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Impacts of Comorbidity and Mental Shock on Organic Micropollutants in Surface Water During and After the First Wave of COVID-19 Pandemic in Wuhan (2.1.–2.2.), china

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Engineering 2024年第6期37卷 40-48页

作者： Jian Zhao Jin Kang Xiaofeng Cao Rui Bian Gang liu Shengchao Hu xinghua Wu {2. li Dianchang {2. Weixiao Qi Cunrui Huang Huijuan liu Jiuhui Qu center for Water and Ecology State Key Joint Laboratory of Environment Simulation and Pollution ControlSchool of EnvironmentTsinghua UniversityBeijing 100084China Hubei Provincial Research Institute of Environmental Science Wuhan 430072China Key Laboratory of Drinking Water Science and Technology Research Centre for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Sanitary Engineering Department of Water ManagementFaculty of Civil Engineering and GeosciencesDelft University of TechnologyDelft 2600 GAThe Netherlands china Three Gorges Corporation Wuhan 430010China Vanke School of Public Health Tsinghua UniversityBeijing 100084China

The first pandemic wave of coronavirus disease 2.1.(COVID-19)induced a considerable increase in several antivirals and antibiotics in surface *** common symptoms of COVID-19 are viral and bacterial infections,while comorbidities(e.g.,hypertension and diabetes)and mental shock(e.g.,insomnia and anxiety)are ***,little is known about the long-term impacts of comorbidities and mental shock on organic micropollutants(OMPs)in surface ***,we monitored 114 OMPs in surface water and wastewater treatment plants(WWTPs)in Wuhan,{2.,between 2.1. and *** pandemic-induced OMP pollution in surface water was confirmed by significant increases in 2. OMP *** increases in four antihypertensives and one diabetic drug suggest that the treatment of comorbidities may induce OMP ***,cotinine(a metabolite of nicotine)increased 155 times to 187 ngL1,which might be associated with increased ***,the increases in zolpidem and sulpiride might be the result of worsened insomnia and ***,it is reasonable to note that mental-health protecting drugs/behavior also contributed to OMP *** the observed OMPs,telmisartan,lopinavir,and ritonavir were associated with significantly higher ecological risks because of their limited WWTP-removal rate and high *** study provides new insights into the effects of comorbidities and mental shock on OMPs in surface water during a pandemic and highlights the need to monitor the fate of related pharmaceuticals in the aquatic environment and to improve their removal efficiencies in WWTPs。

关键词： Coronavirus disease 2.1. Comorbidities Mental shock Micropollutant Surface water

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lipschitz continuity of best approximations and Chebyshev centers

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Chinese Science Bulletin 1998年第3期43卷 185-188页

作者： li chong 1 and wang xinghua 2.1. center for mathematical sciences, zhejiang university, Hangzhou 31002.,{2. 2. Department of Mathematics, Hangzhou university, Hangzhou 31002.,{2. center for mathematical {2. Zhejiang University Hangzhou China Department of Mathematics Hangzhou University Hangzhou China

The lipschitz continuity results are given for best approximations and Chebyshev centers. Consequently, the open problem presented by Septycki and Vleck is solved completely.

关键词： best approximation Chebyshev center uniform convexity.

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Chiral quantum heating and cooling with an optically controlled ion

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light(Science & Applications) 2024年第7期13卷 1393-1400页

作者： Jin-Tao Bu Jian-Qi Zhang Ge-Yi Ding Jia-chong li Jia-Wei Zhang Bin {2. Wen-Qiang Ding Wen-Fei Yuan liang Chen Qi Zhong Ali Keçebaş Şahin KÖzdemir Fei Zhou Hui Jing Mang Feng State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics Wuhan Institute of Physics and MathematicsInnovation Academy of Precision Measurement Science and TechnologyChinese Academy of Sciences430071 WuhanChina. university of the Chinese Academy of sciences 100049 BeijingChina. Research center for Quantum Precision Measurement Guangzhou Institute of Industry Technology511458 GuangzhouChina. Department of Engineering Science and Mechanics and Materials Research InstitutePennsylvania State UniversityUniversity ParkState CollegePA 16802USA. Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education Department of Physics and Synergetic Innovation Center for Quantum Effects and ApplicationsHunan Normal University410081 ChangshaChina. Department of Physics Zhejiang Normal University321004 JinhuaChina

