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An efficient quantum proactive incremental learning algorithm

Science China(Physics,Mechanics & Astronomy) 2025年第1期Mechanics & Astronomy) .卷 49-57页

作者： lingxiao li jing li Yanqi Song Sujuan Qin Qiaoyan Wen Fei Gao State Key Laboratory of Networking and Switching Technology Beijing University of Posts and Telecommunications School of Cyberspace Security Beijing University of Posts and Telecommunications

In scenarios where a large amount of data needs to be learned, incremental learning can make full use of old knowledge, significantly reduce the computational cost of the overall learning process, and maintain high performance. In this paper, taking the MaxCut problem as our example, we introduce the idea of incremental learning into quantum computing, and propose a Quantum Proactive Incremental Learning algorithm(QPIL). Instead of a one-off training of quantum circuit, QPIL contains a multi-phase training on gradually-increased subgraphs of all vertices, proactively reducing large-scale problems to smaller ones to solve in steps, providing an efficient solution for MaxCut. Specifically, some vertices and corresponding edges are randomly selected for training to obtain optimized parameters of the quantum circuit at first. Then, in each incremental phase, the remaining vertices and corresponding edges are gradually added and the parameters obtained from the previous phase are reused in the parameter initialization of the current phase. We perform experiments on 120 different small-scale graphs, and it shows that QPIL performs superior to prevalent quantum and classical baselines in terms of approximation ratio(AR), time cost, anti-forgetting, and solving stability. In particular, QPIL's AR surpasses 20% of mainstream quantum baselines, and the time cost is less than 1/5 of them. The idea of QPIL is expected to inspire efficient and high-quality solutions in large-scale Max Cut and other combinatorial optimization problems.

关键词： variational quantum algorithm incremental learning multi-phase training MaxCut quantum computing

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： jing li Zixuan He Weitai Chai Meng Tian Huali Yu Xiaoxiao He Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu Leng Lei Ma Yu Zheng Ruizhi li Yin Wang Peifeng li Hai Zhu Dong Wang jing li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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基于熵权与集成学习的半监督小样本树种分类研究

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森林工程 2025年第1期41卷 151-161页

作者：王静李静河南机电职业学院信息工程学院郑州451191 河南科技大学信息工程学院河南洛阳471000

针对传统半监督自训练分类方法易导致数据集混乱,影响后续小样本树种分类精度这一问题,基于熵权法(en-tropy weight,EW)与集成学习(ensemble learning,EL)提出EW-EL的半监督小样本树种分类方法。EW-EL在传统半监督自训练分类方法的理论... 详细信息

针对传统半监督自训练分类方法易导致数据集混乱,影响后续小样本树种分类精度这一问题,基于熵权法(en-tropy weight,EW)与集成学习(ensemble learning,EL)提出EW-EL的半监督小样本树种分类方法。EW-EL在传统半监督自训练分类方法的理论上引入EL的思想,以熵权法作为基础理论设计按基分类器当前训练周期下的F1分数计算的信息熵作为计算权重因子,再依信息熵越大基分类器越不稳定思想设计权重,使集成分类器分类概率更集中,减少集成分类器偏向性。结果显示,EW-EL较传统半监督自训练方法能更有效地均衡数据分布,使新加入数据的伪标签样本类别更准确。EW-EL所得到的小样本树种分类总精度(OA)为0.97、召回率(Recall)为0.96及Kappa系数为0.97,3种指标均优于监督分类、传统半监督自训练方法及利用传统EL机制所构建的半监督自训练方法。其中,EW-EL方法较融合软投票机制的半监督自训练方法,OA与Recall均提升了1%。EW-EL联合简单线性迭代聚类所制成的树种图在所选测试区内达到了94%。此外,进一步分析证明,EW-EL能通过集成诸多分类器,来实现更佳的小样本树种分类结果,更适用于低成本下的相关部门进行林业资源统计的工作。

关键词：无人机影像熵权法深度学习集成学习半监督小样本分类树种分类树种制图 EW-EL

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Bifunctional bridging capping layer enables 24.5% efficiency of perovskite solar cells with polymer-based hole transport materials

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Science China Chemistry 2025年第1期 350-359页

作者： Can Zhu Yiyang Wang Lei Meng Beibei Qiu jing li Shucheng Qin Ke Hu Xin Jiang Wenbin Lai Minchao liu Zhe liu Chenxing Lu Jinyuan Zhang Yongfang li Beijing National Laboratory for Molecular Sciences CAS Key Laboratory of Organic Solids Institute of Chemistry Chinese Academy of Sciences School of Chemical Science University of Chinese Academy of Sciences Key Laboratory of Solid State Optoelectronic Devices of Zhejiang Province College of Physics and Electronic Information Engineering Zhejiang Normal University Key Laboratory of Photochemical Conversion and Optoelectronic Materials Technical Institute of Physics and ChemistryChinese Academy of Sciences Laboratory of Advanced Optoelectronic Materials College of Chemistry Chemical Engineering and Materials ScienceSoochow University

