检索结果-南通市图书馆

Journal of Molecular Cell Biology 2014年第2期8卷 154-163页

作者： Jie Yan Qi li ai-Ping Mao hong-Bing Shu College of life Sciences Wuhan University Wuhan 430072 China

RIG-I is a pivotal cytoplasmic sensor that recognizes different species of viral RNAs. This recognition leads to activation of the transcription factors NF-κB and IRF3, which collaborate to induce type I interferons （IFNs） and innate antiviral response. In this study, we identified the TRIM family protein TRIM4 as a positive regulator of RIG-I-mediated IFN induction. Overexpression of TRIM4 potentiated virus-triggered activation of IRF3 and NF-κB, as well as IFN-13 induction, whereas knockdown of TRIM4 had opposite effects. Mechanistically, TRIM4 associates with RIG-I and targets it for K63-linked poiyubiquitination. Our findings demonstrate that TRIM4 is an important regulator of the virus-induced IFN induction pathways by mediating RIG-I for K63-Unked ubiquitination.

关键词： TRIM4 RIG-I ubiquitination type I interferon antiviral response

Serum Gamma-glutamyl Transferase Levels Predict Functional Outcomes after Aneurysmal Subarachnoid Hemorrhage

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2017年第3期30卷 170-176页

作者： XU Tian WANG Wei ZHai lin ZHANG Yun Feng ZHOU hong Zhi WU Xin Min li ai hong XIE li li NING Xiao Jin JI Yu Teng WANG hong Mei KE Kai Fu Department of Neurology Affiliated Hospital of Nantong UniversityNantong 226001JiangsuChina Department of Neurology Nanjing First HospitalNanjing Medical UniversityNanjing 210006JiangsuChina Medical record center Affiliated Hospital of Nantong UniversityNantong 226001JiangsuChina Neurology research institute of Nantong University Nantong 226001JiangsuChina

Objective We aim to explore the potential association between serum gamma-glutamyl transferase levels and functional outcome after aneurysmal subarachnoid hemorrhage in a Chinese population. Methods A total of 386 aneurysmal subarachnoid hemorrhage patients were included in the study from September 2007 to February 2015. Baseline serum gamma-glutamyl transferase levels and 6-month follow-up functional outcomes were determined. A poor outcome was defined as a modified ranking scale score of ≥ 3. The multivariable logistic model was used to analyze the relationship between serum gamma-glutamyl transferase and clinical outcomes after aneurysmal subarachnoid hemorrhage. Results The adjusted poor outcome rates of patients with gamma-glutamyl transferase levels of 〈 30 U/L, 30-50 U/L and ≥ 50 U/L were 16.7%, 19.6%, and 34.4%, respectively （P 〈 0.01）. The age-sex and multivariable adjusted odds ratios （95% confidence intervals） of poor prognosis comparing the top group （≥ 50 U/L） with the lowest group （〈 30 U/L） were 5.76 （2.74-12.13）, 6.64 （2.05-21.52）, and 6.36 （1.92-21.02）. A significant linear trend existed between gamma-glutamyl transferase level and aneurysmal subarachnoid hemorrhage prognosis. This association was also observed among nondrinkers. Conclusion Patients with higher gamma-glutamyl transferase levels were more likely to have a poor prognosis. Serum gamma-glutamyl transferase can be considered to be an independent predictor of functional outcomes after aneurysmal subarachnoid hemorrhage.

关键词： Aneurysmal subarachnoid hemorrhage Gamma-glutamyl transferase Functional outcome Predictor

Morphological Structure and Genetic Mapping of New Leaf-Color Mutant Gene in Rice (Oryza sativa)

在线全文

学校读者我要写书评

暂无评论

Rice science 2012年第2期19卷 79-85页

作者： li Yu-hong WANG Bao-he Dai Zheng-yuan li ai-hong liu Guang-qing Zuo Shi-min ZHANG hong-xi PAN Xue-biao Key Laboratory of Crop Genetics and Physiology of Jiangsu Province Yangzhou University Yangzhou 225009 China lixiahe Region Agricultural Research Institute of Jiangsu Province Nanjing Subcenter of National Rice Improvement Center Yangzhou 225007 China

