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Transplantation of fibrin-thrombin encapsulated human induced neural stem cells promotes functional recovery of spinal cord injury rats through modulation of the microenvironment

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Neural Regeneration Research 2024年第2期19卷 440-446页

作者： Sumei liu baoguo liu Qian li Tianqi Zheng Bochao liu Mo li Zhiguo Chen Cell Therapy Center Beijing Institute of GeriatricsXuanwu HospitalCapital Medical UniversityNational Clinical Research Center for Geriatric Diseasesand Key Laboratory of Neurodegenerative DiseasesMinistry of EducationBeijingChina Center of Neural Injury and Repair Beijing Institute for Brain DisordersBeijingChina Center of Parkinson’s Disease Beijing Institute for Brain DisordersBeijingChina

Recent studies have mostly focused on engraftment of cells at the lesioned spinal cord,with the expectation that differentiated neurons facilitate recovery.Only a few studies have attempted to use transplanted cells and/or biomaterials as major modulators of the spinal cord injury microenvironment.Here,we aimed to investigate the role of microenvironment modulation by cell graft on functional recovery after spinal cord injury.Induced neural stem cells reprogrammed from human peripheral blood mononuclear cells,and/or thrombin plus fibrinogen,were transplanted into the lesion site of an immunosuppressed rat spinal cord injury model.Basso,Beattie and Bresnahan score,electrophysiological function,and immunofluorescence/histological analyses showed that transplantation facilitates motor and electrophysiological function,reduces lesion volume,and promotes axonal neurofilament expression at the lesion core.Examination of the graft and niche components revealed that although the graft only survived for a relatively short period(up to 15 days),it still had a crucial impact on the microenvironment.Altogether,induced neural stem cells and human fibrin reduced the number of infiltrated immune cells,biased microglia towards a regenerative M2 phenotype,and changed the cytokine expression profile at the lesion site.Graft-induced changes of the microenvironment during the acute and subacute stages might have disrupted the inflammatory cascade chain reactions,which may have exerted a long-term impact on the functional recovery of spinal cord injury rats.

关键词： biomaterial fibrinogen functional recovery induced neural stem cell transplantation microenvironment microglia spinal cord injury thrombin

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Influence of nitrogen status on fermentation performances of non-Saccharomyces yeasts:a review

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Food Science and Human Wellness 2024年第2期13卷 556-567页

作者： Jinchen li Mengmeng Yuan Nan Meng Hehe li Jinyuan Sun baoguo Sun Key Laboratory of Brewing Molecular Engineering of China light Industry Beijing Key Laboratory of Flavor ChemistryBeijing Technology&Business UniversityBeijing 100048China

Nitrogen,one of the most crucial nutrients present in grapes and musts,plays a key role in yeast activities during alcoholic fermentation.Such influences are imposed on yeast growth and fermentation performances including the formation of secondary metabolites.Saccharomyces cerevisiae,the main yeast responsible for fermentation,has been studied extensively regarding nitrogen impacts.On the other hand,a similar study for non-Saccharomyces yeasts,whose contributions to winemaking have gradually been acknowledged,remains to be fully explored,with a few studies being reported.This review starts by discussing nitrogen impacts on non-Saccharomyces yeast growth and fermentation kinetics in different case scenarios,then proceeds to summarize the nitrogen preferences of individual yeast strains with regulation mechanisms elucidated by recent studies.Detailed discussions on the influences on the production of volatile compounds and proposed pathways therein are made,followed by future work suggested as the final section.In summarizing the nitrogen impacts on non-Saccharomyces yeasts throughout alcoholic fermentation,this review will be helpful in obtaining a more comprehensive view on these non-conventional wine yeasts in terms of nutrient requirements and corresponding volatile production.Research gaps will therefore be elucidated for future research.

