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Psychological trauma of funnel chest in adolescents and the appropriate age for minimally invasive surgery repair

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Chinese Medical Journal 2013年第15期126卷 2876-2880页

作者： ZHAO Jing LUO li XIAO li-jun GU ling-yun SUN Tian-sheng Beijing Peoples liberat Army Mil Gen Hosp Dept Thorac Surg Beijing 100700 Peoples R China Beijing Peoples liberat Army Mil Gen Hosp Dept Psychol Beijing 100700 Peoples R China Beijing Peoples liberat Army Mil Gen Hosp Dept Tradit Chinese Med Beijing 100700 Peoples R China Beijing Peoples liberat Army Mil Gen Hosp Dept Osteol Beijing 100700 Peoples R China Beijing Peoples liberat Army Mil Gen Hosp Bayi Children Hosp Beijing 100700 Peoples R China

Background Funnel chest has a negative effect on adolescents and it has a strong effect on adolescents＇ psychological and behavior. This study aimed to investigate the psychological characteristics and factors that affect adolescents with funnel chest and to evaluate the relationship between the patients＇ age and their physiological and psychological health. We aimed to establish an age model for maximum surgery benefits for funnel chest patients to provide an objective basis for choosing surgery. Methods The study adopted a general evaluation approach to assess the risk and benefits of minimally invasive surgery for funnel chest. The funnel chest index, the Symptom Checklist-90, and the Eysenck Personality Questionnaire were used as assessment tools to observe physiological and psychological features in funnel chest patients. A sample of 234 adolescents with funnel chest was selected from a third-grade class-A hospital in Beijing. Age groups were adopted as an independent variable, and other factors in funnel chest patients were dependent variables. Results There was a significant difference in the relapse rate for funnel chest in the different age groups （X2=11.883, P=-O.008）. There was a higher relapse rate in patients of 〈10 or 〉-19 years old than in patients of 11-18 years old. There was a significant difference in the SCL-90 total score in the different age groups （F=12.538, P=-0.0001）, the patients older than 13 years had a higher score than those younger than 13 years in the SCL-90. There was a significant difference in the standard score of E （introversion/extraversion） in the different age groups （F=10.06, P=0.0001）. There was also a significance in the funnel chest index before surgery in the different psychological scales （P〈0.01）, with a higher funnel chest index score associated with more obvious psychological trauma. Age and the number of variables, including the relapse rate, SCL-90 score, standard score of E, and standard score of N in the EPQ were

关键词： nuss, surgical procedures, minimally invasive funnel chest mental disorders operation optimum age

Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia

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Neural Regeneration Research 2025年第5期20卷 1397-1398页

作者： Zhenyu Chen Xue-jun li Department of Biomedical Sciences University of Illinois College of Medicine RockfordRockfordILUSA Department of Bioengineering University of Illinois at ChicagoChicagoILUSA

Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower *** is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.

关键词： degeneration diseases hereditary

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空间多点地震动模拟的并行计算方法及软件

系统仿真学报 2005年第5期17卷 1068-1071页

作者：李丽君金先龙上海交通大学高性能计算中心上海200030

在已有的空间相关多点地震动人工模拟方法的基础上,针对整个模拟过程提出对计算量大的部分进行并行计算,并采用Fortran90与MPI语言开发了多点地震动的并行模拟程序,能够有效提高多点地震动模拟的规模与效率;同时,通过对商业性前后处理... 详细信息

在已有的空间相关多点地震动人工模拟方法的基础上,针对整个模拟过程提出对计算量大的部分进行并行计算,并采用Fortran90与MPI语言开发了多点地震动的并行模拟程序,能够有效提高多点地震动模拟的规模与效率;同时,通过对商业性前后处理有限元软件的二次开发,将多点地震动并行模拟程序作为模块嵌入原软件,使用户能够通过可视化界面方便快捷地应用人造地震动,使人造地震动与结构地震响应分析成为一个完整的流程。

关键词：地震动非平稳并行数据分布加速比

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复杂网络能控性鲁棒性研究进展

自动化学报 2022年第10期48卷 2374-2391页

作者：楼洋李均利李升邓浩四川师范大学计算机科学学院成都610101 香港城市大学电机工程学系中国香港999077

研究复杂网络能控性鲁棒性对包括社会网络、生物和技术网络等在内的复杂系统的控制和应用具有重要价值.复杂网络的能控性是指:可通过若干控制节点和适当的输入,在有限时间内将系统状态驱动至任意目标状态.能控性鲁棒性则是指在受到攻击... 详细信息

