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Effects of the kinetic pattern of dietary glucose release on nitrogen utilization, the portal amino acid profile, and nutrient transporter expression in intestinal enterocytes in piglets

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Journal of Animal Science and Biotechnology 2024年第5期15卷 2106-2121页

作者： Zexi li Yunfei li Yufei Zhao Guifu Wang Rujie liu yue li Qamar Aftab Zewei Sun Qingzhen Zhong Jilin Province Key Laboratory of Animal Nutrition and Feed Science College of Animal Science and TechnologyKey Lab of Animal ProductionProduct Quality and SecurityMinistry of EducationJilin Agricultural University2888 Xincheng StreetChangchun CityJilin ProvincePeople’s Republic of China Dongfeng County Sika Deer Industry Development Service Center Dongfeng CountyLiaoyuan CityJilin ProvinceChina

Background Promoting the synchronization of glucose and amino acid release in the digestive tract of pigs could effectively improve dietary nitrogen *** rational allocation of dietary starch sources and the exploration of appropriate dietary glucose release kinetics may promote the dynamic balance of dietary glucose and amino acid ***,research on the effects of diets with different glucose release kinetic profiles on amino acid absorption and portal amino acid appearance in piglets is *** study aimed to investigate the effects of the kinetic pattern of dietary glucose release on nitrogen utilization,the portal amino acid profile,and nutrient transporter expression in intestinal enterocytes in *** Sixty-four barrows(15.00±1.12 kg)were randomly allotted to 4 groups and fed diets formulated with starch from corn,corn/barley,corn/sorghum,or corn/cassava combinations(diets were coded A,B,C,or D respectively).Protein retention,the concentrations of portal amino acid and glucose,and the relative expression of amino acid and glucose transporter m RNAs were *** vitro digestion was used to compare the dietary glucose release *** Four piglet diets with different glucose release kinetics were constructed by adjusting starch *** in vivo appearance dynamics of portal glucose were consistent with those of in vitro dietary glucose release *** nitrogen excretion was reduced in the piglets in group B,while apparent nitrogen digestibility and nitrogen retention increased(P<0.05).Regardless of the time(2 h or 4 h after morning feeding),the portal total free amino acids content and contents of some individual amino acids(Thr,Glu,Gly,Ala,and Ile)of the piglets in group B were significantly higher than those in groups A,C,and D(P<0.05).Cluster analysis showed that different glucose release kinetic patterns resulted in different portal amino acid patterns in piglets,which decreased gradually with the

关键词： Glucose release kinetics Nitrogen utilization Nutrient transporter Piglet

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Androgens exert multifaceted functions in sex differences analyzed through single-cell transcriptome

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Science China life Sciences 2024年第11期67卷 2530-2531页

作者： Xinxin Tang Yinkun Fu Zhihui Zou yue li Ming He Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education Shanghai Frontiers Science Center of Cellular Homeostasis and Human Diseases Department of Pathophysiology School of Medicine Shanghai Jiao Tong University Department of Pathology The Affiliated Hospital of Youjiang Medical University for Nationalities

Sex differences are ubiquitous in human development, aging and disease. For example, the overwhelming majority of non-reproductive system cancers are more common in males(Mauvais-Jarvis et al., 2020), while autoimmune diseases are more common in females. Hormones,especially androgens and oestrogens, contribute to sex-biased phenotypes(Khramtsova et al., 2019).

关键词： PROSTATE CASTRATION

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Convergence Towards the Population Cross-Diffusion System from Stochastic Many-Particle System

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Communications in Mathematical Research 2024年第1期40卷 43-63页

作者： yue li li Chen Zhipeng Zhang Department of Mathematics Nanjing UniversityNanjing 210093P.R.China Institute for Analysis and Scientific Computing Vienna University of TechnologyWiedner Hauptstrafβe 8-10Vienna 1040Austria School of Business Informatics and Mathematics University of MannheimMannheim 68131Germany

In this paper,we derive rigorously a non-local cross-diffusion system from an interacting stochastic many-particle system in the whole *** convergence is proved in the sense of probability by introducing an intermediate particle system with a mollified interaction potential,where the mollification is of algebraic *** main idea of the proof is to study the time evolution of a stopped process and obtain a Gronwall type estimate by using Taylor's expansion around the limiting stochastic process.

