检索结果-南通市图书馆

Postoperative outcomes and recurrence patterns of intermediatestage hepatocellular carcinoma dictated by the sum of tumor size and number

引用

World Journal of Gastroenterology 2022年第44期28卷 6271-6281页

作者： Xin-Sheng Hu Hui-Yuan Yang Chao leng Zhi-wei Zhang Hepatic Surgery Center Tongji HospitalTongji Medical College of Huazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND The selection criteria for Barcelona Clinic Liver Cancer(BCLC)intermediate-stage hepatocellular carcinoma(HCC)patients who would truly benefit from liver resection(LR)remain *** To identify BCLC-B HCC patients more suitable for *** We included patients undergoing curative LR for BCLC stage A or B multinodular HCC(MNHCC)and stratified BCLC-B patients by the sum of tumor size and number(N+S).Overall survival(OS),recurrence-free survival(RFS),recurrence-to-death survival(RTDS),recurrence patterns,and treatments after recurrence in BCLC-B patients in each subgroup were compared with those in BCLC-A *** In total,143 patients who underwent curative LR for MNHCC with BCLC-A(n=25)or BCLC-B(n=118)were retrospectively *** to the N+S,patients with BCLC-B HCC were divided into two subgroups:BCLC-B1(N+S≤10,n=83)and BCLC-B2(N+S>10,n=35).Compared with BCLC-B2 patients,those with BCLC-B1 had a better OS(5-year OS rate:67.4%vs 33.6%;P<0.001),which was comparable to that in BCLC-A patients(5-year OS rate:67.4%vs 74.1%;P=0.250),and a better RFS(median RFS:19 mo vs 7 mo;P<0.001),which was worse than that in BCLC-A patients(median RFS:19 mo vs 48 mo;P=0.022).Further analysis of patients who developed recurrence showed that both BCLC-B1 and BCLC-A patients had better RTDS(median RTDS:Not reached vs 49 mo;P=0.599),while the RTDS in BCLC-B2 patients was worse(median RTDS:16 mo vs not reached,P<0.001;16 mo vs 49 mo,P=0.042).The recurrence patterns were similar between BCLC-B1 and BCLC-A patients,but BCLC-B2 patients had a shorter recurrence time and a higher proportion of patients had recurrence with macrovascular invasion and/or extrahepatic metastasis,both of which were independent risk factors for *** BCLC-B HCC patients undergoing hepatectomy with N+S≤10 had mild recurrence patterns and excellent OS similar to those in BCLC-A MNHCC patients,and LR should be considered in these patients.

关键词： Hepatocellular carcinoma Multinodular Intermediate-stage Liver resection Recurrence pattern Prognosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Data augmentation and machine learning techniques for control strategy development in bio-polymerization process

引用

Environmental Science and Ecotechnology 2022年第3期11卷 40-48页

作者： Sizhou wei Zhiyuan Chen Senthil Kumar Arumugasamy Irene Mei leng Chew School of Computer Science University of NottinghamNottinghamNG81BBUnited Kingdom School of Computer Science University of Nottingham MalaysiaSemenyih43500Malaysia Department of Chemical and Environmental Engineering University of Nottingham MalaysiaSemenyih43500Malaysia School of Engineering Monash University MalaysiaSubang Jaya47500Malaysia

Machine learning has been increasingly used in ***,in organic chemistry and other experiment-based fields,data collected from real experiments are inadequate and the current coronavirus disease(COVID-19)pandemic has made the situation even *** limited data resources may result in the low performance of modeling and affect the proper development of a control *** paper proposes a feasible machine learning solution to the problem of small sample size in the biopolymerization *** avoid overfitting,the variational auto-encoder and generative adversarial network algorithms are used for data *** random forest and artificial neural network algorithms are implemented in the modeling *** results prove that data augmentation techniques effectively improve the performance of the regression *** machine learning models were compared and the experimental results show that the random forest model with data augmentation by the generative adversarial network technique achieved the best performance in predicting the molecular weight on the training set(with an R^(2) of 0.94)and on the test set(with an R^(2) of 0.74),and the coefficient of determination of this model was 0.74.

