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A Damage-tolerant Bulk Metallic Glass at Liquid-nitrogen Temperature

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journal of Materials Science & Technology 2014年第6期30卷 627-630页

作者： jun Yi S.Mohsen Seifi Weihua Wang john j.lewandowski Department of Materials Science and Engineering Case Western Reserve UniversityClevelandOH 44106-7204 USA Institute of Physics Chinese Academy of Sciences

Tensile tests and notch toughness tests were conducted on Zr61Ti2Cu25Al12 glass （ZT） at room temperature and liquid-nitrogen temperature. The tensile strength of ZT was improved from 1.63 GPa at room temperature to 1.72 GPa at liquid-nitrogen temperature. Micro-notches with a root radius of 1-3μm were introduced to test the notch toughness of ZT at room temperature and liquid-nitrogen temperature. The test results revealed that the notch toughness of ZT at liquid-nitrogen temperature is comparable to that of ZT at room temperature. The combination of high yield strength and notch toughness of ZT at liquid-nitrogen temperature is comparable to that of the best cryogenic engineering materials.

关键词： Metallic glasses Yield strength Fracture toughness Liquid-nitrogen temperature

Targeting TrkB–PSD-95 coupling to mitigate neurological disorders

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Neural Regeneration Research 2025年第3期20卷 715-724页

作者： Xin Yang Yu-Wen Alvin Huang john Marshall Department of Molecular Biology Cell Biology and BiochemistryBrown UniversityProvidenceRIUSA Department of Neurology Warren Alpert Medical School of Brown UniversityProvidenceRIUSA Center for Translational Neuroscience Robert J.and Nancy D.Carney Institute for Brain Science and Brown Institute for Translational ScienceBrown UniversityProvidenceRIUSA

Tropomyosin receptor kinase B(TrkB)signaling plays a pivotal role in dendritic growth and dendritic spine formation to promote learning and *** activity-dependent release of brain-derived neurotrophic factor at synapses binds to pre-or postsynaptic TrkB resulting in the strengthening of synapses,reflected by long-term ***,the association of postsynaptic density protein-95 with TrkB enhances phospholipase Cγ-Ca^(2+)/calmodulin-dependent protein kinaseⅡand phosphatidylinositol 3-kinase-mechanistic target of rapamycin signaling required for long-term *** this review,we discuss TrkB-postsynaptic density protein-95 coupling as a promising strategy to magnify brain-derived neurotrophic factor signaling towards the development of novel therapeutics for specific neurological disorders.A reduction of TrkB signaling has been observed in neurodegenerative disorders,such as Alzheimer's disease and Huntington's disease,and enhancement of postsynaptic density protein-95 association with TrkB signaling could mitigate the observed deficiency of neuronal connectivity in schizophrenia and *** with brain-derived neurotrophic factor is problematic,due to poor pharmacokinetics,low brain penetration,and side effects resulting from activation of the p75 neurotrophin receptor or the truncated TrkB.T1 *** TrkB agonists and antibodies that activate TrkB are being intensively investigated,they cannot distinguish the multiple human TrkB splicing isoforms or cell type-specific *** TrkB–postsynaptic density protein-95 coupling provides an alternative approach to specifically boost TrkB signaling at localized synaptic sites versus global stimulation that risks many adverse side effects.

关键词： Angelman syndrome autism brain-derived neurotrophic factor depression neurodegenerative disorder neurodevelopmental disorder postsynaptic density protein-95 synaptic plasticity TrkB

铝合金材料AA-6061-T6和AA-6061-OA的动态拉伸力学性能(英文)

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实验力学 2007年第3期22卷 305-313页

作者：唐欣 Vikas Prakash john lewandowski 凯斯西部保留地大学力学与航空工程系凯斯西部保留地大学材料科学与工程系

铝合金材料蜂窝夹层板结构具有在较低体重情况下的高硬度和高抗冲击性能力。近年来许多关于其在低应变率下冲击能量吸收性质的文献纷纷涌现,但是对于其在高应变率下的能量吸收力学性能的研究却非常贫乏。为了更好地研究铝合金材料蜂窝... 详细信息

铝合金材料蜂窝夹层板结构具有在较低体重情况下的高硬度和高抗冲击性能力。近年来许多关于其在低应变率下冲击能量吸收性质的文献纷纷涌现,但是对于其在高应变率下的能量吸收力学性能的研究却非常贫乏。为了更好地研究铝合金材料蜂窝夹层板结构在高应变率下的能量吸收力学性能,其结构组成材料本身的动态力学性能必须首先得到充分研究。本文介绍和总结了铝合金材料AA-6061的两种热处理成品,T6与OA,在室温(24℃)与低温( -170℃)下的动态拉伸力学性能。在本研究中,霍普金生拉伸杆被应用,拉伸应变率为103每秒。

关键词：铝合金材料AA-6061-T6/OA 室温(24℃)与低温(-170℃)试验霍普金生拉伸杆高应变率

Financial Accounting Information for Decisions john j. Wild 3rd ed.

