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QS Alex 755 nm激光对黑素细胞p16INK4a表达的影响

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中华皮肤科杂志 2004年第7期37卷 413-415页

作者：项蕾红 henry HL chan Joseph cK leung 复旦大学附属华山医院皮肤科上海200040 香港大学玛丽医院皮肤科

目的了解激光对黑素细胞潜在恶变作用的可能性。方法QSAlex755nm激光体外照射HTB66、Sk-mel-24和G3613种黑素瘤细胞株,照射剂量为0.85～2J/cm2,24h后收集细胞。应用流式细胞仪和RT-PcR方法分别测定p16INK4a蛋白和p16INK4amRNA在激光照... 详细信息

目的了解激光对黑素细胞潜在恶变作用的可能性。方法QSAlex755nm激光体外照射HTB66、Sk-mel-24和G3613种黑素瘤细胞株,照射剂量为0.85～2J/cm2,24h后收集细胞。应用流式细胞仪和RT-PcR方法分别测定p16INK4a蛋白和p16INK4amRNA在激光照射前后和不同剂量照射后的表达水平。结果激光照射后,HTB66细胞株(p16INK4a蛋白阳性株)的p16INK4a蛋白表达明显增加;而低水平表达的Sk-mel-24和G361细胞株无明显变化。在HTB66细胞株中虽然p16INK4a蛋白的表达上调,但对其功能的测定发现它并不能阻止细胞周期从G0/G1向S/G2m转变。HTB66细胞株的p16INK4amRNA的表达也增加。结论经研究剂量的激光照射后DNA有损伤。具有黑素瘤家族史或个人史的患者可能有p16INK4a基因的突变或丢失,不提倡用激光治疗此类患者的色素性疾病。

关键词： QS Alex 755nm激光黑素细胞 p16INK4a 黑素瘤基因突变

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染料敏化太阳电池光电极厚度的研究

电源技术 2006年第11期30卷 917-920,924页

作者：倪萌 leung m.K.H. leung D.Y.c. 香港大学机械工程系香港

根据电子在半导体中的扩散理论，建立了模拟染料敏化太阳电池（DSSc）J-V输出特性的数学模型。研究表明，随着光电极厚度（d）的增大，开路电压（VOc）下降：短路电流密度（JSc）先迅速增大。后缓慢减小：最大功率输出值mPP则先迅速增... 详细信息

根据电子在半导体中的扩散理论，建立了模拟染料敏化太阳电池（DSSc）J-V输出特性的数学模型。研究表明，随着光电极厚度（d）的增大，开路电压（VOc）下降：短路电流密度（JSc）先迅速增大。后缓慢减小：最大功率输出值mPP则先迅速增大，再迅速减小，表明d对DSSc光电转化效率影响显著。对DSSc的各参数进行了分析，发现操作参数，如光强、温度，对最佳电极厚度的确定没有影响，而物性参数，如光吸收系数、电子扩散系数及电子生命则决定了DSSc光电极厚度的大小。将模型结果与文献实验结果进行了对比，两者符合良好。说明模型结果可靠，可以为DSSc的优化设计提供理论依据。

关键词：染料敏化太阳电池(DSSc) 最大功率输出值mPP 光电极厚度

Ultra-Dense Networking Architectures and Technologies for 5G

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ZTE c.m.unications 2018年第2期16卷 1-2页

作者： victor c.m.leung zhang haijun the University of Brit⁃ish columbia(UBS) Canada the Royal Soci⁃ety of canada the Canadian Academy of Engineering and the Engineering Institute of Canada IEEE University of Science and Technology Beijing China Department of Electrical and c.m.uter Engineering the University of British Columbia(UBC)Canada

With the continuous enric.m.nt of mobile c.m.unication application scenarios in the future, the traditional macro-cellular-based mobile c.m.unication network architecture will be difficult to meet the explosive growth... 详细信息

关键词： In Ultra-Dense Networking Architectures and Technologies for 5G

Advanc.m.nts in Web3 Infrastructure for the metaverse

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ZTE c.m.unications 2024年第2期22卷 1-2页