Leaf-color mutations are a widely-observed class of mutations, playing an important role in the study of chlorophyll biosynthesis and plant chloroplast structure, function, genetics and development. A naturally-occurring leaf-color rice mutant, Baihuaidao 7, was analyzed. Mutant plants typically exhibited a green-white-green leaf-color progression, but this phenotype was only expressed in the presence of a stress signal induced by mechanical scarification such as transplantation. Prior to the appearance of white ~eaves, mutant plant growth, leaf color, chlorophyll content, and chloroplast ultrastructure appeared to be identical to those of the wild type. After the changeover to white leaf color, an examination of the mutated leaves revealed a decrease in total chlorophyll, chlorophyll a, chlorophyll b, and carotenoid content, a reduction in the number of chloroplast grana lamella and grana, and a gradual degradation of the thylakoid lamellas. At maturity, the mutant plant was etiolated and dwarfed compared with wild-type plants. Genetic analysis indicated that the leaf mutant character is controlled by a recessive nuclear gene. Genetic mapping of the mutant gene was performed using an F2 population derived from a Baihuaidao 7 ~ Jiangxi 1587 cross. The mutant gene was mapped to rice chromosome 11, positioned between InDel markers L59.2-7 and L64.8-11, which are separated by approximately 740.5 kb. The mutant gene is believed to be a new leaf-color mutant gene in rice, and is tentatively designated as gwgl.

关键词： Oryza sativa leaf-color mutant morphological structure genetic analysis gene mapping

A Review of International Arms Control and Disarmament in the Past Decade

在线全文

学校读者我要写书评

暂无评论

International Understanding 2011年第4期 11-15页

作者： li Changhe ai hong

We have already bid farewell to the first decade of this century, which is also the first decade after the 9/11 terrorist attack. This decade has witnessed remarkable progress in global multi-polarization and economic globalization, as well as profound changes in human society brought about by scientific and technological revolution. Meanwhile, the world is

关键词：裁军国际经济全球化恐怖袭击技术革命人类社会安全威胁多极化

在线全文

学校读者我要写书评

暂无评论

联合监护预测脐带绕颈的临床价值

上海交通大学学报（医学版） 2006年第3期26卷 294-296页

作者：李爱红上海交通大学医学院瑞金医院集团闵行医院妇产科上海201100

目的采用B超、胎心电子监护、彩色多普勒脐血流联合监护预测脐带绕颈及胎儿在宫内的缺氧状态，指导医务人员选择适当的分娩方式。方法2004年7～12月间住院分娩的孕妇1233例，于35～38周间行B超检查，对提示脐带绕颈的291例孕妇再进行胎... 详细信息

目的采用B超、胎心电子监护、彩色多普勒脐血流联合监护预测脐带绕颈及胎儿在宫内的缺氧状态，指导医务人员选择适当的分娩方式。方法2004年7～12月间住院分娩的孕妇1233例，于35～38周间行B超检查，对提示脐带绕颈的291例孕妇再进行胎心电子监护和彩色多普勒脐血流联合监护。结果产前B超脐带绕颈预测准确率为76．98％，S／D≥3．0的81例孕妇产后证实均有1～3周绕颈，脐带绕颈的难产率随着绕颈周数增加而上升，新生儿轻度窒息5例，无重度窒息儿。结论脐带绕颈对围产儿存在严重危害，采用联合监护可预测脐带绕颈胎儿的宫内缺氧状态，对分娩方式的选择有很大的帮助。

关键词：联合监护预测脐带绕颈临床价值

在线全文

学校读者我要写书评

暂无评论

68例胎盘早剥的临床分析

上海交通大学学报（医学版） 2006年第5期26卷 541-543页

作者：李爱红上海交通大学医学院瑞金医院集团闵行医院妇产科上海201100

目的探讨上海本地人口及流动人口胎盘早剥的高危因素以及对母婴的影响和预防。方法回顾分析该院近5年间胎盘早剥的发病情况、产前检查情况和母婴结局。结果在9345例住院分娩产妇中，胎盘早剥68例（0．73％）。合并妊娠期高血压疾病（29... 详细信息

