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The effect of celastrol in combination with 5-fluorouracil on proliferation and apoptosis of gastric cancer cell lines

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Oncology Research 2024年第7期32卷 1231-1237页

作者： MOHAMMAD-TAGHI MORADI DHIYA ALTEMEMY MAJID ASADI-SAMANI PEGAH KHOSRAVIAN MARZIYEH SOLTANI leila hashemi AZADEH SAMIEI-SEFAT Medical Plants Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran Department of Pharmaceutics College of PharmacyAl-Zahraa University for WomenKarbalaIraq Cellular and Molecular Research Center Basic Health Sciences InstituteShahrekord University of Medical SciencesShahrekordIran

Background:Despite the availability of chemotherapy drugs such as 5-ﬂuorouracil(5-FU),the treatment of some cancers such as gastric cancer remains challenging due to drug resistance and side *** study aimed to investigate the effect of celastrol in combination with the chemotherapy drug 5-FU on proliferation and induction of apoptosis in human gastric cancer cell lines(AGS and EPG85-257).Materials and Methods:In this in vitro study,AGS and EPG85-257 cells were treated with different concentrations of celastrol,5-FU,and their *** proliferation was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide(MTT)*** synergistic effect of 5-FU and celastrol was studied using Compusyn *** DNA content at different phases of the cell cycle and apoptosis rate was measured usingﬂow ***:Co-treatment with low concentrations(10%inhibitory concentration(IC10))of celastrol and 5-FU signiﬁcantly reduced IC50(p<0.05)so that 48 h after treatment,IC50 was calculated at 3.77 and 6.9μM for celastrol,20.7 and 11.6μM for 5-FU,and 5.03 and 4.57μM for their combination for AGS and EPG85-257 cells,*** mean percentage of apoptosis for AGS cells treated with celastrol,5-FU,and their combination was obtained 23.9,41.2,and 61.9,and for EPG85-257 cells 5.65,46.9,and 55.7,*** addition,the 5-FU and celastrol-5-FU combination induced cell cycle arrest in the synthesis ***:Although celastrol could decrease the concentration of 5-ﬂuorouracil that sufﬁced to suppress gastric cancer cells,additional studies are required to arrive at conclusive evidence on the anticancer effects of celastrol.

关键词： Gastric cancer Celastrol Terpenoid Cell cycle regulation Apoptosis Synergism

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Country Roads

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China Weekly 2024年第10期 63-63页

作者： leila hashemi 不详

"Stop complaining;there are literally people living outside of the Third Ring Road!"For the first seven years I lived here,I thought there could be nothing worse than living on the outskirts of *** I first arrived in China,I was whisked away from the airport and taken to the far-flung east of Beijing to my new *** I signed up to come,I was shown beautiful hutong apartments,flooded with light and surrounded by bustling ***,when I got to my new"home,"I wondered if there had beensomemistake.

关键词： airport Road outside

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Designing a locating-routing three-echelon supply chain network under uncertainty

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International Journal of Intelligent Computing and Cybernetics 2022年第4期15卷 562-588页

作者： leila hashemi Armin Mahmoodi Milad Jasemi Richard C.Millar Jeremy Laliberte Department of Industrial Management Islamic Azad University South Tehran BranchTehranIslamic Republic of Iran Department of Industrial Management Islamic Azad University ofMasjid-i-SoliemanMasjid-i-SoliemanIslamic Republic of Iran Stephens College of Business University of MontevalloMontevalloAlabamaUSA Department of Engineering Management and Systems Engineering The George Washington UniversityWashingtonDistrict of ColumbiaUSA Department of Mechanical and Aerospace Engineering Carleton UniversityOttawaCanada

