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Swelling characteristics of andesite foundation induced by water immersion and their influence on ballastless track subgrade

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Journal of Mountain Science 2020年第4期17卷 1001-1012页

作者： DUAN Jun-yi YANG Guo-lin HU Min lei xiao-qin LIN Yu-liang School of Civil Engineering Central South UniversityChangsha 410075China Key Laboratory of Mountain Hazards and Earth Surface Processes Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China

To study the mechanical and deformation characteristics of ballastless track subgrade filled with micro-expansion fillers in a water-immersed environment, a physical model of ballastless track subgrade was constructed on a 1:2 scale with expansive andesite fillers. A water immersion test was carried out to model the soaking of the expansive soil foundation caused by rising groundwater. The swelling behaviors of the foundation and their influences upon the mechanics and deformations of the subgrade were analyzed. The lateral swelling pressure of the foundation and the heave of the subgrade obviously increased due to the water immersion, and the values were closely related to the overlying load and lateral restraint. The heave deformation of the double-line ballastless track subgrade showed significant nonuniformity along the lateral direction, causing the track slab to incline with a maximum inclination angle of 1.55×10^-3 deg. The heave of the foundation caused a heave in subgrade, but this transferred heave was significantly attenuated. The attenuation rate of the heave at the midline of the track slab was up to 13.38%. The attenuation characteristic can be fully utilized for the anti-heave deformation measures of railway subgrade in expansive soil areas.

关键词： High-speed railway Expansive andesite Heave deformation Lateral swelling pressure Inclination angle Deformation attenuation

Hydro-mechanical analysis of rainfall-induced fines migration process within unsaturated soils

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Journal of Mountain Science 2017年第12期14卷 2603-2619页

作者： lei xiao-qin YANG Zong-ji HE Si-ming LIU En-long WONG Henry LI Xin-po Key Laboratory of Mountain Hazards and Earth Surface Process Institute of Mountain Hazards and EnvironmentChinese Academy of Sciences College of Water Resource & Hydropower Sichuan University Center for Excellence in Tibetan Plateau Earth Sciences CAS Laboratoire de Génie Civil et Batiment Ecole Nationale des Travaux Publics de l’Etat Université de Lyon

Seepage-induced fines migration under rainfall infiltration is a main cause leading to shallow failures in loose colluvial slopes. To describe the full process of fines migration within unsaturated soils during rainfall infiltration and the associated hydromechanical behaviors, a seepage-erosion-deformation coupled formulation is proposed in this paper. The governing equations proposed are implemented into a finite element code and used to investigate the influences of skeleton deformation on the rainfall infiltration process through unsaturated soil *** numerical results were presented in detail for a better understanding of the rainfall-induced fines migration process within unsaturated soils. Further,the obtained results are integrated into an infinite slope model for slope stability analysis. The results show that, the skeleton deformation will affect the rainfall infiltration rate and hence the timing of slope failures; meanwhile their influences are more evident if the fines deposition process is taken into ***, the slope stability could be reduced gradually due to the soil strength loss along with loss of fine particles. Therefore, particular attentions should be paid to analyzing the stability of soil slopes susceptible to internal erosion.

关键词： Rainfall infiltration Fines migration Internal erosion Seepage deformation Slope stability

Stage 3B Coats＇ disease in a premature and low-birth-weight infant

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Chinese Medical Journal 2012年第20期125卷 3759-3760页

作者： SONG Hu-Ping AI Hua ZHU Qi lei Chun-ling WANG Jian-zhou lei xiao-qin Department of Ophthalmology Xi'an No.4 HospitalXi'anShannxi 710004China Department of Ophthalmology Yulin No.1 HospitalYulinShannxi 719000China

Coats＇ disease is characterized by the formation of telangiectatic and microaneurysms changes of theretinal vessels and a large amount of yellowish subretinal exudates but withont appreciable signs of retinal or vitreal traction. It usually occurs unilaterally and mainly in young males. According to the appearance of the fundns, Coats＇ disease has been classified as stage 1-5.z The age at diagnosis has been as young as 3 months m one case,

关键词： Goats disease premature Iow-birth-weight

边界面模型在FLAC^(3D)中的开发及验证

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岩土力学 2012年第2期33卷 635-640页

作者：雷小芹杨果林中南大学土木建筑学院长沙410075 法国里昂国立应用科学学院土木与环境实验室里昂69100

利用FLAC3D程序提供的二次开发平台UDM在VC++编译环境下实现了一基于修正剑桥模型的简化边界面模型的开发。介绍了边界面模型的基本原理,并给出了开发关键技术和具体实施方法。通过三轴加卸载试验、不排水静三轴试验、不排水动三轴试验... 详细信息

