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Mechanism of action of linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： Huan Pei Ren-lin li xin-Ran Song Qian-Qian wan Yu-Ming wang Han-Zhou li Wei-Quan Xu Jia-Bao liao Wei-bo Wen Jing miao Huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

Gamma-glutamyl transferase 5 overexpression in cerebrovascular endothelial cells improves brain pathology,cognition,and behavior in APP/PS1 mice

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Neural Regeneration Research 2025年第2期20卷 533-547页

作者： Yanli Zhang Tian li Jie miao zhina Zhang Mingxuan Yang Zhuoran wang bo Yang Jiawei Zhang Haiting li Qiang Su Junhong Guo Department of Neurology First Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Neurology Sixth Hospital of Shanxi Medical University(General Hospital of Tisco)TaiyuanShanxi ProvinceChina Department of Physiology Key Laboratory of Cellular PhysiologyMinistry of EducationShanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Hernia and Abdominal Wall Surgery Shanxi Bethune HospitalShanxi Academy of Medical SciencesTongji Shanxi HospitalThird Hospital of Shanxi Medical UniversityTaiyuanShanxi ProvinceChina Department of Laboratory Medicine of Fenyang College Shanxi Medical UniversityFenyangShanxi ProvinceChina

In patients with Alzheimer’s disease,gamma-glutamyl transferase 5(GGT5)expression has been observed to be downregulated in cerebrovascular endothelial ***,the functional role of GGT5 in the development of Alzheimer’s disease remains *** study aimed to explore the effect of GGT5 on cognitive function and brain pathology in an APP/PS1 mouse model of Alzheimer’s disease,as well as the underlying *** observed a significant reduction in GGT5 expression in two in vitro models of Alzheimer’s disease(Aβ_(1-42)-treated hCMEC/D3 and bEnd.3 cells),as well as in the APP/PS1 mouse ***,injection of APP/PS1 mice with an adeno-associated virus encoding GGT5 enhanced hippocampal synaptic plasticity and mitigated cognitive ***,increasing GGT5 expression in cerebrovascular endothelial cells reduced levels of both soluble and insoluble amyloid-βin the brains of APP/PS1 *** effect may be attributable to inhibition of the expression ofβ-site APP cleaving enzyme 1,which is mediated by nuclear factor-kappa *** findings demonstrate that GGT5 expression in cerebrovascular endothelial cells is inversely associated with Alzheimer’s disease pathogenesis,and that GGT5 upregulation mitigates cognitive deficits in APP/PS1 *** findings suggest that GGT5 expression in cerebrovascular endothelial cells is a potential therapeutic target and biomarker for Alzheimer’s disease.

关键词： Alzheimer’s disease amyloid-β APP/PS1 mice cerebrovascular endothelial cells cognitive deficits gamma-glutamyl transferase 5 neurovascular unit nuclear factor‐kappa B synaptic plasticity β-site APP cleaving enzyme 1

Microstructure simulation of rapidly solidified ASP30 high-speed steel particles by gas atomization

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International Journal of Minerals,Metallurgy and Materials 2016年第3期23卷 294-302页

作者： Jie Ma bo wang zhi-liang Yang Guang-xin wu Jie-yu Zhang shun-li Zhao State Key Laboratory of Advanced Special Steel Shanghai University School of Materials Science and Engineering Shanghai University Research Institute Baoshan Iron & Steel Co. Ltd.

In this study, the microstructure evolution of rapidly solidified ASP30 high-speed steel particles was predicted using a simulation method based on the cellular automaton-finite element （CAFE） model. The dendritic growth kinetics, in view of the characteristics of ASP30 steel, were calculated and combined with macro heat transfer calculations by user-defined functions （UDFs） to simulate the microstructure of gas-atomized particles. The relationship among particle diameter, undercooling, and the convection heat transfer coefficient was also inves- tigated to provide cooling conditions for simulations. The simulated results indicated that a columnar grain microstructure was observed in small particles, whereas an equiaxed microstructure was observed in large particles. In addition, the morphologies and microstructures of gas-atomized ASP30 steel particles were also investigated experimentally using scanning electron microscopy （SEM）. The experimental re- suits showed that four major types ofmicrostructures were formed： dendritic, equiaxed, mixed, and multi-droplet microstructures. The simu- lated results and the available experimental data are in good agreement.

