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Improving the Level and Quality of Ethics Review in Chinese Medicine and Integrative Medicine

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Chinese Journal of Integrative Medicine 2018年第4期24卷 315-319页

作者： ZHANG Cheng-bin li en-chang Health and Bioethics Research Center Wenzhou Medical University

Three features of ethics review in Chinese medicine（CM） and integrative medicine（IM） were put forward in this paper. It is consistent with the principles of ethical review in Western medicine; it has to be compliant with the laws of CM and IM; emphasis should be laid on the review of clinical practice facts and experience. Three problems were pointed out. The characteristics of CM and IM are not distinctive enough, operation procedures need to be refined and effectiveness remains to be improved. Based on the mentioned above, seven measures were proposed to improve the level and quality of ethics review in CM and IM, including better brand awareness, considerable tolerance, treatment based on disease differentiation and syndrome differentiation, scientific review and toxicity and side effects of CM, perfection of the ethics review system, reasonable procedures of ethics review and more specialized ethics review workers.

关键词： Chinese medicine integrative medicine ethics review medical research

Policies on Chinese Medicine in China May Have enlightenments to Complementary and Alternative Medicine in the World

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Chinese Journal of Integrative Medicine 2018年第10期24卷 789-793页

作者： CHen Wei li en-chang ZHenG Wei-rong Center for Health and Bioethics Wenzhou Medical University

From the event of TU You-you winning the Nobel Prize, this paper briefly reviewed the history of formation and development of policies on Chinese medicine （CM） in China. On the basis of analyzing the causes of policies on CM, it is believed that policies on CM in China may have 4 kinds of enlightenments to the development of complementary and alternative medicine （CAM） in the world. Forming the political advantages of policy-making by main leaders of the country attaching importance to CAM; implementing a diversified health care system policy for the goal of maximizing people＇s health interests; ensuring development of CAM by the coerciveness of law and the timeliness of policy adjustment; and promoting the protection and mining, sorting out and improving of CAM based on open and comprehensive policies.

关键词： complementary and alternative medicine Chinese medicine policies on Chinese medicine integrated Chinese and Western medicine

The First Generation of New China Leaders' Thought of Developing Integrated Chinese and Western Medicine

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Chinese Journal of Integrative Medicine 2018年第5期24卷 385-389页

作者： WenG Pan-feng1 li en-chang1 ZHUANG Xing-zhong2 Health and life Ethics Center Wenzhou Medical University Department of Organizational Work Wenzhou Medical University

The history of integrated Chinese medicine （CM） and Western medicine （WM） witnesses the development of public health under the significant support and guidance of the first generation leaders of new China who aimed at maximizing people＇s health interests. According to the available documents, it can be found out that, among the first generation of new China leaders, MAO Ze-dong, ZHOU en-lai, liU Shao-qi, ZHU De and DenG Xiao-ping made more statements on the integration of CM and WM due to different division of labor and other historical reasons. This paper will focus on the issue to study the emergence, formation and development of their thoughts on the integration of CM and WM and analyze its process and significance, so as to enlighten the current integration of CM and WM, and even the world＇s integrative medicine.

关键词： In De Thought of Developing Integrated Chinese and Western Medicine The First Generation of New China Leaders WM

An Ethical Evaluation Index System for Clinical Approval of Medical Technology in China:A Structural Equation Model Study

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Chinese Journal of Integrative Medicine 2017年第6期23卷 474-480页

作者： li Jing-xian QIAO Zhi-cheng MA Hong-xia li Yi-ting li en-chang JI Peng-cheng HUANG Gang Collaborative Innovation Center of Network and Big Data Applications Lingnan Normal University Department of Finance College of EconomicsJinan University Department of Pediatric Affiliated Hospital of Guangdong Medical University Teaching and Research Section of Health Care Management School of Health Management and EducationCapital Medical University Chinese Journal of Medical Ethics Xi'an Jiaotong University

Objective： To construct a quantitative ethical evaluation index system for the clinical approval of medical technology in China. Methods： Exploratory factor analysis （EFA） and first-order confirmatory factor analysis （CFA） based on a structure equation model （SEM）, higher-order CFA and normalisation were used to establish an ethical evaluation index system for the clinical approval of medical technology. Data were processed in SPSS 13.0 and lisre 15.3. Results： There were 52 third class indices, 15 second class indices, and 3 first class indices in this ethical evaluation index system. The weight of each index was calculated by normalisation. Conclusion： This study developed a three-level ethical evaluation index system, comprising 70 indices, for the clinical approval of medical technology.

