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Regulatory Effect of JAK2/STAT3 on the Immune Function of Endotoxin-tolerant Dendritic Cells and its Involvement in Acute liver Failure

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Journal of Clinical and Translational Hepatology 2022年第5期10卷 879-890页

作者： Yukai Chen Chaochen Hou Naibin Yang Yanyan Yang Youran Chen deyong Kong Yuchun Jiang Minghao lin Sijie Zheng Shanshan li Mingqin Lu Ningbo Puji Hospital NingboZhejiangChina Department of Infectious Diseases The First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiangChina Department of Infectious Diseases Ningbo First HospitalNingboZhejiangChina

Background and Aims:Acute liver failure(ALF)is a potentially fatal clinical syndrome with no effective *** study aimed to explore the role of Janus kinase 2/signal transducer and activator of transcription 3(JAK2/STAT3)pathway in modulating the phenotype and immune function of endotoxin-tolerant dendritic cells(ETDCs).In addition,we explored the use of EDTCs in an experimental model of ALF and investigated the associated ***:In the in vitro experiment,ETDCs were transfected with adenovirus to induce SOCS1^(+/+)ETDCs and SOCS1^(−/−)***,costimulatory molecules and mixed lymphocyte reaction were *** mice were randomly divided into normal control,ALF,ALF+mock-ETDCs,ALF+SOCS1^(+/+)ETDCs,ALF+AG490,and ALF+AG490+SOCS1^(+/+)ETDCs *** examined the therapeutic effect of adoptive cellular immunotherapy by tail-vein injection of target ETDCs 12 h before ALF ***490,a JAK2/STAT3 inhibitor,was used in the in vivo experiment to further explore the protective mechanism of SOCS1^(+/+)***:Compared with control ETDCs,SOCS1^(+/+)ETDCs had lower expression of costimulatory molecules,weaker allostimulatory ability,lower levels of IL-6 and TNF-αexpression and higher IL-10 ***1^(−/−)ETDCs showed the opposite *** the in vivo experiments,the ALF+SOCS1^(+/+)ETDCs and ALF+AG490+SOCS1^(+/+)ETDCs groups showed less pathological damage and suppressed activation of JAK2/STAT3 *** changes were more pronounced in the ALF+AG490+SOCS1^(+/+)ETDCs *** of SOCS1^(+/+)ETDCs had a protective effect against ALF possibly via inhibition of JAK2 and STAT3 ***:The SOCS1 gene had an important role in induction of endotoxin ***1^(+/+)ETDCs alleviated lipopolysaccharide/D-galactosamine-induced ALF by downregulating the JAK2/STAT3 signaling pathway.

关键词： liver failure Acute Janus kinase 2/signal transducers and activators of transcription 3(JAK2/STAT3) Endotoxin tolerance Dendritic cells

Water Absorption Capcapability and Moisture Content Seasonal Changing of Salt-Crust in Lop Nur Dry Lake

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Acta Geologica Sinica(English Edition) 2014年第S1期88卷 183-184页

作者： KONG deyong li Baoguo MA lichun JIANG Ping'an WU Hongqi liU Hongpeng College of Resources and Environment China Agricultural University Institute of Mineral Resources Chinese Academy of Geological Sciences College of Grassland and Environment Science Xinjiang Agricultural University

The Lop Nur dry salt lake,Xinjiang province,is charactered by typical physiognomy salt-crust,located *** and *** thickness of salt-crust is about from 20 cm to 100 cm,and

关键词： Lop Nur Dry Lake Salt-Crust Moisture Content Water Absorption Capcapability

Atypical Atm-p53 genetic interaction in osteogenesis is mediated by Smad1 signaling

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分子细胞生物学报:英文版 2012年第2期4卷 118-120页

作者： Gang Ma lili li Yuanyu Hu Jenny Fung ling Chau Bi Jin Au deyong Jia Huijuan liu James Yeh lin He Aijun Hao Baojie li The Bio-X Institutes Key Laboratory for the Genetics of Developmental and Neuropsychiatric DisordersMinistry of EducationShanghai Jiao Tong UniversityShanghai 200030China Key Laboratory of the Ministry of Education for Experimental Teratology Shandong University School of MedicineJinan 250012China The Institute of Molecular and Cell Biology Agency for ScienceTechnologyand ResearchSingapore 138632Singapore

Dear Editor,Tumor suppressor p53 is activated in re-sponse to genotoxic stress by Atm and other PI3K-like kinases,which phosphoryl-ate p53 and stabilize p53(Barlow et al.,1997),leading to cell cycle arrest,senes-cence... 详细信息