Developing a bridge capping layer between perovskite and hole transport layer materials（HTMs） in the n-i-p perovskite solar cells（pero-SCs） is an effective approach to modify the morphology of HTMs and passivate the perovskite ***, we select the quinoxaline-based bifunctional passivation agent, quinoxalin-6-yl-methylamine hydrochloride（Qx MACl）,as the bridging layer, and a D-A copolymer PBQ12 containing the same quinoxaline unit as an HTM for the n-i-p pero-SCs. Due to the π-π stacking among the common quinoxaline units in the bridge layer and HTM, Qx MACl induces the π-π stacking of the PBQ12 film and improves the film morphology of HTMs with better conductivity. Additionally, Qx MACl can effectively passivate the perovskite surface, and PBQ12 possesses appropriate energy levels and high hole mobility. The pero-SCs based on FAPbI3with PBQ12/Qx MACl treatment showed a higher power conversion efficiency（PCE） of 24.05% and outstanding stability, maintaining 95.4% and 92.1% of its initial PCE after 750 h of storage and after over 800 h of thermal annealing at 85 °C, respectively. To further enhance the PCE of the PBQ12/Qx MACl-based devices, we developed a non-metal ion dopant for the PBQ12 HTM. Through trace doping of PBQ12 HTM by the non-metal ion dopant, the PCE of the PBQ12/Qx MACl-based devices reached 25.24%（the calibrated PCE of 24.55% by the National Institute of Metrology, China）.

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逐向导航辅助对大尺度环境下空间记忆的影响及改进方法

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心理科学进展 2025年第1期33卷 77-91页

作者：张艳霞李晶南京师范大学心理学院南京210097

科技的迅速发展使得人的行为越来越“自动化”,借助逐向导航人们可以按照正确路线快速到达目的地,然而如此高效率的寻路方式带来的可能是空间记忆的削弱。众多研究结果显示逐向导航辅助不利于空间知识的获取,研究者们开始改进逐向导航... 详细信息

科技的迅速发展使得人的行为越来越“自动化”,借助逐向导航人们可以按照正确路线快速到达目的地,然而如此高效率的寻路方式带来的可能是空间记忆的削弱。众多研究结果显示逐向导航辅助不利于空间知识的获取,研究者们开始改进逐向导航或设计新的导航系统。在此基础上本文提出了逐向导航辅助对空间记忆的影响模型,针对如何改进逐向导航提出相关建议。未来研究应改进大尺度环境下空间知识的测量方法,探究逐向导航辅助削弱空间记忆的神经机制,关注个体因素的影响以构建一个更全面的解释机制,开发兼具寻路效率和空间知识获取的新导航系统。

关键词：逐向导航导航辅助空间记忆

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Reducibility for Schrodinger Operator with Finite Smooth and Time-Quasi-periodic Potential

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Chinese Annals of Mathematics,Series B 2020年第3期41卷 419-440页

作者： jing li School of Mathematics Shandong UniversityJi5nan 250100China School of Mathematics and Statistics Shandong UniversityWeihai 264209ShandongChina

In this paper, the author establishes a reduction theorem for linear Schr?dinger equation with finite smooth and time-quasi-periodic potential subject to Dirichlet boundary condition by means of KAM(Kolmogorov-Arnold-Moser) technique. Moreover, it is proved that the corresponding Schr?dinger operator possesses the property of pure point spectra and zero Lyapunov exponent.

关键词： Reducibility Quasi-periodic Schrodinger operator KAM theory Finite smooth potential Lyapunov exponent Pure-Point spectrum

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Mesh-supported V2O5-WO3/TiO2 nanosheet array catalysts for efficient removal of NOx

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Tungsten 2025年第1期 100-111页

作者： Zhi-Qi Zhang liu Yang Wen Luo Vladimir An jing li Bao-Dan liu School of Materials Science and Engineering Northeastern University Foshan Graduate School of Innovation Northeastern University Kizhner Research Center School of Advanced Manufacturing Technologies Tomsk Polytechnic University

The design and synthesis of vanadium-based denitration catalysts with low-temperature activity pose significant challenges in the field of toxic gas *** this study,we have developed a novel approach to fabricate highly efficient V2O5-WO3/TiO2monolithic mesh catalysts for NOxreduction at low ***,TiO2nanosheets with strong adhesion and large surface area were grown on Ti mesh using plasma electrolytic oxidation technology and hydrothermal ***,super-small traces of WO3and V2O5active nano-species were subsequently deposited on TiO2nanosheets using the deposition-precipitation *** to traditional ceramic-based V2O5-WO3/TiO2catalysts,our V2O5-WO3/TiO2monolithic mesh catalyst exhibits superior mechanical performance,excellent thermal conductivity,lower pressure drop,higher utilization of active components,and stronger synergistic ***,the V2O5-WO3/TiO2monolithic mesh catalysts exhibited excellent low-temperature catalytic activity with 98% of NOxconversion at 220℃,and remarkable long-term SO2tolerance and water resistance in the selective catalytic reduction（SCR） of NOxwith *** SCR reaction of tiny V2O5and WO3active species supported on TiO2nanosheets directly demonstrated to follow the Eley-Rideal mechanism by in situ infrared spectra.

