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Venetoclax and Azacitidine in Chinese patients with untreated acute myeloid leukemia ineligible for intensive chemotherapy

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2451-2454页

作者： Leiming Xia Wanlu Tian Yiming Zhao lingling Jiang Wei Qian Lei Jiang ling Ge jianjun li Fengbo Jin Mingzhen Yang Department of Hematology the first affiliated hospital of Anhui Medical UniversityHefeiAnhui230022China Anhui Public Health Clinical Center HefeiAnhui230031China Anhui Provincial Institute of Translational Medicine HefeiAnhui230092China

Dear Editor,Acute Myeloid Leukemia(AML)patients are often found ineligible for aggressive standard chemotherapy in clinic because of old age and poor *** evidences suggest that targeted combination therapy might help these patients achieve a higher response rate with acceptable adverse events(AEs).^(1)Venetoclax(VEN),a selective small-molecule BCL2 inhibitor,combined with hypomethylating agent(HMA),such as azacytidine(AZA).

关键词： patients chemotherapy Acute

South China Sea:Disputes and Great Powers

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Contemporary International Relations 2011年第4期21卷 69-92页

作者： li Jinming Hong jianjun Zhao Jinfu 不详

In the South China Sea disputes,China has ample proof to claim sovereignty over the Xisha Islands(the Paracel Islands)and Nansha Islands(the Spratly Islands)while the claims of certain southeast Asian countries do not hold any *** South China Sea disputes have their origins in the San Francisco Peace Treaty signed in 1951,the result of intervention by the United States and Great Britain in regional *** today,the United States has not discarded its Cold War mentality and continues to intervene in the South China Sea *** only change in the United States' attitude is that it has changed its pretext for intervention from "containing Communist expansion" in the past to "preserving freedom of navigation in the South China Sea" in the present.

关键词：中国南海纠纷南沙群岛西沙群岛东南亚国家共产主义旧金山美国

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模具协同设计系统的信息模型及实现架构

中国机械工程 2007年第4期18卷 446-449页

作者：李畅李建军华中科技大学塑性成形模拟及模具技术国家重点实验室武汉430074

分析了模具企业对协同设计系统的需求,提出了满足模具协同设计过程的集成信息模型的组织结构,并据此构建了具有四层组织结构的模具协同设计框架,阐述了各层的功能和实现机理。

关键词：协同设计模具信息模型信息交换

陡峭地形条件山岭隧道免刷坡绿色洞口修建技术

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现代隧道技术 2013年第4期50卷 158-163页

作者：李建军中铁十二局集团第三工程有限公司太原030024

凤凰岭隧道全长5 896.9m,是山西省忻阜高速公路全线的控制工程。由于是在陡峭地形条件下修建隧道,因此首先对隧道基础及偏压墙基础采用梅花型垂直小导管注浆加固措施,以增强地基承载力;然后施作混凝土偏压墙基础、洞身基础、仰拱填充、... 详细信息

凤凰岭隧道全长5 896.9m,是山西省忻阜高速公路全线的控制工程。由于是在陡峭地形条件下修建隧道,因此首先对隧道基础及偏压墙基础采用梅花型垂直小导管注浆加固措施,以增强地基承载力;然后施作混凝土偏压墙基础、洞身基础、仰拱填充、钢筋混凝土护拱、衬砌混凝土等;并采用三台阶七步流水开挖法,进入暗洞15m左右开始正常掘进,实现免刷坡安全进洞。

关键词：山岭隧道偏压斜交免刷坡注浆加固台阶法

Combined transplantation of GDAs^(BMP) and hr-decorin in spinal cord contusion repair

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Neural Regeneration Research 2013年第24期8卷 2236-2248页

作者： liang Wu jianjun li liang Chen Hong Zhang li Yuan Stephen JA Davies School of Rehabilitation Medicine Capital Medical University Department of Neural Functional Reconstruction of Spine and Spinal Cord China Rehabilitation Research Center Rehabilitation Center Beijing Xiaotangshan Rehabilitation Hospital Department of Neurosurgery University of Colorado Denver

Following spinal cord injury, astrocyte proliferation and scar formation are the main factors inhibiting the regeneration and growth of spinal cord axons. Recombinant decorin suppresses inflammatory reactions, inhibits glial scar formation, and promotes axonal growth. Rat models of T8 spinal cord contusion were created with the NYU impactor and these models were subjected to combined transplantation of bone morphogenetic protein-4-induced glial-restricted precursor-derived astro- cytes and human recombinant decorin transplantation. At 28 days after spinal cord contusion, dou- ble-immunofluorescent histochemistry revealed that combined transplantation inhibited the early in- flammatory response in injured rats. Furthermore, brain-derived neurotrophic factor, which was se- creted by transplanted cells, protected injured axons. The combined transplantation promoted ax- onal regeneration and growth of injured motor and sensory neurons by inhibiting astrocyte prolif- eration and glial scar formation, with astrocytes forming a linear arrangement in the contused spinal cord, thus providing axonal regeneration channels.