利用FLAC3D程序提供的二次开发平台UDM在VC++编译环境下实现了一基于修正剑桥模型的简化边界面模型的开发。介绍了边界面模型的基本原理,并给出了开发关键技术和具体实施方法。通过三轴加卸载试验、不排水静三轴试验、不排水动三轴试验等几种数值试验与修正剑桥模型进行了对比研究。计算结果验证了所开发的边界面模型的正确性及相对修正剑桥模型的优越性。

关键词：边界面模型 FLAC3D 二次开发三轴数值试验

Atomically Precise Cu Nanoclusters:Recent Advances,Challenges,and Perspectives in Synthesis and Catalytic Applications

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Nano-Micro Letters 2025年第4期17卷 130-165页

作者： Mengyao Chen Chengyu Guo Lubing qin lei Wang Liang Qiao Kebin Chi Zhenghua Tang New Energy Research Institute School of Environment and EnergySouth China University of TechnologyGuangzhou Higher Education Mega CentreGuangzhou 510006People’s Republic of China Petrochemical Research Institute PetroChina Company LimitedBeijing 102206People’s Republic of China Key Laboratory of Functional Inorganic Material Chemistry(Heilongjiang University) Ministry of EducationHarbin 150001People’s Republic of China

Atomically precise metal nanoclusters are an emerging type of nanomaterial which has diverse interfacial metal-ligand coordination motifs that can significantly affect their physicochemical properties and *** that,Cu nanoclusters have been gaining continuous increasing research attentions,thanks to the low cost,diversified structures,and superior catalytic performance for various *** this review,we first summarize the recent progress regarding the synthetic methods of atomically precise Cu nanoclusters and the coordination modes between Cu and several typical ligands and then discuss the catalytic applications of these Cu nanoclusters with some explicit examples to explain the atomical-level structure-performance ***,the current challenges and future research perspectives with some critical thoughts are *** hope this review can not only provide a whole picture of the current advances regarding the synthesis and catalytic applications of atomically precise Cu nanoclusters,but also points out some future research visions in this rapidly booming field.

关键词： Atomically precise Cu nanoclusters Controllable synthesis Catalytic applications Structure-performance relationship Challenges and perspectives

BIBR1532 inhibits proliferation and metastasis of esophageal squamous cancer cells by inducing telomere dysregulation

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 214-225页

作者： qin Wang qing-Rong Li lei Xu Zi-Chun Yuan xiao Liu Mao-Ju Tang Man Luo xiao-Wu Zhong Qiang Ma xiao-Lan Guo Department of Clinical Laboratory Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina School of Laboratory Medicine&Translational Medicine Research Center North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina

BACKGROUND Esophageal squamous cell carcinoma(ESCC)is a malignant tumor with high morbidity and mortality,and easy to develop resistance to chemotherapeutic *** are DNA-protein complexes located at the termini of chro-mosomes in eukaryotic cells,which are unreplaceable in maintaining the stability and integrity of ***,an RNA-dependent DNA polymerase,play vital role in telomere length maintain,targeting telomerase is a promising therapeutic strategy for ***150 and KYSE410 cells were cultured and exposed to various concentrations of *** viability was assessed at 48 hours and 72 hours to determine the IC50 *** effects of BIBR1532 on ESCC cell proliferation,migration,and cellular senescence were evaluated using the cell counting kit-8 assay,plate colony formation assay,scratch assay,transwell assay,andβ-galactosidase staining,*** blotting was performed to detect the expression of RESULTS The IC50 values for KYSE150 and KYSE410 cells after 48 hours of BIBR1532 exposure were 48.53μM and 39.59μM,*** values decreased to 37.22μM and 22.71μM,respectively,following a longer exposure of 72 ***1532 exhibited dose-dependent effects on KYSE150 and KYSE410 cells,including decreased hTERT expression,inhibition of proliferation and metastasis,and induction of cellular ***,BIBR1532 upregulated the expression of the DDR protein,γ-H2AX,and activated the ataxia telangiectasia and Rad3-related protein(ATR)/check point kinase 1(CHK-1)and ataxia-telangiectasia mutated gene(ATM)/CHK2 ***1532 downregulated the expression of telomere-binding proteins,including telomeric-repeat binding factor 1(TRF1),TRF2,protection of telomeres 1,and TIN2-interacting protein *** a nude mouse xenograft model,BIBR1532 significantly suppressed tumor growth,reduced hTERT expression,and increasedγ-H2AX protein *** and eosin staining of various organs,including the heart,liver,s

