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Unraveling the complex roles of macrophages in obese adipose tissue:an overview

Frontiers of Medicine 2024年第2期18卷 205-236页

作者： chang Peng Jun Chen Rui Wu Haowen Jiang Jia li Hangzhou Institute for Advanced Study University of Chinese Academy of SciencesHangzhou310000China State Key Laboratory of Drug Research Shanghai Institute of Materia MedicaChinese Academy of SciencesShanghai201203China University of Chinese Academy of Sciences Beijing100049China Department of Prosthodontics Shanghai Engineering Research Center of Advanced Dental Technology and MaterialsShanghai Key Laboratory of Stomatology&Shanghai Research Institute of StomatologyNational Clinical Research Center for Oral DiseasesShanghai Ninth People’s HospitalCollege of StomatologyShanghai Jiao Tong University School of MedicineShanghai200011China

Macrophages,a heterogeneous population of innate immune cells,exhibit remarkable plasticity and play pivotal roles in coordinating immune responses and maintaining tissue homeostasis within the context of metabolic *** activation of inflammatory macrophages in obese adipose tissue leads to detrimental effects,inducing insulin resistance through increased inflammation,impaired thermogenesis,and adipose tissue ***,adipose tissue macrophages also play a beneficial role in maintaining adipose tissue homeostasis by regulating angiogenesis,facilitating the clearance of dead adipocytes,and promoting mitochondrial *** the heterogeneity of macrophages in obese adipose tissue is crucial for unraveling the pathogenesis of obesity and holds significant potential for targeted therapeutic ***,the dual effects and some potential regulatory mechanisms of macrophages in adipose tissue have been elucidated using single-cell *** this review,we present a comprehensive overview of the intricate activation mechanisms and diverse functions of macrophages in adipose tissue during obesity,as well as explore the potential of drug delivery systems targeting macrophages,aiming to enhance the understanding of current regulatory mechanisms that may be potentially targeted for treating obesity or metabolic diseases.

关键词： obesity inflammation adipose tissue macrophages adipose tissue homeostasis

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Sustainability-oriented social responsibility and corporate innovation

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China Journal of Accounting Research 2024年第2期17卷 193-215页

作者： li chang Qian Yu School of Accounting Dongbei University of Finance and EconomicsChina

This paper empirically examines how sustainability-oriented social responsibility influences corporate innovation quantity and radical innovation from the perspectives of environment-and employee-oriented social *** forms of social responsibility are found to contribute significantly to corporate *** environment-oriented responsibility increases innovation by increasing R&***-oriented responsibility increases innovation by helping firms retain talent;by motivating employees,employeeoriented social responsibility promotes both innovation quantity and radical ***,both environment-and employee-oriented responsibility can alleviate financing constraints,and the positive effects of environment-and employee-oriented responsibility on radical innovation and innovation quantity,respectively,increase total factor ***lowing sustainable development theory,this paper analyzes the heterogeneous mechanisms of the influences of environment-and employee-oriented social responsibility on corporate innovation and provides empirical evidence of high-quality,innovation-driven corporate development through social responsibility.

关键词： Sustainable Development Theory Corporate Social Responsibility Innovation Quantity Radical Innovation

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Data-driven surrogate model for aerodynamic design using separable shape tensor method

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Chinese Journal of Aeronautics 2024年第9期37卷 41-58页

作者： Bo PANG Yang ZHANG Junlin li Xudong WANG Min chang Junqiang BAI State Key Laboratory for Srrenglh and Vibration of Mechanical Structures Xi'an Jiaotong UniversityXi'an 710049China Unmanned System Research Institute Northwestern Polytechmical UniversityXi'an 710072China

