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Correlation of aPKC-ι and E-cadherin expression with invasion and prognosis of cholangiocarcinoma

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Hepatobiliary & Pancreatic Diseases international 2008年第1期7卷 70-75页

作者： Qiang li, Jian-Ming Wang, Cong liu, bao-Lai Xiao, Jin-Xi Lu and Sheng-Quan ZouAuthor Affiliations: department of General Surgery , and department of Pathology , Tongji Hospital, Tongji Medical College, Huazhong university of Science and Technology, Wuhan 430030, China department of General Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan 430030 China.

BACKGROUND: The abnormal expression of atypical protein kinase C-ι (aPKC-ι) subtype and E-cadherin play important roles in tumor occurrence and progression This study was designed to investigate the correlation of expression of aPKC-ι and E-cadherin with the clinicopathological characteristics and prognosis of cholangiocarcinoma, and to analyze the molecular mechanisms of invasion and metastasis of the tumor. METHODS: EnVision immunohistochemistry was used to detect the expression of aPKC-ι and E-cadherin in 9 specimens of benign bile duct tissues, 35 specimens of cholangiocarcinoma and 6 specimens of metastatic cholangiocarcinoma. The relationship of the expression with clinicopathological characteristics, invasion and prognosis of cholangiocarcinoma was analyzed. A multivariate regression analysis was made of these data by the Cox proportional hazard model. RESULTS: The positive expression level of aPKC-ι in cholangiocarcinoma was remarkably higher than that in benign bile duct tissues (68.6% vs. 11.1%, P=0.006) but the expression level of E-cadherin was lower in cholangiocarcinoma than in benign bile duct tissues (37.1% vs. 88.9%, P=0.016). Correlation analysis revealed that the expression of aPKC-ι was positively related to tumor differentiation and invasion, whereas that of E-cadherin was entirely the contrary. Moreover, there wasa negative relationship between the expression of aPKC-ι and that of E-cadherin (r=-0.287, Pflect the differentiation and invasive potential of cholangiocarcinoma. aPKC-ι and E-cadherin may be independent prognostic factors an

关键词： atypical protein kinase C E-cadherin cholangiocarcinoma immunohistochemistry

Anti-nutritional characteristics and mechanism of soybean agglutinin

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BIOCELL 2021年第3期45卷 451-459页

作者： li PAN JIAWEI liU MOHAMMED HAMDY FAROUK GUIXIN qin NAN bao YUAN ZHAO HUI SUN Key Laboratory of Animal Production Product Quality and SecurityMinistry of EducationKey Laboratory of Animal Nutrition and Feed ScienceCollege of Animal Science and TechnologyJilin Agricultural UniversityChangchun130118China Animal Production department Faculty of AgricultureAl-Azhar UniversityCairo11884Egypt

Soybean agglutinin(SBA)is an important anti-nutritional factor in *** can induce animal growth inhibition,cause pathological changes of intestinal tissue,and decrease in the immune system ***,a great deal of research has been done on the effects of SBA on cell morphology,division,apoptosis,autophagy,as well as the correlated signal transduction *** review mainly covers the chemical and biological characteristics of SBA,describes the multifaceted aspects of SBA anti-nutritional functions,and highlights the possible cellular and molecular mechanism of anti-nutritional effects of *** review has important implications for the prevention and treatment of SBA-induced diseases,drug development,processing techniques of plant products,prevention of food-borne toxins,as well as human and animal health protection.

关键词： Soybean agglutinin Autophagy Cell apoptosis Anti-nutritional functions Cell signaling

听神经瘤患者经迷路切除术前后视频头脉冲试验的变化

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中南大学学报（医学版） 2024年第5期49卷 679-686页

作者：李葳邹曙光杨涛彭安全张智雯汪芹中南大学湘雅二医院耳鼻咽喉头颈外科长沙410011 湖南省耳科临床医学研究中心长沙410011 深圳市宝安区妇幼保健院耳鼻咽喉头颈外科广东深圳518100

