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Ankylosing spondylitis coexisting with Clonorchis sinensis infection: A case report

World Journal of Clinical Cases 2024年第5期12卷 1018-1024页

作者： Tian-Xin Yi Wei Liu Wen-Fei leng Xiao-Chuan Wang Liang Luo Department of Rheumatology Traditional Chinese Medicine Hospital Dianjiang ChongqingChongqing 408300China Department of Orthopaedic Traditional Chinese Medicine Hospital Dianjiang ChongqingChongqing 408300China Department of Chinese Medicine The People's Hospital of Yubei District of Chongqing CityChongqing 401120China

BACKGROUND Ankylosing spondylitis(AS)is a chronic immune-mediated inflammatory *** prevailing theory links AS onset to infections in susceptible ***,infections may impair the immune *** studies have investigated links between AS and various infections-bacterial,viral,fungal,and other microorganism ***,limited attention has been given to the association between AS and Clonorchis sinensis(***)*** SUMMARY A 27-year-old male with a 10-yr history of AS presented to our hospital with inflammatory lower back pain as the primary *** years ago,the patient had achieved a stable condition after treatment with biological ***,he experienced a recurrence of lumbosacral pain with an unexplained cause 10 d before hospital admission.A lumbosacral magnetic resonance imaging(MRI)scan revealed bone marrow edema in the left sacroiliac joint,and laboratory indicators were ***,the presence of *** eggs was detected in the *** patient was prescribed praziquantel,resulting in the disap-pearance of *** eggs in subsequent routine stool tests and relief from lumbosacral pain.A follow-up MRI scan performed after 4 months revealed a reduction in bone marrow edema around the left sacroiliac *** *** infections could potentially trigger the exacerbation of *** should pay attention to investigating the presence of *** Ankylosing spondylitis(AS)is a chronic inflammatory and rheumatic disease resulting from an imbalance between innate and acquired immune responses[1].While it can affect any part of the spine,its primary symptoms are persistent back pain and stiffness in the lower back and *** prevalence of AS per 10000 individuals is 23.8 in Europe,31.9 in North America,16.7 in Asia,10.2 in Latin America,and 7.4 in Africa[2].Infections commonly occur in the first 3 months and may act as potential triggers for the

关键词： Ankylosing spondylitis Clonorchis sinensis Parasites Infection Case report

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High power tunable Raman fiber laser at 1.2μm waveband

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Frontiers of Optoelectronics 2024年第1期17卷 1-8页

作者： Yang Zhang Jiangming Xu Junrui Liang Jun Ye Sicheng Li Xiaoya Ma Zhiyong Pan Jinyong leng Pu Zhou College of Advanced Interdisciplinary Studies National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Hunan Provincial Key Laboratory of High Energy Laser Technology National University of Defense TechnologyChangsha 410073China

Development of a high power fiber laser at special waveband,which is difficult to achieve by conventional rare-earth-doped fibers,is a significant *** of the most common methods for achieving lasing at special wavelength is Raman ***-doped fiber(PDF),due to the phosphorus-related large frequency shift Raman peak at 40 THz,is a great choice for large frequency shift Raman ***,by adopting 150 m large mode area triple-clad PDF as Raman gain medium,and a novel wavelength-selective feedback mechanism to suppress the silica-related Raman emission,we build a high power cladding-pumped Raman fiber laser at 1.2μm waveband.A Raman signal with power up to 735.8 W at 1252.7 nm is *** the best of our knowledge,this is the highest output power ever reported for fiber lasers at 1.2μm ***,by tuning the wavelength of the pump source,a tunable Raman output of more than 450 W over a wavelength range of 1240.6–1252.7 nm is *** work proves PDF’s advantage in high power large frequency shift Raman conversion with a cladding pump scheme,thus providing a good solution for a high power laser source at special waveband.