关键词： medical technology ethical review factor analysis structural equation model

The OsCLV2s-OsCRN1 co-receptor regulates grain shape in rice

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Journal of Genetics and Genomics 2024年第7期51卷 691-702页

作者： Xingxing li Meng-en Wu Juncheng Zhang Jingyue Xu Yuanfei Diao Yibo li National Key Laboratory of Crop Genetic Improvement and National Centre of Plant Gene Research(Wuhan) Huazhong Agricultural UniversityWuhanHubei 430070China Hubei Hongshan Laboratory WuhanHubei 430070China

The highly conserved CLV–WUS negative feedback pathway plays a decisive role in regulating stem cell maintenance in shoot and floral meristems in higher plants,including Arabidopsis,rice,maize,and ***,we find significant natural variations in the OsCLV2c,OsCLV2d,and OsCRN1 loci in a genome-wide association study of grain shape in ***2a,OsCLV2c,OsCLV2d,and OsCRN1 negatively regulate grain length–width ratio and show distinctive geographical distribution,indica–japonica differentiation,and artificial selection ***,OsCLV2a and OsCRN1 interact biochemically and genetically,suggesting that the two components function in a complex to regulate grain shape of ***,the genetic contributions of the haplotypes combining OsCLV2a,OsCLV2c,and OsCRN1 are significantly higher than those of each single gene alone in controlling key yield *** findings identify two groups of receptor-like kinases that may function as distinct co-receptors to control grain size in rice,thereby revealing a previously unrecognized role of the CLV class genes in regulating seed development and proposing a framework to understand the molecular mechanisms of the CLV–WUS pathway in rice and other crops.

关键词： Rice Grain shape OsCLV2s OsCRN1 Natural variations Indica-japonica differentiation

Reaction Mechanism of Actin ATP Hydrolysis Studied by QM/MM Calculations

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Chemical Research in Chinese Universities 2024年第5期40卷 849-855页

作者： WANG Yiwen liN lirui XU li-Yan li en-Min DONG Geng Department of Biochemistry and Molecular Biology Shantou University Medical CollegeShantou515041P.R.China Department of Bioinformatics Shantou University Medical CollegeShantou515041P.R.China Medical Informatics Research Center Shantou University Medical CollegeShantou515041P.R.China Key Laboratory of Molecular Biology in High Cancer Incidence Coastal Area of Guangdong Higher Education Institutes Shantou University Medical CollegeShantou515041P.R.China Cancer Research Center Shantou University Medical CollegeShantou515041P.R.China Guangdong Provincial Key Laboratory of Infectious Diseases and Molecular Immunopathology Shantou University Medical CollegeShantou515041P.R.China

Actin fibers are an important part of the cytoskeleton,providing vital support for the plasma *** function is driven by its ATPase(ATP:adenosine triphosphate)activity,i.e.,ATP+H_(2)O→ADP+*** seemingly simple reaction has attracted much attention because the hydrolysis of ATP provides energy to support life ***,the reaction mechanism of ATP hydrolysis in actin is not *** order to gain deep insights into the functions of actin,it is essential to elucidate the reaction mechanism of the actin ATP *** this paper,we have studied the reaction mechanism of the ATP hydrolysis in actin by the combined quantum mechanical and molecular mechanics(QM/MM)*** results show that 1)bond cleavage of the Pγ—OS of ATP and bond formation between oxygen of the lytic water and Pγatoms take place simultaneously,and this is the rate-limiting step of the hydrolysis;2)the proton on the lytic water transfers to the phosphate to form H_(2)P_(γ)O_(4)−via one bridge *** energy barrier of the complete reaction is 17.6 kcal/mol(1 kcal=4.184 kJ),which is in high agreement with the experimental value.

关键词： Actin Adenosine triphosphate(ATP)hydrolysis Quantum mechanical and molecular mechanics(QM/MM) Reaction mechanism

Near real-time gravitational wave data analysis of the massive black hole binary with TianQin

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 175-186页

作者： Hong-Yu Chen Xiang-Yu Lyu en-Kun li Yi-Ming Hu MOE Key Laboratory of TianQin Mission TianQin Research Center for Gravitational Physics&School of Physics and AstronomyFrontiers Science Center for TianQinGravitational Wave Research Center of CNSASun Yat-sen University(Zhuhai Campus)Zhuhai 519082China

Space-borne gravitational wave(GW)detectors can detect the merger of massive black *** early warning and localization of GW events before merging can be used to inform electromagnetic telescopes and conduct multimessenger ***,this requires real-time data transmission and analysis *** geocentric orbit of the space-borne GW detector Tian Qin makes it possible to conduct real-time data *** this study,we develop a search and localization pipeline for massive black hole binaries(MBHBs)with Tian Qin under both regular and real-time data transmission *** demonstrate that,with real-time data transmission,MBHBs can be accurately localized on the *** the approaching merger,each analysis can be finished in only 40 *** an MBHB system at a distance of 1 Gpc,if we receive data every hour,then we can pinpoint its location to within less than 1 deg^(2)on the final day before the merger.