关键词： Stochastic particle systems cross-diffusion system mean-field limit population dynamics

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Diet xylo-oligosaccharide supplementation improves growth performance, immune function, and intestinal health of broilers

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Animal Nutrition 2024年第2期17卷 165-176页

作者： Zhiyong Rao yue li Xiaopeng Yang Yongpeng Guo Wei Zhang Zhixiang Wang School of Animal Science and Technology Henan Agricultural University

The effects of xylo-oligosaccharides(XOS) on broiler growth performance, immune function, and intestinal health were investigated. A total of 540 one-d-old Arbor Acres Plus broilers were randomly divided into 5 groups with 6 replicates per group and 18 chickens per replicate. Broilers in the control(CON) group received a corn-soybean meal based basal diet, those in the antibiotics(ANT) group received the basal diet plus 500 mg/kg oxytetracycline, and those in XOS groups received the basal diet plus 150, 300, or 450 mg/kg XOS. Compared with CON, the body weight at 42 d and average daily gain from 1 to 42 d were significantly increased in the 150, 450 mg/kg XOS-added and ANT groups(P = 0.018),and the relative expression of claudin-1 and ZO-1 m RNA in the ileum was significantly higher in the 300and 450 mg/kg XOS-added groups(P listipes) was also significantly higher(P < 0.001). Meanwhile, ileal villus height(P < 0.001) and ratio of villus height to crypt depth(V:C)(P = 0.001) were significantly increased in XOS-added broilers. In analysis of relationships between cecal microbes and the physical barrier of the gut, [Ruminococcus]＿torques＿group was positively correlated with m RNA expression of ileal ZO-1 and claudin-1(P < 0.05), and Bacteroides was positively correlated with increased ileal villus height and V:C(P < 0.05). Overall, XOS addition to broiler diets improved growth performance, promoted intestinal health by enh

关键词： Xylo-oligosaccharide Growth performance Intestinal health Immunity Broiler

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The Role of Renewable Protocatechol Acid in Epoxy Coating Modification: Significantly Improved Antibacterial and Adhesive Properties

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Chinese Journal of Polymer Science 2024年第1期42卷 63-72,I0008页

作者： Ming-Xuan Chen Jin-yue Dai li-yue Zhang Shuai-Peng Wang Jing-Kai liu Yong-Gang Wu Xin-Wu Ba Xiao-Qing liu School of Chemistry and Materials Science Hebei UniversityBaoding 071000China Ningbo Institute of Materials Technology and Engineering Chinese Academy of SciencesNingbo 315201China Key Laboratory of Marine Materials and Related Technologies Chinese Academy of SciencesNingbo 315201China

It is of great significance to design epoxy coatings with superior antibacterial properties and high adhesive properties, as well as excellent processing, superior durability, and high transparency. However, it is still a challenge because of the common complex design and synthesis. Herein, the bio-based monomer protocatechuic acid(PCA) was used as raw material, the catechol structure with high bonding and antibacterial properties was introduced into the flexible alkane segment of ethylene glycol diglycidyl ether(EGDE) through an efficient, and green method, and it was cured with isophorone diamine(IPDA) to prepare corresponding thermosets. The cured resins exhibited excellent allaround qualities, particularly in bonding and antibacterial. When 30% PCA was added to pure epoxy resin, the adhesion between substrate and coating increased from 4.40 MPa to 13.60 MPa and the antibacterial rate of coating against E. coli and S. aureus could approach 100%. All of this is due to the fact that the catechol structure present in PCA has the ability to interact with various substrates and alter the permeability of bacterial cell membranes. The architecture of this method offers a fresh approach to dealing with the issues of challenging raw material selection and complex synthesis techniques.

