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Analysis of Preoperative Factors Influencing Hypoglossal-facial ‘Side’-to-side Neurorrhaphy for Facial Paralysis after Excision of Acoustic Neuroma

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Biomedical and Environmental Sciences 2020年第1期33卷 30-36页

作者： SU Di Ya WAN Hong li de zhi QIAO Hui SCHUMACHER Michael liU Song Beijing Neurosurgical Institute and Beijing Key Laboratory of Central Nervous System Injury Capital Medical UniversityBeijing 100070China Dalian University Affiliated Xinhua Hospital Dalian 116000LiaoningChina department of Neurosurgery and China National Clinical Research Center for Neurological Diseases Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China U 1195 INSERM and University Paris-Sud and University Paris Saclay94276 Le Kremlin-BicêtreFrance

Objective Hypoglossal nerve-facial nerve‘side’-to-side neurorrhaphy is a new method for the treatment of potential incomplete facial paralysis after acoustic ***,there are differences in postoperative outcomes among *** study analysed preoperative factors that may influence the treatment outcomes of *** We performed a retrospective study of 53 patients who were treated by neurorrhaphy for facial paralysis after acoustic neuroma *** a one-year follow-up period,the patients were divided into two groups according to facial functional outcome:better recovery or ordinary *** analysed the following factors:gender,age,tumour size,and characteristics,tumour adhesion to the facial nerve,the duration of facial paralysis(DFP)and F wave appearance prior to neurorrhaphy(F wave).Results Univariate analysis showed significant differences between the two groups in DFP(P=0.0002),tumour adhesion to the facial nerve(P=0.0079)and F waves(P=0.0048).Logistic regression analysis of these factors also showed statistical significance with P values of 0.042 for the DFP,0.043 for F waves,and 0.031 for tumour adhesion to the facial *** Tumour adhesion to the facial nerve,F waves appearance and DFP prior to neurorrhaphy are the predominant factors that influence treatment outcomes.

关键词： Facial nerve injury Nerve regeneration Preoperative factors analysis

An Experimental Study on the Optimal Timing for the Repair of Incomplete Facial Paralysis by Hypoglossal-facial‘Side'-to-side Neurorrhaphy in Rats

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Biomedical and Environmental Sciences 2018年第6期31卷 413-424页

作者： WANG Bin Bin ZHANG Shao Dong FENG Jie li Jun Hua liU Song li de zhi WAN Hong Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100050China department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100050China

Objective To investigate the optimal timing for the repair of persistent incomplete facial paralysis by hypoglossal-facial ‘side＇-to-side neurorrhaphy in rats. Methods A total of 30 adult rats with crushed and bulldog-clamped facial nerve injury were randomly divided into 5 groups（n = 6 each） that were subjected to injury without nerve repair or with immediate repair, 2-week-delayed repair, 4-week-delayed repair, or 8-week-delayed repair. Three months later, the effects of repair in each rat were evaluated by facial symmetry assessment, electrophysiological examination, retrograde labeling, and axon regeneration measurement. Results At 3 months after injury, the alpha angle significantly increased in the group of rats with 4-week-delayed repair compared with the other four groups. Upon stimulation of the facial nerve or Pre degenerated nerve, the muscle action potentials MAPs were recorded in the whisker pad muscle, and the MAP amplitude and area under the curve in the 4-week-delayed repair group were significantly augmented at 3 months post-injury. Similarly, the number of retrograde-labeled motor neurons in the facial and hypoglossal nuclei was quantified to be significantly greater in the 4-week-delayed repair group than in the other groups, and a large number of regenerated axons was also observed. Conclusion The results of this study demonstrated that hemi HN-FN neurorrhaphy performed 4 weeks after facial nerve injury was most effective in terms of the functional recovery of axonal regeneration and activation of facial muscles.

