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A Computer Software-Epitimulator~ for Simulating Temporal Dynamics of Plant Disease Epidemic Progress

Agricultural Sciences in China 2010年第2期9卷 242-248页

作者： TAN Wan-zhong li cheng-wen BI Chao-wei SUN Xian-chao Fungal Pathology Laboratory Southwest University Beibei 400716 P.R.China Agricultural Department of Wushan County Chongqing 404700 P.R.China

The objective of the present study was to develop a computer software for simulating the temporal development of plant disease epidemics using Richards, logistic, Gompertz, monomolecular, and exponential functions, respectively, and for predicting disease with a fitted model. The software was programmed using Visual Basic （VB6.0） and packaged with the Wise Installation System. The Fibonacci （＇0.618＇） section strategy was used to find out the most appropriate value for the shape parameter （m） in Richards function simulation through looping procedures. The software program was repeatedly tested, debugged and edited until it was run through favorably and produced ideal outputs. It was named Epitimulator based on the phrase ＇epidemic time simulator＇ and has been registered by the National Copyright Department of China （Reg. no. 2007SR18489）. It can be installed and run on personal computers with all versions of Windows operational systems. Data of disease index and survey time are keyed in or imported from Access files. The output of fitted models and related data of parameters can be pasted into Microsoft Excel worksheet or into Word document for editing as required and the simulated disease progress curves can be stored in separate graphic files. After being finally tested and completed, Epitimulator was applied to simulate the epidemic progress of corn northern leaf blight （Exserohilum turcicum） with recorded data from field surveys of corn crops and the fitted models were output. Comparison of the simulation results showed that the disease progress was always best described by Richards function, which resulted in the most accurate simulation model. Result also showed that forecast of northern leaf blight development was highly accurate by using the computed progress model from Richards function.

关键词： plant disease dynamics Richards function Epitimulator fitted model output epidemic forecast

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Application of Grey Situation Decision-Making Theory in Site Selection of a Waste Sanitary Landfill

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Journal of China University of Mining and Technology 2006年第4期16卷 393-398页

作者： CAO li-wen cheng Yun-huan ZHANG Jing ZHOU Xiao-zhi liAN Cui-xia College of Mineral Resource and Earth Science China University of Mining ＆ Technology Xuzhou Jiangsu 221008 China

An application of an unequal-weighted multi-objective decision making method in site selection of a waste sanitary landfill is discussed. The eight factors, which affected possible options, were: size and capacity of the landfill, permeability of the stratum, the average difference in elevation between the groundwater level and the bottom of the landfill pit, quality and source of clay, the quality grade of the landfill site, the effect of landfill engineering on nearby residents, distance to the water supply and the water source as well as the cost of construction and waste transport. These are determined, given the conditions of the geological environment, the need for environmental protection and landfill site construction and transportation related to the design and operation of a sanitary landfill. The weights of the eight factors were further investigated based on the difference in their relevance. Combined with practical experience from Xuzhou city (Jiangsu province, China), the objectives, effects and weights of grey decision-making were deter- mined and the process and outcome of the landfill site selection are stated in detail. The decision-making results have been proven to be acceptable and correct. As we show, unequal-weighted multi-objective grey situation decision-mak- ing is characterized by easy calculations and good maneuverability when used in landfill site selection. The number of factors (objectives) affecting the outcome and the quantitative method of qualitative indices can be adjusted on the basis of concrete conditions in landfill site selection. Therefore, unequal-weighted multi-objective grey situation decision making is a feasible method in selecting landfill sites which offers a reference method for landfill site selection else- where. It is a useful, rational and scientific exploration in the choice of`a landfill site.

关键词： solid waste sanitary landfill site selection grey decision-making unequal-weighted multi-objective

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Mercury consumption and contamination of environment in gold mining in China

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Journal of Environmental Sciences 2000年第S1期12卷 39-44页

作者： HE Yong-liang liN Yu-huan li wen-cheng China National Gold Management Bureau BeijingChina Research Center for Eco Environmental Sciences Chinese Academy of SciencesBeijing 100085China Institute of Geography in Changchun Chinese Academy of SciencesChangchun 130021China

Amalgamation (sluice methods) used in the extraction of golds from ores and concentrates causes mercury contamination of the environment, which is increasingly concerned in China. The mercury specific consumption in the technical procedures has been evaluated based on the investigation of 33 mines. The average consumption of Hg is 14.6 g/ton raw ores, the ratio of Hg to gold is 6.35 g(Hg)/g(Au), total consumption of Hg in 1995 was 80 tons. The mercury amount entering into environment was 20 tons/a. Up to now 13.26% total gold produced in China is still using amalgamation, although prohibition of amalgamation since 1985 was officially proclaimed. At present, the amalgamation usage tendds to go up in some companies becasue of the benefic promotion. The irreversible mercury consumption was dispersed in the air(50%), tailing (23%) and partly(27%) entered into the downward products in the production, such as ore concentrates which was refined in the plants and caused pollution of environment near the smelter.