关键词： Non-Saccharomyces yeasts Nitrogen Fermentation kinetics Nitrogen preference Wine aroma

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Infanticide in golden snub-nosed monkeys with multilevel society

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Current Zoology 2024年第2期70卷 273-275页

作者： Wei li Shixuan Dong Fei Niu Nianlong li Ziyi Su Chengliang Wang Kang Huang Haitao Zhao Ruliang Pan Pei Zhang baoguo li Shaanxi Key Laboratory for Animal Conservation College of Life SciencesNorthwest UniversityXi'an 710069China Shaanxi Key Laboratory for Animal Conservation Shaanxi Institute of ZoologyXi'an 710032China School of Anatomy Physiology and Human BiologyThe University of Western AustraliaWestern Australia 6907Australia International Centre of Biodiversity and Primate Conservation Dali UniversityDali 671003China Division of ExpressiveTherapies.Lesley University.Cambridae.MA02138.USA

Infanticide,killing unweaned offspring in conspecifics,occurs widely among mammals,such as rodents,ungulates,and carnivores,especially in primates(Lukas and Huchard 2014).Such scenarios are often triggered by intruders that have replaced the former dominant males in nonhuman primates(Borries 1997).It has widely been viewed that infanticide is one of the solutions of sexually driven evolutionary selection:males kill infants to end lactational amenorrhea of the victim's mothers,forcing them to return to estrus and providing infanticidal males with the opportunities to sire their new offspring(Hrdy 1979).There is a broad spectrum regarding the patterns and mechanisms causing such events,referring to alternative breeding behaviors and mating systems-monogamy,polyandry,polygyny,and promiscuity(Qi et al.2020).

关键词： primates breeding mother

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Shrinkage Characteristics of lime Concretion Black Soil as Affected by Biochar Amendment

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Pedosphere 2018年第5期28卷 713-725页

作者： WEI Cuilan GAO Weida William Richard WHALLEY li baoguo Key Laboratory of Arable Land Conservation (North China) Ministry of Agriculture Key Laboratory of Plant-Soil Interactions Ministry of Education College of Resources and Environmental Sciences China Agriculture University Rothamsted Research West Common

Studies have reported that biochar is a sustainable amendment that improves the chemical and physical properties of soil.In this study,an incubation experiment was conducted to investigate the effects of different application rates of biochar on the cracking pattern and shrinkage characteristics of lime concretion black soil after three wetting and drying cycles.Biochar derived from the corn straw and peanut shell mixture was applied to the soil at rates of 0,50,100,and 150 g kg^(-1)dry weight,representing the treatments T_(0),T_(50),T_(100),and T_(150),respectively.During the wetting and drying cycles,the cracking pattern and shrinkage characteristics of the unamended and amended soil samples were recorded.Application of biochar significantly increased soil organic carbon content in the samples.During soil desiccation,biochar significantly reduced the rate of water loss.Cracks propagated slowly and stopped due to the relatively higher water content in the soil applied with biochar.The cracking area density(ρ_c),equivalent width,fractal dimension,and cracking connectivity index decreased during the drying process with increasing application rate of biochar.Theρ_(c )value of the T_(50),T_(100),and T_(150) treatments decreased by 33.6%,52.1%,and 56.9%,respectively,after three wetting and drying cycles,whereas the T_(0) treatment exhibited a marginal change.The coefficient of linear extensibility,an index used to describe onedimentional shrinkage,of the unamended soil sample(T_(0))was approximately 0.23.Application of 100 and 150 g kg^(-1)biochar to the soil significantly reduced the shrinkage capacity by 41.45%and 45.54%,respectively.The slope of the shrinkage characteristics curve,which indicates the ralationship between soil void ratio and moisture ratio,decreased with increase in the application rate of biochar.Furthermore,compared with the T_(0) treatment,the proportional shrinkage zone of the shrinkage characteristic curve of the T_(50),T_(100),and T_(150) treatments decreased by 5.8%,13.1%,and 12.1%,respectiv

关键词：土壤特征收缩凝固石灰修正案花生壳稻草

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Assessment of the influence of global dimming on the photosynthetic production of rice based on three-dimensional modeling

