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Comparison efficacy and safety of total laparoscopic gastrectomy and laparoscopically assisted total gastrectomy in treatment of gastric cancer

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World Journal of Gastrointestinal Surgery 2024年第6期16卷 1871-1882页

作者： Long Li Dong-Yuan Liu Jing leng Xue-Mei Tao Hui-Qin Wu yan-Peng Zhu Department of General Surgery The 971^(st)Hospital of Chinese People's Liberation ArmyQingdao 266071Shandong ProvinceChina Department of Surgery Qingdao Municipal HospitalQingdao 266071Shandong ProvinceChina Hyperbaric Oxygen Department The Eighth Peoples Hospital of QingdaoQingdao 266121Shandong ProvinceChina Department of Gastrointestinal Surgery The First Affiliated Hospital of Naval Medical UniversityShanghai 200433China

BACKGROUND The development of laparoscopic technology has provided a new choice for surgery of gastric cancer(GC),but the advantages and disadvantages of laparoscopic total gastrectomy(LTG)and laparoscopic-assisted total gastrectomy(LATG)in treatment effect and safety are still *** purpose of this study is to compare the efficacy and safety of the two methods in the treatment of GC,and to provide a basis for clinical *** To compare the efficacy of totally LTG(TLTG)and LATG in the context of radical gastrectomy for ***,we investigated the safety and feasibility of the total laparoscopic esophagojejunostomy *** Literature on comparative studies of the above two surgical methods for GC(TLTG group and LATG group)published before September 2022 were searched in the PubMed,Web of Science,Wanfang Database,CNKI,and other Chinese and English *** addition,the following search keywords were used:Gastric cancer,total gastrectomy,total laparoscopy,laparoscopy-assisted,esophagojejunal anastomosis,gastric/stomach cancer,total gastrectomy,totally/completely laparoscopic,laparoscopic assisted/laparoscopy assisted/laparoscopically assisted,and esophagojejunostomy/esophagojejunal *** Manager 5.3 software was used for the meta-analysis after two researchers independently screened the literature,extracted the data,and evaluated the risk of bias in the included *** After layer-by-layer screening,258 pieces of literature were recovered,and 11 of those pieces were eventually *** resulted in a sample size of 2421 instances,with 1115 cases falling into the TLTG group and 1306 cases into the LATG *** or sex differences between the two groups were not statistically significant,according to the meta-analysis,however the average body mass index of the TLTG group was considerably higher than that of the LATG group(P=0.01).Compared with those in the LATG group,the incision length in the TLTG

关键词： Total laparoscopic gastrectomy Laparoscopically assisted total gastrectomy Gastric cancer Meta-analysis

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Minimizing interfacial energy losses in inverted perovskite solar cells by a dipolar stereochemical 2D perovskite interface

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Journal of Energy Chemistry 2024年第3期90卷 496-503,I0011页

作者： Junjie Qian Jingjing He Qihang Zhang Chenyue Zhu Shilin Chen Zhanpeng Wei Xuesong leng Ziren Zhou Benben Shen Yu Peng Qiang Niu Shuang yang Yu Hou Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Hierarchical NanomaterialsSchool of Materials Science and EngineeringEast China University of Science and TechnologyShanghai 200237China National Enterprise Technology Center Inner Mongolia Erdos Electric Power and Metallurgy Group Company LimitedOrdos 016064Inner MongoliaChina

Inverted perovskite solar cells(PSCs) have attracted broad research and industrial interest owing to their suppressed hysteresis,cost-effectiveness,and ***,the issue of non-radiative recombination losses at the n-type interface between the perovskite and fullerene has impeded further improvement of photovoltaic ***,we modify the n-type interface of FAPbI_(3) perovskite films by constructing a stereochemical two-dimensional(2D) perovskite interlayer,in which the organic cations comprise both pyridine and ammonium *** pyridine N donor can create stable bonding with the surface-uncoordinated Pb on the perovskite,thereby passivating the shallow-level defects and enhancing the air stability of the ***,the pyridine N donor also offers a positive polar interface to decrease the surface work function of the perovskite film,enabling n-type ***,we employ a p-i-n photovoltaic(PV) device with the positive dipole interlayer at perovskite/fullerene contact and achieve remarkable photoelectric conversion efficiency(PCE) of 22.0%.