关键词： gold mining mercury pollution

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Analyses of the Temporal Development and Yield Losses due to Sheath Blight of Rice (Rhizoctonia solani AG1.1a)

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Agricultural Sciences in China 2007年第9期6卷 1074-1081页

作者： TAN Wan-zhong ZHANG Wei OU Zeng-qi li cheng-wen ZHOU Guan-jun WANG Zhi-kun YIN li-li College of Plant Protection Southwest University Chongqing 400716 P.R.China Department of Plant Seeds Administration Chongqing Agriculture Bureau Chongqing 400020 P.R.China College of Mathematics Southwest University Chongqing 400715 P.R.China

Sheath blight of rice, caused by Rhizoctonia solani AG 1. 1a, has become the most important disease and caused serious yield losses in some major rice-growing regions in China in recent years. In the present study, field plot experiment was conducted to examine the relationships between disease intensity and inoculum density （ID）, the seasonal disease epidemic dynamics, and yield reductions due to disease damages. Results from the experiment demonstrated that the areas under progress curves of disease severity and those of percent rice tillers diseased were positively and closely related to the relative initial ID of the pathogen. The inoculum density-disease （IDD） relationships were simulated and the impractical linear models were obtained. Both logistic and Gompertz functions could be used to simulate the disease progress dynamics in time, but the progress curves of the disease severity were modeled better by the Gompertz than by logistic function. However, the Richards function was found to be the best in simulating the disease progress curves when a most appropriate value was chosen for the shape parameter m by using the computer software Epitimulator. Sheath blight infection decreased rice yield very significantly and a yield reduction of 40% was recorded in rice crop with the highest inoculum density. Rice yield was linearly and negatively correlated with the disease severity and the percent tillers affected. The simulated models for all these relationships were computed through executing Epitimulator software and were presented in this paper.

关键词： rice sheath blight inoculum potential development dynamics yield losses simulated models

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Multiple dose pharmacokinetics of quetiapine and some of its metabolites in Chinese suffering from schizophrenia

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Acta Pharmacologica Sinica 2004年第3期25卷 136-140页

作者： Kun-yan li,Xin li,Ze-neng cheng,wen-xing PENG,Bi-kui ZHANG,Huan-de li1 Clinic Pharmacy Research Institute,Xiangya Second Hospital,Central South University,Changsha 410011,China Clinic Pharmacy Research Institute Xiangya Second Hospital Central South University

AIM: To study the multiple dose pharmacokinetics of quetiapine and its sulfoxide-, 7-hydroxy-, 7-hydroxy-N- dealkyl-metabolites in Chinese suffering from schizophrenia. METHODS: Twenty-one patients (11 females and 10 males) were given quetiapine twice daily to control the symptoms. After the dose reached 200 mg twice daily, blood were sampled to study the pharmacokinetics. The plasma concentrations of quetiapine and its metabolites were assayed by HPLC-MS. RESULTS: The main pharmacokinetic parameters of quetiapine, 7-hydroxy-N-dealkyl- quetiapine, quetiapine sulfoxide, and 7-hydroxy-quetiapine were as follows: tmax were 2.0 (0.3-5.0), 4.0 (1.5-6.0), 3.0 (0.5-5.0), and 3.0 (0.5-5.0) h respectively; t1/2 were (7±3), (9.4±2.7), (7±3), and (8±5) h, respectively; Cm SS ax were (678±325), (19±5), (451±216), and (58±22) μg/L, respectively; CSS were (51±68), (3.3±1.6), (35±36), and min (5±4) μg/L, respectively; Cav were (295±144), (13±4), (209±71), and (28±9) μg/L, respectively; AUC0?12 were SS SS (3 538±1 728), (153±44), (2 512±854), and (335±104) μg·h·L-1, respectively; AUC0 were (5 534±4 198), (287±107), SS -∞ (3 858±2 012), and (529±262) μg·h·L-1, respectively; Ke were (0.11±0.03), (0.079±0.019), (0.11±0.03), and (0.103±0.028) h-1, respectively; CL/F and V/F of quetiapine were (67±25) L·h-1 and (672±394) L, respectively. The plasma concentrations for the four compounds reached a steady state within 48 h at the dose of 200 mg initiation. These parameters were not statistically different between genders. CONCLUSIONS: Quetiapine was absorbed quickly, distributed widely, and metabolized mainly to be quetiapine sulfoxide. The elimination speeds of quetiapine and its three metabolites were similar. Gender had no effect on the pharmacokinetics of quetiapine and its metabolites. The clinical dosage regime caused no drug accumulation.