关键词： Phosphosilicate fiber Raman fiber laser 1.2μm waveband Wavelength tunable

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Red-emissive carbon quantum dots minimize phototoxicity for rapid and long-term lipid droplet monitoring

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Chinese Chemical Letters 2024年第10期35卷 341-347页

作者： Fengkai Zou Borui Su Han leng Nini Xin Shichao Jiang Dan Wei Mei Yang Youhua Wang Hongsong Fan Department of Orthopedics Affiliated Hospital of Nantong UniversityNantong 226001China Graduate School Dalian Medical UniversityDalian 116044China National Engineering Research Center for Biomaterials College of Biomedical EngineeringSichuan UniversityChengdu 610064China School of Chemistry and Chemical Engineering Liaoning Normal UniversityDalian 116029China

Long-term fluorescence monitoring of subcellular organelles is crucial for cellular physiology and pathology *** droplets(LDs)are increasingly recognized for their involvement in various biological processes,to influence disease development through diverse behaviors However,existing LD probes face challenges in achieving high targeting and long-term monitoring due to poor photostability and long-term *** quantum dots(CQDs)have gained prominence due to their exceptional fluorescence properties,but their prevalent blue excitation wavelength presents difficulties for long-term ***,we synthesized red-emissive carbon quantum dot(R-CQDs)with superior photobleaching resistance and red-emission,thus enabling harmlessly fluorescence monitoring of cells longer than3 *** addition,R-CQD exhibits suitable amphiphilicity and remarkable solvatochromic effect,allowing rapid targeting to LDs for immediate imaging without cumbersome washing ***,R-CQD shows high performance for extended observation of dynamic LD behavior in various biological processes,which is confirmed by documenting the course of LDs during starvation as well as *** to commercial probes,R-CQD extends live cell imaging time by at least 9-fold,facilitating the study of LD behavioral characteristics under diverse physiological or pathological *** work provides a reliable fluorescence tool for tracking intercellular microenvironment dynamically thus to understand the divers biological or disease mechanism.

关键词： Carbon quantum dots Solvatochromism Lipid droplet probe Fluorescence imaging Wash-free

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CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： lin Yin Yalan Xu Jie Mu Yu leng Lei Ma Yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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Electrostatic Interaction-directed Construction of Hierarchical Nanostructured Carbon Composite with Dual Electrical Conductive Networks for Zinc-ion Hybrid Capacitors with Ultrastability

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Energy & Environmental Materials 2024年第1期7卷 184-192页

作者： changyu leng Zongbin Zhao Xuzhen Wang Yuliya V.Fedoseeva Lyubov G.Bulusheva Alexander V.Okotrub Jian Xiao Jieshan Qiu State Key Lab of Fine Chemicals School of Chemical EngineeringLiaoning Key Lab for Energy Materials and Chemical Engineering Dalian University of TechnologyDalian 116024China Nikolaev Institute of Inorganic Chemistry Siberian Branch of the Russian Academy of Sciences3 Acad.Lavrentiev Ave.Novosibirsk 630090Russia College of Chemical Engineering Beijing University of Chemical Technology Beijing 100029China

Metal-organic framework(MOF)-derived carbon composites have been considered as the promising materials for energy ***,the construction of MOF-based composites with highly controllable mode via the liquid-liquid synthesis method has a great challenge because of the simultaneous heterogeneous nucleation on substrates and the self-nucleation of individual MOF nanocrystals in the liquid ***,we report a bidirectional electrostatic generated self-assembly strategy to achieve the precisely controlled coatings of single-layer nanoscale MOFs on a range of substrates,including carbon nanotubes(CNTs),graphene oxide(GO),MXene,layered double hydroxides(LDHs),MOFs,and SiO_(2).The obtained MOF-based nanostructured carbon composite exhibits the hierarchical porosity(V_(meso)/V_(micro)∶2.4),ultrahigh N content of 12.4 at.%and"dual electrical conductive networks."The assembled aqueous zinc-ion hybrid capacitor(ZIC)with the prepared nanocarbon composite as a cathode shows a high specific capacitance of 236 F g^(-1)at 0.5 A g^(-1),great rate performance of 98 F g^(-1)at 100 A g^(-1),and especially,an ultralong cycling stability up to 230000 cycles with the capacitance retention of 90.1%.This work develops a repeatable and general method for the controlled construction of MOF coatings on various functional substrates and further fabricates carbon composites for ZICs with ultrastability.