Purpose-In the present research,location and routing problems,as well as the supply chain,which includes manufacturers,distributor candidate sites and retailers,are *** goal of addressing the issue is to reduce delivery times and systemcosts for retailers so that routing and distributor locationmay be ***/methodology/approach-By adding certain unique criteria and limits,the issue becomes more *** expect simultaneous deliveries and pickups,and retail service start times have soft and hard time *** expenses,noncompliance with the soft time window,distributor construction,vehicle purchase or leasing,andmanufacturing costs are all part of the system *** problem’s conceptual model is developed and modeled first,and then General Algebraic Modeling System software(GAMS)and Multiple Objective Particle Swarm Optimization(MOPSO)and non-dominated sorting genetic algorithm II(NSGAII)algorithms are used to solve it in small ***-According to the mathematical model’s solution,the average error of the two suggested methods,in contrast to the exact answer,is less than 0.7%.In addition,the performance of algorithms in terms of deviation from the GAMS exact solution is pretty satisfactory,with a divergence of 0.4%for the biggest problem(N 5100).As a result,NSGAII is shown to be superior to *** limitations/implications-Since this paper deals with two bi-objective models,the priorities of decision-makers in selecting the best solution were not taken into account,and each of the objective functions was given an equal weight based on the weighting *** model has not been compared or studied in both robust and deterministic *** is because,with the exception of the variable that indicates traffic mode uncertainty,all variables are deterministic,and the uncertainty character of demand in each level of the supply chain is *** implications-The suggested model’s conclusions

关键词： Metaheuristic algorithms Time windows Supply chain management Robust optimization Location-routing problems

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Home Truths

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China Weekly 2023年第3期 62-62页

作者： leila hashemi 不详

Why is the food so salty?Why is everything so expensive?Almost US$15 to get a taxi two kilometers down the road?These are just a few of the questions I asked myself after making my longawaited pilgrimage“home”after almost three years mainly spent in Beijing.I almost forgot about daunting longdistanceflights,annoying layovers with short transfer times and insane airport prices,but I didn't care,I was too excited to get home and see my family(and eat all thefood I had been missing,of course).

关键词： airport prices everything

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Failure to Assimilate

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China Weekly 2022年第1期 62-62页

作者： leila hashemi 不详

Meituan,***,Taobao,JD-these are a few of my favorite things...so when I hear fellow expats saying they don't know how to use online delivery apps or other popular Chinese apps and services,I think to myself that what we have here is a failure to *** late-night cravings for a soda,to scanning a share bike to get to a friend's house,the convenience of China is one of the biggest draws to me.

关键词： favorite get hear

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Beijing vs Paradise

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China Weekly 2023年第8期 63-63页

作者： leila hashemi 不详

Living on a tropical island,with waves lappingup on thesand and the sun shining-sounds like a dream come true,right?Well,for me,it was a 100-percent *** seven years in China and always wondering what it would be like ... 详细信息

关键词： destination island dise

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Scooter of Life and Death

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China Weekly 2022年第5期 62-62页

作者： leila hashemi 不详

My headphones were in and I was listening to my favorite station(Disney Hits),the sun was shining,my backpack was full of snacks,the roads were open and clear and my scooter was fully *** as I was hitting my stride on the open road-WHAM!The bike in front of me stopped suddenly and hard and I gripped my two brake handles tightly,causing my bike to flip.

关键词： favorite suddenly brake

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Puff or Pass?

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China Weekly 2022年第6期 63-63页

作者： leila hashemi 不详

First of all,I want to say I don't condone or want to make smoking seem glamorous in any way,but there is an undeniable trend in China that has taken the country by *** I first came to China,I was a cigarette *** I di... 详细信息

关键词： smoke storm cigarette

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Finding the Balance

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中国新闻周刊:英文版 2023年第11期 62-62页

作者： leila hashemi 不详

With over eight years of work experience in China,I've come to appreciate the nuances of the work culture in this dynamic *** I never expected it to mirror my home country's norms,I did encounter some stark differences.

关键词： mirror norms dynamic

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Dress to Impress……Yourself!

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China Weekly 2022年第4期 63-63页

作者： leila hashemi 不详

I have never been one to care much about fashion or pay top-dollar for clothing and *** home,I knew my fair share of“fashionistas”but here in China,I have seen some of the most amazing and crazy *** my sister was coming to visit,she messaged me and asked,“What kind of style do people wear there?What kind of clothes should I bring:”I think this is really the first time I stopped to think about it because I didn't have an answer.I started to think about styles and what I have seen.

关键词： dollar stopped fashion

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