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Pre-hospital care-seeking in patients with acute myocardial infarction and subsequent quality of care in Beijing

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Chinese Medical Journal 2010年第6期123卷 664-669页

作者： SONG li YAN Hong-bing hu Da-yi YANG Jin-gang SUN Yi-hong The 28th Division Beijing Anzhen HospitalCapital Medical UniversityBeijing 100029China

Background Cumulative evidence demonstrates that primary percutaneous coronary intervention（PCI）is a mperfusion strategy for ST-elevation myocardial Infarction（STEMI）.This study was undertaken to evaluate the pre-hospital care-seeking pathway and subsequent care quality in patients with STEMI in the Beijing health care system,which offers patients a choice between seeking care in a small community hospital（SH group）or a large hospital（LH group）.Methods Between January 1 and December 31,2006, a cross-sectional and multicenter survey was conducted in 11 hospitals qualified as tertiary centers in Beijing and included consecutive patients with STEMI admitted within 24 hours after onset of *** Among the 566 patients interviewed,28.3%first arnved at a small community hospitaI and were transferred to large hospitals with the ability to perform primary *** median total pre-hospital delay in the SH group（n=160）was significantly longer than in the LH group（n=406）（225 vs.120 minutes,P〈0.001）.Multivariate analysis showed that interpreting symptoms to non-cardiac origin（OR,1.996;95%CI： 1.264-3.155）,absence of history of myocardial infarction（OR,1.595;95%CI：1.086-3.347）,non-health insuranca coverage（OR,1.931;95%Cl：1.079-3.012）and absence of sense of impending doom （OR,4.367;95%CI：1.279-1 4.925） were independent predictors for choosing small *** adjusting for demographics and medical history,patients in the SH group were 1.698 times（95% CI： 1.1 82-3.661） less likely to receive primary PCI compared with those in the LH group. Conclusions Above one fourth of the STEMI patients in Beijing experienced inter-hospital *** including symptoms interpretation,symptoms,history of myocardial infarcUon,and insurance coverage were associated with the patients＇pre-hospital care-seeking *** patients who were transferred had longer pre-hospital delays and were less Iikely to receive primary PCI.

关键词： acute myocardial infarction care-seeking pre-hospital delay percutaneous coronary intervention

The application of computer technology in digital museum

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通讯和计算机（中英文版） 2009年第9期6卷 58-61页

作者： JI Ya-li liU He-bing hu Xiao-hong College of lnformation and Management Henan Agricultural University Zhengzhou 450002 China

Mechanism by which Rab5 promotes regeneration and functional recovery of zebrafish Mauthner axons

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Neural Regeneration Research 2025年第6期20卷 1816-1824页

作者： Jiantao Cui Yueru Shen Zheng Song Dinggang Fan bing hu Center for Advanced Interdisciplinary Science and Biomedicine of IHM Division of Life Sciences and MedicineUniversity of Science and Technology of ChinaHefeiAnhui ProvinceChina

Rab5 is a GTPase protein that is involved in intracellular membrane trafficking. It functions by binding to various effector proteins and regulating cellular responses, including the formation of transport vesicles and their fusion with the cellular membrane. Rab5 has been reported to play an important role in the development of the zebrafish embryo;however, its role in axonal regeneration in the central nervous system remains unclear. In this study, we established a zebrafish Mauthner cell model of axonal injury using single-cell electroporation and two-photon axotomy techniques. We found that overexpression of Rab5 in single Mauthner cells promoted marked axonal regeneration and increased the number of intra-axonal transport vesicles. In contrast, treatment of zebrafish larvae with the Rab kinase inhibitor CID-1067700markedly inhibited axonal regeneration in Mauthner cells. We also found that Rab5 activated phosphatidylinositol 3-kinase(PI3K) during axonal repair of Mauthner cells and promoted the recovery of zebrafish locomotor function. Additionally, rapamycin, an inhibitor of the mechanistic target of rapamycin downstream of PI3K, markedly hindered axonal regeneration. These findings suggest that Rab5 promotes the axonal regeneration of injured zebrafish Mauthner cells by activating the PI3K signaling pathway.

关键词： axonal regeneration Mauthner cell nerve regeneration Rab5 zebrafish

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镀锡溶液中添加剂含量测定的新方法

东北大学学报（自然科学版） 2014年第10期35卷 1432-1436页

作者：李兵虎刘常升唐钢锋贾瑜东北大学材料各向异性与织构教育部重点实验室辽宁沈阳110819 复旦大学化学系上海200433

利用锡离子及亚铁离子在磷酸二氢钠缓冲溶液形成沉淀物被除去方式进行样品预处理,以安捷伦ZORBAX Eclipse XDB-C18色谱柱为分离柱,以20 mmol/L磷酸二氢钠溶液-甲醇体系（48∶52）为流动相,215 nm为波长检测条件,提出了监测电渡液中有效... 详细信息