目的探讨上海本地人口及流动人口胎盘早剥的高危因素以及对母婴的影响和预防。方法回顾分析该院近5年间胎盘早剥的发病情况、产前检查情况和母婴结局。结果在9345例住院分娩产妇中，胎盘早剥68例（0．73％）。合并妊娠期高血压疾病（29例，42．65％）是胎盘早剥的首发病因，其次为胎膜早破、滥用催产素、脐带过短、血小板减少、外伤、双胎一胎娩出后一胎滞留宫内、羊水过多、妊娠期糖尿病及其他不明原因。患者进行产前检查〉3次和1～3次者胎盘早剥的发生率明显低于无产前检查者；流动人口的胎盘早剥的发病率明显高于上海本地人口。结论预防是降低胎盘早剥发病率的关键，加强孕期宣教，提高流动人口的产前检查率；及早发现妊娠期并发症和合并症，积极治疗妊娠期高血压疾病；严厉打击非法接生；政府培育流动人口低收费的定点产科医院。

关键词：胎盘早剥高危因素产前检查妊娠期高血压疾病

Quantum public-key crypto via EPR pairs

在线全文

学校读者我要写书评

暂无评论

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 58-63页

作者： Xiang-Qun Fu hong-Wei li Jian-hong Shi Tan li Wan-Su Bao Henan Key Laboratory of Quantum Information and Cryptography Information Engineering University Synergetic Innovation Center of Quantum Information and Quantum Physics University of Science and Technology of China

With the development of quantum computing technology, quantum public-key cryptography is gradually becoming an alternative to the existing classical public-key cryptography. This paper designs a quantum trapdoor one-way function via EPR pairs and quantum measurements. Based on this, a new quantum public-key cryptosystem is presented, which offers forward security,and can resist the chosen-plaintext attack and chosen-ciphertext attack. Compared with the existing quantum public-key cryptos,eavesdropping can be automatically detected in this new quantum public-key cryptosystem under a necessary condition, which is also detailed in the paper.

关键词： quantum public-key crypto trapdoor one-way function EPR pairs

Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 26-34页

作者： Yutao Zhang Juan li Wei-hong Zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

关键词： chemiluminescnece sequence-activation in-vivo bioimaging cyclic peroxide

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

小波包神经网络在数控机床故障诊断中的应用

煤矿机械 2010年第12期31卷 211-214页

作者：李爱红常州纺织服装职业技术学院江苏常州213164

为了能够提高数控机床故障诊断的正确率。提出了小波包模糊神经网络方法对数控机床进行故障诊断，也提出了小波包分析提取特征向量的程序，利用小波包分析可以获得数控机床的特征向量，应用模糊神经网络对数控机床进行故障诊断。利用小... 详细信息

为了能够提高数控机床故障诊断的正确率。提出了小波包模糊神经网络方法对数控机床进行故障诊断，也提出了小波包分析提取特征向量的程序，利用小波包分析可以获得数控机床的特征向量，应用模糊神经网络对数控机床进行故障诊断。利用小波包模糊神经网络对数控机床常见的8种故障进行了诊断，证明小波包神经网络进行故障诊断的有效性。

关键词：小波包模糊神经网络数控机床故障诊断

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

ERP环境下业务流程再造与分销方案设计

制造业自动化 2011年第5期33卷 8-12页

作者：李爱红武汉理工大学机电工程学院武汉430070

为了充分体现和发挥ERP的优势,在复杂多变的网络环境下需要对业务流程进行重组和再造。本文利用层次分析法,以供应链中销售环节为研究对象,针对企业生产销售的特点,提出了食品加工企业分销系统结构框架,构建了ERP环境下分销系统功能模... 详细信息

为了充分体现和发挥ERP的优势,在复杂多变的网络环境下需要对业务流程进行重组和再造。本文利用层次分析法,以供应链中销售环节为研究对象,针对企业生产销售的特点,提出了食品加工企业分销系统结构框架,构建了ERP环境下分销系统功能模型。在此理论研究基础上,以某食品加工企业为例,给出了ERP环境下的分销系统具体解决方案,充分利用信息共享,有效地弱化和抑制了供应链中牛鞭效应,提高了整个供应链的运作效率。

关键词： ERP 分销系统业务流程再造食品加工企业供应链