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Chinese Medical journal 1933年第4期47卷 350-356页

作者： leo j.miltner Division of Orthopedic Surgery Department of SurgeryPeiping Union Medical CollegePeipingChina.

The indications,technique and after-care for open amputation arediscussed briefly,with special reference to the use of the method in casesof severe infection or extensive *** open flapless amputationis preferred for lesions which,like gas-gangrene,tend to spread veryrapidly;but flaps are added when the tissues at the site of division areinfected with less virulent organisms or when the presence of organismsin those tissues is *** is applied to the soft tissues at the end of the stump forseveral weeks after operation 1)to prevent shortening of those struc-tures and protrusion of the bone and 2)to preserve some of the muscletonus and improve the power and the ultimate use of the stump,Thewound is irrigated with Dakin’s solution or normal saline until thegranulations appear clean and healthy,when the edges are broughttogether loosely with adhesive tape or sutures;or irrigation is continueduntil the bacteria-count shows only one or two organisms per high-power microscopic field,when the wound is sutured more firmlytogether. A method of applying traction is described,which has great advan-tage over methods employing adhesive tape,for it permits the woundmargin to be drawn divergently apart without danger of loosening thetractors from the tissues,it does not constrict the tissues in any way,and the attachment of the tractors is not jeopardized by the use *** tractors are silkworm-gut sutures inserted in the sub-cuticular tissues,deep fascia and outer layer of muscle,with the endsleft long and attached to rubber *** sutures are placed atintervals of one to two inches about the stump.A Thomas splint ofspecial design is appl ed to the extremity and serves to maintain thetr ction from the rubber *** first,the sutures are directeddivergently,so as to allow wide-open drainage;and when the timecomes for loose closure,the sutures are crossed bringing the anteriorand posterior edges of the wound *** silkworm-gut cutsthrough the

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THE PATHOLOGY AND TREATMENT OF jOINT SPRAIN

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中华医学杂志(英文版) 1935年第6期49卷 521-528页

作者： leo j.miltner H.C.FANG From the Division of Orthopedic Surgery Department of Surgery and the Department of PathologyPeiping Union Medical CollegePeipingChina

The term sprain signifies an injury of the soft tissues within oraround a joint when the movements of that joint are carried beyondtheir normal physiological limits,or when the bones entering into theformation of the joint are deflected in some abnormal plane,withoutactual *** conditions such as previous injury or mal-alignment due to congenital or acquired causes(i.e.,congenital clubfoot,rachitic knock knee,etc.),predispose to *** lesions which occur during sprain vary consider-

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TYPHOID SPINE

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中华医学杂志(英文版) 1932年第1期46卷 1-11+115-117页

作者： L.K.WANG leo j.miltner Division of Orthopedic Surgery Department of SurgeryPeiping Union Medical CollegePeiping.

1.A review oF the etiology,pathology,diagnosis,and treatmentof typhoid spine is *** cases of typhoid spine are reported,one of which alsopresented a sacro-iliac arthritis of similar etiology.

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Corrosion testing of X52 and X80 steels immersed in stimulated emulsions using a real petroleum sample

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Petroleum Research 2024年第2期9卷 304-316页

作者： L.M.Quej-Ake j.L.Alamilla A.Contreras Instituto Mexicano del Petróleo Eje Central Lázaro CárdenasNorte 152San Bartolo AtepehuacanGustavo A.MaderoCiudad de MéxicoC.P.07730México

The aim of this study is to evaluate the internal corrosion process on X52 and X80 steels/real petroleum interfaces containing condensed hydrocarbon plus oilfield-produced water,which were subjected to stimulated emulsions using 50/50 vol ratio mixtures at 45℃,different hydrodynamic conditions,1 h,and 24 h.A washing process by using deionized water was proposed to simulate and identify the corrosiveness of the hydrocarbon phase after 24 h of exposure *** characterization by electrochemical impedance spectroscopy and the monitoring of the polarization curves indicated that X80 steel/oilfield-produced water interfaces were more susceptible to corrosion than X52 steel exposed to oilfield-produced *** combined speed rotation of 600 rpm using a magnetic stirrer+600 rpm using a rotating disk electrode decreased the corrosion rate on X52 *** stimulated emulsions made of hydrocarbon+oilfield-produced water and hydrocarbon+deionized water at 24 h increased the corrosion rate on X80 steel(0.34 mm/year and 0.43 mm/year,respectively),promoting the formation of erosion and pitting *** types of corrosion depended mainly on the physicochemical properties of the hydrocarbon,oilfield-produced water,exposure times,and hydrodynamic systems in which the hydrocarbon was studied.