关键词： Perovskite solar cells Dipole interlayer Stereochemistry Non-radiative recombination

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人工智能加速GPCR配体的发现

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Engineering 2024年第1期32卷 18-28页

作者： Wei Chen Chi Song Liang leng Sanyin Zhang Shilin Chen State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China

G protein-coupled receptors(GPCRs)are crucial players in various physiological processes,making them attractive candidates for drug ***,traditional approaches to GPCR ligand discovery are time-consuming and *** emergence of artificial intelligence(AI)methods has revolutionized the field of GPCR ligand discovery and has provided valuable tools for accelerating the identification and optimization of GPCR *** this study,we provide guidelines for effectively utilizing AI methods for GPCR ligand discovery,including data collation and representation,model selection,and specific ***,the online resources that are instrumental in GPCR ligand discovery were summarized,including databases and repositories that contain valuable GPCR-related information and ligand ***,GPCR and ligand representation schemes that can convert data into computer-readable formats were ***,the key applications of AI methods in the different stages of GPCR drug discovery were discussed,ranging from GPCR function prediction to ligand design and agonist ***,an AI-driven multi-omics integration strategy for GPCR ligand discovery that combines information from various omics disciplines was ***,the challenges and future directions of the application of AI in GPCR research were *** conclusion,continued advancements in AI techniques coupled with interdisciplina ry collaborations will offer great potential for improving the efficiency of GPCR ligand discovery.

关键词： G protein-coupled receptor Ligand Artificial intelligence Multi-omics Drug discovery

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Optimization for epitaxial fabrication of infinite-layer nickelate superconductors

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Frontiers of physics 2024年第3期19卷 61-69页

作者： Minghui Xu yan Zhao Xiang Ding Huaqian leng Shu Zhang Jie Gong Haiyan Xiao Xiaotao Zu Huiqian Luo Ke-Jin Zhou Bing Huang Liang Qiao School of Physics University of Electronic Science and Technology of ChinaChengdu 610054China Beijing Computational Science Research Center Beijing 100193China Diamond Light Source Harwell CampusDidcot OX110DEUnited Kingdom Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China Songshan Lake Materials Laboratory Dongguan 523808China

The discovery of nickelates superconductor creates exciting opportunities to unconventional superconductivity. However, its synthesis is challenging and only a few groups worldwide can obtain samples with zero-resistance. This problem becomes the major barrier for this field. From plume dynamics perspective, we found the synthesis of superconducting nickelates is a complex process and the challenge is twofold, i.e., how to stabilize an ideal infinite-layer structure Nd_(0.8)Sr_(0.2)NiO_(2), and then how to make Nd_(0.8)Sr_(0.2)NiO_(2) superconducting? The competition between perovskite Nd_(0.8)Sr_(0.2)NiO_(3) and Ruddlesden−Popper defect phase is crucial for obtaining infinite-layer structure. Due to inequivalent angular distributions of condensate during laser ablation, the laser energy density is critical to obtain phase-pure Nd_(0.8)Sr_(0.2)NiO_(3). However, for obtaining superconductivity, both laser energy density and substrate temperature are very important. We also demonstrate the superconducting Nd_(0.8)Sr_(0.2)NiO_(2) epitaxial film is very stable in ambient conditions up to 512 days. Our results provide important insights for fabrication of superconducting infinite-layer nickelates towards future device applications.

关键词： nickelate superconductivity infinite-layer plasma condensate plume dynamics

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早期胚胎极性建立及对谱系分化的影响

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遗传 2024年第3期46卷 199-208页

作者：朱奕陈雪沁冷丽智林戈中南大学基础医学院生殖与干细胞工程研究所长沙410000 中信湘雅生殖与遗传专科医院长沙410000

极性建立是影响早期胚胎发育的关键因素之一。极性建立起始于8细胞胚胎的肌球蛋白磷酸化,磷酸化激活肌动蛋白导致其启动收缩力。随后,肌动蛋白发生重组在每个卵裂球的非接触表面形成富含微绒毛的顶端结构域,并在极性蛋白复合物等的共同... 详细信息

