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Synthesis and Properties of Non-isocyanate Crystallizable Aliphatic Thermoplastic Polyurethanes

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Journal of Wuhan University of Technology(Materials Science) 2018年第5期33卷 1275-1280页

作者： li suqing DENG Yong ZHAO Jingbo ZHANG Zhiyuan ZHANG Jnuying YANG Wantai Key Laboratory of Carbon Fiber and Functional Polymers（Bering University of Chemical Technology） Ministry of Educatio State Key Laboratory of Chemical Resource Engineering College of Materials Science and EngineeringBeijing University of Chemical TechnologyBeijing 100029China

A simple non-isocyanate route synthesizing thermoplastic polyurethanes（TPUs） with good thermal and mechanical properties is described. Melt transurethane polycondensation of dimethyl 1,6-hexamethylene dicarbamate with 1,4-butanediol and 1,6-hexanediol was conducted at different molar ratios under the catalysis of tetrabutyl titanate. A series of crystallizable non-isocyanate TPUs with high molecular weight were prepared. The TPUs were characterized by gel permeation chromatography, FT-IR, 1 H-NMR, differential scanning calorimetry, thermogravimetric analysis, wide angle X-ray diffraction, AFM, and tensile tests. The TPUs exhibited Mn ranging from 12 500 to 26 400 g/mol, Mw from 16 700 to 56 400 g/mol, Tm up to 151.4 °C, and initial decomposition temperature over 241.8 °C. Their tensile strength reached 42.99 MPa with a strain at break of 30.00%. TPUs constructed simply with butylene, hexylene, and urethane linkages were successfully synthesized through a non-isocyanate route.

关键词： thermoplastic polyurethanes non-isocyanate route transurethane polycondensation properties dimethyl 1 6-hexamethylene dicarbamate

Systematic review of nutrition screening and assessment in inflammatory bowel disease

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World Journal of Gastroenterology 2019年第28期25卷 3823-3837页

作者： suqing li Michael Ney Tannaz Eslamparast Ben Vandermeer Kathleen P Ismond Karen Kroeker Brendan Halloran Maitreyi Raman Puneeta Tandon Division of Internal Medicine Department of Medicine Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta T6G 2G3 Canada Division of Gastroenterology and Hepatology Department of Medicine University of Calgary Calgary Alberta T2N 2T9 Canada Cirrhosis Care Clinic Division of Gastroenterology Department of Medicine Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta T6G 2X8 Canada Alberta Research Centre for Health Evidence Biostatistician Faculty of Medicine and Dentistry University of Alberta Edmonton Alberta T6G 1C9 Canada

BACKGROUND Malnutrition is prevalent in inflammatory bowel disease (IBD). Multiple nutrition screening (NST) and assessment tools (NAT) have been developed for general populations, but the evidence in patients with IBD remains unclear. AIM To systematically review the prevalence of abnormalities on NSTs and NATs, whether NSTs are associated with NATs, and whether they predict clinical outcomes in patients with IBD. METHODS Comprehensive searches performed in Medline, CINAHL Plus and PubMed. Included: English language studies correlating NSTs with NATs or NSTs/NATs with clinical outcomes in IBD. Excluded: Review articles/case studies;use of body mass index/laboratory values as sole NST/NAT;agelitis. Four NSTs (the Malnutrition Universal Screening Tool, Malnutrition Inflammation Risk Tool (MIRT), Saskatchewan Inflammatory Bowel Disease Nutrition Risk Tool (SaskIBD-NRT) and Nutrition Risk Screening 2002 (NRS-2002) were significantly associated with nutritional assessment measures of sarcopenia and the Subjective Global Assessment (SGA). Three NSTs (MIRT, NRS-2002 and Nutritional Risk Index) were associated with clinical outcomes including hospitalizations, need for surgery, disease flares, and length of stay (LOS). Sarcopenia was the most commonly evaluated NAT associated with outcomes including the need for surgery and post-operative complications. The SGA was not associated with clinical outcomes aside from LOS. CONCLUSION There is limited evidence correlating NSTs, NATs and clinical outcomes in IBD. Although studies support the association of NSTs/NATs with relevant outcomes, the heterogeneity calls for further studies before an optimal tool can be recommended. The NRS-2002, measures of sarcopenia and developments of novel NSTs/NATs, such as the MIRT, represent key, clinically-relevant areas for future exploration.