利用锡离子及亚铁离子在磷酸二氢钠缓冲溶液形成沉淀物被除去方式进行样品预处理,以安捷伦ZORBAX Eclipse XDB-C18色谱柱为分离柱,以20 mmol/L磷酸二氢钠溶液-甲醇体系（48∶52）为流动相,215 nm为波长检测条件,提出了监测电渡液中有效添加剂（α-萘酚聚氧乙烯醚,α-萘酚磺酸聚氧乙烯醚）含量的高效液相色谱法（HPLC）.此方法样品损失率小于4%,α-萘酚聚氧乙烯醚和α-萘酚磺酸聚氧乙烯醚的平均回收率为96.6%~98.9%,分析结果偏差在0.05 g/L之内.该方法快速、准确、灵敏度高、重现性好,完全满足镀锡工艺监测的要求.

关键词：高效液相色谱镀锡溶液添加剂磷酸二氢钠镀锡工艺

Relation among Summer Rainfall in South Shandong and High Pressure in South Asia and Atmospheric Circulation

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Meteorological and Environmental Research 2011年第7期2卷 41-46页

作者： GAO An-chun,SHEN Pei-lu,li bing-wen,hu Yan,YU Yan-min,Zhu Yi-qing linyi Meteorological Bureau of Shandong Province,linyi 276004,China

[Objective] The aim was to study the relation among summer rainfall in south Shandong and high pressure in South Asia and atmospheric circulation.[Method] Taking the precipitation in south Shandong along the Yellow River and huaihe River,using the NCEP/NCAR data and summer rainfall data in south Shandong in summer from 1961 to 2005,the characteristics of high pressure in South Asia and atmospheric circulation in drought year and flood year in summer in south Shandong Province were *** mechanism of 100 hPa pressure in South Asian influencing precipitation in south Shandong Province was *** interaction of different equipment,different altitude and different system of atmosphere circulation in low and high layer was expounded.[Results] The first mode of EOF decomposition of precipitation in summer in south Shandong Province explained above 63% variances and reflected universal form of *** difference of central position of the central position of height field of high pressure in South Asia in drought and flood year was *** the wind field center was *** the area of SAH was smaller and its eastern ridge line stretched to the Western Pacific between the middle of south Shandong and Changjiang Estuary,flood summer occurred when there was an unusual cyclone lied in the east of 90° E and south of Lake *** area of SAH was larger and its eastern ridge line stretching to the Western Pacific over Changjiang Estuary,drought summer occurred,when there was an unusual anticyclone lied in the east of 90° E and south of Lake *** and summer rainfall also had close relationship with Tele-connection Patterns over the Eurasia continent and EAP *** the height anomaly was in '+-+' form in the north of the Caspian Sea,around Lake Baikal and Kamchatka,and when the height anomaly in East Asia-West Pacific area was in '-+' form from low altitude to high altitude,there was much precipitation in summer;and conversel

关键词： Summer rainfall in the south of Shandong Province Drought and flood High pressure in South Asia Atmospheric circulation China

Repetitive traumatic brain injury–induced complement C1–related inflammation impairs long-term hippocampal neurogenesis

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Neural Regeneration Research 2025年第3期20卷 821-835页

作者： Jing Wang bing Zhang Lanfang li Xiaomei Tang Jinyu Zeng Yige Song Chao Xu Kai Zhao Guoqiang liu Youming Lu Xinyan li Kai Shu Department of Neurosurgery Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Neurosurgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Pathophysiology School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Institute for Brain Research Wuhan Center of Brain ScienceHuazhong University of Science and TechnologyWuhanHubei ProvinceChina Department of Graduate Student Chongqing Medical UniversityChongqingChina Department of Basic Medicine School of Medical ScienceHubei University for NationalitiesEnshiHubei ProvinceChina Department of Anatomy School of Basic Medicine and Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei ProvinceChina

Repetitive traumatic brain injury impacts adult neurogenesis in the hippocampal dentate gyrus,leading to long-term cognitive ***,the mechanism underlying this neurogenesis impairment remains *** this study,we established a male mouse model of repetitive traumatic brain injury and performed long-term evaluation of neurogenesis of the hippocampal dentate gyrus after repetitive traumatic brain *** results showed that repetitive traumatic brain injury inhibited neural stem cell proliferation and development,delayed neuronal maturation,and reduced the complexity of neuronal dendrites and *** with repetitive traumatic brain injuryalso showed deficits in spatial memory ***,following repetitive traumatic brain injury,neuroinflammation was enhanced in the neurogenesis microenvironment where C1q levels were increased,C1q binding protein levels were decreased,and canonical Wnt/β-catenin signaling was *** inhibitor of C1 reversed the long-term impairment of neurogenesis induced by repetitive traumatic brain injury and improved neurological *** findings suggest that repetitive traumatic brain injury–induced C1-related inflammation impairs long-term neurogenesis in the dentate gyrus and contributes to spatial memory retrieval dysfunction.