目的:听神经瘤(acoustic neuroma,AN)是一种良性肿瘤,通常会影响患者的听觉和前庭功能。对于AN的筛查和诊断,传统方法主要依赖于听力学检查和磁共振成像(magnetic resonance imaging,MRI),而忽略了对病变部位进行前庭功能评估的重要性... 详细信息

目的:听神经瘤(acoustic neuroma,AN)是一种良性肿瘤,通常会影响患者的听觉和前庭功能。对于AN的筛查和诊断,传统方法主要依赖于听力学检查和磁共振成像(magnetic resonance imaging,MRI),而忽略了对病变部位进行前庭功能评估的重要性。视频头脉冲试验(video head impulse test,vHIT)是一种新兴的前庭功能检测方法,已广泛应用于临床,但其应用于AN诊断的研究相对较少。本研究通过在术前及术后对经迷路入路AN切除术的单侧AN患者采用v HIT进行动态检测,以探究vHIT在AN诊断、前庭功能障碍评估、术后代偿建立中的价值。方法:回顾性纳入2020年10月至2022年3月中南大学湘雅二医院耳鼻咽喉头颈外科的27例经迷路入路AN切除术单侧患者。术前1周进行v HIT以评估前庭功能,纯音测听(pure tone audiometry,PTA)评估听力水平,耳部MRI评估肿瘤大小;分别于术后1周、1个月、6个月、1年复查vHIT,并分析vHIT与听力、肿瘤大小之间的相关性。结果:术前vHIT显示患侧后半规管是前庭眼反射(vestibulo-ocular reflex,VOR)增益降低最常见的半规管。术前患侧vHIT的VOR增益与听力水平(r=-0.47,P<0.05)或肿瘤大小(r=-0.54,P<0.01)存在显著相关性。术后患侧vHIT结果显示水平半规管和前半规管的平均VOR增益随时间略有上升;3个半规管显性扫视的振幅和扫视波百分比均增加,而潜伏期时间缩短,并且在术后1周变化最明显。结论:vHIT能有效监测AN患者手术前后的前庭功能变化,对辅助诊断和治疗AN患者前庭功能障碍具有临床应用价值。

关键词：听神经瘤冷热试验视频头脉冲试验头脉冲抑制试验前庭功能

Mass Loss from Glaciers in the Chinese Altai Mountains between 1959 and 2008 Revealed Based on Historical Maps, SRTM, and ASTER Images

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Journal of Mountain Science 2015年第2期12卷 330-343页

作者： WEI Jun-feng liU Shi-yin XU Jun-li GUO Wan-qin bao Wei-jia SHANGGUAN Dong-hui JIANG Zong-li State Key Laboratory of Cryospheric Sciences Cold and Arid Regions Environmental and Engineering Research InstituteChinese Academy of Sciences university of Chinese Academy of Sciences department of Geography University of Zürich Hunan Province Key Laboratory of Coal Resources Clean-Utilization and Mine Environment Protection Hunan University of Science and Technology

Mass loss of glaciers in the Chinese Altai was detected using geodetic methods based on topographical maps(1959), the Shuttle Radar Topography Mission(SRTM) Digital Elevation Model(DEM)(2000), and the Advanced Space-borne Thermal Emission and Reflection Radiometer(ASTER) stereo images(2008). The results indicate that a continued and accelerating shrinkage has occurred in the Chinese Altai Mountains during the last 50 years, with mass deficits of 0.43 ± 0.02 and0.54 ± 0.13 m a-1 water equivalent(w.e.) during the periods 1959-1999 and 1999-2008, ***, the Chinese Altai Mountains have lost 7.06 ±0.44 km3 in ice volume(equivalent to-0.43 ± 0.03 m a-1 w.e.) from 1959-2008. The spatial heterogeneity in mass loss was potentially affected by comprehensive changes in temperature and precipitation, and had a substantial correlation withglacier size and topographic settings. Comparison shows that in the Chinese Altai Mountains glaciers have experienced a more rapid mass loss than those in the Tianshan and northwestern Tibetan Plateau(TP), and the mass balance of glaciers was slightly less negative relative to those in the Russian Altai, Himalaya, and southern TP.