关键词： quetiapine pharmacokinetics metabolism schizophrenia Chinese

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Authors＇ Reply to Letter to the Editor ＂Comparing Sedation Regimens for Awake Fiberoptic Intubation＂

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Chinese Medical Journal 2016年第4期129卷 503-504页

作者： cheng-wen li Yan-Dong li Hai-Tao Tian Department of Anesthesiology Jining No. 1 People's Hospital Jining Shandong 272011 China Department of Anesthesiology Affiliated Hospital of Jining Medical University Jining Shandong 272029 China

We appreciate Prof. Xue et al. for their thoughtful comments on our studyJ H We agree with them that history of smoking and respiratory comorbidities can increase airway reactivity to airway irritation, resulting in an increased severity of cough. In our study, patients with a history of smoking and respiratory comorbidities were excluded and the demographic data of patients were comparable between tile groups.

关键词：插管法钙调蛋白结合蛋白质类咳嗽磷蛋白磷酸酶类内皮缩血管肽类书信吸烟

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The molecular characterization of maize B chromosome specific AFLPs

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Cell Research 2002年第1期12卷 63-68页

作者： ZHONG XIA QI, Hui ZENG, Xiu LAN li, cheng BIN CHEN, wen QIN SONG, RUI YANG CHEN The College of life Sciences, Nankai University, Tianjin 300071, China 1The College of life Sciences Nankai University Tianjin 300071 China 1The College of life Sciences Nankai University Tianjin 300071 China 1The College of life Sciences Nankai University Tianjin 300071 China 1The College of life Sciences Nankai University Tianjin 300071 China 1The College of life Sciences Nankai University Tianjin 300071 China 1The College of life Sciences Nankai University Tianjin 300071 China

The origin and evolution of B chromosomes could be explained by the specific DNA sequence on them. But the specific sequences known were quite limited. To investigate maize B chromosome sqicific DNA sequeces, maize genomes with and without B chromosomes were analyzed by AFLP. Only 5 markers were found specific to genomes with B chromosomes among about 2000 AFLP markers. Southern hybridization and sequence analysis revealed that only the sequence of M8-2D was a B chromosome specific sequence. This sequence contained the telomeric repeat unit AGGGTTT conserved in plant chromosome telomeres. In addition, the sequence of M8-2D shared low homology to clones from maize chromosome 4 centromere as well. M8-2D were localized to B chromosome centrorneric and telomeric regions.

关键词： Maize B chromosome AFLP FISH.

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An Improvement on the Junction Temperature Measurement of light-Emitting Diodes by using the Peak Shift Method Compared with the Forward Voltage Method

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Chinese Physics Letters 2012年第12期29卷 215-218页

作者： HE Su-Ming LUO Xiang-Dong ZHANG Bo FU Lei cheng li-wen WANG Jin-Bin LU Wei Key Laboratory of Low-Dimensional Materials and Application Technology of Ministry of Education Xiangtan UniversityXiangtan 411105 National Lab for Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083

The junction temperature of red,green and blue high power light emitting diodes(LEDs)is measured by using the emission peak shift method and the forward voltage *** the emission peak shift and the forward voltage decrease show a linear relationship relative to junction *** linear coefficients of the red,green and blue LEDs for the peak shift method and the forward voltage method range from 0.03 to 0.15 nm/℃ and from 1.33 to 3.59 mV/℃,*** with the forward voltage method,the peak shift method is almost independent of bias current and sample *** variation of the slopes is less than 2%for the peak shift method and larger than 30%for the forward voltage method,when the LEDs are driven by different bias *** is indicated that the peak shift method gives better stability than the forward voltage method under different LED working conditions.