关键词： Corrosion Emulsions X52 steel X80 steel

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Lethal means and suicide prevention among military veterans

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Military Medical Research 2023年第1期10卷 139-140页

作者： joshua Levine leo Sher Veterans’Administration New York Harbor Healthcare System BrooklynNY 11209USA james j.Peters Veterans’Administration Medical Center BronxNY 10468USA

Dear Editor,Suicide amongst the military veteran population is a significant *** VeteranSuicidePreventionAnnualReportrevealedthat6261 died by suicide in 2019[1]. The lingering effects of the coronavirus disease 2019 (... 详细信息

关键词： Suicide Depression Public health Lethal means Military veterans

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Method to assess component contribution to toxicity of complex mixtures： Assessment of puberty acquisition in rats exposed to disinfection byproducts

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journal of Environmental Sciences 2017年第8期29卷 311-321页

作者： Shahid Parvez Glenn E.Rice Linda K.Teuschler jane Ellen Simmons Thomas F.Speth Susan D.Richardson Richard j.miltner E.Sidney Hunter Ⅲ jonathan G.Pressman Lillian F.Strader Gary R.Klinefelter jerome M.Goldman Michael G.Narotsky Indiana University Richard M. Fairbanks School of Public Health Department of Environmental Health Sciences IUPUI Campus Indianapolis IN 46202 USA National Center for Environmental Assessment Office of Research and Development U.S. Environmental Protection Agency Cincinnati OH 45268 USA Lincla Teuschler and Associates St. Petersburg FL 33707 USA National Health and Environmental Effects Research Laboratory Office of Research and Development U.S. Environmental Protection Agency Research Triangle Park NC 27711 USA National Risk Management Research Laboratory Office of Research and Development U.S. Environmental Protection Agency Cincinnati OH 45268 USA Department of Chemistry and Biochemistry University of South Carolina Columbia SC 29208 USA

A method based on regression modeling was developed to discern the contribution of component chemicals to the toxicity of highly complex, environmentally realistic mixtures of disinfection byproducts（DBPs）. Chemical disinfection of drinking water forms DBP *** of concerns about possible reproductive and developmental toxicity, a whole mixture（WM） of DBPs produced by chlorination of a water concentrate was administered as drinking water to Sprague–Dawley（S–D） rats in a multigenerational study. Age of puberty acquisition,i.e., preputial separation（PPS） and vaginal opening（VO）, was examined in male and female offspring, respectively. When compared to controls, a slight, but statistically significant delay in puberty acquisition was observed in females but not in males. WM-induced differences in the age at puberty acquisition were compared to those reported in S–D rats administered either a defined mixture（DM） of nine regulated DBPs or individual DBPs. Regression models were developed using individual animal data on age at PPS or VO from the DM study. Puberty acquisition data reported in the WM and individual DBP studies were then compared with the DM models. The delay in puberty acquisition observed in the WM-treated female rats could not be distinguished from delays predicted by the DM regression model, suggesting that the nine regulated DBPs in the DM might account for much of the delay observed in the WM. This method is applicable to mixtures of other types of chemicals and other endpoints.

关键词： Drinking water disinfection byproducts DBP Puberty delay Four Lab Study Mixtures risk assessment

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THE TREATMENT OF OLD DISLOCATION OF THE SHOULDER

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中华医学杂志(英文版) 1936年第9期50卷 1161-1172+1324-1326页

作者： C. M. MENG leo j. miltner M.D. Division of Orthopedic Surgery Department of SurgeryPeiping Union Medical College Peiping China

1. The pathological anatomy of old traumatic dislocation of the shoulder is reviewed and discussed. The dangers of late manipulation are cmphasized.2. The iadications for surgical treatment are outlined. Surgical interference is not advised for old dislocation of the shoulder if good function of the arm is present.3. The technique of open redaction is described and the alternativemethods of surgical treatment such as resection, arthroplasty and artbrodesis are mentioned.4. Fifteen cases of old traumatic dislocation of the shoulder (14 anterior and I posterior), treated by open operation, are reported. Open reduction was successful in 13 cases. In one case, resection of the head of the humerus was necessary because of fracture of the surgical neck during operation. In another case, the open reduction was not completed because of uncontrollable hemorrhage.5. Particular emphasis is placed upon the necessity for carefully applied and prolonged past-operative physiotherapeutie treatment.

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The “mitochondrial stress responses”: the “Dr. jekyll and Mr. Hyde” of neuronal disorders

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Neural Regeneration Research 2022年第12期17卷 2563-2575页

作者： Simone Patergnani Giampaolo Morciano Marianna Carinci Sara leo Paolo Pinton Alessandro Rimessi Department of Medical Sciences Section of Experimental MedicineLaboratory for Technologies of Advanced TherapiesUniversity of FerraraFerraraItaly Center of Research for Innovative Therapies in Cystic Fibrosis University of FerraraFerraraItaly

Neuronal disorders are associated with a profound loss of mitochondrial functions caused by various stress conditions,such as oxidative and metabolic stress,protein folding or import defects,and mitochondrial DNA *** engage in different coordinated responses to safeguard mitochondrial *** this review,we will explore the contribution of mitochondrial stress responses that are activated by the organelle to perceive these dangerous conditions,keep them under control and rescue the physiological condition of nervous *** the sections to come,particular attention will be dedicated to analyzing how compensatory mitochondrial hyperfusion,mitophagy,mitochondrial unfolding protein response,and apoptosis impact human neuronal ***,we will discuss the relevance of the new concept:the“mito-inflammation”,a mitochondria-mediated inflammatory response that is recently found to cover a relevant role in the pathogenesis of diverse inflammatory-related diseases,including neuronal disorders.