关键词： neural regeneration spinal cord injury astrocytes glial scar neural stem cells combined trans-plantation glial progenitor cells glial cells human recombinant decorin brain-derived growth factor glial fibrillary acidic protein grants-supported paper neuroregeneration

A Multilevel Design Method of Large-scale Machine System Oriented Network Environment

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武汉理工大学学报 2006年第S2期28卷 565-569页

作者： li Shuiping HE jianjun (School of Mechanical & Electronical Engineering,Wuhan University of Technology,Wuhan 430070 ,China School of Mechanical & Electronical Engineering Wuhan University of TechnologyWuhan 430070China

The design of large-scale machine system is a very complex *** design problems usually have a lot of design variables and constraints so that they are difficult to be solved rapidly and efficiently by using conventional *** this paper,a new multilevel design method oriented network environment is proposed,which maps the design problem of large-scale machine system into a hypergraph with degree of linking strength (DLS) between *** decomposition of hypergraph,this method can divide the complex design problem into some small and simple subproblems that can be solved concurrently in a network.

关键词： design large-scale machine system degree of linking strength

Enhanced Degradation of Methyl Orange with CoFe_(2)O_(4)@Zeolite Catalyst as Peroxymonosulfate Activator:Performance and Mechanism

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无机材料学报 2023年第4期38卷 I0003-I0004页

作者： WANG Lei li jianjun NING Jun HU Tianyu WANG Hongyang ZHANG Zhanqun WU linxin School of Materials Science and Engineering Anhui University of Science and TechnologyHuainan 232001China Institute of Environment-friendly Materials and Occupational Health Anhui University of Science and TechnologyWuhu 241000China Anhui Shuiyun Environmental Protection Co. Ltd.Wuhu 241000China

Reagents:PMS(KHSO_(5)·0.5KHSO_(4)·0.5K_(2)SO_(4),KHSO_(5)),MO,cobalt chloride(CoCl_(2)·6H_(2)O),ferric chloride(FeCl3·6H_(2)O),sodium metasilicate nonahydrate(Na_(2)SiO_(3)·9H_(2)O),methanol(MeOH),tert-butyl alcohol(TBA),p-Benzoquinone(p-BQ),furfuryl alcohol(FFA),sodium carbonate(Na_(2)CO_(3)),sodium sulfate(Na_(2)SO_(4)),sodium chloride(NaCl)and potassium phosphate monobasic(KH_(2)PO_(4))were purchased from Aladdin Reagent Co.,Ltd(Shanghai,China).Coal gangue were collected from Huainan,*** chemicals above are analytical grade,and deionized water was used throughout all experiments.

关键词： alcohol methanol potassium

CDK4/6 inhibition blocks cancer metastasis through a USP51-ZEB1-dependent deubiquitination mechanism

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Signal Transduction and Targeted Therapy 2020年第1期5卷 2214-2226页

作者： Zhen Zhang jianjun li Yang Ou Guang Yang Kaiyuan Deng Qiong Wang Zhaoyang Wang Wenhao Wang Quansheng Zhang Hang Wang Wei Sun Peiqing Sun Shuang Yang Tianjin Key Laboratory of Tumor Microenvironment and Neurovascular Regulation Medical College of Nankai UniversityTianjin 300071China College of Pharmacy Nankai UniversityTianjin 300071China Tianjin Key Laboratory of Organ Transplantation Tianjin First Center HospitalTianjin 300192China Department of Cancer Biology Wake Forest University School of MedicineWinston-SalemNC 27157USA

Tumor metastasis is the most common cause of cancer-related deaths,yet it remains poorly *** transcription factor zinc-finger E-box binding homeobox 1(ZEB1)is involved in the epithelial-to-mesenchymal transition(EMT)and plays a pivotal role in tumor ***,the underlying mechanisms of the posttranslational modification of ZEB1 remain largely ***,we demonstrated that specific inhibition of CDK4/6 was able to block tumor metastasis of breast cancer by destabilizing the ZEB1 protein in vitro and in ***,we determined that the deubiquitinase USP51 is a bona fide target of CDK4/*** phosphorylation and activation of USP51 by CDK4/6 is necessary to deubiquitinate and stabilize ***,we found a strong positive correlation between the expression of p-RB(an indicator of CDK4/6 activity),p-USP51 and ZEB1 in metastatic human breast cancer ***,the high expression of p-RB,p-USP51,and ZEB1 was significantly correlated with a poor clinical *** together,our results provide evidence that the CDK4/6-USP51-ZEB1 axis plays a key role in breast cancer metastasis and could be a viable therapeutic target for the treatment of advanced human cancers.

关键词： metastasis CDK4 ubiquitin

Optimized design model for sediment-trapped dam by GIS techniques

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Science China(Technological Sciences) 2003年第z1期46卷 175-187页

作者： li Fabin, TU jianjun & HU Kaiheng Institute of Mountain Hazards and Environment, Chinese Academy of Sciences and Ministry of Water Resources, Chengdu 610041, China Chinese Acad Sci Inst Mt Hazards & Environm Chengdu 610041 Peoples R China Minist Water Resources Chengdu 610041 Peoples R China

The sediment-trapped dam (STD) is one of the major engineering measures in preventing debris flow, while the design of such an STD has been proven as the most complicated systematic engineering. Supported by geographical information system (GIS)method and techniques, this paper presents an optimized STD design model which is built through calculating STD height and reservoir capacity, designing cross section,analyzing load capacity and structural stability. Guided by a principle of taking both the stability of STD as the constraint condition and the optimized design as a nonlinear programming, this model makes it possible for a precise calculation of the STD volume and its reservoir capacity, aiming at getting the minimum ratio between project investment and reservoir capacity. This model preliminarily achieves the optimized designing of important parameters of STD involving in STD volume (project investment), dam stability and reservoir capacity (sediments trapped by STD), and also provides a new solution attempting for the optimized design of project in preventing debris flow.

关键词： debris flow, sediment-trapped dam, geographical information system, optimized design, model.