关键词： temperature. diodes method

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Dexmedetomidine-midazolam versus Sufentanil-midazolam for Awake Fiberoptic Nasotracheal Intubation： A Randomized Double-blind Study

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Chinese Medical Journal 2015年第23期128卷 3143-3148页

作者： cheng-wen li Yan-Dong li Hai-Tao Tian Xian-Gang Kong Kui Chen Department of Anesthesiology Jining No. 1 People's Hospital Jining Shandong 272011 China Department of Anesthesiology Affiliated Hospital of Jining Medical University Jining Shandong 272029 Chin

Background： Awake fiberoptic intubation （AFOI） is usually performed in the management of the predicted difficult airway. The aim of this study was to evaluate the feasibility of dexmedetomidine with midazolam （DM） and sufentanil with midazolam （SM） for sedation for awake fiberoptic nasotracheal intubation. Methods： Fifty patients with limited mouth opening scheduled for AFOI were randomly assigned to two groups （n = 25 per group） by a computer-generated randomization schedule. All subjects received midazolam 0.02 mg/kg as premedication and airway topical anesthesia with a modified ＂spray-as-you-go＂ technique. Group DM received dexmedetomidine at a loading dose of 0.5 μg/kg over 10 min followed by a continuous infllsion of 0.25 μ***^-1.h ^-1, whereas Group SM received sufentanil at a loading dose of 0.2 μg/kg over 10 rain followed by a continuous infusion of 0.1 μ***^-1.h ^-1. As necessary, since the end of the administration of the loading dose of the study drug, an additional dose ofmidazolam 0.5 mg at 2-min intervals was given to achieve a modified Observers＇Assessment of Alertness/Sedation of 2-3. The quality of intubation conditions and adverse events were observed.Results： The scores of ease of the AFOI procedure, patient＇s reaction during AFOI, coughing severity, tolerance after intubation, recall of the procedure and discomfort during the procedure were comparable in both groups （z = 0.572, 0.664, 1.297, 0.467, 0.895, and 0.188, respectively, P 〉 0.05）. Hypoxic episodes similarly occurred in the two groups, but the first partial pressure of end-tidal CO, after intubation was higher in Group SM than that in Group DM （45.2 ± 4.2 mmHg vs. 42.2 ±4.3 mmHg, t = 2.495, P 〈 0.05）. Conclusions： Both dexmedetomidine and sufentanil are effective as an adjuvant for AFOI under airway topical anesthesia combined with midazolam sedation, but respiratory depression is still a potential risk in the sufentanil regimen.

关键词： Awake Fiberoptic lntubation: Conscious Sedation: Dexmedetomidine Midazolam Sufentanil

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Real-world evidence on the efficacy and safety of vonoprazanamoxicillin dual therapy for Helicobacter pylori treatment in elderly patients

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World Journal of Gastroenterology 2025年第1期31卷 68-78页

作者： wen Gao Jing-wen li Hui Ye Xue-Zhi Zhang Jian-Xiang liu Hong cheng Department of Gastroenterology Peking University First HospitalBeijing 100034China School of Medicine Tsinghua MedicineTsinghua UniversityBeijing 100034China Department of Traditional Chinese Medicine and Integrative Medicine Peking University First HospitalBeijing 100034China

BACKGROUND A dual therapy regimen containing amoxicillin is a common treatment option for the eradication of Helicobacter pylori(***).While substantial research supports the efficacy and safety of vonoprazan and amoxicillin(VA)dual therapy in the general population,there is still a lack of studies specifically focusing on its safety in elderly *** To evaluate efficacy and safety of VA dual therapy as first-line or rescue treatment for *** in elderly *** As a real-world retrospective study,data were collected from elderly patients aged 60 years and above who accepted VA dual therapy(vonoprazan 20 mg twice daily+amoxicillin 1000 mg thrice daily for 14 days)for *** eradication in the Department of Gastroenterology at Peking University First Hospital between June 2020 and January *** status was evaluated by^(13)C-urease breath test 6 weeks after *** adverse events(AEs)during treatment were *** In total,401 cases were ***-one cases were excluded due to loss to follow-up,lack of re-examination,or unwillingness to take *** total of 380 included cases comprised 250 who received VA dual therapy as first-line treatment and 130 who received VA dual therapy as rescue *** was successfully eradicated in 239 cases(95.6%)in the first-line treatment group and 116 cases(89.2%)in the rescue treatment *** overall incidence of AEs was 9.5%for both ***,9.2%of patients experienced an AE in the first-line treatment group and 10.0%in the rescue treatment *** patients discontinued treatment due to AE,with a discontinuation rate of 1.3%.No serious AE *** The VA dual therapy regimen as a first-line treatment and a rescue therapy was effective and safe for elderly patients aged 60 and older.

关键词： Helicobacter pylori Vonoprazan Amoxicillin Dual therapy Elderly

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