关键词： Alzheimer’s disease apoptosis mitochondrial dynamics mito-inflammation mitophagy multiple sclerosis neurodegeneration Parkinson’s disease UPRmt

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Supplementing oat hulls to the diet of suckling piglets altered their intestinal tract and colonic microbiota development

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Animal Nutrition 2023年第1期12卷 284-296页

作者： Hubèrt M.j.van Hees Koen Chiers leo A.den Hartog Theo A.T.G.van Kempen Dominiek Maes Sam Millet Geert P.j.janssens Department of Veterinary and Biosciences Ghent UniversityMerelbekeBelgium Trouw Nutrition Research and Development Amersfoortthe Netherlands Department of Pathology Ghent UniversityMerelbekeBelgium Animal Nutrition Wageningen University and ResearchWageningenthe Netherlands Department of Animal Science North Carolina State UniversityRaleighNCUSA Department of Reproduction Obstetrics and Herd HealthGhent UniversityMerelbekeBelgium ILVO(Flanders Research Institute for Agriculture Fisheries and Food)MelleBelgium

Current study evaluated the effect of a fine and coarsely ground insoluble dietary fibre source on the gastrointestinal development of suckling *** hulls(OH)were selected as a model feedstuff,rich in cellulose,lignin,and insoluble dietary *** experimental supplemental diets were formulated:a finely ground,low fibre and nutrient dense diet served as control(CON).For the 2 high fibre diets,15%heat-treated starch in CON was exchanged with OH,either finely(OH-f)or coarsely ground(OH-c).Litters of 10 primi-and multiparous sows(mean litter size 14.6±0.84)were *** a litter,experimental diets were allotted to triplets of 4 *** approximately 12 d of age,piglets’individual feed intakes were recorded 2 times per day when separated from their dam for 70 *** could suckle with their dam for the remainder of the *** d 24 and 25,from the total pool of 120 piglets,seven healthy well-eating piglets per treatment were selected for post-mortem evaluation,resulting in 14 replicates per *** of OH-c and OH-f did not impede clinical health and production performance of *** full stomach weights tended to be greater for OH-c compared to OH-f whereas CON was intermediate(P=0.083).Supplementing OH significantly increased ileal villus height and caecal dry matter concentration(P<0.05).For the colon,OH increased its length,contents weight,short-chain fatty acid concentration and reduced total bacterial count as well asγ-proteobacteria count and proportion(P<0.05).The OH-c treatment specifically increased full gastrointestinal tract weight and caecum contents weight compared to piglets fed CON and ***,OH-c reduced colonic crypt depth when compared to OH-f(P=0.018).In conclusion,supplementing OH to a diet for suckling piglets exerted subtle developmental effects on gastrointestinal morphology and colonic microbial *** effects were largely independent from the particle size of the OH.

关键词： Oat hull Insoluble fibre Gastrointestinal development Suckling piglet

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Nonlinear analysis of pile load-settlement behavior in layered soil

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journal of Central South University 2015年第9期22卷 3615-3623页

作者：吕述晖王奎华张鹏 C.j.leo Key Laboratory of Soft Soils and Geoenvironmental Engineering of Ministry of Education (Zhejiang University) CCCC Fourth Harbon Engineering Institute Co. Ltd. School of Computing Engineering and Mathematics University of Western Sydney Locked Bag 1797 Penrith Sydney NSW 2751 Australia

A simplified approach is presented to analyze the single pile settlement in multilayered soil. First, a fictitious soil-pile model is employed to consider the effect of layered soil beneath pile toe on pile settlement behavior. Two approximation methods are proposed to simplify the nonlinear load transfer function and simulate the nonlinear compression of fictitious soil-pile, respectively. On this basis, an efficient program is developed. The procedures for determining the main parameters of mathematical model are discussed. Comparisons with two well-documented field experimental pile loading tests are conducted to verify the rationality of the present method. Further studies are also made to evaluate the practicability of the proposed approach when a soft substratum exists, and the results suggest that the proposed method can provide a constructive means for assessing the settlement of a single pile for use in engineering design.

关键词：荷载传递函数非线性分析沉降特性中桩层状土单桩沉降数学模型软弱下卧层

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