Quantum heat engines and refrigerators are open quantum systems,whose dynamics can be well understood using a non-Hermitian formalism.A prominent feature of non-Hermiticity is the existence of exceptional points(EPs),which has no counterpart in closed quantum *** has been shown in classical systems that dynamical encirclement in the vicinity of an EP,whether the loop includes the EP or not,could lead to chiral mode ***,we show that this is valid also for quantum systems when dynamical encircling is performed in the vicinity of their liouvillian EPs(LEPs),which include the effects of quantum jumps and associated noise—an important quantum feature not present in previous *** demonstrate,using a Paul-trapped ultracold ion,the first chiral quantum heating and refrigeration by dynamically encircling a closed loop in the vicinity of an *** witness the cycling direction to be associated with the chirality and heat release(absorption)of the quantum heat engine(quantum refrigerator).Our experiments have revealed that not only the adiabaticity breakdown but also the Landau–Zener–Stückelberg process play an essential role during dynamic encircling,resulting in chiral thermodynamic *** observations contribute to further understanding of chiral and topological features in non-Hermitian systems and pave a way to exploring the relation between chirality and quantum thermodynamics.

关键词： quantum chiral dynamical

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Chinese expert consensus on the diagnosis and treatment of balanoposthitis

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Chinese Medical Journal 2024年第13期137卷 1519-1521页

作者： li Zhang Amer A.A.Abdulrahman Hao Guo Jia’an Zhang xinghua Gao Weihua Pan Gang {2. Jinhua Xu Yuling Shi liuqing Chen Hongxiang Chen Songmei Geng Yuping Ran Hongwei {2. Xiaoyong Man Jianmin Chang Furen Zhang litao Zhang Guangwen Yin Jianzhong Zhang Wei Lai Zhibin Niu Hongkun Jiang Haibo liu Yaolong Chen Jianjian {2. Department of Dermatology The First Hospital of China Medical UniversityShenyangLiaoning 110001China Key Laboratory of Immunodermatology Ministry of Education and NHCNational Joint Engineering Research Center for Theranostics of Immunological Skin DiseasesShenyangLiaoning 110001China Department of Dermatology Chinese Academy of Medical Science and Peking Union Medical CollegeNanjingJiangsu 210042China Department of Dermatology Second Affiliated Hospital of Naval Medical UniversityShanghai 200003China Department of Dermatology Xijing HospitalFourth Military Medical UniversityXi’anShaanxi 710032China Department of Dermatology Huashan HospitalFudan UniversityShanghai 200040China Department of Dermatology Shanghai Skin Disease HospitalTongji University School of MedicineShanghai 200443China Department of Dermatology Wuhan No.1 HospitalWuhanHubei 430022China Department of Dermatology Huazhong University of Science and Technology Union Shenzhen HospitalShenzhenGuangdong 518052China Department of Dermatology Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’anShaanxi 710004China Department of Dermatovenereology West China HospitalSichuan UniversityChengduSichuan 610041China Department of Dermatology Huadong HospitalFudan UniversityShanghai 200040China Department of Dermatology Second Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiang 310009China Department of Dermatology Beijing HospitalBeijing 100730China Shandong Provincial Hospital for Skin Diseases&Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University&Shandong Academy of Medical SciencesJinanShandong 250061China Department of Dermatology Tianjin Academy of Traditional Chinese Medicine Affiliated HospitalTianjin 300120China Department of Dermatology The First Affiliated Hospital of Zhengzhou UniversityZhengzhouHenan 450052China Department of Dermatology Peking University People’s HospitalBeijing 100044 China Department of Dermatology Third Affi