关键词： Nutrition Inflammatory bowel disease Ulcerative colitis Crohn’s disease Screening Outcomes research

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李素卿教授治小儿抽动-秽语综合征

中医药通报 2009年第2期8卷 18-19页

作者：艾敏李素卿（指导）云南省昭通市昭阳区中医院 657000

李素卿教授是北京中医药大学东直门医院主任医师、教授、硕士生导师、全国名老中医，北京中西医结合学会儿科专业委员会委员。兼任中医药高等教育学会儿科分会副理事长，从事中西医结合儿科临床、教学、科研工作40年。有着丰富的临床经... 详细信息

李素卿教授是北京中医药大学东直门医院主任医师、教授、硕士生导师、全国名老中医，北京中西医结合学会儿科专业委员会委员。兼任中医药高等教育学会儿科分会副理事长，从事中西医结合儿科临床、教学、科研工作40年。有着丰富的临床经验和较高的学术造诣。余有幸跟从李老学习，现将她以钩藤益宫散治疗小儿抽动一秽语综合征的思路归纳总结出来，以飧同道。

关键词：小儿抽动-秽语综合征钩藤益宫散李素卿

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李素卿治疗过敏性鼻炎用药规律数据挖掘研究

中国民间疗法 2022年第17期30卷 30-33页

作者：郭宙薛丹李素卿北京市昌平区中西医结合医院北京102208 北京中医药大学东直门医院北京100007

目的:分析李素卿教授治疗过敏性鼻炎的用药配伍规律。方法:以李素卿教授在东直门医院门诊治疗的小儿过敏性鼻炎病例为研究对象。基于R语言软件和Python语言,使用Apriori算法(arules和arulesViz软件包)进行药物关联规则分析,使用***方法(... 详细信息

目的:分析李素卿教授治疗过敏性鼻炎的用药配伍规律。方法:以李素卿教授在东直门医院门诊治疗的小儿过敏性鼻炎病例为研究对象。基于R语言软件和Python语言,使用Apriori算法(arules和arulesViz软件包)进行药物关联规则分析,使用***方法(igraph软件包中的自旋玻璃法)进行药物社群分析,使用ward’s method(sklearn软件包)进行凝聚法层次聚类分析。结果:关联分析支持度>0.5的药物组合为浙贝母和甘草、黄芩和甘草、白芷和苍耳子、黄芩和浙贝母、白芷和甘草、蝉蜕和甘草等14条。社群网络分析可将常用中药分为两个社群。社群1:浙贝母、苍耳子、路路通、徐长卿、甘草、白芷、芦根、蝉蜕、辛夷、紫菀、白茅根;社群2:黄芩、牛蒡子、桔梗、石膏、金银花、前胡、地龙、桑叶、麻黄、苦杏仁、枇杷叶。层次聚类可以将常用中药聚成两类。第1类与社群网络分析的社群1相比缺少紫菀和浙贝母两味药,第2类与社群网络分析的社群2相比缺少麻黄,多出紫菀和浙贝母两味药,其他药物分类结果都一致。结论:李素卿教授治疗过敏性鼻炎时,以清热通络、疏风解表、止咳平喘、抗敏祛邪为主要治则。治疗过敏性鼻炎无下呼吸道症状的患儿时,常以苍耳子散疏风通窍为主方,芦根、白茅根、徐长卿、路路通清热通络,甘草、蝉蜕抗过敏。在治疗兼有咳喘症状的患儿时,以麻杏石甘汤加黄芩、地龙清热平喘为主方,金银花、桑叶、牛蒡子疏风清热,枇杷叶、紫菀、前胡、桔梗、浙贝母止咳化痰。