关键词： Smad1 PI3K damage p53

Genome-wide association study and transcriptome analysis reveal new QTL and candidate genes for nitrogen-deficiency tolerance in rice

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The Crop Journal 2022年第4期10卷 942-951页

作者： Qing li Xueli Lu Changjian Wang Lan Shen liping Dai Jinli He Long Yang Peiyuan li Yifeng Hong Qiang Zhang Guojun Dong Jiang Hu Guangheng Zhang deyong Ren Zhenyu Gao Longbiao Guo Qian Qian li Zhu Dali Zeng State Key Laboratory of Rice Biology China National Rice Research InstituteChinese Academy of Agricultural SciencesHangzhou 311401ZhejiangChina

The development of rice cultivars with improved nitrogen use efficiency(NUE)is desirable for sustainable *** this goal depends in part on understanding how rice responds to low soil nitrogen(N)and identifying causative genes underlying this *** identify quantitative trait loci(QTL)or genes associated with low N response,we conducted a genome-wide association study(GWAS)using a diverse panel of 230 rice accessions and performed a transcriptomic investigation of rice accessions with differential responses to low N stress at two N *** detected 411 GWAS-associated genes in 5 QTL and 2722 differentially expressed genes in response to low N,of which 24 were identified by both methods and ranked according to gene annotations,literature queries,gene expression,and genetic diversity *** large-scale datasets obtained from this study reveal low N-responsive characteristics and provide insights towards understanding the regulatory mechanisms of N-deficiency tolerance in rice,and the candidate genes or QTL would be valuable resources for increasing rice NUE via molecular biotechnology.

关键词： Nitrogen NUE Rice GWAS RNA-seq

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维生素U生产工艺优化及其热分解机理

化工进展 2024年第9期43卷 5157-5167页

作者：王禹程郭雄栾昕奇周健李想幸林广周雪芸刘颖汪德勇吴雪娟潘琦刘建新赵祯霞赵钟兴广西大学化学化工学院广西高校低碳绿色化工新技术重点实验室广西南宁530004 广西南宁百会药业集团有限公司广西南宁5330032

为提高维生素U收率和最终产品纯度,并减少其热分解产物对最终产品质量的影响,对维生素U生产工艺优化和热分解产物分析。首先,通过对维生素U合成、脱色和浓缩等3个工序的优化,得到最佳维生素U生产条件为:合成温度为54℃,蛋氨酸与氯甲烷... 详细信息

为提高维生素U收率和最终产品纯度,并减少其热分解产物对最终产品质量的影响,对维生素U生产工艺优化和热分解产物分析。首先,通过对维生素U合成、脱色和浓缩等3个工序的优化,得到最佳维生素U生产条件为:合成温度为54℃,蛋氨酸与氯甲烷的投料摩尔比为1∶2.6,脱色时活性炭用量为2g/L,脱色时间为8min,浓缩温度控制在55℃,浓缩时间为8h。然后再对维生素U的热解产物进行高效液相色谱-质谱联用和气相色谱-质谱联用分析,确定了维生素U在水溶液中的主要热分解产物组成和可能的降解路径。最后,通过分子模拟计算印证甲醇可作为精制溶剂去除维生素U生产过程中产生的热解产物。优化后的工艺平均收率提高了8.5百分点,平均纯度提高了0.8百分点,平均误差分别减少了5.1百分点和0.33百分点,平均熔程减小了0.8℃,工艺稳定性显著提升,所得维生素U的纯度在满足国家标准的基础上进一步提高。该工作对进一步优化维生素U生产工艺具有借鉴意义。

关键词：维生素U 生产分解产物分子模拟优化

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The pleiotropic ABNORMAL FLOWER AND DWARF1 affects plant height, floral development and grain yield in rice

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Journal of Integrative Plant Biology 2016年第6期58卷 529-539页

作者： deyong Ren Yuchun Rao liwen Wu Qiankun Xu Zizhuang li Haiping Yu Yu Zhang Yujia Leng Jiang Hu li Zhu Zhenyu Gao Guojun Dong Guangheng Zhang Longbiao Guo Dali Zeng Qian Qian State Key Lab for Rice Biology China National Rice Research Institute College of Chemistry and life Sciences Zhejiang Normal University College of life and Environmental Sciences Hangzhou Normal University