Balanoposthitis(BP),a common male genitalia inflammation,is managed by clinicians from different specialties,including urology,pediatrics,dermatology,and *** to this diverse array of clinicians involved,there exists a lack of consistent,evidence-based recommendations for *** development of the consensus engaged 19 representative hospitals and it adhered to rigorous protocols,encompassing international registration(IPGRP-2.2.CN003)and the application of evidence grading criteria and recommendation standards[Appendix S1,Supplementary File,http://***/CM9/C42..Over the period from December 2.2. to October 2.2.,consensus on 12.clinical issues was reached through comprehensive evidence searches and two iterations of Delphi surveys[Supplementary File,http://***/CM9/C42..

关键词： Delphi diagnosis rigorous

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Regulation of the cellular uptake of nanopartides by the orientation of helical polypeptides

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Nano Research 2019年第4期12卷 889-896页

作者： chong Zhang Jianhua Lu Falin Tian lindong li Yingqin Hou Yaoyi wang lingdong Sun {2. Shi Hua Lu Beijing National Laboratory for Molecular sciences College of Chemistry and Molecular Engineering Peking University Beijing 100871 China center for Soft Matter Science and Engineering Key Laboratory of Polymer Chemistry and Physics of Ministry of Education Peking University Beijing 100871 China CAS Key Laboratory of Nanosystem and Hierarchical Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Beijing 100190 China State Key Laboratory of Rare Earth Materials Chemistry and Applications PKU-HKU Joint Laboratory in Rare Earth Materials and Bioinorganic Chemistry Peking University Beijing 100871 China

Controlling the cellular interactio n and internal izatio n of polymer-modified nan oparticles (NPs) is of central importa nee to the developme nt of promisi ng nano medici nes. Here, we describe the use of synthetic polypeptides for NP surface coati ng and regulati on of their cellular uptake behaviors by simply switching the conformation and anchoring orientation. Our results show that gold NPs (AuNPs) coated with a helical poly(Y-(2.(2.(2.methoxyethoxy)ethoxy)ethoxy)esteryl「glutamate)(L-P(EG3Glu)5o) from the C-terminus ((L-C)-AuNPs) exhibit greater zeta potential and more cellular uptake (2.0-5.5 fold higher) than those coated with the same polypeptide but anchored from the N-terminus ((L-N)-AuNPs), or from both the C- and N-terminus at a 1/1 molar ratio ((L-C/L-N)-AuNPs). A similar orientation-regulated cellular internalization pattern is observed in D-P(EG3Glu)50 but not the unstructured DL-P(EG3Glu)5o-rnodified AuNPs, suggesting an important and universal role of the helix-derived macrodipole in cellular uptake. Moreover, this orientation-governed internalization is successfully reproduced in P(EG3Glu)50-coated gold nano rods (AuNRs), and applied to the desig n of doxorubici reloaded polypeptide micelles. Simulation study offers time-resolved in sights regarding the NP-membrane in teracti ons and membrane remodeling. Thus, our study provides a delicate way of regulating the surface chemistry of NPs and the subsequent NP-cell interactions. Moreover, the results highlight the uniqueness of polypeptides in NP surface engineering, and urge a more careful consideration on the polymer orientation effect.

关键词： helix orientation polypeptides cellular uptake gold nanoparticles

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Molecular simulation of diffusion of rigidity-tuned nanoparticles in biological hydrogels

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Acta Mechanica Sinica 2019年第2期35卷 376-383页

作者： Falin Tian Hui wang Huawei li Ping Cheng xinghua Shi Laboratory of Theoretical and Computational Nanoscience CAS Key Laboratory for Nanosystem and Hierarchy Fabrication CAS Center for Excellence in Nanoscience National Center for Nanoscience and Technology Chinese Academy of Sciences Beijing 100190 China university of Chinese Academy of sciences Beijing 100049 China