关键词： high-speed steel rapid solidification microstructure grain growth gas atomization

Structures of GMC W37

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Research in Astronomy and Astrophysics 2016年第4期16卷 27-36页

作者： Xiao-liang Zhan zhi-bo Jiang zhi-Wei Chen miao-miao Zhang Chao Song Purple Mountain Observatory & Key Laboratory for Radio Astronomy Chinese Academy of Sciences

We carried out observations toward the giant molecular cloud W 37 with the J = 1 - 0 transitions of 12CO, 13CO and C180 using the 13.7 m single-dish telescope at the Delingha station of Purple Mountain Observatory. Based on these CO lines, we calculated the column densities and cloud masses for molecular clouds with radial velocities around ＋20 km s-1. The gas mass of W 37, calculated from 13CO emission, is 1.7 × 10^5 M, above the criterion to be considered a giant molecular cloud. The dense ridge of W 37 is a dense filament, which is supercritical in terms of linear mass ratio. Dense clumps found by C180 emission are aligned along the dense ridge at regular intervals of about 2.8 pc, similar to the clump separation caused by large-scale ＇sausage instability＇. We confirm the identification of the giant molecular filament （GMF） G 18.0-16.8 and find a new giant filament, G 16.5-15.8, located ~ 0.7° to the west of G 18.0-16.8. both GMFs are not gravitationally bound, as indicated by their low linear mass ratio （- 80 M pc-l）. We compared the gas temperature map with the dust temperature map from Herschel images, and found similar structures. The spatial distributions of class I objects and the dense clumps are reminiscent of triggered star formation occurring in the northwestern part of W 37, which is close to NGC 6611.

关键词： ISM: clouds - ISM: structure - ISM: kinematics and dynamics - ISM: individual objects(W 37 M 16)

Thiazoloisoindigo-based Polymer Semiconductors: Synthesis,Structure-Property Relationship, Charge Carrier Polarity, and Field-Effect Transistor Performance

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Chinese Journal of Polymer Science 2024年第1期42卷 24-31,I0006页

作者： bo-Wen li miao Xiong Mei-Hua liu zhi-Gao li Long Sang Zi-Han Xiong Biao Xiao Jian Pei Xiao-bo wan Key Laboratory of Optoelectronic Chemical Materials and Devices Ministry of EducationSchoolofOptoelectronic Materials&TechnologyJianghan UniversityWuhan430056China Bejing National Laboratoryfor Molecular Sciences the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringPeking UniversityBeijing 100871China

Developing new polymeric semiconductors with excellent device performance is essential for organic electronics. Herein, we synthesized two new thiazoloisoindigo(Tz II)-based polymers, namely, P(Tz II-d Th-d Th) and P(Tz II-d Th-d Tz), by copolymerizing thiophene-flanked Tz II with bithiophene and bithiazole, respectively. Owing to the more electron-deficient nature of bithiazole than bithiophene, P(Tz II-d Th-d Tz)possesses deeper LUMO/HOMO levels of-3.45/-5.47 e V than P(Tz II-d Th-d Th)(-3.34/-5.32 e V). The organic field-effect transistor(OFET) devices based on P(Tz II-d Th-d Th) exhibited p-type behaviors with an average hole mobility value as high as 1.43 cm^(2)·V^(-1)·s^(-1), while P(Tz II-d Th-d Tz)showed typical ambipolar characteristics with average hole and electron mobilities of 0.38 and 0.56 cm^(2)·V^(-1)·s^(-1). In addition, we compared the performances of both polymers with other Tz II-based polymers reported in our previous work, and showed that the charge carrier polarity can be manipulated by adjusting the number of the thiophene units between the acceptor unit. As the increase of the number of thiophene rings,charge carrier polarity shifts from electron-dominated ambipolar transport to hole-dominated ambipolar transport and then to unipolar hole transport in OFETs, which provides an effective molecular design strategy for further optimization of polymer OFET performance.

关键词： Field-effect transistor Charge carrier polarity Thiazoloisoindigo

Distributed hydrological models for addressing effects of spatial variability of roughness on overland flow

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Water Science and Engineering 2016年第3期9卷 249-255页

作者： Sheng-tang Zhang Yin liu miao-miao li bo liang College of Earth Science and Engineering Shandong University of Science and Technology College of Mining and Safety Engineering Shandong University of Science and Technology

In this study, we investigated the origin of the overland flow roughness problem and divided the current overland flow roughness research into three types, as follows: the first type of research takes into account the effects of roughness on the volume and velocity of surface runoff, flood peaks, and the scouring capability of flows, but has not addressed the spatial variability of roughness in detail; the second type of research considers that surface roughness varies spatially with different land usage types, land-cover conditions, and different tillage forms, but lacks a quantitative study of the spatial variability; and the third type of research simply deals with the spatial variability of roughness in each grid cell or land type. We present three shortcomings of the current overland flow roughness research, including(1) the neglect of roughness in distributed hydrological models when simulating the overland flow direction and distribution,(2) the lack of consideration of spatial variability of roughness in hydrological models, and(3) the failure to distinguish the roughness formulas in different overland flow regimes. To solve these problems,distributed hydrological model research should focus on four aspects in regard to overland flow: velocity field observations, flow regime mechanisms, a basic roughness theory, and scale problems.