关键词： Altai Mountains Geodetic method Glacier change Mass balance

应用托珠单抗的重症新型冠状病毒感染患者炎性标志物变化及与临床结局的关系

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国际病毒学杂志 2024年第4期31卷 306-310页

作者：秦峤朱赛楠李海霞李双玲北京大学第一医院重症医学科 100034 北京大学第一医院医学统计室 100034 北京大学第一医院检验科 100034

目的探究重症新冠感染患者应用托珠单抗前后炎性标志物的变化及其与临床预后的关系。方法采用回顾性队列方法,纳入2022年12月至2023年2月于北京大学第一医院集中收治的诊断为重症新型冠状病毒感染、应用托珠单抗免疫治疗且动态监测炎性... 详细信息

目的探究重症新冠感染患者应用托珠单抗前后炎性标志物的变化及其与临床预后的关系。方法采用回顾性队列方法,纳入2022年12月至2023年2月于北京大学第一医院集中收治的诊断为重症新型冠状病毒感染、应用托珠单抗免疫治疗且动态监测炎性标志物的患者。收集临床资料,并根据第14日的临床结局分为临床恶化组及非临床恶化组。通过广义线性混合模型描述托珠单抗给药前后白细胞介素-6(interleukin-6,IL-6)及超敏C反应蛋白(hypersensitive C-reactive protein,hsCRP)的变化,并比较其在不同临床结局组的差异。结果共46例患者纳入分析,14 d后出现临床恶化22例,未出现临床恶化24例。广义线性混合模型显示,IL-6在应用托珠单抗后第1日呈升高趋势,第3日、第5日呈下降趋势,hsCRP在应用托珠单抗后呈持续下降趋势;临床恶化组的IL-6水平持续高于非临床恶化组,第5日两组的变化有出现分化的趋势,即临床恶化组IL-6水平较前升高,非临床恶化组IL-6较前继续下降。结论应用托珠单抗后IL-6水平偏高且在第5日出现升高趋势的患者临床预后可能不佳。

关键词：新型冠状病毒感染托珠单抗炎性标志物动态临床结局

Roux-en-Y choledochojejunostomy using novel magnetic compressive anastomats in canine model of obstructive jaundice

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Hepatobiliary & Pancreatic Diseases international 2012年第1期11卷 81-88页

作者： Chao Fan,Xiao-Peng Yan,Shi-Qi liu,Chun-bao Wang,Jian-Hui li,liang Yu,Zheng Wu and Yi Lv department of Hepatobiliary Surgery and department of Pathology,First Affiliated Hospital,School of Medicine,Xi’an Jiaotong university,Xi’an 710061,China department of Surgical Oncology,Third Affiliated Hospital,School of Medicine,Xi’an Jiaotong university,Xi’an 710068,China [a] department of Hepatobiliary Surgery School of Medicine Xi'an Jiaotong University Xi'an 710061 Xi'an China [b] department of Pathology First Affliated Hospital School of Medicine Xi'an Jiaotong University Xi'an 710061 Xi'an China [c] department of Surgical Oncology Third Affliated Hospital School of Medicine Xi'an Jiaotong University (Shaanxi Provincial People's Hospital) Xi'an 710068 Xi'an China

BACKGROUND:The traditional hand-sewn Roux-en-Y choledochojejunostomy is technically complicated,and the incidence of postoperative complications has remained high.A set of novel magnetic compressive anastomats was introduced to facilitate choledochojejunostomy and improve the prognosis of ***:After ligating the common bile duct for 7 days,16 dogs were randomly divided into two groups (n=8 per group).Anastomats were used in the study group,and the traditional hand-sewn method was used in the control group for standard Roux-en-Y *** compared the operation time,incidence of complications,gross appearance,and pathological disparity in stoma between the two groups in 1-month and 3-month follow-up ***:The time spent on constructing the anastomosis for the study group was significantly *** no anastomotic stenosis occurred in the two groups,the narrowing rate of biliary-enteric anastomosis was much higher in the control *** was one case of bile leakage in the control group,whereas no bile leakage occurred in the study group.A smoother surface,an improved layer apposition,and a lower local inflammatory response were identified in the anastomosis of the study ***:The structures of the novel magnetic compressive anastomats are simple,and they are time-saving,safe and efficient for performing Roux-en-Y choledocho- jejunostomy procedures in a canine model of obstructive jaundice.