In the context of increasing dimensionality of design variables and the complexity of con-straints,the effcacy of Surrogate-Based Optimization(SBO)is *** traditional linear and nonlinear dimensionality reduction algorithms are mainly to decompose the mathematical matrix composed of design variables or objective functions in various forms,the smoothness of the design space cannot be guaranteed in the process,and additional constraint functions need to be added in the optimization,which increases the calculation *** study presents a new parameterization method to improve both problems of *** new parameterization is addressed by decoupling affine transformations(dilation,rotation,shearing,and translation)within the Grassmannian sub-manifold,which enables a separate representation of the physical information of the airfoil in a high-dimensional *** upon this,Principal Geodesic Analysis(PGA)is employed to achieve geometric control,compress the design space,reduce the number of design variables,reduce the dimensions of design variables and enhance predictive performance during the surrogate optimiza-tion *** comparison,a dimensionality reduction space is defined using 95%of the energy,and RAE 2822 for transonic conditions are used as *** method significantly enhances the optimization efficiency of the surrogate model while effectively enabling geometric *** three-dimensional problems,it enables simultaneous design of planar shapes for various components of the aircraft and high-order perturbation *** was applied to the ONERA M6 wing,achieving a lift-drag ratio of 18.09,representing a 27.25%improvement com-pared to the baseline *** comparison to conventional surrogate model optimization methods,which only achieved a 17.97%improvement,this approach demonstrates its superiority.

关键词： Aerodynamicdesign Grassmannian manifold Shape parameterization Surrogate-based optimiza-tion Data dimensionality reduction

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Broadband absorption performance of 3D-printed polyetheretherketone-based electromagnetic wave-absorbing composites

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Chinese Journal of Aeronautics 2024年第8期37卷 547-558页

作者： lin BAI Nan chang Meiying ZHAO Chi HOU Yi CAO Dichen li School of Aeronautics Northwestern Polytechnical UniversityXi’an 710072China Chengdu Aircraft Design and Research Institute Chengdu 610091China Xi’an Key Laboratory of Advanced Structure Design and Application of Aircraft Northwestern Polytechnical UniversityXi’an 710072China State Key Laboratory for Manufacturing System engineering Xi’an Jiaotong UniversityXi’an 710054China

The rapid development of additive manufacturing technology has offered a new avenue for designing and fabricating high wave-absorbing meta *** this study,the mechanical properties and broadband absorption performance of Poly-Ether-Ether-Ketone(PEEK)–based electromagnetic wave–absorbing composite materials was *** high-performance polymer PEEK was used as the matrix,and the materials with electromagnetic wave loss,such as reduced graphene oxide,Carbonyl Iron(CI),and Flake CI(FCI),were used as *** on the theory of impedance matching,a wave-absorbing structure with a gradual impedance gradient was designed and *** test results showed that at the 2.0–18.0 GHz frequency band,the coverage rate of the effective absorption bandwidth was up to 72.0%,the average optimal reflectivity was–18.09 dB,and the wide-angle absorption range was 0°–30°.The advantages of additive manufacturing technology in designing and fabricating wave-absorbing structures are presented,demonstrating that the technology is an effective method for creating broadband absorbing structures.

关键词： Absorption performance Additive manufacturing Electromagnetic absorption PEEK composite materials Gradual structure Broadband absorption

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Machine learning enabled film pressure sensor to identify surface contacts:An application in surface transmission of infectious disease

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Building Simulation 2024年第6期17卷 1023-1036页

作者： Baotian chang Jianchao Zhang Yingying Geng Jiarui li Doudou Miao Nan Zhang Beijing Key Laboratory of Green Built environment and energy Efficient Technology Beijing University of TechnologyBeijing100124China

The global prevalence of infectious diseases has emerged as a significant challenge in recent *** transmission is a potential transmission route of most gastrointestinal and respiratory infectious diseases,which is related to surface touch *** observation,the traditional method of surface touching data collection,is characterized by limited accuracy and high labor *** this work,we proposed a methodology based on machine learning technologies aimed at obtaining high-accuracy and low-labor-cost surface touch behavioral data by means of sensor-based contact *** touch sensing device,primarily utilizing a film pressure sensor and Arduino board,is designed to automatically detect and collect surface contact data,encompassing pressure,duration and *** make certain the surface touch behavior and to describe the behavioral data more accurately,six classification algorithms(*** Vector Machine and Random Forest)have been trained and tested on an experimentally available dataset containing more than 500 surface *** classification results reported the accuracy of above 85%for all the six classifiers and indicated that Random Forest performed best in identifying surface touch behaviors,with 91.8%accuracy,91.9%precision and 0.98 *** study conclusively demonstrated the feasibility of identifying surface touch behaviors through film pressure sensor-based data,offering robust support for the calculation of viral load and exposure risk associated with surface transmission.