关键词： Facial paralysis Hypoglossal-facial nerve anastomosis Nerve autograft Optimal time

Comparison of the Nerve Regeneration Capacity and Characteristics between Sciatic Nerve Crush and Transection Injury Models in Rats

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Biomedical and Environmental Sciences 2023年第2期36卷 160-173页

作者： WANG Bin Bin GUO Chao SUN Sheng Qiao ZHANG Xing Nan li Zhen li Wei Jie li de zhi SCHUMACHER Michael liU Song Beijing Neurosurgical Institute Capital Medical UniversityBeijing 100070China department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijing 100070China U1195 Inserm et Universite Paris-SaclayLe Kremlin-Bicetre 94276France

Objective To provide useful information for selecting the most appropriate peripheral nerve injury model for different research purposes in nerve injury and repair studies,and to compare nerve regeneration capacity and characteristics between *** Sixty adult SD rats were randomly divided into two groups and underwent crush injury alone(group A,n=30)or transection injury followed by surgical repair(group B,n=30)of the right hind *** group was subjected to the CatWalk test,gastrocnemius muscle evaluation,pain threshold measurement,electrophysiological examination,retrograde neuronal labeling,and quantification of nerve regeneration before and 7,14,21,and 28 days after *** Gait analysis showed that the recovery speed in group A was significantly faster than that in group B at 14 *** 21 days,the compound muscle action potential of the gastrocnemius muscle in group A was significantly higher than that in group B,and the number of labeled motor neurons in group B was lower than that in group *** number of new myelin sheaths and the g-ratio were higher in group A than in group *** was a 7-day time difference in the regeneration rate between the two injury *** The regeneration of nerve fibers was rapid after crush nerve injury,whereas the transection injury was relatively slow,which provides some ideas for the selection of clinical research models.

关键词： Sciatic nerve injury degeneration Regeneration Myelination

Numerical Simulation of the demagnetization of a Permanent Magnet Retarder in High Temperature

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International Journal of Plant Engineering and Management 2009年第4期14卷 238-242页

作者： YE Le-zhi li de-sheng College of Mechanical Engineering and Applied Electronics Technology Beijing University of Technology Beijing 100124 China

As a auxiliary brake, Permanent Magnet Retarder （PMR） generates lots of energy and has greater temperature-rise when PMR works, so that it has a direct impact on PMR work performance and even causes demagnetization seriously. In order to analyze permanent magnet （PM） demagnetization in high-temperature in PMR, PMR mathematical model is established firstly, and the boundary conditions of finite element analysis are determined. Then the eddy current field distribution in the rotor is determined by solving eddy current demagnetization field, and PM dynamic permeance coefficient is obtained. Combined with PM demagnetization curve analysis, PMR permanent magnet demagnetization properties are analyzed. The analysis result is validated by the bench test. It shows that part of PM is demagnetized when PRM continues working for about 15 minutes, and the braking performance is declined. Finally, three PMR optimization design methods are proposed.

关键词： auxiliary brake demagnetization in high temperature finite element analysis permanent magnet retarder

Survival Outcome of Squamous Cell Carcinoma Arising from Sinonasal Inverted Papilloma

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Chinese Medical Journal 2015年第18期128卷 2457-2461页

作者： Qing-Zhuang liang de-zhi li Xiao-LeiWang Hui Huang Zhen-Gang Xu Yue-HuangWu department of Breast and Thyroid Surgery Peking University Shenzhen Hospital Shenzhen Guangdong 518036 China department of Head and Neck Surgery Cancer Hospital Chinese Academy of Medical Sciences Peking Union Medical College Beijing 100021 China

Background： Sinonasal inverted papilloma （IP） is a rare benign tumor of the nasal cavities and paranasal sinuses. It is destructive or bone-rcmodeling, tends to recur alter surgical resection, and has a significant malignant potential. The present study aimed to pertbnn a retrospective analysis of patients with squamous cell carcinoma （SCC） arising from IP, including characteristics, survival outcome, and predictors of associated malignancy. Methods： The medical records of 213 patients diagnosed with IP from January 1970 to January 2014 were retrospectively reviewed. Eighty-seven patients were diagnosed with SCC/IP; their clinical characteristics, treatments, and survival outcomes were analyzed. Results： Of the 87 patients with SCC/IP, the 5- and 10-year overall survival outcomes were 39.6% and 31.8%, respectively. Twenty-nine of these patients received surgery and 58 received combined surgery and radiation. Of the patients with stages III-IV, the 5-year survival rate was 30.7% for those treated with surgery only and 39.9% for those given the combination treatment （P = 0.849）. Factors associated with significantly poor prognosis were advanced-stage, metachronous tumors, or with cranial base and orbit invasion. Age, synchronous or metachronous tumors, and pathological stage were independent risk factors for mortality, shown by multivariate analysis. Conclusion： Patients with SCC/IP had low overall survival outcomes. Advanced age, stage, and metachronous tumors are the main factors affecting prognosis. Treatment planning should consider high-risk factors to improve survival outcome.