关键词： Bio-polymerization Variational autoencoder generative adversarial network Random forest Artificial neural network

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Boron-Oxygen Bond Cleavage of Pinacolborane and Catecholborane Mediated by a Scandium Phosphinidene Complex

引用

Chinese Journal of Chemistry 2014年第8期32卷 752-756页

作者： wei Wang Yingdong Lv Xiaofeng Gou Xuebing leng Yaofeng Chen Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education College of Chemistry and Materials ScienceNorthwest UniversityXi'anShaanxi 710069China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghai 200032China

Reactions of bis-scandium bridged phosphinidene complex,[LSc(μ-PAr)]_(2)(L=MeC(NDIPP)CHC(Me)(NCH_(2)CH_(2)N(^(i)Pr)_(2)),DIPP=2,6-(^(i)Pr)_(2)C_(6)H_(3);Ar=2,6-Me_(2)C_(6)H_(3))(1),with pinacolborane,catecholborane,and 9-borabicyclo[3.3.1]nonane(9-BBN)are *** 1 reacts with pinacolborane and catecholborane to give scandium pinacolate(2)and catecholate(3),showing B-O bond *** two scandium complexes contain an unusual[P(Ar)B(H)P(Ar)]^(2−)dianion,which displays aμ-η^(2):η^(2) coordination *** the other hand,reaction of complex 1 with 9-BBN affords the B-H bond cleavage product,1,3-diphospha-2,4-diboracyclobutane(4).

关键词： catecholborane phosphinidene pinacolborane scandium reactivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Formation and rupture of liver hematomas caused by intrahepatic gallbladder perforation:A case report and review of literature

引用

World Journal of Gastrointestinal Surgery 2024年第10期16卷 3301-3311页

作者： Hong-wei Huang Hao Wang Chao leng Bin Mei Hepatic Surgery Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030Hubei ProvinceChina

BACKGROUND Gallbladder perforation is a serious complication of acute *** perforation is a rare but life-threatening situation that can lead to the formation and rupture of liver ***,we report a case of a ruptured intrahepatic hematoma caused by intrahepatic gallbladder perforation,and we present a literature *** SUMMARY A 70-year-old male was admitted to the hospital with a complaint of right upper quadrant abdominal pain,flustering and *** preoperative diagnosis was a ruptured malignant liver tumor,and the patient’s medical images and increased level of carbohydrate antigen-199 suggested that the gallbladder had been ***,the tumor was proven to be a liver hematoma secondary to gallbladder perforation after *** patient was discharged uneventfully on the fifteenth postoperative *** Intrahepatic gallbladder perforation is difficult to diagnose *** examinations play a crucial role in the diagnosis but only for partial *** diagnosis and appropriate surgery are key to managing this rare condition.

关键词： Intrahepatic gallbladder perforation Cholecystitis Liver rupture Intraperitoneal hemorrhage Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

β-Receptor blocker enhances the anabolic effect of PTH after osteoporotic fracture

引用

Bone Research 2024年第2期12卷 302-313页

作者： Jie Huang Tong Wu Yi-Rong Jiang Xuan-Qi Zheng Huan Wang Hao Liu Hong Wang Hui-Jie leng Dong-wei Fan Wan-Qiong Yuan chun-Li Song Department of Orthopedics Peking University Third Hospital100191 BeijingChina Beijing Key Laboratory of Spinal Disease 100191 BeijingChina Engineering Research Center of Bone and Joint Precision Medicine 100191 BeijingChina