极性建立是影响早期胚胎发育的关键因素之一。极性建立起始于8细胞胚胎的肌球蛋白磷酸化,磷酸化激活肌动蛋白导致其启动收缩力。随后,肌动蛋白发生重组在每个卵裂球的非接触表面形成富含微绒毛的顶端结构域,并在极性蛋白复合物等的共同作用下形成标志着顶端结构域成熟的肌动球蛋白环。从极性建立的过程可知,顶端结构域的形成受到肌动蛋白相关蛋白以及极性蛋白复合物的影响,并且部分合子基因组激活(zygote genome activation,ZGA)和谱系分化特异性基因也会调控极性建立。在早期胚胎发育过程中,极性建立是第一次细胞谱系分化的基础。它通过影响不对称细胞分裂、谱系分化因子的不对称定位以及Hippo信号通路的活性来调控谱系分离和形态发生。本文对哺乳动物早期胚胎极性建立及对谱系分化影响的相关研究进行了梳理和总结,并讨论了目前已有研究在调控机制和物种方面的不足,以期为阐明早期胚胎极性建立提供线索与系统性视角。

关键词：早期胚胎发育胚胎极性建立谱系分化

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On the relationship between imprint and reliability in Hf_(0.5)Zr_(0.5)O_(2) based ferroelectric random access memory

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Journal of Semiconductors 2024年第4期45卷 42-47页

作者： Peng Yuan Yuting Chen Liguo Chai Zhengying Jiao Qingjie Luan Yongqing Shen Ying Zhang Jibin leng Xueli Ma Jinjuan Xiang Guilei Wang Chao Zhao Beijing Superstring Academy of Memory Technology Beijing 100176China

The detrimental effect of imprint,which can cause misreading problem,has hindered the application of ferroelectric HfO_(2).In this work,we present results of a comprehensive reliability evaluation of Hf_(0.5)Zr_(0.5)O_(2)-based ferroelectric random access *** influence of imprint on the retention and endurance is ***,a solution in circuity is pro-posed to effectively solve the misreading problem caused by imprint.

关键词： FeRAM HZO imprint reliability

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General anesthetic agents induce neurotoxicity through astrocytes

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Neural Regeneration Research 2024年第6期19卷 1299-1307页

作者： yanchang yang Tiantian Liu Jun Li Dandan yan Yuhan Hu Pin Wu Fuquan Fang Patrick M.McQuillan Wenxin Hang Jianhang leng Zhiyong Hu Department of Anesthesiology The First Affiliated Hospital Zhejiang University School of Medicine Department of Anesthesiology Ningbo Women and Children's Hospital 3. Department of Anesthesiology Shulan (Hangzhou) Hospital Affiliated to Zhejiang Shuren University Shulan International Medical College 4. Cell Biology Department Yale University 5. Department of Anesthesiology Penn State Hershey Medical Centre Penn State College of Medicine 6. Department of Central Laboratory Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine

Neuroscientists have recognized the importance of astrocytes in regulating neurological function and their influence on the release of glial transmitters. Few studies, however, have focused on the effects of general anesthetic agents on neuroglia or astrocytes. Astrocytes can also be an important target of general anesthetic agents as they exert not only sedative, analgesic, and amnesic effects but also mediate general anesthetic-induced neurotoxicity and postoperative cognitive dysfunction. Here, we analyzed recent advances in understanding the mechanism of general anesthetic agents on astrocytes, and found that exposure to general anesthetic agents will destroy the morphology and proliferation of astrocytes, in addition to acting on the receptors on their surface, which not only affect Ca2+signaling, inhibit the release of brain-derived neurotrophic factor and lactate from astrocytes, but are even involved in the regulation of the pro-and anti-inflammatory processes of astrocytes. These would obviously affect the communication between astrocytes as well as between astrocytes and neighboring neurons, other neuroglia, and vascular cells. In this review, we summarize how general anesthetic agents act on neurons via astrocytes, and explore potential mechanisms of action of general anesthetic agents on the nervous system. We hope that this review will provide a new direction for mitigating the neurotoxicity of general anesthetic agents.

关键词： astrocytes brain-derived neurotrophic factor general anesthetic agents neuron neurotoxicity N-methyl-D-aspartate receptor perioperative neurocognition Toll-like receptor γ-aminobutyric acid receptor

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光纤陀螺热致漂移分析及算法补偿技术研究

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光学学报 2024年第2期44卷 127-134页

作者：冷悦钟胜华中科技大学人工智能与自动化学院湖北武汉430074 多谱信息智能处理技术全国重点实验室湖北武汉430074 华中光电技术研究所武汉光电国家研究中心湖北武汉430223

通过对光纤陀螺温度漂移的剖析推导,分析了温度扰动引起陀螺漂移误差的深层次原因,并结合过程相关性理论,对各个温度项影响因子与光纤陀螺实际输出相关性进行验证分析,提出一种同时考虑温度、温变速率、温度梯度以及三者乘积耦合项的算... 详细信息