关键词： Sinonasal Inverted Papilloma Squamous Cell Carcinoma Survival Outcome

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论公司有限责任制度

现代法学 2005年第5期27卷 123-129页

作者：李德智沈阳建筑大学文法学院辽宁沈阳110168

公司有限责任制度的核心是公司责任与公司成员责任的分离,股东作为投资者无须对公司的债务承担除了其投资之外的进一步的责任。该制度的建立与发展对调动潜在投资者投资的积极性、发展规模经济、促进公司法律制度完善等方面功不可没。... 详细信息

公司有限责任制度的核心是公司责任与公司成员责任的分离,股东作为投资者无须对公司的债务承担除了其投资之外的进一步的责任。该制度的建立与发展对调动潜在投资者投资的积极性、发展规模经济、促进公司法律制度完善等方面功不可没。有限责任制度有其客观存在的价值,但并非十全十美,这主要表现在该制度被不当利用而对债权人和其它利益相关者造成的损害,实践中各国多采用有限责任制度例外适用来补救该制度之不足。由于历史原因,我国公司有限责任制度的设立和实施存在诸多问题,必须采取必要的措施完善我国的有限责任制度。

关键词：公司有限责任制度中国《公司法》股东权利债权人

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网络文化超文本新词认知分析

外语学刊 2014年第3期 70-72页

作者：李德志黑龙江大学哈尔滨150080

本文以基于网络文化超文本新词"微博"、"微信"为例,从认知角度分析隐喻在超文本新词汉译中的作用,阐释认知语境和词语发展的关系,加深了解超文本语言的隐喻学。在此基础上,探索加强理解和预测网络文化超文本中新词语发展趋势的策略。

关键词：网络文化超文本隐喻认知

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电子式互感器校验仪的USB接口设计

仪表技术与传感器 2011年第8期 45-47页

作者：李志得广东省计量科学研究院东莞分院广东东莞523120

USB接口具有连接简单、使用方便等优点,因而在数据采集与传输领域得到广泛应用。在电子式互感器校验仪中,采用TMS320F2812作为微处理器,利用ISP1161A芯片实现USB2.0主机接口,将校验结果实时保存到U盘里,实现数据的快速存储。通过硬件平... 详细信息

USB接口具有连接简单、使用方便等优点,因而在数据采集与传输领域得到广泛应用。在电子式互感器校验仪中,采用TMS320F2812作为微处理器,利用ISP1161A芯片实现USB2.0主机接口,将校验结果实时保存到U盘里,实现数据的快速存储。通过硬件平台的搭建和软件程序的设计,实现了DSP与U盘之间的高速数据传输。经测试,该USB接口具有速度快、热插拔和低功耗等特点。

关键词：电子式互感器校验仪 DSP USB ISP1161A

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一种智能绝缘电阻测试仪设计

电测与仪表 2011年第5期48卷 63-67页

作者：李志得广东计量科学研究院东莞分院广东东莞523000

为保证电力设备安全经济地运行,必须定期对其绝缘电阻进行测试,本文为此设计并实现了一种基于ARM7的智能绝缘电阻测试仪,它由高压产生电路、测量电路、按键显示以及一些智能控制模块组成,实现了低电压激励条件下的绝缘电阻测试。大大地... 详细信息

为保证电力设备安全经济地运行,必须定期对其绝缘电阻进行测试,本文为此设计并实现了一种基于ARM7的智能绝缘电阻测试仪,它由高压产生电路、测量电路、按键显示以及一些智能控制模块组成,实现了低电压激励条件下的绝缘电阻测试。大大地提高了测试速度,缩短了测试时间,杜绝了人为操作误差。经过大量实验测试表明,该测试仪具有测试高压输出稳定、负载能力强、测试精度高、操作方便等优点,并具有时间显示、电池电量检测、自动存储测量数据等功能。

关键词：绝缘电阻直流高压电源 ARM7 AD7705