The penetration capability of the drug nano-carriers (NCs) in biological hydrogels, such as mucus and tumor interstitial matrix, would typically influence the efficiency of drug delivery. Understanding the effect of the physicochemical property of the drug carriers on their diffusion capability in biological hydrogel becomes important for designing and optimizing the nano-carriers. Here, using a coarse-grained molecular dynamics model, we studied how the rigidity of NCs affected their diffusivity in biological hydrogel. The results showed that semi-elastic NCs have higher diffusivity than the hard and the soft NCs. Furthermore, the affinity between the NCs and biological hydrogels and the size ratio between the hydrogel meshes and NCs have also affected the diffusivity of the NCs. Further analysis revealed the mechanism that the deformation of the NCs dominates their diffusivity. These findings demonstrated that the rigidity of NCs is a key parameter in designing efficient NCs for deep penetration into the biological hydrogels.

关键词： Diffusion Biological hydrogel Drug delivery Extracellular matrix

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相空间重构后矿井涌水量序列地质学含义及其应用研究

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河南理工大学学报（自然科学版） 2024年第5期43卷 43-52页

作者：李建林贺奇王树威王心义王冲薛杨无河南理工大学资源环境学院河南焦作454000 煤炭安全生产与清洁高效利用省部共建协同创新中心河南焦作454000 中化地质矿山总局浙江地质勘查院浙江杭州310002 天津华北地质勘查局核工业二四七大队天津301800

目的为了确定相空间重构矿井涌水量序列的地质学含义并提高涌水量预测精度,方法以王行庄矿为例,在涌水量序列相空间重构后,对重构后相空间列向量与涌水量主控因素进行相关性分析,并在此基础上建立混沌理论与人工神经网络耦合(Chaos-ENN... 详细信息

目的为了确定相空间重构矿井涌水量序列的地质学含义并提高涌水量预测精度,方法以王行庄矿为例,在涌水量序列相空间重构后,对重构后相空间列向量与涌水量主控因素进行相关性分析,并在此基础上建立混沌理论与人工神经网络耦合(Chaos-ENN)的涌水量预测模型。结果结果表明:相空间的嵌入维数等于矿井涌水量主控因素个数;相空间的第1,2.4,5,6列向量分别与C_(2.tL_(7-8)含水层水位埋深、O_(2.m+Є_(3)ch含水层水位埋深、采空区面积、C_(2.tL_(1-4)含水层水位埋深、开拓长度具有较高的相关性,第3列与不易量化的其他综合因素有关;构建的Chaos-ENN涌水量预测模型在王兴庄矿的预测精度达到97.91%。结论涌水量序列重构后相空间的列向量具有明确的地质学含义。利用混沌理论可以量化涌水量预测模型中ENN输入层的个数及取值,所以仅需涌水量序列值就可以建立矿井涌水量预测的Chaos-ENN模型,该模型解决了涌水量预测中存在的主控因素难以确定和不易量化的难题,且预测精度高,具有较高的推广价值。

关键词：矿井水文系统相空间重构涌水量主控因素混沌特征 Chaos-ENN预测模型

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High-performance and multifunctional organic field-effect transistors

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中国化学快报:英文版 2023年第9期34卷 100-118页

作者： Yujie Zhao Wei wang Zihan He Boyu Peng chong-An Di Hanying {2. MOE Key Laboratory of Macromolecular Synthesis and Functionalization International Research Center for X PolymersDepartment of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China Beijing National Laboratory for Molecular sciences CAS Key Laboratory of Organic SolidsInstitute of ChemistryChinese Academy of SciencesBeijing 100190China School of Chemical sciences University of Chinese Academy of SciencesBeijing 100049China

Organic field-effect transistors(OFETs)refer to field-effect transistors that use organic semiconductors as channel *** to the advantages of organic materials such as solution processability and intrinsic flexibility,OFETs are expected to be applicable in emergent technologies including wearable electronics and sensors,flexible displays,internet-of-things,neuromorphic computing,*** the electrical performance and developing multifunctionalities of OFETs are two major and closely relevant aspects for OFETs-related *** former one aims for investigating the device physics and expanding the horizons of OFETs,while the later one is critical for leading OFETs into practical and emergent *** development in each of the two aspects would undoubtfully promote the other and bring more confidence for future development of ***,this review is divided into two parts that respectively summarize the recent progress in high-performance OFETs and multifunctional OFETs.