Moderate plant height and successful establishment of reproductive organs play pivotal roles in rice grain production. The molecular mechanism that controls the two aspects remains unclear in rice. In the present study,we characterized a rice gene, ABNORMAL FLOWER AND DWARF1（AFD1） that determined plant height, floral development and grain yield. The afd1 mutant showed variable defects including the dwarfism, long panicle, low seed setting and reduced grain yield. In addition, abnormal floral organs were also observed in the afd1 mutant including slender and thick hulls, and hull-like ***1 encoded a DUF640 domain protein and was expressed in all tested tissues and organs. Subcellular localization showed AFD1-green fluorescent fusion protein（GFP） was localized in the nucleus. Meantime, our results suggested that AFD1 regulated the expression of cell division and expansion related genes.

关键词： Plant height hull lodicule grain yield AFD1 rice(Oryza sativa)

恩施黑猪行政村落保种促进生猪产业良性循环发展路径探索

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中国畜禽种业 2024年第9期20卷 102-108页

作者：谭德俊胡百顺陈潇飞李蓉谢骏辉杨德永李秋方马世龙马进唐霄湖北省恩施土家族苗族自治州农业科学院湖北恩施445000 湖北省恩施市芭蕉侗族乡农业服务中心湖北恩施445033

为改变恩施黑猪依托企业保种的时空局限、种群萎缩等现状,解决保种效益亏损及开发利用滞后等问题,该文研究探索利用行政村落区域实施保种,推动村集体建设恩施黑猪核心保种群、专业户建扩繁群,农户发展商品生产,创建集恩施黑猪保种、饲... 详细信息

为改变恩施黑猪依托企业保种的时空局限、种群萎缩等现状,解决保种效益亏损及开发利用滞后等问题,该文研究探索利用行政村落区域实施保种,推动村集体建设恩施黑猪核心保种群、专业户建扩繁群,农户发展商品生产,创建集恩施黑猪保种、饲养、加工、销售于一体的村落保种新模式。并利用行政村落的绿色饲料、生态环境、富裕劳力等资源,降低保种成本,打造健康品牌,提升养殖效益,不断扩大恩施黑猪饲养地域空间,促进保种和开发利用的双赢发展。

关键词：恩施黑猪行政村落品种保护开发利用良性发展

Developments of Gussasphalt System on Steel Deck Pavement

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World Journal of Engineering and Technology 2017年第3期5卷 141-147页

作者： Min Wang deyong Hu li Xiao Fei Shang China Merchants Chongqing Communications Research & Design Institute Co. Ltd. Chongqing China Chongqing Zhixiang Paving Technology Engineering Co. Ltd. Chongqing China

With the development of steel deck paving technology, the associated gussasphalt pavement system also develops maturely. In this paper, the structure characteristics and performance advantages are thoroughly explained by introducing the development course of gussasphalt. The material composition, properties and application effect of three typical pavement methods are analyzed. This paper is intended to give a relatively clear understanding regarding the specific features of gussasphalt, and provide some guidance to further expansion concerning gussasphalt pavement.

关键词： Steel Deck Gussasphalt Pavement System Property Advantage

Functional Analysis of Three Rice Chloroplast Transit Peptides

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Rice science 2019年第1期26卷 11-20页

作者： HE Lei CHEN Guang ZHANG Sen QIU Zhennan HU Jiang ZENG Dali ZHANG Guangheng DONG Guojun GAO Zhenyu REN deyong SHEN Lan GUO Longbiao QIAN Qian ZHU li State Key Laboratory of Rice Biology China National Rice Research Institute

Chloroplast transit peptides(CTPs) can be used to transport non-chloroplastic proteins into the chloroplasts. Here, we studied the CTPs of three rice(Oryza sativa L.) chloroplast-localized proteins and found that their CTPs could be used to transport non-chloroplast-localized proteins into the chloroplasts. Fusion proteins lacking the CTP remained located in the cytoplasm. Furthermore, we constructed green fluorescent protein fusion vectors with the three CTPs and three non-chloroplast-localized proteins, Ghd10, MULTI-FLORET SPIKELET1(MFS1), and SHORTENED UPPERMOST INTERNODE 1(SUI1). After transforming these constructs into rice protoplasts, the fusion proteins all localized in the chloroplasts. Collectively, our results showed that these CTPs can transport non-chloroplast-localized proteins into the chloroplasts, and more importantly, these CTPs can be applied to engineer chloroplast metabolism.

关键词： rice chloroplast transit peptide translocated function subcellular location