关键词： surface transmission touch behavior film pressure sensor random forest infectious disease

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Near-infrared non-fused electron acceptors for efficient organic photovoltaics

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Chinese Chemical Letters 2024年第4期35卷 436-441页

作者： Wenxiang Ma Xinyu He Tianyi Chen De-li Ma Hongzheng Chen chang-Zhi li State Key Laboratory of Silicon and Advanced Semiconductor Materials Department of Polymer Science and EngineeringZhejiang UniversityHangzhou 310027China

Developing narrow-bandgap organic semiconductors is important to facilitate the advancement of organic photovoltaics(OPVs). Herein, two near-infrared non-fused ring acceptors(NIR NFRAs), PTBFTT-F and PTBFTT-Cl have been developed with A-π_A-π_D-D-π_D-π_A-A non-fused structures. It is revealed that the introduction of electron deficient π-bridge(π_A) and multiple intramolecular noncovalent interactions effectively retained the structural planarity and intramolecular charge transfer of NFRAs, extending strong NIR photon absorption up to 950 nm. Further, the chlorinated acceptor, with the enlarged π-surface compared to the fluorinated counterpart, promoted not only molecular stacking in solid, but also the desirable photochemical stability in ambient, which are helpful to thereby improve the exciton and charge dynamics for the corresponding OPVs. Overall, this work provides valuable insights into the design of NIR organic semiconductors.

关键词： Organic photovoltaic Near-infrared Non-fused electron acceptor Noncovalent interaction Stability

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Toward high performance microwave absorber by implanting La_(0.8)CoO_(3)nanoparticles on rGO

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Journal of Materials Science & Technology 2024年第7期174卷 176-187页

作者： li chang Yu-Ze Wang Xin-Ci Zhang lin li Hua-Zhang Zhai Mao-Sheng Cao Key Laboratory for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics&Electronic EngineeringHarbin Normal UniversityHarbin 150025China School of Materials Science and engineering Beijing Institute of TechnologyBeijing 100081China

The advent of“intelligent era”brings our life more convenience,but the electromagnetic radiation sur-rounding us not only greatly threatens human health,also makes information leakage and hidden trouble to national defense ***,it is very urgent to develop novel electromagnetic wave absorption materials with lightweight,strong absorption,tunable absorption frequency and broad band ***,a novel electromagnetic wave absorber is obtained by constructing La_(0.8)CoO_(3)-rGO nanocompos-ite,where La_(0.8)CoO_(3)nanoparticles are anchored on graphene nanosheets by the electrostatic interaction between GO and La_(0.8)CoO_(3).The effect of hybridization ratio of La_(0.8)CoO_(3)and rGO on microwave ab-sorption properties is carefully *** optimal reflection loss of La_(0.8)CoO_(3)-rGO nanocomposite can reach-62.34 dB with the maximum effective bandwidth of 6.08 GHz,presenting 48.78%and 245.45%increment compared to bare La_(0.8)CoO_(3)nanoparticles,*** effective absorption bandwidth covers a broad electromagnetic wave absorption band from Ku band to the C band by tailoring thickness of the absorbers from 2.4 mm to 4.4 *** fascinating electromagnetic wave absorption performance is attributed to the synergy effect of La_(0.8)CoO_(3)and rGO,which integrates magnetic and dielectric loss caused by resonance,conductance,relaxation,and scattering *** result confirms that La_(0.8)CoO_(3)-rGO nanocomposite is potential candidates toward high-efficiency microwave absorbers and provides a valuable pathway for designing high-performance microwave attenuation materials in the future.

关键词： Perovskite La_(0.8)CoO_(3)nanoparticles Graphene Nanocomposite Microwave absorbing Broad band absorption

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Dislocation density-me diate d creep ageing behavior of an Al-Cu-li alloy

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Journal of Materials Science & Technology 2024年第7期174卷 204-217页

作者： chang Zhou lihua Zhan Chunhui liu Minghui Huang College of Mechanical and Electrical engineering Central South UniversityChangsha 410083China State Key Laboratory of Precision Manufacturing for Extreme Service Performance Central South UniversityChangsha 410083China light Alloys Research Institute Central South UniversityChangsha 410083China