研究复杂网络能控性鲁棒性对包括社会网络、生物和技术网络等在内的复杂系统的控制和应用具有重要价值.复杂网络的能控性是指:可通过若干控制节点和适当的输入,在有限时间内将系统状态驱动至任意目标状态.能控性鲁棒性则是指在受到攻击的情况下,复杂网络依然维持能控性的能力.设计具有优异能控性鲁棒性的复杂网络模型和优化实际网络的能控性鲁棒性一直是复杂网络领域的重要研究内容.本文首先比较了常用的能控性鲁棒性定义及度量,接着从攻击策略的角度分析了3类攻击的特点及效果,包括随机攻击、基于特征的蓄意攻击和启发式攻击.然后比较了常见模型网络的能控性鲁棒性.介绍了常用优化策略,包括模型设计和重新连边等.目前的研究在攻击策略和拓扑结构优化方面都取得了进展,也为进一步理论分析提供条件.最后总结全文并提出潜在研究方向.

关键词：复杂网络能控性鲁棒性攻击优化

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统一授信模式下基于道德风险的收益分配模型

东北大学学报（自然科学版） 2020年第6期41卷 896-901页

作者：李丽君衣峻林程富东北大学工商管理学院辽宁沈阳110169

存货质押融资统一授信模式下,银行与物流企业间的信息不对称易使物流企业产生授信审查不努力道德风险,银行作为委托人需要设计激励机制加以防范,收益分配作为一种激励机制,可以对道德风险起到约束作用.基于存货质押统一授信模式,考虑物... 详细信息

存货质押融资统一授信模式下,银行与物流企业间的信息不对称易使物流企业产生授信审查不努力道德风险,银行作为委托人需要设计激励机制加以防范,收益分配作为一种激励机制,可以对道德风险起到约束作用.基于存货质押统一授信模式,考虑物流企业授信审查不努力道德风险,运用委托代理理论研究银行对物流企业的激励问题,构建银行收益分配模型,得到最优收益分配比例决策,并通过数值算例分析了最优收益分配比例变动趋势.研究表明,存在最优收益分配比例使物流企业投入最优努力水平,实现双方联合收益最大化.

关键词：存货质押融资统一授信模式道德风险激励机制收益分配

基于micro-CT图像的骨复合体素模型建模研究

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原子能科学技术 2014年第S1期48卷 773-779页

作者：任丽邱睿武祯李君利清华大学工程物理系粒子技术与辐射成像教育部重点实验室高能辐射成像重点学科实验室北京100084

已建立的人体体素模型中,骨松质均采用均匀模型代替,使骨剂量的计算精度受到影响。目前国际上利用白种人骨松质的NMR、micro-CT图片开展了骨微观模型的建模及剂量学研究,但我国尚未开展这方面的研究。本文利用micro-CT成像,建立了基于... 详细信息

已建立的人体体素模型中,骨松质均采用均匀模型代替,使骨剂量的计算精度受到影响。目前国际上利用白种人骨松质的NMR、micro-CT图片开展了骨微观模型的建模及剂量学研究,但我国尚未开展这方面的研究。本文利用micro-CT成像,建立了基于中国人骨松质的骨微观模型,同时与已建立的中国成年男性参考体素模型中的宏观骨模型相结合,建立了骨复合体素模型。利用该模型初步计算了骨盆骨小梁体源、骨小梁面源和红骨髓源对骨内膜的电子吸收分数。计算结果显示,基于中国人骨松质的骨微观模型计算的吸收分数曲线变化趋势与白种人的计算结果一致,最大差异分别为5.7%、1.4%和2%。

关键词： micro-CT 骨模型体素模型

Effects of insulin, insulin-like growth factor-I and -II on proliferation and intracellular signaling in endometrial carcinoma cells with different expression levels of insulin receptor isoform A

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Chinese Medical Journal 2013年第8期126卷 1560-1566页

作者： WANG Chun-fang ZHANG Guo ZHAO li-jun li Xiao-ping QI Wen-juan WANG Jian-liu WEI li-hui Department of Obstetrics and Gynecology Peking UniversityPeople's Hospital Beijing 100044 China