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Science China Earth Sciences 2011年第2期54卷 290-297页

作者： ZHENG BangYou MA YunTao li baoguo GUO Yan DENG QiYun Key Laboratory of Plant-Soil Interactions Ministry of Education College of Resources and Environment China Agricultural University Beijing 100193 China China National Hybrid Rice R & D Center Changsha 410125 China

Observations indicate that global radiation reaching the Earth's surface has gradually decreased over the past several decades(i.e.,the "global dimming" phenomenon),while the fraction of diffuse radiation in global radiation has increased.It has been found that the increase in diffuse fraction significantly increases photosynthetic production in the canopy,but the mechanism has not been clarified.A three-dimensional light distribution model considering the geometry of incident radiation was employed in this study.This model was used to simulate the light distribution and potential photosynthetic production of rice canopy.The results indicate that the potential photosynthetic production of rice significantly increases in response to an increase in the diffuse fraction as long as global radiation does not decline greatly.The "fertilization effect" of diffuse radiation results from the reduction of leaf area with photosynthetic photon flux density(PPFD) below the light compensation point in response to an increasing diffuse fraction,and an increase in the leaf area with PPFD on the linear part of the light response curve.The increase in the diffuse fraction results in a significant increase in the photosynthetic rate of the upper canopy.High-performance computation is an easy-to-use and economic approach to overcome the computational constraints of the model.

关键词：光合生产潜力三维建模光合作用水稻评估分布模型群体光合速率地球表面

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不同产地酱香型白酒中挥发性含氮化合物的差异分析

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食品科学技术学报 2024年第3期42卷 35-48页

作者：吴李玲裴荣红李行李晴李良好郑福平孙金沅孙宝国北京工商大学食品质量与安全北京实验室/中国轻工业酿酒分子工程重点实验室/食品与健康学院北京100048

酱香型白酒中含氮类化合物含量虽占比较少,但部分化合物气味阈值较低,对酒体风味贡献较大。以20种酱香型白酒为对象,来源产地包括贵州、广西、湖南、北京、天津、山东、黑龙江,采用液-液萃取结合全二维气相色谱-氮化学发光检测器联用技... 详细信息

酱香型白酒中含氮类化合物含量虽占比较少,但部分化合物气味阈值较低,对酒体风味贡献较大。以20种酱香型白酒为对象,来源产地包括贵州、广西、湖南、北京、天津、山东、黑龙江,采用液-液萃取结合全二维气相色谱-氮化学发光检测器联用技术对酱香型白酒中挥发性含氮化合物进行定性定量分析。共定性出49种挥发性含氮化合物,包括16种吡嗪类、12种噻唑类、4种吡啶类、6种吡咯类、2种胺类和9种其他化合物;不同产地的酱香型白酒中挥发性含氮化合物的种类差别不明显。对已报道具有香气的挥发性含氮化合物进行定量分析,结果表明:酱香型白酒挥发性含氮化合物中吡嗪类质量浓度最高;贵州酒样的吡嗪类质量浓度[(5.36±0.96)mg/L]最高,其次高的是中北部地区的酒样[(4.12±1.20)mg/L],湖南酒样的质量浓度[(3.05±0.64)mg/L]和广西酒样的质量浓度(3.00 mg/L)差别不明显,最低的是黑龙江产地的酒样[(1.68±0.42)mg/L]。根据定量结果,采用正交偏最小二乘判别分析,可成功区分不同产地的酱香型白酒;苯并噻唑、吡嗪、2,3,5,6-四甲基吡嗪、2,6-二甲基吡嗪等11种变量投影值大于1的含氮化合物,可作为区分不同产地酱香型白酒的差异成分。研究可为酱香型白酒产地区分和溯源提供理论支持。