关键词： complement C1 dendrite dentate gyrus hippocampus neural stem cell neurogenesis neuroinflammation neurological function neuron traumatic brain injury

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颅内动脉粥样硬化的危险因素

国际脑血管病杂志 2011年第4期19卷 281-285页

作者：黎炳护张莉莉李敬诚第三军医大学大坪医院野战外科研究所神经内科重庆400042

颅内动脉粥样硬化是缺血性卒中的重要病因之一。由于颅内、外动脉在结构和血流动力学方面存在差异，传统血管危险因素，如性别、年龄、高血压、糖尿病等对颅内、外动脉粥样硬化的影响也有所不同。及早识别颅内动脉粥样硬化的危险因素，... 详细信息

颅内动脉粥样硬化是缺血性卒中的重要病因之一。由于颅内、外动脉在结构和血流动力学方面存在差异，传统血管危险因素，如性别、年龄、高血压、糖尿病等对颅内、外动脉粥样硬化的影响也有所不同。及早识别颅内动脉粥样硬化的危险因素，对于积极防治颅内动脉粥样硬化和降低缺血性卒中发病率具有重要意义。然而，针对危险因素和颅内动脉粥样硬化相关性的许多研究结论并不一致。文章对颅内动脉粥样硬化危险因素的研究现状做了综述。

关键词：颅内动脉粥样硬化动脉粥样硬化卒中危险因素

Peripheral blood RNA biomarkers can predict lesion severity in degenerative cervical myelopathy

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Neural Regeneration Research 2025年第6期20卷 1764-1775页

作者： Zhenzhong Zheng Jialin Chen Jinghong Xu Bin Jiang Lei li Yawei li Yuliang Dai bing Wang Department of Spine Surgery The Second Xiangya Hospital of Central South UniversityChangshaHunan ProvinceChina

Degenerative cervical myelopathy is a common cause of spinal cord injury,with longer symptom duration and higher myelopathy severity indicating a worse *** numerous studies have investigated serological biomarkers for acute spinal cord injury,few studies have explored such biomarkers for diagnosing degenerative cervical *** study involved 30 patients with degenerative cervical myelopathy(51.3±7.3 years old,12 women and 18 men),seven healthy controls(25.7±1.7 years old,one woman and six men),and nine patients with cervical spondylotic radiculopathy(51.9±8.6 years old,three women and six men).Analysis of blood samples from the three groups showed clear differences in transcriptomic *** analysis identified 128 differentially expressed genes that were enriched in patients with neurological *** least absolute shrinkage and selection operator analysis,we constructed a five-gene model(TBCD,TPM2,PNKD,EIF4G2,and AP5Z1)to diagnose degenerative cervical myelopathy with an accuracy of 93.5%.One-gene models(TCAP and SDHA)identified mild and severe degenerative cervical myelopathy with accuracies of 83.3%and 76.7%,*** of two immune cell types(memory B cells and memory-activated CD4^(+)T cells)predicted levels of lesions in degenerative cervical myelopathy with 80%*** results suggest that peripheral blood RNA biomarkers could be used to predict lesion severity in degenerative cervical myelopathy.

关键词： biomarkers candidate genes degenerative cervical myelopathy gene expression analysis immune cell types neurological disabilities peripheral blood RNA profiles spinal cord injury

Photo‑Energized MoS_(2)/CNT Cathode for High‑Performance li–CO_(2)Batteries in a Wide‑Temperature Range

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Nano-Micro Letters 2025年第1期17卷 160-175页

作者： Tingsong hu Wenyi lian Kang hu Qiuju li Xueliang Cui Tengyu Yao Laifa Shen Jiangsu Key Laboratory of Materials and Technologies for Energy Storage College of Materials Science and TechnologyNanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

li–CO_(2) batteries are considered promising energy storage systems in extreme environments such as Mars;however,severe performance degradation will occur at a subzero temperature owning to the sluggish reaction ***,a photo-energized strategy adopting sustainable solar energy in wide working temperature range li–CO_(2) battery was achieved with a binder-free MoS_(2)/carbon nanotube(CNT)photo-electrode as *** unique layered structure and excellent photoelectric properties of MoS_(2) facilitate the abundant generation and rapid transfer of photo-excited carriers,which accelerate the CO_(2) reduction and li_(2)CO_(3) decomposition upon *** illuminated battery at room temperature exhibited high discharge voltage of 2.95 V and mitigated charge voltage of 3.27 V,attaining superior energy efficiency of 90.2%and excellent cycling stability of over 120 *** at an extremely low temperature of−30℃,the battery with same electrolyte can still deliver a small polarization of 0.45 V by the photoelectric and photothermal synergistic mechanism of MoS_(2)/CNT *** work demonstrates the promising potential of the photo-energized wide working temperature range li–CO_(2) battery in addressing the obstacle of charge overpotential and energy efficiency.

关键词： li-CO_(2)batteries Photo-energized Wide operation-temperature Kinetics MoS_(2)