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Identification of the preferentially targeted proteins by carbamylation during whole lens incubation by using radio-labelled potassium cyanate and mass spectrometry

2005年

作者： john j. Wild

"Krispy Kreme 2003 annual report" inserted.

ISBN: (数字)0072843179

ISBN: (纸本)0072843179

"Krispy Kreme 2003 annual report" inserted.

关键词： Accounting.

来源：畅想之星图书光盘版（南... 评论

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International journal of Ophthalmology(English edition) 2010年第2期3卷 104-111页

作者： john j Harding Nuffield Laboratory of Ophthalmology University of OxfordJohn Radcliffe HospitalHeadingtonOxfordUK

AIMTo attempt to identify the primary targets of carbamylation in bovine lenses incubated under physiological condition.

关键词： carbamylation cyanate cataract identification lens mass spectrometry post-translational modification ξ-crystallin

Field observations of putative bone-based fluorescence in a gecko

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Current Zoology 2018年第3期64卷 319-320页

作者： john j, SLOGGETT Maastricht Science Programme Maastricht University P.O. Box 616 6200 MD Maastricht The Netherlands

A diversity of animals are biofluorescent, absorbing shortwavelength electromagnetic radiation, and re-emitting it at longer wavelengths, giving a distinctive pattern （Lagorio et al. 2015）. Among terrestrial organisms, biofluorescence has been commonly recorded in arthropods, but rarely from vertebrates （Lagorio et al. 2015）. It has long been known from parrots （Hausmann et al. 2003） and has recently been recorded from a frog （Taboada et al. 2017） and from chameleons （Chamaeleonidae： Protzel et al. 2018）.

关键词： biofluorescence bone Chondrodactylus bibronii Gekkonidae signaling Squarnata

Apoptosis and DNA damage in human spermatozoa

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Asian journal of Andrology 2011年第1期13卷 36-42页

作者： R john Aitken Adam j Koppers ARC Centre of Excellence in Biotechnology and Development Priority Research Centre in Reproductive Science Discipline of Biological Sciences School of Environmental and Life Sciences University of Newcastle Callaghan NSW 2308 Australia Department of Anatomy and Developmental Biology School of Biomedical Sciences Monash University Clayton VIC 3800 Australia

DNA damage is frequently encountered in spermatozoa of subfertile males and is correlated with a range of adverse clinical outcomes including impaired fertilization, disrupted preimplantation embryonic development, increased rates of miscarriage and an enhanced risk of disease in the progeny. The etiology of DNA fragmentation in human spermatozoa is closely correlated with the appearance of oxidative base adducts and evidence of impaired spermiogenesis. We hypothesize that oxidative stress impedes spermiogenesis, resulting in the generation of spermatozoa with poorly remodelled chromatin. These defective cells have a tendency to default to an apeptotic pathway associated with motility loss, caspase activation, phosphatidylserine exteriorization and the activation of free radical generation by the mitochondria. The latter induces lipid peroxidation and oxidative DNA damage, which then leads to DNA fragmentation and cell death. The physical architecture of spermatozoa prevents any nucleases activated as a result of this apoptotic process from gaining access to the nuclear DNA and inducing its fragmentation. It is for this reason that a majority of the DNA damage encountered in human spermatozoa seems to be oxidative. Given the important role that oxidative stress seems to have in the etiology of DNA damage, there should be an important role for antioxidants in the treatment of this condition. If oxidative DNA damage in spermatozoa is providing a sensitive readout of systemic oxidative stress, the implications of these findings could stretch beyond our immediate goal of trying to minimize DNA damage in spermatozoa as a prelude to assisted conception therapy.

关键词： apoptosis DNA damage oxidative stress spermatozoa

Particulate matter and metals partitioning in highway rainfall-runoff

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Frontiers of Environmental Science & Engineering 2010年第1期4卷 35-46页

作者： Gaoxiang YING john j.SANSALONE Environmental Engineering Sciences University of Florida108 Black HallGainesvilleFL 32611USA

This study investigated the particulate matter(PM)and metals in highway dry deposition and rainfallrunoff as a function of hydrologic transport and settling on an event *** were differentiated as mass-limited(ML)and flow-limited(FL).Results indicate that unique and separate suspended sediment concentration(SSC)relationships with turbidity occurred for ML and FL *** minutes of quiescent settling produced a single SSC-turbidity relationship for all *** events transport higher proportions of settleable and sediment PM while FL events transported relatively higher suspended *** batch clarification with one hour of settling,ML events had generally higher treatment efficiencies compared to FL events for the same settling *** dry deposition PM was hetero-disperse and coarse(d50 m=304µm).Results indicate that the acidic rainfall is not a significant contributor to metals in runoff but is capable of leaching metals from dry deposition PM into *** in retained runoff resulted in a particulate-bound predominance for most metals except Ca and *** the finer fraction of dry deposition PM(75µm).

关键词： stormwater particulate matter(PM) turbidity suspended sediment concentration(SSC) unit operations metals dry deposition acid rain

Society the basics john j. Macionis.

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