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Late Jurassic-Early Cretaceous tectonic switching in Liaodong Peninsula of the North China Craton and the implications for gold mineralisation

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Science China Earth Sciences 2021年第9期64卷 1537-1556页

作者： Dan-Ping yan Ruoyan KONG Xiaoyu DONG Liang qiu Huilong LIU State Key Laboratory of Geological Processes and Mineral Resources China University of GeosciencesBeijing100083China Geophysical Investigation Centre China Geological SurveyLangfang065000China

Constraining the processes of deformation during tectonic switching from compression to extension is difficult because of the scarcity or absence of associated sedimentary and magmatic rocks and weak *** east margin of the eastern North China Craton experienced Early to Middle Jurassic compression and Early Cretaceous ***,the period of tectonic quiescence lasting~13 million years(between 153 and 140 Ma)during which this transition occurred is poorly *** paper reports the identification of small-scale N-S-trending thrust and sinistral strike-slip faults(TSS)and NWtrending thrust and dextral strike-slip faults(TDS)in the Tongyuanpu-Aiyang region,which is part of the northern Liaodong *** of the tectonic stress field using striations,fault planes and kinematics reveals a NW-SE-oriented maximum principal axis(σ1),and sub-horizontalσ2 andσ*** of N-S-trending TSS and NW-trending TDS were arranged with right stepping and resulted in local uplift and erosion at the junctions between fault terminations,which partitioned the Early and Middle Jurassic basins into residual smaller volcanic-sedimentary *** basins were unconformably overlain by small Early Cretaceous volcanic-sedimentary basins,such as those at Tongyuanpu and *** ages and the timing of basin formation constrain the initiation of tectonic switching to 156–153 Ma,and its termination to 140–139 *** suggest that R-R’Riedel shears controlled the formation of the N-S-trending TSS and NW-trending *** R-R’shears were produced by continued sinistral strike-slip and northward growth along the Bohai Bay segment of the Tan-Lu fault zone during the Late Jurassic to early Early Cretaceous,simultaneous with a gradual weakening in the tectonic stress field during a switch in the direction of subduction of the Palaeo-Pacific plate from NW-ward to *** tectonic switching might have promoted the dissolution of gold and migra

关键词： Switch from compression-extension Liaodong Peninsula Late Jurassic-Early Cretaceous R-R’shear Tan-Lu fault zone gold mineralisation

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Monitoring the charge bunch-by-bunch for the SSRF storage ring:Development and application

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Nuclear Science and Techniques 2010年第4期21卷 193-196页

作者： leng Yongbin yan Yingbin YU Luyang YUAN Renxian CHEN Zhichu ZHOU Weimin Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied Physics Shanghai 201800 China

Bunch charge uniformity controlling is very important for top-up operation of the storage *** order to monitor filling pattern and measure the bunch charge precisely,a PXI waveform digitizer-based data acquisition system has been developed to retrieve bunch charge information from BPM pickup *** effective sampling rate is extended to 400 GHz by waveform rebuilding technology,which overlays multi-turn data into single turn with real time sampling rate of 8 *** on-line evaluation indicates that resolution and linearity of the charge measurement are better than 0.5% at input range of 0.5-12nC.

关键词：储存环开发监测波形示波器应用光源上海束团

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Protective effects of MCI-186 on oxidative damage in a cell model of Alzheimer's disease

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Neural Regeneration Research 2010年第16期5卷 1226-1230页

作者： Ming Yu Shujuan Li Wenhui leng Han Chen Yingquan Wu Lirong yan Department of Neurology Affiliated Hospital of Jiangsu University Zhenjiang 212001 Jiangsu Province China Department of Gerontology Affiliated Hospital of Jiangsu University Zhenjiang 212001 Jiangsu Province China

Oxidative stress has an important role in the development of Alzheimer＇s disease （AD）. Beta amyloid protein 25-35 （Aβ25-35） can generate oxygen free radicals, and MCI-186 （3-methyl-l-phenyl-2-pyrazolin-5-one, edaravone） can specifically eliminate hydroxyl radicals. The present study introduced Aβ25-35 into PC12 cells to establish a cell model of AD, and investigated the neuroprotective effects of MCI-186 on AD. Results showed that MCI-186 had a positive effect on the prevention and treatment of AD by inhibiting protein oxidative products, advanced glycation end products, lipid oxidative end products and DNA oxidative damage in PC12 cells induced by Aβ25-35.