关键词： Epoxy coatings Thermosets Catechol structure Antibacterial High adhesion

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Two imprinted genes primed by DEMETER in the central cell and activated by WRKY10 in the endosperm

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Journal of Genetics and Genomics 2024年第8期51卷 855-865页

作者： Ke Yang Yuling Tang yue li Wenbin Guo Zhengdao Hu Xuanpeng Wang Frédéric Berger Jing li College of life Science and Technology Huazhong Agricultural UniversityWuhanHubei 430070China Sanya Institute of Breeding and Multiplication Hainan UniversitySanyaHainan 572025China School of Tropical Agriculture and Forestry Hainan UniversityHaikouHainan 570228China Hainan Yazhou Bay Seed Laboratory SanyaHainan 572025China Gregor Mendel Institute Austrian Academy of SciencesVienna BioCenter1030 ViennaAustria

The early development of the endosperm is crucial for balancing the allocation of maternal nutrients to *** process is believed to be evolutionarily associated with genomic imprinting,resulting in parentally biased allelic gene *** Fertilization Independent Seed(FIS)genes,the number of imprinted genes involved in early endosperm development and seed size determination remains *** study introduces early endosperm-expressed HAIKU(IKU)downstream Candidate F-box 1(ICF1)and ICF2 as maternally expressed imprinted genes(MEGs)in Arabidopsis *** these genes are also demethylated by DEMETER(DME)in the central cell,their activation differs from the direct DME-mediated activation seen in classical MEGs such as the FIS ***,ICF maternal alleles carry pre-established hypomethylation in their promoters,priming them for activation by the WRKY10 transcription factor in the *** the contrary,paternal alleles are predominantly suppressed by CG ***,we find that ICF genes partially contribute to the small seed size observed in iku *** discovery reveals a two-step regulatory mechanism that highlights the important role of conventional transcription factors in the activation of imprinted genes,which was previously not fully ***,the mechanism provides a new dimension to understand the transcriptional regulation of imprinting in plant reproduction and development.

关键词： Imprinting Epigenetics DNAmethylation Seedsize Endosperm

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Armoring lithium metal anode with soft±rigid gradient interphase toward high-capacity and long-life all-solid-state battery

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Green Energy & Environment 2024年第8期9卷 1279-1289页

作者： Rui Zhang Biao Chen Yuhan Ma yue li Junwei Sha liying Ma Chunsheng Shi Naiqin Zhao School of Materials Science and Engineering and Tianjin Key Laboratory of Composite and Functional Materials Tianjin University Joint School of National University of Singapore and Tianjin University International Campus of Tianjin University Department of Chemical and Biomolecular Engineering National University of Singapore Collaborative Innovation Centre of Chemical Science and Engineering

Solid polymer electrolytes （SPEs） are highly promising for realizing high-capacity,low-cost,and safe li metal ***,the li dendritic growth and side reactions between li and SPEs also plague these ***,a fluorinated lithium salt coating （FC） with organicinorganic gradient and soft-rigid feature is introduced on li surface as an artificial protective layer by the in-situ reaction between li metal and fluorinated carboxylic *** FC layer can improve the interface stability and wettability between li and SPEs,assist the transport of li ions,and guide li nucleation,contributing to a dendrite-free li deposition and long-lifespan li metal *** symmetric cell with FC-li anodes exhibits a high areal capacity of 1 mAh cm-2at 0.5 mA cm-2,and an ultra-long lifespan of 2000 h at a current density of 0.1 m A ***,the full cell paired with the liFePO4cathode exhibits improved cycling stability,remaining 83.7%capacity after 500 cycles at 1 *** matching with the S cathode,the FC layer can prevent the shuttle effect,contributing to stable and high-capacity li-S *** work provided a promising way for the construction of stable all-solid-state lithium metal batteries with prolonged lifespan.