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乌司他丁治疗急性重度一氧化碳中毒脑损伤的疗效和机制

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脑与神经疾病杂志 2025年第1期33卷 44-48页

作者：杨蕊李伟李敬河北医科大学哈励逊国际和平医院重症监护室

目的探讨早期应用乌司他丁（UTI）治疗急性重度一氧化碳中毒（ASCMP）脑损伤的临床疗效。方法选取哈励逊国际和平医院重症监护室2020年2月至2023年2月收治的ASCMP患者210例,根据治疗方案的不同分为常规组90例和观察组120例。观察组在... 详细信息

目的探讨早期应用乌司他丁（UTI）治疗急性重度一氧化碳中毒（ASCMP）脑损伤的临床疗效。方法选取哈励逊国际和平医院重症监护室2020年2月至2023年2月收治的ASCMP患者210例,根据治疗方案的不同分为常规组90例和观察组120例。观察组在常规治疗基础上给予UTI注射液30万单位+5%葡萄糖注射液100ml,静脉滴注,8·h-1,连续14d。分别于治疗前,治疗后5d、14d,检测内皮素-1（ET-1）、多配体蛋白聚糖-1 （SDC-1）、透明质酸（HA）、血栓调节蛋白（TM）、S100钙结合蛋白β（S100B）、神经元特异性烯醇化酶（NSE）以及监测脑电双频指数（BIS）。记录美国国立卫生研究院卒中量表（NIHSS）评分和蒙特利尔认知评估量表（MoCA）评分。结果治疗后,观察组总有效率高于常规组,差异有统计学意义（χ2=4.269,P=0.033）。观察组昏迷时间短于常规组,平均住院天数较常规组减少,差异有统计学意义（P0.05）。治疗后5d,SCD-1、HA、TM、ET-1、S100β、NSE、NIHSS评分低于治疗前,BIS评分、MoCA评分高于治疗前,治疗后14 d,SCD-1、HA、TM、ET-1、S100β、NSE、NIHSS评分低于治疗后5 d,BIS评分、MoCA评分高于治疗后5 d,观察组各检测指标改善均优于常规组,差异有统计学意义（P<0.01）。采用Logistic逐步回归,结果显示:SCD-1、HA升高、BIS降低的ASCMP患者发生持续性神经精神后遗症（PNS）的危险因素升高。结论 UTI通过改善血管内皮功能及减轻内皮糖萼脱落来降低血-脑脊液屏障（BCFB）通透性,降低S100β、NSE,提高BIS,促进神经功能损伤的恢复,降低PNS的发生。

关键词：急性重度一氧化碳中毒脑损伤乌司他丁治疗

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Ni-Cu bimetallic alloy anchored on nitrogen-doped carbon nanotubes for CO_(2)-to-CH_(4) electrochemical conversion

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Nano Research 2024年第8期17卷 6922-6930页

作者： jing li Chuanyong jing Jin Wang School of Environment Beijing Key Laboratory of Aqueous Typical Pollutants Control and Water Quality SafeguardBeijing Jiaotong UniversityBeijing 100044China State Key Laboratory of Environmental Chemistry and Ecotoxicology Research Center for Eco-Environmental SciencesChinese Academy of SciencesBeijing 100085China Tangshan Research Institute Beijing Jiaotong UniversityTangshan 063000China

Electrocatalytic CO_(2) reduction to CH_(4) remains challenging due to multi-electron transfer and intermediates ***,we synthesized electrocatalysts by growing Ni-Cu alloy structure on nitrogen-doped carbon nanotubes(NixCuy-NCNT)for electrocatalytic CO_(2) reduction reaction(CO_(2)RR)via hydrothermal method followed by *** optimized Ni_(1)Cu_(1)-NCNT demonstrated a superior CO_(2)RR performance,achieving 99.7%FECH_(4)(FE=Faradaic efficiency)and 11.54 mA·cm^(−2) current density at−1.2 V *** hydrogen electrode(RHE),which outperformed single metal *** outstanding performance was due to the electrons transferred from Cu to Ni and Ni-Cu alloy shifted the d-band center toward the Fermi level,which was more conducive to the intermediate *** situ electrochemical attenuated total reflection(EC-ATR)and density functional theory(DFT)calculations revealed the appearance of *CHO intermediate and the pathway during the CO_(2)RR *** design of the bimetallic electrocatalyst in this study provides a new perspective for the highly selective reduction of CO_(2).

关键词： electrocatalytic CO_(2) reduction Ni-Cu alloy nitrogen-doped carbon nanotube(NCNT) electrochemical attenuated total reflection(EC-ATR) density functional theory(DFT)calculations

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