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衣被蛋白复合物亚基β-2在膀胱癌中的分子机制研究

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泌尿外科杂志（电子版） 2024年第2期16卷 18-24页

作者：石泽玢李寿春左立张力峰无南京医科大学附属常州第二人民医院泌尿外科江苏常州213000 南京医科大学常州医学中心江苏常州213000 常州市第七人民医院泌尿外科江苏常州213000

目的研究衣被蛋白复合物亚基β-2(coatomer protein complex subunitβ2,COPB2)的表达对膀胱癌发病的影响,探讨COPB2在膀胱癌中的分子作用机制。方法从癌症基因组图谱(the cancer genome atlas,TCGA)数据库下载膀胱癌中COPB2的相关数据... 详细信息

目的研究衣被蛋白复合物亚基β-2(coatomer protein complex subunitβ2,COPB2)的表达对膀胱癌发病的影响,探讨COPB2在膀胱癌中的分子作用机制。方法从癌症基因组图谱(the cancer genome atlas,TCGA)数据库下载膀胱癌中COPB2的相关数据,探究COPB2的表达水平与预后关系。根据膀胱癌不同分期将样本进行分组。使用Kaplan-Meier法对不同组别间的生存情况进行分析。使用COPB2-shRNA慢病毒和阴性对照慢病毒感染5637细胞(人膀胱癌细胞),RT-qPCR和蛋白印迹检测细胞中COPB2表达变化。使用平板克隆实验评估细胞的增殖能力。对细胞中p27 kip1、半胱天冬酶-3和多腺苷二磷酸多聚酶的表达水平进行蛋白印迹检测。检测细胞中与上皮-间充质转化(epithelial-to-mesenchymal transition,EMT)相关的N-钙黏蛋白和Snail的表达水平。结果肿瘤免疫浸润评分数据库(tumor immune estimation resource,TIMER)显示,相比于正常膀胱,COPB2在膀胱癌中过表达。COPB2表达水平越高,患者预后越差(P<0.05)。COPB2敲低后膀胱癌细胞增殖能力减弱,凋亡相关蛋白表达增加,EMT相关蛋白表达减弱。结论COPB2在膀胱癌中的高表达显著促进膀胱癌发生发展,是一种有前途的膀胱癌治疗靶点。

关键词：衣被蛋白复合物亚基β-2 膀胱癌发病机制生物标志物治疗靶点

High Response Gas Sensors for Formaldehyde Based on Er-doped In_2O_3 Nanotubes

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Journal of Materials Science & Technology 2015年第12期31卷 1175-1180页

作者： Xuesong Wang Jinbao Zhang lianyuan Wang shouchun li li liu Chang Su lili liu State Key Laboratory of Superhard Materials College of PhysicsJilin University

Pure and Er-doped In 2O 3 nanotubes were systematically fabricated by using a single nozzle eletrospinning method followed by *** as-synthesized nanotubes were characterized by scanning electron microscopy（SEM）,energy-dispersive X-ray（EDX） spectrometry and X-ray powder diffraction（XRD）.Compared with pure In 2O 3 nanotubes,Er-doped In 2O 3 nanotubes exhibit improved formaldehyde sensing properties at 260 ℃.The response of Er-doped In 2O 3 nanotubes to 20 ppm formaldehyde is about 12,which is 4 times larger than that of pure In 2O 3 *** response and recovery times of Er-doped In 2O 3 nanotubes to 20 ppm formaldehyde are about 5 and 38 s,***,the response of Er-doped In 2O 3 nanotubes to 100 ppb formaldehyde is 2.19.

关键词： Er-doped In 2O 3 nanotubes Formaldehyde Gas sensor

Micro-structure sensors based on ZnO microcrystals with contact-controlled ethanol sensing

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Chinese Science Bulletin 2009年第23期54卷 4371-4375页

作者： liU li ZHANG Tong li shouchun WANG lianYuan TIAN YunXia College of Physics Jilin University Changchun 130012 China National Laboratory of Superhard Materials Jilin University Changchun 130012 China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changchun 130012. China

ZnO microcrystals are synthesized through a facile solution method and characterized by field-emission scanning electron microscopy, transmission electron microscopy, selected area electron diffraction and X-ray diffraction. The ethanol sensing properties of these microcrystals are investigated by spin-coating them on a silicon substrate with Pt electrodes to fabricate a micro-structure sensor. The sensitivity is up to 8 when the sensor is exposed to 50 ppm ethanol, and the response time and recovery time are 10 s and 20 s, respectively. A contact-controlled model is established to explain the sensing properties of the microcrystals, which provides another approach to realize high-performance gas sensors.