作者： Victor c.m.leung cAI Wei the Artificial Intelligence Research Institute Shenzhen MSU-BIT University Shenzhen mSU-BIT University Shenzhen University the Wireless Networks and mobile Systems(WiNmoS)Laboratory at UBc the School of Science and Engineering at The chinese University of Hong Kong Shenzhen the Human-crypto Society Laboratory the cUHK(SZ)White matrix Joint metaverse Laboratory

Web3,also known as Web 3.0,has recently been attracting increasing attention from industry and *** the potential of blockchain technologies,Web3 has emerged as a pivotal foundation in the realm of metaverse development,which is considered by many as the next-generation ***,Web3 technologies such as smart contracts and protocols like non-fungible tokens(NFTs)have supported the immersive and content-rich experience of current Web3 metaverse projects.

关键词： Web token attracting

The effect of downstream resistance on flow diverter treatment of a cerebral aneurysm at a bifurcation: A joint c.m.utational-experimental study

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Journal of Hydrodynamics 2018年第5期30卷 803-814页

作者： ANDerson c.O.Tsang Billy Y.S.Yiu Abraham Y.S.Tang W.c.chung Gilberto K.K.leung AlexANDer K.K.Poon Alfred c.H.Yu Simon S.m.Lai K.W.chow Department of Surgery Li Ka Shing Faculty of Medicine University of Hong Kong Department of Electrical and c.m.uter Engineering University of Waterloo Department of mechanical Engineering University of Hong Kong Department of Electrical and Electronic Engineering University of Hong Kong

Intracranial aneurysm can lead to hemorrhagic stroke upon rupture. Deployment of flow diverters can restrict the blood flow into aneurysm and mitigate the rupture risk. c.m.utational fluid dynamics（cFD） and ultrasonography with pulse-wave and color Doppler ultrasound measurements were employed jointly to investigate the c.m.lex flow pattern in cerebral aneurysms, both before and after the deployment of flow diverters. Patient-specific configurations of both bifurcation and side-wall aneurysms were selected. The effect of downstream flow resistance was investigated by adjusting the volume flow rate and pressure at the outlet vessels c.m.utationally and experimentally. Velocity profiles in the aneurysm measured from ultrasonography showed good agreement with those from c.m.uter simulations. The discrepancy in velocity between the c.m.utational and experimental sets of data is less than 10%. The downstream resistance can alter the volume flux into a bifurcation aneurysm with a flow diverter deployed by 236%, while the corresponding value of a side-wall aneurysm is negligible. The vorticity of the aneurysmal flow was reduced by more than 80% in both cases after stenting. This study demonstrated that careful investigation of downstream flow resistance of a bifurcation aneurysm is essential to provide an accurate assessment of the aneurysmal flow dynamics after flow diverter deployment.

关键词： Intracranial aneurysms c.m.utational fluid dynamics (cFD) doppler ultrasound

Enhancing Fairness and Throughput of TcP in Heterogeneous Wireless Networks

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Enhancing Fairness and Throughput of TCP in Heterogeneous Wi...

基于深度强化学习的空天地一体化网络信息物理系统垂直切换策略

IEEE第14届国际个人无线移动通信大会

作者： Victor c.m.leung Dept.of Electrical ＆ c.m.uter Engineering University of British Columbia Vancouver BCCanada V6T1Z4

TcP exhibits inherent unfairness towards connectionswith long round-trip times and connections that have to traversemultiple congested routers. We have previously proposed a TcPBandwidth Allocation (T

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通信学报 2024年第8期45卷 180-191页

作者：武艳潘广川姚明旿杨清海梁中明西安电子科技大学空天地一体化综合业务网全国重点实验室陕西西安710071 深圳大学计算机与软件学院物联网研究中心广东深圳518060

针对空天地一体化网络信息物理系统模型复杂、很难获得网络拓扑先验知识和模型化假设的特点,研究其基于深度强化学习的垂直切换策略。首先,综合考虑系统稳定性、切换开销和网络使用成本约束,将垂直切换策略问题建模为约束马尔可夫决策过... 详细信息