关键词： anastomosis,Roux-en-Y choledochostomy jaundice,obstructive magnetic compressive anastomats

Synthesis and biological evaluation of 4-methyl-1,2,3-thiadiazole-5-carboxaldehyde benzoyl hydrazone derivatives

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Chinese Chemical Letters 2017年第6期28卷 1238-1242页

作者： Jing-Peng Zhang Xiang-Yang li Ya-Wen Dong Yao-Guo qin Xin-Lu li bao-An Song Xin-ling Yang department of Applied Chemistry College of ScienceChina Agricultural University Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of EducationResearch and Development Center for Fine ChemicalsGuizhou University

To find new lead compounds with high biological activity,a series of novel 4-methyl-1,2,3-thiadiazole-5-carboxaldehyde benzoyl hydrazone derivatives were designed and *** structures were confirmed by -1H NMR,-（13）C NMR,IR spectrum and elemental *** bioassay indicated that the title compounds exhibited moderate to strong fungicidal activity against six fungi in vitro at50 μg/***,some of the title compounds exhibited good curative activity against TMV in vivo at500 μg/*** structure-activity relationship analysis of compounds against Valsa mali showed that compounds containing halogen at the para position on phenyl exhibited the best *** compound 8k showed broad spectrum fungicidal activities against Valsa mali,Botrytis cinerea,Pythium aphamdermatum,Rhizoctonia solani,Fusarium moniliforme and Altemaria solani with the EC（50） values of8.20,24.42,15.80,40.53,41.48,and 34.16 μg/mL,respectively.

关键词： 1 2 3-Thiadiazole Benzoyl hydrazone Synthesis Fungicidal activity Curative activity against TMV Structure-activity relationship

Synthesis and characterization of CoS ball in cage structures

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Science China Chemistry 2013年第4期56卷 475-480页

作者： CHEN Xu MEI Jie qin ZhiYong SONG lingling ZHANG XiaoBo li XiaoYun bao HaiFeng SHI JianJun ZHAO HuanYu department of Physics Center for Optoelectronics Materials and Devices Key Laboratory of Advanced Textile Materials and Manufacturing Technology Ministry of Education Zhejiang Sci-Tech University School of Biotechnology and Chemical Engineering Taizhou College of Nanjing Normal University department of Chemistry and Chemical Engineering Hangzhou Normal University

Ball in cage structures of cobalt sulfide have been successfully prepared by a facile one-pot hydrothermal synthesis approach employing Co（NO3）2＇6H20 as the cobalt source and S=C（NH2）2 as the sulfur source. The effects of the reaction parameters （volume ratio of distilled water to ethanol, reaction time and reaction temperature） on the morphology and size of the CoS structures were investigated. The synthesized product was characterized by X-ray diffraction, scanning electron microscopy and transmission electron microscopy. It has been confirmed that the volume ratio of distilled water to ethanol played a key role in the formation of the ball in cage structures, and the formation mechanism of the CoS ball in cage structures was also proposed. The electrochemical capacitance performances of the CoS products were studied, and the CoS ball in cage structures show excellent energy storage characteristics.

关键词： cobalt sulfide ball-in-cage structure synthesis characterization

MICROSTRUCTURE　AND　PREPARATION　OF　Ni,Al　AND　Fe　NANOPOWDERS

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中国有色金属学会会刊：英文版 1997年第1期7卷 62-66页

作者： Wei qin a,b , Lai Yingling a , Yang Hong a , li Changgeng a a department of Applied Physics and Heat Engineering, Central South university of Technology, Changsha 410083 b international Centre for Materials Physics, Chinese Aca

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关键词： nanopowder microstructure electronic structure surface energy