关键词： MCI-186 (edaravone) oxidative stress damage beta amyloid protein 25-35 pheochromocytoma (PC12) cells Alzheimer's disease neurodegenerative diseases neural regeneration

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Novel Role of ER Stress and Mitochondria Stress in Serum-deprivation Induced Apoptosis of Rat Mesenchymal Stem Cells

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Current Medical Science 2018年第2期38卷 229-235页

作者： Tong qiu yan-yan HE Xiao ZHANG Xiao-lin MA State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Biomedical Material and Engineering Center Wuhan University of Technology Wuhan 430070 China School of Materials Science and Engineering Wuhan University of Technology Wuhan 430070 China Biomedical Materials and Engineering Research Center of Hubei Province Wuhan University of Technology Wuhan 430070 China International School of Materials Science and Engineering Wuhan University of Techonology Wuhan 430070 China Hubei Key Laboratory of Purification and Application of Plant Anti-cancer Active Ingredients Hubei University of Education Wuhan 430205 China

The poor survival of mesenchymal stem cells （MSCs） compromises the efficacy of stem cell therapy. Growth factor deprivation is one of the important factors that have challenged the survival of donor MSCs in cell therapy. In this study, the aim was to evaluate the effect of serum deprivation on the cell death of MSCs and to investigate the underlying mechanisms. Apoptosis of MSCs was evaluated with Hoechst 33342/PI staining. Signaling pathways involved in serumdeprivation induced apoptosis were analyzed using Western blotting. The results revealed that serum deprivation induced apoptosis in MSCs within 72 h of treatment. Serum deprivation was shown to lead to protein expression alterations in Bax, Bcl-2, casepase-3, casepase-8, GRP78, and CHOP during experiments. The data suggested that the mitochondria death pathway, the extrinsic apoptotic pathway and the endoplastic reticulum（ER） stress pathway were all involved in MSCs apoptosis. The increase in expression of CHOP and the simultaneous decrease in Bcl- 2 expression suggest a synergistic effect in apoptosis induction in both the mitochondrion and the ER.

关键词： mesenchymal stem cells serum deprivation mitochondria pathway endoplasmicreticulum stress synergistic effects

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Optimal timing of preoperative intravitreal anti-VEGF injection for proliferative diabetic retinopathy patients

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International Journal of Ophthalmology(English edition) 2022年第10期15卷 1619-1626页

作者： Yue Xu Chi Xie yan Fang yan Yu Cui qiu Department of Ophthalmology the First Affiliated Hospital of Anhui University of Science&TechnologyHuainan 232001Anhui ProvinceChina Institute of Ophthalmology Anhui University of Science&TechnologyHuainan 232001Anhui ProvinceChina

AIM: To analyze concentrations of vascular endothelial growth factor(VEGF) and fibrosis-related factors in vitreous fluid of proliferative diabetic retinopathy(PDR) patients pretreated with intravitreal anti-VEGF injections(IVI) at different time periods prior to pars plana vitrectomy(PPV), and their correlation with the degree of vitreoretinal fibrosis and explore the optimal timing of preoperative ***: The prospective case-control study from January 2019 to July 2020 included 31 eyes with PDRrelated complications(PDR group) and 21 eyes with nondiabetic ocular disease(control group) requiring PPV. PDR eyes were divided into four groups based on timing of PPV: 3 d after IVI(3-day group);5 d after IVI(5-day group);7 or more days after IVI(≥7-day group);and no IVI. Vitreous fluid samples(0.5-1.0 m L) were collected prior to switching on the infusion before routine 23-G PPV. Concentrations of VEGF, basic fibroblast growth factor(b FGF), periostin(PN), interleukin(IL)-6, IL-8, and tumor necrosis factor(TNF)-α were measured by immunoassay, and concentration differences for each cytokine were compared among the groups. The degree of vitreoretinal fibrosis was graded intraoperatively, and the correlation between the changes in cytokine levels and the severity of vitreoretinal fibrosis was analyzed by univariate ordinal logistic regression ***: PDR eyes without IVI had significantly higher VEGF, b FGF, PN, and IL-6 concentrations than nondiabetic eyes(all P<0.05), and had a significantly higher concentration of VEGF(P<0.05) and a significantly lower concentration of IL-8(P<0.05) than PDR eyes with IVI. Statistically significant differences were also observed for concentrations of VEGF, b FGF, PN, IL-6, and IL-8 among 3-day, 5-day, and ≥7-day groups(all P<0.05);meanwhile there was no significant difference in TNF-α among groups(P=0.226). The 5-day group had the lowest concentration of VEGF and the ≥7-day group had the highest concentration of b FGF and P

关键词： preoperative timing intravitreal anti-VEGF injection angio-fibrosis switch proliferative diabetic retinopathy

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Baseline recovery method to measure bunch charge under low-current mode of SSRF

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Nuclear Science and Techniques 2011年第5期22卷 261-264页

作者： CHEN Zhichu leng Yongbin ZOU Yi yan Yingbin ZHOU Weimin Shanghai Synchrotron Radiation Facility Shanghai Institute of Applied Physics Shanghai 201800 China

The top-up injection mode of Shanghai Synchrotron Radiation Facility(SSRF) needs precise measurement of the beam bunch *** is performed by an integration current transformer,but the beam current is too low to neglect the background *** order to wipe out the noise coming from the ground loops,the adaptable polynomial fitting method is used to extract the baseline,instead of using the constant background or the linear background model. Test results show that the system resolution can be improved to <3%.