针对空天地一体化网络信息物理系统模型复杂、很难获得网络拓扑先验知识和模型化假设的特点,研究其基于深度强化学习的垂直切换策略。首先,综合考虑系统稳定性、切换开销和网络使用成本约束,将垂直切换策略问题建模为约束马尔可夫决策过程(cmDP),并给出保证可行解存在的充分条件;其次,提出约束-近端策略优化(cPPO)算法解决该问题,并在基站侧引入分布式强化学习机制加速训练收敛。相较于基准策略,仿真验证了所提垂直切换策略的优越性和有效性。

关键词：空天地一体化网络信息物理系统深度强化学习垂直切换

Transcript shortening via alternative polyadenylation promotes gene expression during fracture healing

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Bone Research 2023年第1期11卷 163-177页

作者： Deepak Kumar Khajuria Irena Nowak ming leung Vengadeshprabhu Karuppagounder Yuka Imamura christopher c.Norbury Fadia Kamal Reyad A.Elbarbary Department of Orthopaedics and Rehabilitation The Pennsylvania State University College of MedicineHersheyPA17033USA center for Orthopaedic Research and Translational Science(cORTS) The Pennsylvania State University College of MedicineHersheyPA17033USA Institute for Personalized medicine Penn State College of MedicineHersheyPA17033USA Department of Pharmacology The Pennsylvania State University College of MedicineHersheyPA17033USA Department of microbiology and Immunology The Pennsylvania State University College of MedicineHersheyPA17033USA Department of Biochemistry and molecular Biology The Pennsylvania State University College of MedicineHersheyPA17033USA center for RNA molecular Biology Pennsylvania State UniversityUniversity ParkPA16802USA

maturation of the 3′end of almost all eukaryotic.m.ssenger RNAs(m RNAs)requires cleavage and *** mammalian m RNAs are polyadenylated at different sites within the last exon,generating alternative polyadenylation(APA)isoforms that have the same coding region but distinct 3′untranslated regions(UTRs).The 3′UTR contains motifs that regulate m RNA metabolism;thus,changing the 3′UTR length via APA can significantly affect gene *** ossification is a central process in bone healing,but the impact of APA on gene expression during this process is ***,we report the widespread occurrence of APA,which impacts multiple pathways that are known to participate in bone ***,the progression of endochondral ossification involves global 3′UTR shortening,which is coupled with an increased abundance of shortened transcripts relative to other transcripts;these results highlight the role of APA in promoting gene expression during endochondral bone *** mechanistic studies of transcripts that undergo APA in the fracture callus revealed an intricate regulatory network in which APA enhances the expression of the collagen,type I,alpha 1(col1a1)and col1a2 genes,which encode the 2 subunits of the abundantly expressed protein collagen *** exerts this effect by shortening the 3′UTRs of the col1a1 and col1a2 m RNAs,thus removing the binding sites of mi R-29a-3p,which would otherwise strongly promote the degradation of both *** together,our study is the first to characterize the crucial roles of APA in regulating the 3′UTR landscape and modulating gene expression during fracture healing.

关键词： healing metabolism shortening

Primary biliary cholangitis: personalized medicine for optimal therapeutic opportunities

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Science Bulletin 2022年第24期67卷 2498-2501页

作者： Yulong Shang Patrick S.c.leung m.Eric Gershwin Ying Han National clinical Research center for Digestive Diseases and Xijing Hospital of Digestive Diseases Xijing HospitalAir Force Military Medical UniversityXi’an 710032China Division of Rheumatology Allergy and Clinical ImmunologyUniversity of CaliforniaDavis 95616USA

Primary biliary cholangitis (PBc) is a chronic cholestatic liver disease that is characterized by inflammation of the interlobular bile ducts. Although PBc is a slowly progressive disease, with a natural history of 10–15 years leading to end-stage liver disease, highrisk cases may rapidly progress to dec.m.ensated cirrhosis or even death. As the most c.m.on autoimmune liver disease, the prevalence of PBc has been increasing globally, largely due to increased disease awareness, improved diagnosis, and treatment with ursodeoxycholic acid (UDcA). PBc is more likely to occur in middle-aged women, with a female-to-male ratio ranging from 1.6 to10;however, men have a higher disease severity [1,2].

关键词： diagnosis inflammation Primary