripheral organ metabolism and the gut microbiota are closely related to Alzheimer’s disease development,indicating potential new directions for therapeutic strategies.

关键词： Alzheimer’s disease APP/PS1 mice brain-kidney axis gut microbiota heart-brain axis liver-brain axis lung-brain axis microbiota-gut-brain axis peripheral organ metabolism spleen-brain axis

PI3K/AKT signaling and neuroprotection in ischemic stroke:molecular mechanisms and therapeutic perspectives

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Neural Regeneration Research 2025年第10期20卷 2758-2775页

作者： Tianlong liu Xiaolin li Xiaowei Zhou Wei Chen Aidong Wen Minna liu yi Ding Department of Pharmacy Xijing HospitalFourth Military Medical UniversityXi’anShaanxi ProvinceChina Department of Pharmacy The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina Department of Pharmacy The 944 Hospital of Joint Logistics Support Forces of Chinese PLAJiuquanGansu ProvinceChina Department of Nephrology The 940 Hospital of Joint Logistics Support Forces of Chinese PLALanzhouGansu ProvinceChina

It has been reported that the PI3K/AKT signaling pathway plays a key role in the pathogenesis of ischemic *** a result,the development of drugs targeting the PI3K/AKT signaling pathway has attracted increasing attention from *** article reviews the pathological mechanisms and advancements in research related to the signaling pathways in ischemic stroke,with a focus on the PI3K/AKT signaling *** key findings include the following:(1)The complex pathological mechanisms of ischemic stroke can be categorized into five major types:excitatory amino acid toxicity,Ca^(2+)overload,inflammatory response,oxidative stress,and apoptosis.(2)The PI3K/AKT-mediated signaling pathway is closely associated with the occurrence and progression of ischemic stroke,which primarily involves the NF-κB,NRF2,BCL-2,mTOR,and endothelial NOS signaling pathways.(3)Natural products,including flavonoids,quinones,alkaloids,phenylpropanoids,phenols,terpenoids,and iridoids,show great potential as candidate substances for the development of innovative anti-stroke medications.(4)Recently,novel therapeutic techniques,such as electroacupuncture and mesenchymal stem cell therapy,have demonstrated the potential to improve stroke outcomes by activating the PI3K/AKT signaling pathway,providing new possibilities for the treatment and rehabilitation of patients with ischemic *** investigations should focus on the direct regulatory mechanisms of drugs targeting the PI3K/AKT signaling pathway and their clinical translation to develop innovative treatment strategies for ischemic stroke.

关键词： apoptosis autophagy inflammation ischemic stroke neuroprotection oxidative stress pathogenesis phosphatidylinositol 3-kinase protein kinase B therapeutics

MoS2 synaptic transistor with one-step manufacture

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Science China(Information Sciences) 2025年第1期68卷 357-365页

作者： yihao GUO Yang WANG Wenjie DENG yi WU Jingtao li Kexin li Yuehui ZHAO Songlin YU Xiaoting WANG Yongzhe ZHANG Hui YAN Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of Technology Key Laboratory of Advanced Functional Materials Ministry of Education Faculty of Materials and ManufacturingBeijing University of Technology The 11th Research Institute of Electronics Technology Group Corporation

The synaptic transistor,which is a neuromorphic device with brain-like functions,has garnered significant attention due to characteristics such as low energy consumption,high integration,multiple functions,and high computational ***,the current synaptic transistor possesses a complicated structure and involves complex manufacturing steps,which is not conducive to low-cost,large-scale bionic ***,we introduce a simple MoS2synaptic transistor exhibiting robust synaptic *** transistor utilizes magnetron sputtering manufacture to combine the process of device metal electrode deposition and the introduction of defect states,which helps streamline the manufacturing process into a single *** long-term potentiation and long-term depression in photoelectric coordination are initially ***,biological functions,such as double pulse facilitation and the transformation behavior of short-term memory to long-term memory,are thoroughly evaluated,along with learning-forgetting-relearning ***,the device exhibits robust synaptic plasticity until incident light angles down to 30° to imitate the multi-to-one axon-cellular ***,a classical simulation of Pavlov's dog conditioned reflex is demonstrated along with the multiview extraction *** experimental results demonstrate a promising synaptic transistor with a simple structure,manufacturing technique,and excellent *** further indicates the potential for large-scale integration of bionic neuromorphic systems.

关键词： process optimization artificial synaptic device one-stepmanufacture synaptic plasticity bionic simulation

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思想政治教育创新的社会公正维度

连云港职业技术学院学报 2017年第4期30卷 39-42页

作者：李传义连云港职业技术学院政治教学部江苏连云港222006

思想政治教育是意识形态教育,社会制度是意识形态的重要体现,社会公正是社会观的重要内容,也是思想政治教育时代创新的重要突破口。思想政治教育应积极应对社会公正负面问题的挑战,传播正确的社会公正观,并以社会公正为载体,加强思想政... 详细信息

思想政治教育是意识形态教育,社会制度是意识形态的重要体现,社会公正是社会观的重要内容,也是思想政治教育时代创新的重要突破口。思想政治教育应积极应对社会公正负面问题的挑战,传播正确的社会公正观,并以社会公正为载体,加强思想政治教育创新研究,以推进社会主义核心价值观教育。

关键词：社会公正思想政治教育社会主义核心价值观