关键词：酱香型白酒挥发性含氮化合物产地正交偏最小二乘判别分析全二维气相色谱-氮化学发光检测器

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6种武陵酱香型白酒中挥发性含硫化合物差异分析

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食品科学技术学报 2024年第1期42卷 83-93页

作者：李行吴李玲裴荣红朱琳郑福平孙金沅李凡李义孙宝国北京工商大学食品质量与安全北京实验室/中国轻工业酿酒分子工程重点实验室北京100048 中粮生化能源(肇东)有限公司黑龙江绥化152001 玉米深加工国家工程研究中心吉林中粮生化有限公司吉林长春130033

挥发性含硫化合物由于具有香气特征强、阈值低的特点,对食品风味具有十分重要的影响。然而大多数挥发性含硫化合物在食品中的含量低于气相色谱-质谱联用(G C-MS)分析技术的检出限,难以被鉴定和识别。酱香型是我国白酒的主要香型,产于湖... 详细信息

挥发性含硫化合物由于具有香气特征强、阈值低的特点,对食品风味具有十分重要的影响。然而大多数挥发性含硫化合物在食品中的含量低于气相色谱-质谱联用(G C-MS)分析技术的检出限,难以被鉴定和识别。酱香型是我国白酒的主要香型,产于湖南的武陵酱香型白酒是酱香型白酒的重要代表之一。为深入探究我国酱香型白酒中重要的痕量挥发性含硫化合物的组成,研究采用顶空固相微萃取结合全二维气相色谱-硫化学发光检测(GC×G C-SCD)技术,以6种不同类型武陵酱香型白酒为研究对象,对其中的含硫化合物进行了分析。研究共定性鉴定出27种含硫化合物,其中共有含硫化合物19种,非共有含硫化合物8种,主要包括4种硫醇、6种硫酯、5种多硫醚、5种噻唑、6种噻吩、1种噻烷;对其中信噪比大于100的23种含硫化合物,采用外标曲线法进行了定量分析。依据定量分析结果,采用主成分分析和正交偏最小二乘判别分析,研究确定了6种不同类型武陵酱香型白酒中挥发性含硫化合物含量的差异;14种变量投影值大于1的含硫化合物,可作为区分6种不同类型武陵酱香型白酒风味特征的差异组分。希望研究可为酱香型白酒的调配提供数据参考,为白酒企业调控生产过程、提高产品质量提供帮助。

关键词：酱香型武陵酒白酒含硫化合物挥发性风味化合物

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我国特种食品产业现状与发展趋势

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中国食品学报 2024年第5期24卷 58-74页

作者：梁莉郝利民赵金山张玉玉孙宝国北京工商大学食品与健康学院北京100048 北京工商大学中原食品实验室北京100048 军事科学院系统工程研究院军需工程技术研究所北京100029 青岛特种食品研究院山东青岛266109

特种食品能够满足特殊环境和特殊岗位作业人群的营养健康需求,同时可以快速响应各类突发紧急事件,其产业发展关系到安全应急、国家稳定和人民健康事业。近年来,我国特种食品产业发展势头强劲,创新能力不断增强,产业规模持续扩大,正逐步... 详细信息

特种食品能够满足特殊环境和特殊岗位作业人群的营养健康需求,同时可以快速响应各类突发紧急事件,其产业发展关系到安全应急、国家稳定和人民健康事业。近年来,我国特种食品产业发展势头强劲,创新能力不断增强,产业规模持续扩大,正逐步成为新时期食品产业发展的新动向。本文回顾国内外特种食品的发展历程及产品特点,探讨其对保障特殊环境下人体营养健康的重要作用。通过文献调研系统梳理当前特种食品产业基础研究及技术发展现状。在此基础上,总结并展望特种食品产业面临的挑战以及未来发展趋势,旨在为我国特种食品研发及产业发展提供参考。