关键词：过敏性鼻炎变应性鼻炎用药规律关联规则社群网络层次聚类数据挖掘李素卿

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山西黎城野生萱草群落特征及稳定性

生态学杂志 2024年第7期43卷 2083-2092页

作者：李志娟李素清山西农业大学园艺学院太原030031 山西大学黄土高原研究所太原030006

为了解野生萱草群落组成与多样性的变化,本研究在进行野生萱草群落样方调查的基础上,整合TWINSPAN分类和DCA排序、α与β多样性、Godron群落稳定性等方法,分析了山西黎城野生萱草群落特征及稳定性。结果表明:(1)TWINSPAN分类将该区野生... 详细信息

为了解野生萱草群落组成与多样性的变化,本研究在进行野生萱草群落样方调查的基础上,整合TWINSPAN分类和DCA排序、α与β多样性、Godron群落稳定性等方法,分析了山西黎城野生萱草群落特征及稳定性。结果表明:(1)TWINSPAN分类将该区野生萱草群落72个样方划分为两大类12个野生萱草群丛类型。(2)样方的DCA第一、二排序轴显示了不同野生萱草群丛优势种和物种多样性的梯度变化,沿DCA第一轴从左至右,共有优势种由以北萱草为主的群丛(Ⅷ-Ⅺ)逐渐转变为以黄花菜为主的群丛(Ⅰ-Ⅶ、Ⅻ);沿第二轴从上到下,群丛物种多样性呈递减趋势。72种植物DCA排序和样方DCA排序的变化趋势基本一致。(3)12个群丛的Shannon和Simpson多样性指数、Patrick和Margalef丰富度指数差异明显,且其变化趋势基本一致;群丛相似性的Sørensen系数与Jaccard系数变化趋势基本一致,12个群丛的物种组成和生境条件均存在一定程度的差异。(4)12个群丛不稳定,且群丛多样性与稳定性关系不一致。综上,黎城野生萱草群落不稳定,受生境条件和人为干扰(旅游、放牧等)影响较大,未来应加强其种质资源的科学保护。

关键词：野生萱草群落分类与排序物种多样性群落稳定性

The effect of subbranch for the quantification of local hemodynamic environment in the coronary artery:a computed tomography angiography–based computational fluid dynamic analysis

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Emergency and Critical Care Medicine 2022年第4期2卷 181-190页

作者： Yibing Shi Jin Zheng Ning Yang Yang Chen Jingxi Sun Ying Zhang Xuanxuan Zhou Yongguang Gao suqing li Haijing Zhu Julio Acosta-Cabronero Ping Xia Zhongzhao Teng Department of Radiology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical UniversityXuzhouJiangsuChina Department of Radiology University of CambridgeUnited Kingdom Nanjing Jingsan Medical Science and Technology LtdJiangsuChina PLA Rocket Force Characteristic Medical Centre BeijingChina Tenoke LtdCambridgeUnited Kingdom.

Background:Hemodynamic parameters derived from computed tomography angiography–based computational fluid dynamics(CFD)analysis have been widely used for clinical decision-making and researches to assess the vulnerability of atherosclerotic plaques and explain the initialization and development of *** in the CFD model might affect the accuracy of hemodynamic parameters,but the effectiveness has been least ***:A coronary artery baseline model was generated with focal stenosis at the proximal left anterior descending *** comparing models were created by systematically removing various subbranches to examine the changes in hemodynamic parameters,including time-averaged pressure(TAP),time-averaged wall shear stress(TAWSS),oscillatory shear index(OSI),and particle relative residence time(RRT).Changes in these parameters were assessed quantitatively around the stenosis and near the region where subbranches were ***:The removal of subbranches caused a significant change in outflow rate,and there was generally a decrease in all CFD parameters in the regions of interest with a decrease in outflow *** subbranch removal had a significant impact on the calculation of TAWSS,OSI,and RRT,whereas TAP was insensitive to the removal with approximately 0.25%variation in all 19 *** local effect from removing branch segments generally became negligible after 5 diameters away from the cutting-off position,but the decrease could be affected by other factors,such as a large ***:The outflow rate is a dominant factor for the calculation of TAP,TAWSS,OSI,and *** of subbranches has a minor effect on the TAP calculation,but its effect is considerable on the TAWSS,OSI,and *** effect of subbranch removal is limited in a region with 5 local diameters.