关键词： All-solid-state battery Solid polymer electrolyte li metal anode li nucleation Interface stability

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Bortezomib depended on PRDM1 and TP53 to exert therapeutic effect in activated B-cell-like diffuse large B-cell lymphoma

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Genes & Diseases 2024年第2期11卷 550-553页

作者： Jing Tang yue li Jiazhu Wu Haorui Shen Hua Yin Jinhua liang li Wang Jianyong li Yi Xia Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China

PR/SET domain 1(PRDM1)gene is located on chromosome 6q21,encoding the B lymphocyte-induced maturation protein 1(BliMP1).1 It is reported that loss of PRDM1 function is exacerbated in activated B-cell-like(ABC)-diffuse large B cell lymphoma(DLBCL)and associated with inferior ***,it remains unclear what leads to PRDM1 inactivation and the drug resistance mechanism caused by abnormal inactivation of *** investigated the contribution of PRDM1 gene as a prognosis and potential therapeutic target for ABC-DLBCL patients and further clarified the possible mechanism of PRDM1 abnormal *** first proposed that TP53 could regulate PRDM1 by histone ubiquitination modification at the post-transcriptional level.

关键词： PRDM1 TP53 therapeutic

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Genotyping on circulating tumor DNA improves mutation detection rate in high-risk diffuse large B-cell lymphoma

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Genes & Diseases 2024年第4期11卷 116-119页

作者： Yi Xia li Wang Jinhua liang Haorui Shen Jiazhu Wu Hua Yin yue li Huayuan Zhu Jianyong li Wei Xu Department of Hematology The First Affiliated Hospital of Nanjing Medical UniversityJiangsu Province HospitalNanjingJiangsu 210029China Key Laboratory of Hematology of Nanjing Medical University NanjingJiangsu 210029China Collaborative Innovation Center for Cancer Personalized Medicine NanjingJiangsu 210029China

Diffuse large B-cell lymphoma(DLBCL)is the most common lymphoma with heterogeneous clinical *** who are primarily refractory to the frontline therapy or relapse less than 12 months after diagnosis have an extremely di... 详细信息

关键词： lymphoma diagnosis clinical

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Digital measuring the ocular morphological parameters of guinea pig eye in vivo with Python

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 239-246页

作者： yue Di Zhong-Bao Qiao Hai-Yun Ye Xin-yue li Wen-Ting Luo Wang-Yi Fang Tong Qiao Department of Ophthalmology Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200062China

AIM:To quantitatively measure ocular morphological parameters of guinea pig with Python ***:Thirty-six eyeballs of eighteen 3-weekold guinea pigs were measured with keratometer and photographed to obtain the horizontal,coronal,and sagittal planes *** corresponding photo pixels-actual length ratio was acquired by a proportional *** edge coordinates were identified artificially by ginput *** and conic curve fitting were applied to fit the contour of the eyeball in the sagittal,coronal and horizontal *** curvature,curvature radius,eccentricity,tilt angle,corneal diameter,and binocular separation angle were calculated according to the geometric ***,the eyeballs were removed,canny edge detection was applied to identify the contour of eyeball in *** results were compared between in vivo and in ***:Regarding the corneal curvature and curvature radius on the horizontal and sagittal planes,no significant differences were observed among results in vivo,in vitro,and the *** horizontal and vertical binocular separation angles were 130.6°±6.39°and 129.8°±9.58°*** the corneal curvature radius and eccentricity in vivo,significant differences were observed between horizontal and vertical ***:The Graphical interface window of Python makes up the deficiency of edge detection,which requires too much definition in *** are significant differences between guinea pig and human beings,such as exotropic eye position,oblique oval eyeball,and obvious discrepancy of *** study helps evaluate objectively the ocular morphological parameters of small experimental animals in emmetropization research.

关键词： ocular morphological parameters guinea pig digital measurement Python

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