Creep aging is well-known to be a time-dependent,coupled process of deformation and precipitation strengthening for age-hardening *** existing mechanisms are mainly attributed to those interac-tions between atomic diffusion and dislocation ***,an understanding of the relationship between dislocation density and a special multistage creep behavior,i.e.,double steady creep feature,is still far *** we investigate the effect of various dislocation density levels on such an abnormal multistage creep of an Al-Cu-li *** find that the increased dislocation densities enable an apparent time decrease(from 6.2 h to 0.8 h)of their first steadyⅡ-*** yield strength of post-aged sam-ples increases from 425.0 MPa to 580.0 MPa while the corresponding elongation decreases from 12.3%to 7.3%for the creep-aged samples#1 to#*** results also reveal that a great difference in dislocation configuration,tailored by various density levels,results in varying creep processes of theⅡ-*** stage is closely related to the nucleation and early growth of T_(1)*** number densities(maximum:2.9×10^(19)m^(-3))and the average length(maximum:21.3 nm)of T_(1)precipitates are much smaller than those of the stable peak-aged T_(1)phases,suggesting that creepⅡ-stage of all three creep-aged samples is dominant by the nucleation and initial growth of those T_(1)*** study provides valuable insights into the dislocation density-mediated creep deformation of an Al-Cu-li alloy.

关键词： Dislocation density Al-Cu-li alloy Creep ageing T_(1)precipitation

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Orientation controlled photogenerated carriers on selfsupporting CdS/Ni_(3)S_(2) paper toward photocatalytic hydrogen evolution and biomass upgrading

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Rare Metals 2024年第5期43卷 2015-2025页

作者： Xiao-Yan liu Qing Cao Gui-Xiang li Hui liu li-li Zeng li-li Zhao Bin chang Xi-Wen Wang Hong liu Wei-Jia Zhou Institute for Advanced Interdisciplinary Research School of Chemistry and Chemical EngineeringUniversity of JinanJinan 250022China Institute of Chemical Sciences and engineering Ecole Polytechnique Federale de Lausanne1015LausanneSwitzerland KAUST Catalysis Center King Abdullah University of Science and TechnologyThuwal 23955-6900Kingdom of Saudi Arabia School of environment and energy South China University of TechnologyGuangzhou Higher Education Mega CenterGuangzhou 510006China State Key Laboratory of Crystal Materials Shandong UniversityJinan250100China School of Mechanical engineering Xi'an Jiaotong UniversityXi'an 710054China

The appropriate regulation of band structure is an effective strategy in constructing efficient photocatalytic *** photocatalytic system mainly employs powder photocatalysts,which makes their recovery reliant on expensive separation processes and severely limits their industrial ***,we constructed a novel CdS/Ni_(3)S_(2)heterostructure using free-standing and flexible nickel fiber paper as the *** regulated energy band structure achieves effective electron–hole *** as-synthesized flexible photocatalyst exhibits considerable photocatalytic activity toward the H_(2)evolution reaction under visible-light irradiation,with an H_(2)production rate of5.63μmol·cm^(-2)·h^(-1)(14.1 mmol·g^(-1)cat·h^(-1)according to the catalyst loading content).Additionally,the otherwisewasted excited holes simultaneously drive organic transformations to yield value-added organic products,thus markedly improving the photocatalytic H_(2)evolution *** a photocatalytic system is scaled up further,where a self-supported 20 cm×25 cm sample achieves a champion H_(2)production rate of 60-80μmol·h^(-1)under practical sun *** newly developed self-supported photocatalyst produces opportunities for practical solar H2production with biomass upgrading.

关键词： Self-supporting photocatalyst CdS/Ni_(3)S_(2) heterojunction Hydrogen evolution Biomass upgrading Large-scaleapplication

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Single-cell RNA sequencing to understand host-virus interactions

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Virologica Sinica 2024年第1期39卷 1-8页

作者： Jia-Tong chang li-Bo liu Pei-Gang Wang Jing An Department of Microbiology School of Basic Medical SciencesCapital Medical UniversityBeijing 100069China

Single-cell RNA sequencing(scRNA-seq)has allowed for the profiling of host and virus transcripts and host-virus interactions at single-cell *** review summarizes the existing scRNA-seq technologies together with their strengths and *** applications of scRNA-seq in various virological studies are discussed in depth,which broaden the understanding of the immune atlas,host-virus interactions,and immune ***-seq can be widely used for virology in the near future to better understand the pathogenic mechanisms and discover more effective therapeutic strategies.

关键词： Single-cell RNA sequencing(scRNA-seq) Host-virus interaction COVID-19 Flavivirus

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