关键词： Distributed hydrological model Overland flow Roughness Spatial variability

Oxygen gettering in Si by He ion implantation-induced cavity layer

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Nuclear Science and Techniques 2009年第4期20卷 202-207页

作者： OU xin ZHANG bo wu Aimin ZHANG miao wanG Xi State Key Laboratory of Functional Materials for lnformatics Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China

Oxygen gettering in Si by the He induced cavity layer was investigated in this work.A cavity layer was generated in Si sample by He implantation and *** morphology of the cavity layer depending on the dose of He and the annealing temperature was presented in the *** cavity layer may serve as an efficient oxygen gettering layer during the high temperature oxidation process and accumulate the oxygen from the annealing atmosphere as well as the implanted *** phenomenon gives the idea that the cavity layer can be employed to define the oxide formation in Si and further to facilitate the formation of the buried oxide layer(boX) in Si aiming at the Si-on-Insulator(SOI) structure *** oxygen gettering ability of the cavity layer in Si was investigated by cross section transmission electron microscopy and auger electron spectroscopy.

关键词：氦离子空穴核技术能级

High Cr(Ⅵ) adsorption capacity of rutile titania prepared by hydrolysis of TiCl4 with AlCl3 addition

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International Journal of Minerals,Metallurgy and Materials 2020年第8期27卷 1157-1163页

作者： shun wu Xiao-bo He li-jun wang Kuo-Chih Chou Collaborative Innovation Center of Steel Technology University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Advanced Metallurgy University of Science and Technology BeijingBeijing 100083China

Rutile titania(TiO2)was successfully prepared via hydrolysis of TiCl4 in the presence of *** powders were characterized by X-ray powder diffraction(XRD),scanning electron microscopy(SEM),and Brunauer-Emmett-Teller(BET)surface area *** the present system,AlCl3 functions as a nucleating agent and induces the formation of rutile *** influences of HCl and isopropanol concentrations on the purity and morphology of the rutile TiO2 were *** purity of the rutile TiO2 increased with increasing concentration of *** dispersed rutile TiO2 particles with a spherical morphology were obtained when the HCl and isopropanol concentrations were 0.5 and 1 mol·L-1,***,the prepared TiO2 powders were used in adsorption tests of the heavy metal pollutant Cr(Ⅵ).Rutile TiO2 sample S-9 demonstrated greater adsorption performance and a removal efficiency that was greater than 99.95%after60 min of adsorption when the Cr(Ⅵ)concentration was 200 mg·*** maximum adsorption capacity on rutile TiO2 was 28.9 mg·*** work provides an easy path to prepare a high-performance rutile TiO2 adsorbent with potential applications in water pollution treatment.

关键词： rutile titania hydrolysis spherical particles adsorption

Genesis of the Nuri Cu-W-Mo Deposit,Tibet,China:Constraints from in situ Trace Elements and Sr Isotopic Analysis of Scheelite

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Acta Geologica Sinica(English Edition) 2024年第1期98卷 117-131页

作者： wanG Yiyun wu zhishan CHEN Wenqing DU Qing’an TANG liwei SHI Hongzhao MA Guotao ZHANG zhi liang Wei wu bo miao Hengyi Chengdu Center China Geological Survey(Geoscience Innovation Center of Southwest China)Chengdu 610081China The Second Geological Institute of China’s Metallurgical Geology Bureau Fuzhou 351111China

The Nuri deposit is the only Cu-W-Mo polymetallic deposit with large-scale WO3 resources in the eastern section of the Gangdese metallogenic belt,Tibet,***,the genetic type of this deposit has been controversial since its *** on a study of the geological characteristics of the deposit,this study presents mineralization stages,focusing on the oxide stage and the quartz-sulfide stage where scheelite is mainly formed,referred to as Sch-A and Sch-B,*** LA-ICP-MS trace element and Sr isotope analyses,the origin,evolutionary process of the oreforming fluid and genesis of the ore deposit are *** Electron Microscope-Cathodoluminescence(SEMCL)observations reveal that Sch-A consists of three generations,with dark gray homogenous Sch-A1 being replaced by relatively lighter and homogeneous Sch-A2 and Sch-A3,with Sch-A2 displaying a gray CL image color with vague and uneven growth bands and Sch-A3 has a light gray CL image color with hardly any growth *** contrast,Sch-B exhibits a‘core-rim’structure,with the core part(Sch-B1)being dark gray and displaying a uniform growth band,while the rim part(Sch-B2)is light gray and *** normalized distribution pattern of rare earth elements in scheelite and Sr isotope data suggest that the early ore-forming fluid in the Nuri deposit originated from granodiorite porphyry and,later on,some country rock material was mixed in,due to strong water-rock *** the O-H isotope data further indicates that the ore-forming fluid in the Nuri deposit originated from magmatic-hydrothermal sources,with contributions from metamorphic water caused by water-rock interaction during the mineralization process,as well as later meteoric *** intense water-rock interaction likely played a crucial role in the precipitation of scheelite,leading to varying Eu anomalies in different generations of scheelite from the oxide stage to the quartz-sulfide stage,while also causing a

关键词： trace elements in situ Sr isotopes tungsten mineralization Gangdese metallogenic belt Tibet