关键词：上海同步辐射装置电流模式光源基线背景噪声电流互感器 SSRF 接地回路

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Formation of six-coordinated silicon in calcium phosphosilicate xerogels assisted by polyols at low temperature and pressure

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Chinese Chemical Letters 2015年第6期26卷 768-772页

作者： Ai-Ling Li yan-Ping Ma Dong qiu Beijing National Laboratory for Molecular Sciences State Key Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of Sciences

Silicon is usually found to be four-coordinated when neighbored with oxygen. Six-coordinated silicon is only seen in samples at very specific composition or made at high temperature/pressure. In this study, we managed to synthesize calcium phosphosilicate xerogels containing six-coordinated silicon with the help of polyols by sol-gel method, without the need of treatment at high temperature or high pressure. Both phosphorus precursors and polyols were found to be essential for the formation of six-coordinated silicon species; in the absence of either species, only normal four-coordinated silicon was observed under otherwise identical conditions. Samples containing six-coordinated silicon sites were found to release silicon species faster than those without six-coordinated silicon sites upon dissolved in water, suggesting that six-coordinated silicon species have higher reactivity toward hydrolysis.

关键词： Phosphosilicate Six-coordinated silicon PolyolsMAS-NMR

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Synthesis of a di(2-picolyl)amino-b-diketone dual-functional ligand that can coordinate to europium(Ⅲ) for responding to copper(Ⅱ) and sulfide ions

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Chinese Chemical Letters 2015年第12期26卷 1485-1489页

作者： yan Liu qiu-Ling Shi Jing-Li Yuan College of Environmental Science and Engineering Dalian Maritime University State Key Laboratory of Fine Chemicals School of Chemistry Dalian University of Technology

Lanthanide complex-based luminescent probes/chemosensors have shown great utilities in various biological and environmental assays with time-resolved detection mode to eliminate background *** this work,by conjugating di（2-picolyl）amine（DPA）with a tetradentateβ-diketone 1,2-bis[4＇-（1＂,1＂,1＂,2＂,2＂-pentafluoro-3＂,5＂-pentanedion-5＂-yl）benzyl]-4-chlorosulfo-benzene（BPPBCB）,a novel dual-functional ligand that can coordinate to Eu^（3＋）for responding to Cu^（2＋）and S^2 ions in aqueous media,DPA-BPPBCB,has been designed and ***β-diketone moiety of DPA-BPPBCB can form a strongly luminescent complex with Eu^（3＋）.Upon reaction with Cu^（2＋）,accompanied by the formation of heterobimetallic complex Cu^（2＋）-DPA-BPPBCB-Eu^（3＋）,the Eu^（3＋）luminescence was *** in the presence of S^2,owing to the high affinity of S^2 to Cu^（2＋）,stable CuS was formed,which resulted in the release of Cu^（2＋）from Cu^（2＋）-DPA-BPPBCB-Eu^（3＋）,to restore the luminescence of the Eu^（3＋）*** unique＂on-off-on＂luminescence response of the Eu3＋complex enabled Cu^（2＋）and S^2 ions in aqueous media to be detected with time-resolved luminescence detection mode.

关键词： luminescence coordinate luminescent sulfide probes responding restore spectrometer eliminate moiety

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Template-directed synthesis of pyridazine-containing tetracationic cyclophane for construction of[2]rotaxane

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Chinese Chemical Letters 2017年第5期28卷 1013-1017页

作者： qiu-Sheng Fang Ling Chen Qing-yan Liu Department College of Chemistry and Chemical Engineering Key Laboratory of Functional Small Organic MoleculesMinistry of EducationInstitution Jiangxi Normal UniversityNanchang 330022China

Benefiting from its bent molecular structure,3,6-pyridazinyl contained tetracationic cyclophane（1） is synthesized by template-directed method with high isolated yield up to 92%.This template-directed strategy is fur... 详细信息

关键词： Tetracationic cyclophane Template effect Inclusion complex π-Stacking Rotaxane

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Effects of temperature and magnetic field direction on the electron-hole compensation in WTe_2

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Science China(Physics,Mechanics & Astronomy) 2016年第7期59卷 86-87页

作者： yan Li YaBin Zhu YouGuo Shi XiangGang qiu School of Science Beijing Jiaotong University Institute of Physics Chinese Academy of Sciences

Dear Editors, Tungsten ditelluride （WTe2） is a layered transition-metal dichalcogenide （TMD）. The tungsten layers are clipped by adjacent chalcogenide layers. The sandwich structure stacks along the c-axis with Van Der Waals bonding between layers. Particularly, tungsten chains are formed along the a-axis within the dichalcogenide layers.

关键词：补偿效应电子空穴磁场温度范德瓦尔斯过渡金属层间结合夹层结构

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