关键词：特种食品营养功能产业现状未来趋势

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四川泡菜母水的微生物群落与理化特性分析

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中国食品学报 2024年第2期24卷 281-291页

作者：胡此海杨絮郭全友郑尧李保国范逸文上海理工大学健康科学与工程学院上海200093 中国水产科学研究院东海水产研究所上海200090

为明确泡菜母水中的优势微生物与理化特性的相关性,采用高通量测序技术分析母水中的微生物群落结构,并进行相关性分析。结果表明:泡菜母水的总酸含量为3.00~18.90 g/kg,pH值为3.27~4.71,盐含量为11.00~15.50 g/100 g,检出草酸、苹果酸... 详细信息

为明确泡菜母水中的优势微生物与理化特性的相关性,采用高通量测序技术分析母水中的微生物群落结构,并进行相关性分析。结果表明:泡菜母水的总酸含量为3.00~18.90 g/kg,pH值为3.27~4.71,盐含量为11.00~15.50 g/100 g,检出草酸、苹果酸、琥珀酸和乳酸等7种有机酸。微生物主要群落包括厚壁菌门和子囊菌门2个门,占比均超过99.00%。优势细菌是乳杆菌属、片球菌属,优势真菌是毕赤酵母属、哈克斯坦酵母属、德巴利酵母属。相关性分析表明,乳酸杆菌属与乳酸呈显著正相关关系(P<0.05),与乙酸呈极显著正相关关系(P<0.01)。片球菌属与苹果酸呈极显著正相关关系(P<0.01)。结论:乳酸杆菌和片球菌是泡菜母水的优势微生物,研究结果为泡菜母水高效发酵菌株的选育和泡菜工业化生产提供试验参考。

关键词：泡菜母水高通量测序微生物多样性理化特性相关性

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Distribution characteristics of soil organic carbon and nitrogen in farmland and adjacent natural grassland in Tibet

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International Journal of Agricultural and Biological Engineering 2016年第1期9卷 135-145页

作者： liu Heman Cao lihua Xu Changchang Yang Hong li baoguo College of Resources and Environment China Agricultural UniversityBeijing 100093China Research Center of Climate Change and Material Cycle of Pedosphere of Tibet Pleateau Agricultural and Animal Husbandry CollegeTibet UniversityLinzhi 860000China

Land-use significantly affects soil organic carbon(SOC)and nitrogen cycling,eventually leading to global climate change.The cold and arid climate conditions in Tibet are not conducive to transformation of SOC and nitrogen.Hence,research on SOC and nitrogen distribution under different land-use patterns in Tibet is an important basis to assess the soil carbon and nitrogen potential in the land ecosystem of this area.This study aims to explain the effects of two land-use patterns,namely,farmland and grassland,on SOC and nitrogen contents in the cold regions of Tibet.This study also seeks to provide a scientific basis for the agricultural and grass production system.To achieve these goals,the changing features of total nitrogen(TN),mineralized nitrogen(nitrate nitrogen(NN)and ammonium nitrogen(AN)),and SOC were analyzed in different soil depths(0-5,5-10,10-20,20-30,30-40,and 40-50 cm)in farmland and adjacent natural grassland.The differences in carbon and nitrogen contents between the farmland and grassland of the main agricultural area of Tibet were determined through combined field survey and lab analysis.Results showed that the contents of SOC,TN and mineralized nitrogen in the grassland and farmland decreased with increasing soil depth mainly in the surface with depth of 0-20 cm.The effects of the different land-use patterns on the contents of SOC and TN were primarily evident in the 0-10 cm surface layer.The contents of SOC and TN in the farmland were significantly lower than those in the grassland,with mean reduction by 28.36%for SOC and 20.76%for TN.When the soil layer is deeper than 10 cm,the contents of SOC and TN in the farmland were greater than those in the grassland.This finding indicated that the transformation from grassland to farmland in Tibet mainly influenced the SOC and TN in the 0-10 cm surface layer.Moreover,the results showed that the increment of carbon in the deep soil layers of the farmland partially offsets the SOC loss from the surface because of cultivation.The ratio of mineralized nitro

关键词： Tibet farmland grassland soil organic carbon soil total nitrogen nitrate nitrogen ammonium nitrogen

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