检索结果-南通市图书馆

Immediate implantation of ultrafine fiber slow-release system based on cell electrospinning to induce osteogenesis of mesenchymal stem cells

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Regenerative Biomaterials 2024年第2期3卷 76-87页

作者： Tao lu Long Yang Zhuoyang li Yin liu Shun'en Xu chuan Ye Department of Orthopaedics The Affliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Orthopaedics The First People's Hospital of GuiyangGuiyang 550004China Center for Tissue Engineering and Stem Cell Research Guizhou Medical UniversityGuiyang 550004China Department of Otolaryngology Head and Neck Surgery Xinqiao HospitalArmy Medical University(Third Military Medical University)Chongqing 400037China Department of Dental implant Stomatological Hospital of GuiyangGuiyang 550000China

This study presents the development and evaluation of a poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P34HB)ultrafine fiber slow-release system for in vivo osteogenic induction of human umbilical cord mesenchymal stem cells(HUCMSCs).Utilizing dual-nozzle and cell electrospinning techniques,the system encapsulates L-ascorbic acid-2-phosphate magnesium(AsP),βB-glycerophosphate sodium and dexamethasone(DEX)within the'fbers,ensuring sustained osteogenic *** scaffold's morphology,characterization,hydrophilicity,mechanical properties and cellular behavior were *** subcutaneous implantation in rabbits was con-ducted to observe its ectopic osteogenic induction *** fabricated P34HB ultrafine fiber slow-release *** ization *** distribution of HUCMSCs and inducing components within the scaffold,with no chemical reactions affecting the active *** vitro tests showcased a prolonged release of DEX and ASP,while biocompatibility assays highlighted the scaffold's suitability for cellular *** Red,type I collagen,and osteopontin(OPN)staining verifed the scaffold's potent osteogenic induction effect on ***,immediate implantation into New Zealand White rabbits led to significant new bone formation within 8 *** findings underscore the system's potential for immediate in vivo implantation without prior in vitro induction,marking a promising advancement in bone tissue engineering.

关键词： bone tissue engineering cell electrospinning in vivo induction immediate implantation biomaterials

Microwave Generation from an Oscillating Virtual Cathode Produced by Non-homogeneous Electron Beams

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Physics Letters 1997年第2期14卷 117-120页

作者： liU Jin-liang ZHANG Ya-zhou li chuan-lu TAN Qi-mei CHEN Guo-qiang WANG Yong Department of Applied Physics National University of Defense TechnologyChangsha 410073

Microwave generation from a resonant cavity surrounding oscillating virtual cathode,which is produced by non-homogeneous electron beams,is studied *** microwave power is measured by using the crystal detector and frequencies are measured by using the heterodyne technique.A single microwave pulse contains two microwave signals with different frequencies,one peak power is 1.12MW at 5.03GHz and the other is 0.56MW at 5.24GHz,and their 3dB bandwidths are 18 and 25 MHz,respectively.

关键词： technique. Microwave microwave

Trace formula of the integro-differential operator on a quantum graph

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics(A Journal of Chinese Universities) 2024年第2期39卷 311-318页

作者： WEI li-xiao YANG chuan-fu School of Mathematics and Statistics Nanjing University of Science and TechnologyNanjing 210094China.

In this paper we study the eigenvalue problem for integro-differential operators on a lasso *** trace formula of the operator is established by applying the residual technique in complex analysis.

关键词： integro-differential operators eigenvalue trace formula

Physiological and pathological functions of circular RNAs in the nervous system

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第2期19卷 342-349页

作者： Min Zhou Shi li chuan Huang School of life Sciences Chongqing UniversityChongqingChina

Circular RNAs(circRNAs)are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and *** play crucial roles in physiological and pathological processes by sponging microRNAs,modulating gene transcription,controlling the activity of certain RNA-binding proteins,and producing functional peptides.A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 ***,the precise role of circRNAs in the nervous system has yet to be comprehensively *** this review,we first summarize the recently described roles of circRNAs in brain development,maturity,and ***,we focus on the involvement of circRNAs in various diseases of the central nervous system,such as brain cancer,chronic neurodegenerative diseases,acute injuries of the nervous system,and neuropathic pain.A better understanding of the functionality of circRNAs will help us to develop potential diagnostic,prognostic,and therapeutic strategies to treat diseases of the nervous system.