关键词： carbon composite electrostatic interaction metal-organic framework coating self-assembly zinc-ion hybrid capacitor

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Differential Impact of Fertility on Health-Adjusted Life Expectancy of Older Adults Across Countries of Various Levels of Socio-Demographic Index—Worldwide,1995-2019

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China CDC weekly 2024年第39期6卷 991-995页

作者： Shuai Guo Chen Chen Yunhe Wang Yi Cao Zhiwei leng Xiaoying Zheng Department of Population Health and Aging Science School of Population Medicine and Public HealthChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina School of Population Medicine and Public Health Chinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina Nuffield Department of Population Health University of OxfordOxfordUK Center for Health Policy and Health Economics National Infrastructures for Translational MedicineInstitute of Clinical MedicinePeking Union Medical College HospitalChinese Academy of Medical Sciences/Peking Union Medical CollegeBeijingChina Institute for Global Health and Development Peking UniversityBeijingChina

What is already known about this topic?Health-adjusted life expectancy(HALE)is a crucial indicator of global health,which is strongly correlated with the socio-demographic index(SDI)and population *** is added by this report?This study revealed that the correlation between total fertility rate(TFR)and HALE of older adults varies across countries with different SDI levels,offering valuable insights for the development of more targeted health promotion programs and *** are the implications for public health practice?Different health interventions should be tailored to countries with different levels of *** countries with both low fertility rates and low SDI,advanced measures are needed to address the challenge of an aging population that may live longer but face poorer health in the future.

关键词： demographic fertility offering

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A high precision two-axis GMR angular sensor manufactured by post-annealing

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Science China(Information Sciences) 2024年第6期67卷 465-466页

作者： Zitong ZHOU Zhiqiang CAO Shaohua YAN Xiaolong WANG Libo XIE Shiyang LU Dapeng ZHU Qunwen leng Weisheng ZHAO School of Integrated Circuit Science and Engineering Beihang University Beihang Qingdao Microelectronics Research Institute Beihang University National Key Lab of Spintronics Institute of International InnovationBeihang University

Angle sensors are widely used in numerous fields such as industry,military,medical care,and the Internet of Things(IoT)[1].Magnetoresistance angle sensors have become a mainstream approach for angle measurement becaus... 详细信息

关键词： Annealing

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Hard yet tough and self-lubricating(CuNiTiNbCr)C_(x) high-entropy nanocomposite films:Effects of carbon content on structure and properties

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Journal of Materials Science & Technology 2024年第6期173卷 20-30页

作者： Y.T.Li X.M.Chen X.K.Zeng M.Liu X.Jiang Y.X.leng Key Laboratory of Advanced Technologies of Materials Ministry of EducationSchool of Materials Science and EngineeringSouthwest Jiaotong UniversityChengdu 610031China Key Laboratory of Noise and Vibration Research Institute of AcousticsChinese Academy of SciencesBeijing 100190China State Key Laboratory of Acoustics Institute of AcousticsChinese Academy of SciencesBeijing 100190China School of Mechanical and Electrical Engineering Mianyang Teachers’CollegeMianyang 621000China

The single-phase high-entropy alloy film is difficult to meet severe friction conditions due to its low hardness and high friction ***-composite structure film is composed of at least two separated phases,showing the properties of strength and toughness integration and excellent wear *** design of nanocomposite structures can effectively improve the mechanical properties and tribological properties of high-entropy alloy *** this study,the(CuNiTiNbCr)C_(x) nanocomposite high-entropy films(HEFs)integrated with high hardness,high toughness,and self-lubrication were synthesized by the double-target co-sputtering *** effect of carbon content on microstructure,mechanical properties,and tribological properties of(CuNiTiNbCr)C_(x) films was *** the increase of carbon content in the HEFs,the carbon atoms preferentially react with Ti,Nb,and Cr to form a(TiNbCr)C ceramic-reinforced phase,and then the excess carbon atoms precipitate in the form of amorphous carbon(a-C)lubricating phase in the *** structure of the HEFs changes from an amorphous structure to a nanocomposite structure of amorphous(amorphous CuNiTiNbCr phase+a-C phase)/nanocrystalline(TiN-bCr)C *** the carbon content is about 21.2 at.%,the carbide phase in the film reaches saturation and the hardness and modulus of the films are highest,which are 18 GPa and 228 GPa,*** HEFs with a carbon content of 44.0 at.%show the best toughness and tribological properties with a friction coefficient of 0.16 and a wear rate of 2.4×10^(-6) mm^(3)/(N m),which is mainly attributed to the excellent resistance to fatigue crack growth and the interfacial lubricating layer formed in the friction *** nanocomposite(CuNiTiNbCr)C_(x) HEFs show very promising application prospect in the field of friction protection.