通过对光纤陀螺温度漂移的剖析推导,分析了温度扰动引起陀螺漂移误差的深层次原因,并结合过程相关性理论,对各个温度项影响因子与光纤陀螺实际输出相关性进行验证分析,提出一种同时考虑温度、温变速率、温度梯度以及三者乘积耦合项的算法补偿模型。对该模型的补偿效果进行离线补偿验证,结果表明,采用该算法补偿模型能明显抑制光纤陀螺的变温零漂。为了进一步验证该模型的有效性,把离线获得的补偿参数载入陀螺存储器,经过多样本实验测试,补偿后可有效提高光纤陀螺的全变温零偏稳定性,验证了该补偿算法在工程上的可实施性和推广价值。

关键词：光纤光学光纤陀螺 Shupe效应光纤环圈温变速率补偿算法

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Evaluation of the injection and plugging ability of a novel epoxy resin in cement cracks

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Petroleum Science 2024年第2期21卷 1211-1220页

作者： Guang-yao leng Wei yan Hai-Mu Ye Er-Dong yao Ji-Bin Duan Zheng-Xian Xu Ke-Pei Li Jing-Ru Zhang Zhong Li State Key Laboratory of Petroleum Resource&Prospecting China University of Petroleum(Beijing)Beijing102249China CNPC Liaohe Oilfield Gas Storage Co.LTD Panjin124000LiaoningChina CNOOC Research Institute Co. Ltd.Beijing100028China

Sustained casing pressure(SCP)is a crucial issue in the oil and gas production *** resins,exhibiting exceptional compressive strength,ductility,and shear bonding strength,have the potential to form reliable *** injectivity and sealing capacity of the epoxy resin is crucial parameters for the success of shallow remediation *** study aimed to develop and assess a novel solid-free resin sealant as an alternative to Portland cement for mitigating fluid *** investigation evaluated the viscosity,compressive strength,and brittleness index of the epoxy resin sealant,as well as its tangential and normal shear strengths in conjunction with casing *** flow characteristics and sealing abilities of conventional cement and epoxy resin were comparatively analyzed in *** results showed that the application of a viscosity reducer facilitated control over the curing time of the epoxy resin,ranging from 1.5 to 6 h,and reduced the initial viscosity from 865.53 to 118.71 m Pa,*** mechanical properties of the epoxy resin initially increased with a rise in curing agent content before experiencing a minor *** epoxy resin containing 30%curing agent exhibited optimal mechanical *** a 14-day curing period,the epoxy resin's compressive strength reached81.37 MPa,2.12 times higher than that of cement,whereas the elastic modulus of cement was 2.99 times greater than that of the epoxy *** brittleness index of epoxy resin is only 3.42,demonstrating high flexibility and *** tangential and normal shear strengths of the epoxy resin exceeded those of cement by 3.17 and 2.82 times,*** a 0.5 mm-wide crack,the injection pressure of the epoxy resin remained below 0.075 MPa,indicating superior injection and flow ***,the injection pressure of cement surged dramatically to 2.61 MPa within 5 *** breakthrough pressure of0.5 PV epoxy resin reached 7.53 MPa,decreasing the crack's perme

关键词： Sustained casing pressure Epoxy resin sealant Curing agent Viscosity reducer Mechanical properties Crack sealing

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铁路机电设备的自动化改造与维护管理

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科学与信息化 2024年第4期 159-161页

作者：冷亚斌中铁广州工程局集团有限公司广东广州 511459

近些年来,因为高铁动车广泛的投用,导致车辆行驶速度、里程数也在持续提升,由此推动了国内铁路机电设备自动化系统的健全.伴随科技水平的不断提高,现代科技也获得了良好的发展,如网络技术、通信技术与铁路工厂等.把先进科技和机械设备... 详细信息

近些年来,因为高铁动车广泛的投用,导致车辆行驶速度、里程数也在持续提升,由此推动了国内铁路机电设备自动化系统的健全.伴随科技水平的不断提高,现代科技也获得了良好的发展,如网络技术、通信技术与铁路工厂等.把先进科技和机械设备控制系统加以结合,可以显著提高机电设备的发展水平.基于此,本文着重就铁路机电设备的自动化改造与维护管理展开分析.

关键词：铁路机电设备自动化改造维护管理

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