Background Hyperinsulinemia, insulin-like growth factor （IGF）-I and -Ⅱ （IGF-Ⅱ） are associated with increased risk of endometrial carcinoma. Insulin receptor isoform A （IR-A） is more frequently expressed in endombtrial carcinoma than in normal endometrial tissues. To better understand their roles in endometrial carcinoma, we investigated the effects of insulin, IGF-I, and IGF-II in endometrial carcinomas cells with different IR-A expression levels. Methods To explore the role of IR-A in mediating the activity of IGF-I, IGF-II, and insulin, we investigate the cellular proliferation of endometrial carcinoma cell lines RL95-2 and RL95-2-1R-A by MTS assays. Then we examined the protein kinase Akt phosphorylation and extracellular signal-regulated kinase （ERK） 1/2 phosphorylation in both cell lines by Western blotting. The effect of IGF-II and AG1024 on cell cycle progression and apoptosis was assessed by fiowcytometry. To examine whether the effects of IGFs were mediated by IR-A, we blocked IGF-I receptor （IGF-IR） in both cell lines using AG1024, an IGF-IR-specific inhibitor. Results IGF-I and IGF-II significantly enhanced proliferation of both cell lines （P 〈0.05）. By contrast, insulin significantly increased proliferation of RL95-2-1R-A cells only （P 〈0.05）. IGF-I and IGF-II significantly increased pAkt levels in RL95-2 cells and pERK1/2 levels in RL95-2-1R-A cells （all, P 〈0.05）. Insulin increased pERK1/2 levels in RL95-2-1R-A cells only （P 〈0.05）. LY294002 and PD98059 inhibited the specific signaling activities and cellular proliferation. After AG1024 pretreatment, neither IGF-I nor IGF-II affected pAkt levels in RL95-2 cells. IGF-II, but not IGF-I, increased pERK1/2 levels in RL95-2-1R-A cells. After AG1024 pretreatment, the proliferation rate and DNA content corresponding to the S phase increased and apoptosis decreased significantly in IGF-II-treated RL95-2-1R-A cells only （P 〈0.05）. Conclusions The proliferation effect of insulin is mediated by IR-A. When IR-A do

关键词： endometrial carcinoma, insulin receptor isoform A insulin, insulin-like growth factor-I insulin-like growth factor-Ⅱ

Aluminum（Ⅲ）ion sensor based on the sensitive membrane containing ***2O3 powders

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Journal of Chemistry and Chemical Engineering 2008年第4期2卷 47-52页

作者： MA Chuan-li HE li-jun, TIAN li-fang WANG Chun-ming （School of Chemistry. and Chemical Engineering Lanzhou University Lanzhou 730000 China

An AI^3＋ sensor based on the membrane of acetyl cellulose containing nano γ-Al2O3 crystals was studied. In the buffer solution of 0.5 mol/L CH3COOH-CH3COONa （pH=5.0）, the sensor responds to AI^3＋ in a linear range from 1.00×10^-5 to 1.00x10-^2 mol/L. A near-Nernstian response was obtained and the regression equation was E （mv） = -161.4-26.54 Ig [AI^3＋] with a detection limit of 7.90x10^-6 mol/L. More than 14 different ions as the considered interferences were tested and the relevant selectivity coefficients were determined using the separate solution method （SSM）. The sensor possesses many advantages including short conditioning time, fast response, and, especially, very good selectivity over a wide variety of other co-existing ions. The sample analysis on the aluminium migration amount from aluminium utensils to the solution was determined by this sensor. The analytical results were agreed with that of inductively coupled plasma-atomic emission spectroscopy（ICP-RES）.

关键词： sensor aluminum (Ⅲ) acetyl cellulose membrane nano γ-Al2O3

GC-MS STUDY ON DIURETICS IN URINE Ⅱ.DETECTION METHOD USING TRIMETHYLSILYLATION

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Chinese Chemical Letters 1991年第1期2卷 19-22页

作者： Ya Wei li jun li Tong Hui ZHOU Institute of Materia Medica,Chinese Academy of Medical Sciences Beijing 100050,China

A reliable method is described for the detection of amitoride,triamterene. canrenone and spironolactone in human urine using GC-MS analysis after *** mass spectrometric and metabotic features of the compounds are disc... 详细信息

关键词： mode GC-MS STUDY ON DIURETICS IN URINE DETECTION METHOD USING TRIMETHYLSILYLATION OC MS