关键词： High-entropy films Nanocomposite Double-target co-sputtering Strengthening-toughening Tribological properties

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人工智能加速GPCR配体的发现

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Engineering 2024年第1期32卷 18-28页

作者： Wei Chen Chi Song Liang leng Sanyin Zhang Shilin Chen State Key Laboratory of Southwestern Chinese Medicine Resources Innovative Institute of Chinese Medicine and PharmacyChengdu University of Traditional Chinese MedicineChengdu 611137China Institute of Herbgenomics Chengdu University of Traditional Chinese MedicineChengdu 611137China

G protein-coupled receptors(GPCRs)are crucial players in various physiological processes,making them attractive candidates for drug ***,traditional approaches to GPCR ligand discovery are time-consuming and *** emergence of artificial intelligence(AI)methods has revolutionized the field of GPCR ligand discovery and has provided valuable tools for accelerating the identification and optimization of GPCR *** this study,we provide guidelines for effectively utilizing AI methods for GPCR ligand discovery,including data collation and representation,model selection,and specific ***,the online resources that are instrumental in GPCR ligand discovery were summarized,including databases and repositories that contain valuable GPCR-related information and ligand ***,GPCR and ligand representation schemes that can convert data into computer-readable formats were ***,the key applications of AI methods in the different stages of GPCR drug discovery were discussed,ranging from GPCR function prediction to ligand design and agonist ***,an AI-driven multi-omics integration strategy for GPCR ligand discovery that combines information from various omics disciplines was ***,the challenges and future directions of the application of AI in GPCR research were *** conclusion,continued advancements in AI techniques coupled with interdisciplina ry collaborations will offer great potential for improving the efficiency of GPCR ligand discovery.

关键词： G protein-coupled receptor Ligand Artificial intelligence Multi-omics Drug discovery

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Mode division multiplexing reconstructive spectrometer with an all-fiber photonics lantern

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Frontiers of Optoelectronics 2024年第3期17卷 29-38页

作者： Junrui Liang Jun Ye Xiaoya Ma Yao Lu Jun Li Jiangming Xu Zilun Chen Jinyong leng Zongfu Jiang Pu Zhou College of Advanced Disciplinary Studies National University of Defense TechnologyChangsha 410073China Nanhu Laser Laboratory National University of Defense TechnologyChangsha 410073China Hunan Provincial Key Laboratory of High Energy Laser Technology National University of Defense TechnologyChangsha 410073China Space Engineering University Beijing 101416China

This study presents a high-accuracy,all-fber mode division multiplexing(MDM)reconstructive spectrometer(RS).The MDM was achieved by utilizing a custom-designed 3×1 mode-selective photonics lantern to launch distinct spatial modes into the multimode fber(MMF).This facilitated the information transmission by increasing light scattering processes,thereby encoding the optical spectra more comprehensively into speckle *** resolution of 2 pm and the recovery of 2000 spectral channels were *** to methods employing single-mode excitation and two-mode excitation,the three-mode excitation method reduced the recovered error by 88%and 50%respectively.A resolution enhancement approach based on alternating mode modulation was proposed,reaching the MMF limit for the 3 dB bandwidth of the spectral correlation *** proof-of-concept study can be further extended to encompass diverse programmable mode *** is not only succinct and highly efcient but also well-suited for a variety of high-accuracy,high-resolution spectral measurement scenarios.

关键词： High-accuracy Resolution enhancement Reconstructive spectrometer Mode division multiplexing Photonics lantern

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