关键词： Organic filed-effect transistors Organic semiconductors High-performance Multifunctionality Organic electronics

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai Yang Bai Vipul Bairathi Csaba Balazs Philip Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-Jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Biglietti Shalva Bilanishvili Deng Binglin Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapaglia Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Calibbi Junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Mali Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Zelin Chen Zilin Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Ziliang Chu Guglielmo Coloretti Andreas Crivellin Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi ling-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Filippis Christophe De La Taille Francesca De Mori Chiara De Sio Elisa Del Core Shuangxue Deng Wei-Tian Deng Zhi Deng Ziyan Deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing Beijing Computational Science Research center Beijing Beijing Conveyi LTD Beijing Beijing Glass Research Institute Co. LtdBeijing Beijing Institute of Technology Beijing Beijing Normal university Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal university WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Jiliang {2. HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of Geo{2. Beijing china university of Geo{2. WuhanHubei china university of Mining and Technology XuzhouJiangsu china West Normal university NanchongSichuan chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu university DalianLiaoning Dalian university of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov Laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china university Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by china,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1 GeV Damping Ring,a Booster capable of achieving energies up to 180 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 100 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×10^(34)cm^(-2.s^(-1)per interaction point(IP),resulting in an integrated luminosity of 13 ab^(-1)for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.1.)and the Conceptual Design Report(CDR,2.1.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

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MELLT3 protects against cerebral ischemia-reperfusion (I/R) injury through up-regulation of m6A modification

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BIOCELL 2023年第3期47卷 619-626页

作者： JING JIN xinghua wang XIAOXIAO ZHENG JIAHUA LAN {2. ZHENG YING CAI HUI CHEN HONGWEI wang {2.FANG ZHENG Department of Neurosurgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou310003China Department of Neurology Puren Hospital Affiliated to Wuhan University of Science and TechnologyWuhan430081China Cancer Institute of Integrated Traditional Chinese and Western Medicine Zhejiang Academy of Traditional Chinese MedicineTongde Hospital of Zhejiang ProvinceHangzhou310012China Department of Animal Experimental center The First Affiliated HospitalZhejiang University School of MedicineHangzhou10003China Department of Anesthesiology Tongde Hospital of Zhejiang ProvinceHangzhou310012China Department of Neurology Yantian Hospital of Southern University of Science and TechnologyShenzhen518000China

Ischemic cerebrovascular disease is a leading cause of death globally and is often exacerbated by cerebral ischemic/reperfusion injury(CIRI).The exact mechanisms underlying I/R injury are *** this study,we aimed to determine the role of m6A-modified methylase complex methyltransferase-like 3(METTL3)in cerebral ischemiareperfusion(I/R)*** found that m6A and METTL3 levels increased in OGD/RX-induced mouse astrocytescerebellar(MA-C)and the brain of middle cerebral artery occlusion(MCAO)model ***3 siRNA treatment reduced OGD-RX-induced MAC cell viability and proliferation,which increased with METTL3 *** cytometry analysis showed that silencing METTL3 significantly enhanced OGD/RX-induced MAC apoptosis,which was significantly reduced with METTL3 *** an MCAO model,METTL3 overexpression significantly reduced cerebral infarction area and decreased brain cell apoptosis,indicating that METTL3 OE treatment could ameliorate brain edema and ***,METTL3 could be used as a target to treat I/R injury.

关键词： METTL3 m6A Cerebral ischemia-reperfusion

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