The autonomic nervous system plays a crucial role in regulating bone metabolism,with sympathetic activation stimulating bone resorption and inhibiting bone *** found that fractures lead to increased sympathetic tone,enhanced osteoclast resorption,decreased osteoblast formation,and thus hastened systemic bone loss in ovariectomized(OVX)***,the combined administration of parathyroid hormone(PTH)and theβ-receptor blocker propranolol dramatically promoted systemic bone formation and osteoporotic fracture healing in OVX *** effect of this treatment is superior to that of treatment with PTH or propranolol *** vitro,the sympathetic neurotransmitter norepinephrine(NE)suppressed PTH-induced osteoblast differentiation and mineralization,which was rescued by ***,NE decreased the PTH-induced expression of Runx2 but enhanced the expression of Rankl and the effect of PTH-stimulated osteoblasts on osteoclastic differentiation,whereas these effects were reversed by ***,PTH increased the expression of the circadian clock gene Bmal1,which was inhibited by NE-βAR ***1 knockdown blocked the rescue effect of propranolol on the NE-induced decrease in PTHstimulated osteoblast *** together,these results suggest that propranolol enhances the anabolic effect of PTH in preventing systemic bone loss following osteoporotic fracture by blocking the negative effects of sympathetic signaling on PTH anabolism.

关键词： blocker metabolism inhibited

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Study of the crosstalk evaluation for cavity BPM

引用

Nuclear Science and Techniques 2018年第6期29卷 67-75页

作者： Jian Chen Yong-Bin leng Lu-Yang Yu Long-wei Lai Ren-Xian Yuan Shanghai Institute of Applied Physics Chinese Academy of Science Shanghai 201204 China University of the Chinese Academy of Science Beijing 100049 China

In order to pursue high-precision beam position measurements for free-electron laser facilities, a cavity beam position monitor(CBPM) is employed to measure the transverse position that can meet the requirement of position resolution at a sub-micrometer or even nanometer scale. However, for the pill-box cavity BPM, crosstalk between the cavities will have an effect on the accurate measurement of beam position. To reduce the effect of crosstalk on CBPM performance and ease the measurement of the isolation between the cavities, the cavities with a slight difference in resonant frequency were designed and applied in the Dalian coherent light source and Shanghai soft X-ray free-electron laser facilities. Furthermore, two methods, the principal component analysis method and the method of harmonic analysis, are proposed in this paper to evaluate the crosstalk. The results demonstrate that the two methods are feasible in evaluating the crosstalk between the cavities.

关键词： BPM 串音评估位置分辨率学习精确测量激光设备主要部件

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Mathematical method in optical molecular imaging

引用

Science China(Information Sciences) 2015年第3期58卷 4-16页

作者： leng ChengCai TIAN Jie School of Mathematics and Information Sciences Nanchang Hangkong University Key Laboratory of Molecular Imaging Institute of Automation Chinese Academy of Sciences

Optical molecular imaging is an important technique of studies at molecular level and provides promising tools to non-invasively delineate in vivo physiological and pathological activities at cellular and molecular levels,and it has been widely used for diagnosing,managing diseases,metastasis detection and drug *** a mathematical perspective,this paper mainly focuses on the forward problem and inverse problem in biological tissues based on the radiative transfer equation(RTE).The forward problem is accustomed to describing photon propagation in biological tissues and the inverse problem is used to reconstruct internal source distribution from the signal detected on the external *** also introduce the detailed derivation of the RTE and Robin boundary condition and discretization of the forward problem,along with the reconstruction methods and iterative solution algorithms summarized for the inverse ***,the current and future challenges of optical molecular imaging are *** survey aims to construct a mathematical method,a state-of-the-art framework for optical molecular imaging,from which future research may benefit.