关键词：结构传感器微晶涂层控制模型氧化锌乙醇感应基础选区电子衍射

The morphological and molecular detection for the presence of toxic Cylindrospermopsis(Nostocales, Cyanobacteria) in Beijing city, China

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Journal of Oceanology and limnology 2018年第2期36卷 263-272页

作者： XIE Jinlin YU Gongliang XU Xudong li shouchun li Renhui College of life Sciences Jiangxi Normal University Nanchang 330022 China Key Laboratory of Algal Biology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China

Cylindrospermopsis raciborskii and its highly similar relatives Raphidiopsis species have been recognized as globally invasive and expansive filamentous cyanobacteria causing water blooms. Reports on C. raciborsMi/Raphidiopsis species and their harmful metabolites such as hepatotoxic cylindrospermopsins （CYNs） in Chinese waters have been increasing, but mostly restricted to the southern regions of China. To further explore the existence and distribution of C. raciborskii in China, six water samples from Beijing city were morphologically and molecularly examined. Five samples of the six were shown to have Cylindrospermopsis filaments with straight and spiral morphotypes. PCR detection targeting on Cylindrospermopsis/Raphidiopsis specific 16S rRNA gene region also showed the positive amplification, and such amplifications were confirmed by sequencing and phylogenetic analysis. As well, three of the five Cylindrospermopsis containing samples were shown to have cyrJ--a gene of CYN synthesis gene duster. The results represented the presence of toxic Cylindrospermopsis at the most northern line in China so far, indicating rapid expansion of this harmful invasive cyanobacterium. It is strongly suggested that the monitoring on C. raciborskii/Raphidiopsis species and their production of cylindrospermopsin should be emphasized in Beijing and even more northem parts of China.

关键词： Beijing Cyanobacteria Cylindrospermopsin Cylindrospermopsis raciborskii Raphidiopsis

Improved and excellent ethanol sensing properties of SnO_2/multiwalled carbon nanotubes

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Chinese Science Bulletin 2010年第4期55卷 382-385页

作者： liU li ZHUANG Juan liU KuiXue WANG lianYuan li shouchun li Wei li XiaoLong National Laboratory of Superhard Materials College of Physics Jilin University Changchun 130012 China School of Physics and Optoelectronic Engineering Dalian University of Technology Dalian 116024 China State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changchun 130012 China College of lnstrumentation and Electrical Engineering Jilin University Changchun 130026 China

SnO2/multiwalled carbon nanotubes (MWNTs) have been studied as gas sensing materials. Compared with pure SnO2, SnO2/MWNTs exhibit improved ethanol sensing properties such as higher sensitivity and quicker response/recovery at 300°C. The sensitivity is 35, 65, 166 and 243 to 500, 1000, 2000 and 3000 ppm ethanol, respectively. The response time is about 1 s, and the recovery time is about 5 s. The sensing improvement is explained in terms of the appropriate basal resistance and enhanced signal transfer brought by MWNTs.

关键词：多壁碳纳米管气敏性能乙醇斯诺 MWNTs 气敏材料响应时间信号传输

Synthesis and acetone gas sensing properties of α-Fe_2O_3 nanotubes

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Science China Chemistry 2013年第12期56卷 1722-1726页

作者： SHAN Hao liU ChangBai liU li WANG lianYuan li shouchun ZHANG XiaoBo BO XiaoQing CHI Xiao State Key Laboratory of Superhard Materials College of Physics Jilin University College of Electronic Science & Engineering Jilin University

α-Fe2O3 nanotubes was successfully prepared by single nozzle electrospinning method. Scanning electron microscope （SEM） was used to characterize the morphology of α-Fe2O3 nanotubes. The gas sensing properties of α-Fe2O3 nanotubes were investigated in detail. The results exhibit relatively good sensing properties to acetone at 240℃. The response and recovery times are about 3 and 5 s, respectively. The structure of nanotubes is beneficial to the gas sensing properties, which will enlarge the surface-to-volume ratio of α-Fe2O3 and then be available for the transfer of gas, and thus improved the sensor performance consequentially.

关键词： nanotubes gas sensor electrospinning

Polyphasic examination on Merismopedia tenuissima CHAB 7021 from Ganjiang River,China revealed the polyphyly of the genus Merismopedia(Cyanobacteria)

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Journal of Oceanology and limnology 2018年第4期36卷 1157-1165页

作者： SHEN liqin MA Suchao CAI Fangfang YU Gongliang li shouchun li Renhu College of life Science Jiangxi Normal University Nanchang 330022 China Key Lab of Algal Biology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China University of Chinese Academy of Sciences Beijing 100049 China