关键词： Coronary artery Hemodynamics Pressure Shear stress Side branch Stenosis

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土钉支护技术在路基边坡工程中的应用

路基工程 2006年第3期 91-93页

作者：李素清中铁十八局温台甬铁路指挥部浙江温州325000

介绍了某路基边坡工程采用土钉技术支护的实例。通过选用合理的破裂面形式,用极限平衡理论进行设计和分析,并通过施工过程中的动态监测的反馈数据,及时调整支护参数、开挖深度和支护时间,控制了施工过程中边坡的变形,保证了软岩高边坡... 详细信息

介绍了某路基边坡工程采用土钉技术支护的实例。通过选用合理的破裂面形式,用极限平衡理论进行设计和分析,并通过施工过程中的动态监测的反馈数据,及时调整支护参数、开挖深度和支护时间,控制了施工过程中边坡的变形,保证了软岩高边坡的整体稳定。

关键词：边坡土钉支护技术信息化施工

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粉喷桩与土工织物联合加固软土地基的研究

铁道建筑 2006年第7期46卷 62-63页

作者：李素清中铁十八局甬台温铁路建设指挥部浙江台州317000

结合实际工程,对比采用粉喷桩和粉喷桩与土工织物联合加固软土地基的方法,试验测试了沉降量与沉降速率、路基上竖向变形和深层土的侧向位移,对比了加固效果,为今后类似工程提供了经验借鉴。

关键词：粉喷桩土工织物软土地基加固

晋西皇姑梁小流域人工植物群落优势种生态位和种间关系研究

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干旱区资源与环境 2017年第12期31卷 179-183页

作者：狄晓艳李素清山西大学黄土高原研究所太原030006

在野外102个样方调查数据和双向指示种分析法(TWINSPAN)分类的基础上,采用生态位宽度、生态位重叠、χ2检验和Spearman秩相关系数,对晋西皇姑梁小流域12个群落的12个优势种的生态位和种间关系进行了研究。结果表明:乔灌层Levins生态位... 详细信息

在野外102个样方调查数据和双向指示种分析法(TWINSPAN)分类的基础上,采用生态位宽度、生态位重叠、χ2检验和Spearman秩相关系数,对晋西皇姑梁小流域12个群落的12个优势种的生态位和种间关系进行了研究。结果表明:乔灌层Levins生态位宽度较大的种为油松、柠条锦鸡儿、沙棘。12个优势种组成的66个种对中,Pianka重叠指数≥0.4的种对占总对数的45.45%。呈极显著和显著关联的种对数较少,正负关联比均小于1。说明该小流域人工植物群落结构简单,种间资源竞争较激烈,仍处于演替的初、中期阶段。优势种华北落叶松与沙棘,沙棘与鹅观草呈显著正相关,它们均为地带性物种,生态适应性强,可作为皇姑梁小流域人工植被恢复的优选物种进行混种,而油松与小叶杨、小叶杨与沙棘或柠条锦鸡儿等种对间呈极显著负相关,在植被恢复中不宜混种。根据Spearman秩相关系数结果,将12个优势种划分为3个生态种组。

关键词：皇姑梁人工植物群落优势种生态位种间关系生态种组