关键词： Alzheimer’s disease amyotrophic lateral sclerosis brain development circRNAs neuropathic pain Parkinson’s disease

Study on the effective elastic performance of composites containing decagonal symmetric two-dimensional quasicrystal coatings

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2024年第9期45卷 1655-1664页

作者： Yurun WU lu li lianhe li School of Mathematics and Science Inner Mongolia Normal UniversityHohhot 010022China Inner Mongolia Applied mathematics Center Hohhot 010022China Key Laboratory of Infinite Dimensional Hamiltonian System and Its Algorithm Application Ministry of EducationHohhot 010022China

On account of the Mori-Tanaka approach,the effective elastic performance of composites containing decagonal symmetric two-dimensional(2D)quasicrystal(QC)coatings is *** expressions for the effective elastic constants of rare-earth QC reinforced magnesium-based composites are *** discussion is presented on the effects of the volume fraction of the inclusions,the aspect ratio of the inclusions,the coating thickness,and the coating material parameters on the effective elastic constants of the *** results indicate that considering the coating increases the effective elastic constants of the composites to some extent.

关键词： Mori-Tanaka approach coated inclusion decagonal symmetric twodimensional(2D)quasicrystal(QC)

Hydrogel loaded with bone marrow stromal cell-derived exosomes promotes bone regeneration by inhibiting inflammatory responses and angiogenesis

在线全文

学校读者我要写书评

暂无评论

World Journal of Stem Cells 2024年第5期16卷 499-511页

作者： Shuai Zhang chuan lu Sheng Zheng Guang Hong Division for International Collaborative and Innovative Dentistry Tohoku University Graduate School of DentistrySendai 980-8575MiyagiJapan School of Stomatology Zhejiang Chinese Medical UniversityHangzhou 310053Zhejiang ProvinceChina

BACKGROUND Bone healing is a complex process involving early inflammatory immune regu-lation,angiogenesis,osteogenic differentiation,and *** repair poses challenges for orthopedic surgeons,necessitating the search for efficient healing *** To investigate the underlying mechanism by which hydrogel-loaded exosomes derived from bone marrow mesenchymal stem cells(BMSCs)facilitate the process of fracture *** Hydrogels and loaded BMSC-derived exosome(BMSC-exo)gels were charac-terized to validate their *** vitro evaluations were conducted to assess the impact of hydrogels on various stages of the healing *** could recruit macrophages and inhibit inflammatory responses,enhance of human umbilical vein endothelial cell angiogenesis,and promote the osteogenic differen-tiation of primary cranial ***,the effect of hydrogel on fracture healing was confirmed using a mouse fracture *** The hydrogel effectively attenuated the inflammatory response during the initial repair stage and subsequently facilitated vascular migration,promoted the formation of large vessels,and enabled functional vascularization during bone *** effects were further validated in fracture *** We successfully fabricated a hydrogel loaded with BMSC-exo that modulates macrophage polarization and angiogenesis to influence bone regeneration.

关键词： Hydrogel Bone marrow mesenchymal stem cells Macrophage polarization Angiogenesis Bone regeneration

A Deep Mantle Source for the Late Neoarchean Metamorphosed Basalts in Eastern Hebei,North China Craton:Insights from Whole-Rock Geochemistry and Sm-Nd Isotopes,and Zircon U-Pb-Hf Isotopes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Earth Science 2024年第1期35卷 29-40页

作者： Zhuang li Chunjing Wei chuan Yang Xi Zhang College of Geosciences China University of PetroleumBeijing 102249China MOE Key Laboratory of Orogenic Belts and Crustal Evolution School of Earth and Space SciencesPeking UniversityBeijing 100871China China Transport Telecommunications and Information Center Beijing 100011China

