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Rifampicin quinone pretreatment improves neuronal survival by modulating microglia inflammation induced by α-synuclein

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Neural Regeneration Research 2020年第8期15卷 1473-1474页

作者： leonardo acuna Natalia S.Corbalán Rita Raisman-Vozari Consejo Nacional de Investigaciones Científicas y Técnicas(CONICET) Universidad Nacional de Salta(UNSa)SaltaArgentina Institut du Cerveau et de la Moelleépinière(ICM) Inserm U 1127CNRS UMR 7225Sorbonne UniversitéParisFrance

The World Health Organization has predicted that neurodegenerative diseases affecting the motor function will become the second most prevalent cause of death in the next 20 *** therapies can result from three main sources:synthetic compounds,natural products,and existing ***’s disease(PD)is a common neurodegenerative disease affecting 1–3%of the adult population over 50 years of age *** is initially characterized by the death of dopaminergic neurons in the substantia nigra pars compact and later by the widespread loss of nondopaminergic neurons,including those in the cortex.

关键词： inflammation death drugs

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Anti-proliferative effect of Annona extracts on breast cancer cells

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BIOCELL 2023年第8期47卷 1835-1852页

作者： MARIA-LUISA VEISAGA MARIAM AHUMADA STACY SORIANO leonardo acuna WEI ZHANG IVY LEUNG ROBERT BARNUM MANUEL A.BARBIERI Biomolecular Sciences Institute Florida International UniversityMiami33199USA Department of Biological Sciences Florida International UniversityMiami33199USA Biochemistry Ph.D.Program Florida International UniversityMiami33199USA Fairchild Tropical Botanic Garden Coral Gables33156USA International Center of Tropical Botany Florida International UniversityMiami33199USA

Backgorund:Fruits and seed extracts of Annona montana have significant cytotoxic potential in several cancer *** study evaluates the effect of *** leaves hexane extract on several signaling cascades and gene expression in metastatic breast cancer cells upon insulin-like growth factor-1(IGF-1)***:MTT assay was performed to determine the proliferation of cancer *** iodide staining and flow cytometry analysis of Annexin V binding was utilized to measure the progression of the cell cycle and the induction of *** expression and phosphorylation were determined by western blotting analysis to examine the underlying cellular mechanism triggered upon treatment with *** leaves hexane ***:*** leaves hexane(subfraction V)blocked the constitutive stimulation of the PI3K/mTOR signaling *** inhibitory effect was associated with apoptosis induction as evidenced by the positivity with Annexin V and terminal deoxynucleotidyl transferase dUTP nick end labeling(TUNNEL)staining,activation of caspase-3,and cleavage of *** also limited the expression of various downstream genes that regulate proliferation,survival,metastasis,and angiogenesis(i.e.,cyclin D1,survivin,COX-2,and VEGF).It increased the expression of p53 and ***,we also observed that this extract blocked the activation of AKT and ERK without affecting the phosphorylation of the IGF-1 receptor and activation of Ras upon IGF-1 ***:Our study indicates that *** leaves(sub-fraction V)extract exhibits a selective anti-proliferative and proapoptotic effect on the metastatic MDA-MB-231 breast cancer cells through the involvement of PI3K/AKT/mTOR/S6K1 pathways.

关键词： Annona montana Cancer cell lines Apoptosis Anti-proliferative Cell cycle AKT mTOR

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