Species in the cyanobacterial genus Merismopedia are present in freshwaters at different trophic levels, with some species even as the components of cyanobacterial blooms. However, species diversity in this genus was not fully verified by molecular investigation and polyphasic taxonomic studies. In this study, Merismopedia-like strain tenuissima CHAB 7021 was isolated from Ganjiang River in Jiangxi Province, China, and polyphasic characterization of this strain was performed by morphological observation, ultrastructural examination, chemical detection of pigments and phylogenetic analysis based on 16 S rRNA gene sequences. Morphological identification of the strain was supported by the ultrastructural features, as the tiny species Merismopedia tenuissima Lemmermann. The phylogeny based on 16 S rRNA gene sequences revealed at least three clades formed by the strains of Merismopedia. The three M. tenuissima strains including M. tenuissima CHAB 7021 was gathered in clade III with distant relationship to the clade I formed by the six Merismopedia strains including the type species M. punctata, and such a genetic distance may propose Merismopedia tenuissima to separate from Merismopedia genus. However intermixture relationship in between strains of M. punctate and M. glauca in the phylogenetic tree still complicated the taxonomic status in the genus Merismopedia. The process for taxonomic revision in the Merismopedia genus still await for examination and further information on more strains of type species M. punctata.

关键词： cyanobacteria Merismopedia polyphasic phylogeny taxonomic revision

Analysis of impact pressure,rock-breaking effect,and ground vibration induced by the disposable CO_(2)fracturing tube

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第8期16卷 3099-3121页

作者： Chong Yu Yongan Ma Haibo li shouchun Deng Yafei Hao Kuan Zhu State Key Laboratory of Geomechanics and Geotechnical Engineering Institute of Rock and Soil MechanicsChinese Academy of SciencesWuhan430071China University of Chinese Academy of Sciences Beijing100049China Explosives Co.Ltd. Changsha410000China Wuhan University of Science and Technology Wuhan430000China Gezhouba EXPL(Hunan)Technology Co.Ltd. Liuyang410300China

The technology of expansion fracturing with liquid CO_(2)(EFLCO_(2))has attracted increasing attention due to reduced vibration and *** disposable fracturing tube has been developed and is gradually replacing the Cardox ***,there is a lack of impact pressure testing of disposable tubes under real working conditions,selection of gas explosion design parameters,and systematic analysis of blasting *** limitation has constrained the widespread application of disposable fracturing tubes in engineering.A joint monitoring of the pressure-time curves in the disposable tubes and boreholes was *** rock-breaking effect of varying hole spacing parameters in the EFLCO_(2)design was analyzed,and a systematic study was carried out on the vibration peak value,frequency,and energy *** results show that(1)the pressure distribution characteristics,stress peak value,and duration in the disposable tubes are different from those of Cardox tubes,which show multi-peak distribution,low-pressure peak value,and short *** correlation between the pressure in the disposable tube,filling pressure,and liquid CO_(2)weight is established,and a theoretical calculation method for the borehole wall pressure is proposed;(2)The hole spacing in rocks of different hardness is suggested;and(3)At the same scale distance,the peak particle velocity(PPV)caused by EFLCO_(2)(PPVCO_(2))is significantly smaller than that caused by blasting(PPVexplosive).The ratio of PPVexplosive to PPVCO_(2)is a power function related to scale distance,and a distance-related zonality exist in this *** frequency composition of the vibration signal caused by EFLCO_(2)is relatively simple with a narrow frequency *** PPV and energy are mainly concentrated in the low-frequency *** research contributes to the optimization of disposable fracturing tubes,gas explosion design,and vibration hazard control.

关键词： Disposable tube liquid CO_(2) Impact pressure Hole spacing Vibration effect Cardox tube

Progress of additives for morphology control in organic photovoltaics

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Chinese Chemical Letters 2024年第6期35卷 38-46页

作者： Zhongjie li Xiangyue Kong Yuhao liu Huayu Qiu lingling Zhan shouchun Yin Key Laboratory of Organosilicon Chemistry and Materials Technology of Ministry of Education College of MaterialChemistry and Chemical EngineeringHangzhou Normal UniversityHangzhou 311121China

The microstructure of the active layer in organic photovoltaics(OPVs),such as the size of phase separation,purity of the phases,and molecular packing within each phase,plays a crucial role in influencing the behavior of excitons and charge carriers within the active *** is also a key determinant of the photovoltaic performance of the *** the optimization of OPV devices,the use of additives has been demonstrated to be an effective strategy in microstructure control,leading to enhanced ***,the quest for stable and efficient novel additives,along with an exploration and summarization of the mechanisms underlying additive-induced microstructure control,is essential for a better understanding of the developmental trends of high-performance *** this review,we categorize additives based on their chemical structures and discuss their effects on the microstructure of the active layer from both thermodynamic and kinetic ***,we elaborate on the working mechanisms and their impact on the photovoltaic performance of the *** review provides an overview of recent advances in additives for OPVs,offering potential guidance for the future development of additives and further optimization of the active layer in photovoltaic devices.

关键词： Organic photovoltaics Additives Active layer morphology Mechanisms Photovoltaic performances