The basalts within the greenstone belt worldwide serve as an ideal target to decipher the nature of Archean mantle sources and further to extend the understanding of the early stages of Earth's *** provide important insights into the issues,we carried out a detailed investigation of whole-rock geochemistry and Sm-Nd isotopes,and zircon U-Pb-Hf isotopes for the Late Neoarchean metamorphosed basalts in eastern Hebei,North China Craton.U-Pb isotopic dating using the LA-ICPMS on zircons reveals that the basalts in eastern Hebei erupted at ca.2.48-2.51 Ga and subsequently experienced multiple regional metamorphic events at 2477 and 1798 Ma,*** metamorphosed basalts are featured by low SiO_(2),MgO,K_(2)O+Na_(2)O,and high Fe O contents,endowed with the subalkaline and high-Fe tholeiitic *** radiogenic initial Nd and Hf isotope values and correlations among V,Ni and Cr contents strongly imply that the basalts experienced significant clinopyroxene and olivine fractionation and minor crustal contamination during magma *** are also characterized by the relatively low total REE contents and exhibit significant depletions to moderate enrichments in the LREE contents,indicating the derivation from a deep mantle source in an Archean proto-mantle plume setting.

关键词： zircon U-Pb-Hf isotopes geochemistry Late Neoarchean basaltic magmatism North China Craton Archean proto-mantle plume

FedDAA:a robust federated learning framework to protect privacy and defend against adversarial attack

在线全文

学校读者我要写书评

暂无评论

Frontiers of Computer Science 2024年第2期18卷 107-122页

作者： Shiwei lu Ruihu li Wenbin liU Fundamentals Department Air Force Engineering UniversityXi’an 710051China Institute of Advanced Computational Science and Technology Guangzhou UniversityGuangzhou 510006China

Federated learning(FL)has emerged to break data-silo and protect clients’privacy in the field of artificial ***,deep leakage from gradient(DLG)attack can fully reconstruct clients’data from the submitted gradient,which threatens the fundamental privacy of *** cryptology and differential privacy prevent privacy leakage from gradient,they bring negative effect on communication overhead or model ***,the original distribution of local gradient has been changed in these schemes,which makes it difficult to defend against adversarial *** this paper,we propose a novel federated learning framework with model decomposition,aggregation and assembling(FedDAA),along with a training algorithm,to train federated model,where local gradient is decomposed into multiple blocks and sent to different proxy servers to complete *** bring better privacy protection performance to FedDAA,an indicator is designed based on image structural similarity to measure privacy leakage under DLG attack and an optimization method is given to protect privacy with the least proxy *** addition,we give defense schemes against adversarial attack in FedDAA and design an algorithm to verify the correctness of aggregated *** results demonstrate that FedDAA can reduce the structural similarity between the reconstructed image and the original image to 0.014 and remain model convergence accuracy as 0.952,thus having the best privacy protection performance and model training *** importantly,defense schemes against adversarial attack are compatible with privacy protection in FedDAA and the defense effects are not weaker than those in the traditional ***,verification algorithm of aggregation results brings about negligible overhead to FedDAA.

关键词： federated learning privacy protection adversarial attacks aggregated rule correctness verification

Proposing a development framework for sustainable architecture, engineering, and construction industry in China: Challenges, best practice, and future directions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of Structural and Civil Engineering 2024年第5期18卷 805-814页

作者： Peixian li Yujie lu Xuwen XIAO College of Architecture and Urban Planning Tongji UniversityShanghai 200092China Key Laboratory of Ecology and Energy Saving Study of Dense Habitat(Tongji University) Ministry of EducationShanghai 200092China College of Civil Engineering Tongji UniversityShanghai 200092China Key Laboratory of Performance Evolution and Control for Engineering Structures of Ministry of Education Tongji UniversityShanghai 200092China China State Construction Engineering Corporation Beijing 100029China

China’s architecture,engineering,and construction(AEC)industry needs a clear and sustainable development *** inspiration from speeches delivered at a seminar hosted by the Chinese Academy of Engineering and extensive literature research on Chinese policies,this article presents a summary of the current trends in the AEC industry in four dimensions:industrialization as the foundation,intelligence as the enabler,lean management as the strategy,and green development as the *** four dimensions are intricately interconnected and rooted in multiple *** article provides a detailed review of the current practices,challenges,and future directions associated with each ***,ten grand challenges were proposed to stimulate discussions on the future of the AEC *** article offers an overarching understanding of the AEC industry and presents a four-dimension framework for sustainable development,which can be valuable for AEC practitioners.

关键词： green building lean construction prefabrication smart construction sustainable development