关键词： gravitational wave detectors and experiments black holes data analysis algorithms and implementation data management

Immediate implantation of ultrafine fiber slow-release system based on cell electrospinning to induce osteogenesis of mesenchymal stem cells

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Regenerative Biomaterials 2024年第2期3卷 76-87页

作者： Tao Lu Long Yang Zhuoyang li Yin liu Shun'en Xu Chuan Ye Department of Orthopaedics The Affliated Hospital of Guizhou Medical UniversityGuiyang 550004China Department of Orthopaedics The First People's Hospital of GuiyangGuiyang 550004China Center for Tissue engineering and Stem Cell Research Guizhou Medical UniversityGuiyang 550004China Department of Otolaryngology Head and Neck Surgery Xinqiao HospitalArmy Medical University(Third Military Medical University)Chongqing 400037China Department of Dental implant Stomatological Hospital of GuiyangGuiyang 550000China

This study presents the development and evaluation of a poly(3-hydroxybutyrate-co-4-hydroxybutyrate)(P34HB)ultrafine fiber slow-release system for in vivo osteogenic induction of human umbilical cord mesenchymal stem cells(HUCMSCs).Utilizing dual-nozzle and cell electrospinning techniques,the system encapsulates L-ascorbic acid-2-phosphate magnesium(AsP),βB-glycerophosphate sodium and dexamethasone(DEX)within the'fbers,ensuring sustained osteogenic *** scaffold's morphology,characterization,hydrophilicity,mechanical properties and cellular behavior were *** subcutaneous implantation in rabbits was con-ducted to observe its ectopic osteogenic induction *** fabricated P34HB ultrafine fiber slow-release *** ization *** distribution of HUCMSCs and inducing components within the scaffold,with no chemical reactions affecting the active *** vitro tests showcased a prolonged release of DEX and ASP,while biocompatibility assays highlighted the scaffold's suitability for cellular *** Red,type I collagen,and osteopontin(OPN)staining verifed the scaffold's potent osteogenic induction effect on ***,immediate implantation into New Zealand White rabbits led to significant new bone formation within 8 *** findings underscore the system's potential for immediate in vivo implantation without prior in vitro induction,marking a promising advancement in bone tissue engineering.

关键词： bone tissue engineering cell electrospinning in vivo induction immediate implantation biomaterials

Aerodynamic Performance of Three Flapping Wings with Unequal Spacing in Tandem Formation

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Journal of Bionic engineering 2024年第4期21卷 1662-1676页

作者： Min chang Ziyi Xu Zengshuang Chen li li Xueguang Meng Unmanned System Research Institute National Key Laboratory of Unmanned Aerial Vehicle TechnologyNorthwestern Polytechnical UniversityXi’an710072People’s Republic of China State Key Laboratory for Strength and Vibration of Mechanical Structures School of Aerospace EngineeringXi’an Jiaotong UniversityXi’an710049People’s Republic of China Xi’an Aeronautics Computing Technique Research Institute Aviation Industry Corporation of ChinaXi’an710076People’s Republic of China

To better understand the aerodynamic reasons for highly organized movements of flying organisms,the three-flapping wing system in tandem formation was studied numerically in this *** from previous relevant studies on the multiple flapping wings that are equally spaced,this study emphasizes the impact of unequal spacing between individuals on the aerodynamics of each individual wing as well as the whole *** is found that swapping the distance between the first and second wing with the distance between the second wing and the rearmost wing does not affect the overall aerodynamic performance,but significantly changes the distribution of aerodynamic benefits across each *** the whole flapping cycle,three effects are at *** narrow channel effect and the downwash effect can promote and weaken the wing lift,respectively,while the wake capture effect can boost the *** also shows that these effects could be manipulated by changing the spacing between adjacent *** findings provide a novel way for flow control in tandem formation flight and are also inspiring for designing the formation flight of bionic aircraft.

关键词： Three flapping wings Unequal spacing Aerodynamic performance Tandem formation