关键词： radiative transfer equation(RTE) regularization method source reconstruction optical molecular imaging mathematical method

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Translational analysis of data science and causal learning in real-world clinical evaluation of traditional Chinese medicine

引用

Science of Traditional Chinese Medicine 2024年第1期2卷 57-65页

作者： wei Yang Danhui Yi XiaoHua Zhou Yuanming leng Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijingChina School of Statistics Renmin University of ChinaBeijingChina Beijing International Center for Mathematical Research Peking UniversityBeijingChina Department of Biostatistics School of Public HealthPeking UniversityBeijingChina National Engineering Laboratory of Big Data Analysis and Applied Technology Peking UniversityBeijingChina Department of Biostatistics School of Public HealthBoston UniversityBostonMAUSA

Real-world clinical evaluation of traditional Chinese medicine(RWCE-TCM)is a method for comprehensively evaluating the clinical effects of TCM,with the aim of delving into the causality between TCM intervention and clinical *** study explored data science and causal learning methods to transform RWD into reliable real-world evidence,aiming to provide an innovative approach for *** study proposes a 10-step data science methodology to address the challenges posed by diverse and complex data in *** methodology involves several key steps,including data integration and warehouse building,high-dimensional feature selection,the use of interpretable statistical machine learning algorithms,complex networks,and graph network analysis,knowledge mining techniques such as natural language processing and machine learning,observational study design,and the application of artificial intelligence tools to build an intelligent engine for translational *** goal is to establish a method for clinical positioning,applicable population screening,and mining the structural association of TCM characteristic *** addition,the study adopts the principle of real-world research and a causal learning method for TCM clinical *** constructed a multidimensional clinical knowledge map of“disease-syndrome-symptom-prescription-medicine”to enhance our understanding of the diagnosis and treatment laws of TCM,clarify the unique therapies,and explore information conducive to individualized *** causal inference process of observational data can address confounding bias and reduce individual heterogeneity,promoting the transformation of TCM RWD into reliable clinical *** data science improves efficiency and accuracy for implementing *** proposed data science methodology for TCM can handle complex data,ensure high-quality RWD acquisition and analysis,and provide in-depth insights into clinical benefits of *** method supp

关键词： Traditional Chinese medicine Real-world study Data science Causal learning Health information system Machine learning Artificial intelligence Treatment effects

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Infinite Horizon Backward Doubly Stochastic Differential Equations with Non-degenerate Terminal Functions and Their Stationary Property

引用

Acta Mathematicae Applicatae Sinica 2016年第2期32卷 407-422页

作者： Hui-nan leng Department of Mathematics East China University of Science and Technology

In this paper we consider infinite horizon backward doubly stochastic differential equations （BDS- DEs for short） coupled with forward stochastic differential equations, whose terminal functions are non-degenerate. For such kind of BDSDEs, we study the existence and uniqueness of their solutions taking values in weighted Lp（dx）¤L2（dx）space （p _〉 2）, and obtain the stationary property for the solutions.

关键词： backward doubly stochastic differential equations infinite horizon non-degenerate terminal func-tion stationary property

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Debris flows monitoring and localization using infrasonic signals

引用

Journal of Mountain Science 2017年第7期14卷 1279-1291页

作者： leng Xiao-peng LIU Dun-long wei Fang-qiang HONG Yong DAI De-fu Key Laboratory of Mountain Hazards and Earth Surface Process Chinese Academy of Sciences Institute of Mountain Hazards and Environment Chinese Academy of Sciences College of Information Science and Technology Chengdu University of Technology College of Software Engineering Chengdu University of Information and Technology Kunming Dongchuan Debris Flow Prevention and Control Institute

Infrasonic waves （frequency 〈 2o Hz） are generated during the formation and movement of debris flows, traveling in air with a speed far higher than that of the debris-flow movement. Infrasound monitoring and localization of infrasonic waves can serve as warning properties for debris-flows. Based on the characteristics of infrasonic signals, this study presents a three-point array of infrasound sensors as time-synchronous multiple sensors for acquiring signals. In the meantime, the signals are sorted by mutual correlation of signals to figure out their latency, and by means of array coordinating to Locate the sound source to realize the monitoring and positioning of a debris-flows hazard. The method has been in situ tested and has been proven to be accurate in monitoring debris-flow occurrences and determining their positions, which is particularly effective for pre-event warning of debris-flow hazards.

关键词： Debris flow Infrasound Debris flowmonitoring Localization

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：