关键词： Esophageal squamous cell carcinoma BIBR1532 Human telomerase reverse transcriptase DNA damage response Telomere-binding proteins

Factors influencing accuracy of free swelling ratio of expansive soil

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Journal of Central South University 2022年第5期29卷 1653-1662页

作者： WANG Liang-liang WANG Zhao-teng DING Zhi-ping LIN Yu-liang lei xiao-qin LIU Zhi-jun School of Mechanics and Civil Engineering China University of Mining and TechnologyXuzhou 221116China State Key Laboratory for Geomechanics&Deep Underground Engineering China University of Mining and TechnologyXuzhou 221116China Xuzhou Design Institute China Railway Shanghai Design Institute Group Co.Ltd.Xuzhou 221000China School of Civil Engineering Central South UniversityChangsha 410075China Key Lab Mt Hazards&Earth Surface Proc Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China

Many geotechnical structures,such as the subgrade of high-speed railway,are extremely sensitive to micro *** one of the most commonly used indexes in China to evaluate the potential swelling level of expansive soils,the effectiveness and accuracy of free swelling ratio should be highly ***,due to the deficiency of geotechnical test regulations for the free swelling ratio test,non-negligible variation difference is often observed among the test results of the same type of soil ***,a series of laboratory tests are conducted to figure out the influences of soil particle size,initial soil temperature,and wet-dry circulation on the free swelling ratio of expansive *** results show that the initial soil temperature exerts an obvious influence on free swelling ratio and a relative weak influence on soil mass of expansive soil with the micro soil particle size(d<0.075 mm),and the correlation becomes unclear when soil particle size is within the range of 0.075 mm≤d<0.500 mm.A larger particle size of expansive soils induces a larger free swelling ratio and soil mass in the soil measuring cup regardless of initial soil ***,the enlarging amplitude decreases as the particle size of expansive soils *** is a progressive enlargement of free swelling ratio at the first two wet-dry cycles and then it attenuates gradually when the number of wetdry cycles further increases.

关键词： free swelling ratio particle size soil temperature wet-dry circulation expansive soil

Dietary supplementation with N‑acetyl‑L‑cysteine ameliorates hyperactivated ERK signaling in the endometrium that is linked to poor pregnancy outcomes following ovarian stimulation in pigs

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Journal of Animal Science and Biotechnology 2025年第1期16卷 167-181页

作者： Linghua Cheng Zhicheng Shi Yuan Yue Yue Wang Yusheng qin Wei Zhao Yupei Hu qin Li Min Guo lei An Shumin Wang Jianhui Tian Frontiers Science Center for Molecular Design Breeding(MOE) State Key Laboratory of Animal Biotech BreedingKey Laboratory of Animal GeneticsBreeding and Reproduction of the Ministry of Agriculture and Rural AffairsNational Engineering Laboratory for Animal BreedingCollege of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193People’s Republic of China

Background Exogenous gonadotropin-controlled ovarian stimulation is the critical step in animal reproductive management,such as pig,sheep,bovine and other *** helps synchronize ovulation or stimulate multiple ***,a number of evidence indicated an unexpected decrease in pregnancy outcomes following ovarian *** study aimed to explore the underlying mechanism of the pregnancy defect and develop a practical rescue *** Compared with those in the control group,gilts that underwent ovarian stimulation showed a decrease in pregnancy rate,farrowing rate,and total number of piglets *** gilts also showed an increase in estra-diol(E_(2))*** supraphysiologicalE_(2) level was correlated with the decrease in the number of piglets ***,we found that high levels ofE_(2) impair uterine receptivity,as shown by the overproliferation of endo-metrial epithelial *** vitro mechanistic studies demonstrated that high levels ofE_(2) hyperactivate FGF-FGFR-ERK signaling cascade in the uterine endometrium,and in turn induces overproliferation of endometrial epithelial *** note,N-acetyl-L-cysteine(NAC)supplementation effectively inhibits ERK hyperphosphorylation and ameliorates endometrial epithelial ***,in vivo experiments indicated that dietary NAC supplementa-tion,compared with ovarian stimulation group,improves the uterine receptivity in gilts,and significantly increases the pregnancy rate and total number of piglets *** Ovarian stimulation-induced supraphysiological levels ofE_(2) impairs uterine receptivity by hyperactivat-ing FGF-FGFR-ERK signaling cascade,thereby reducing pregnancy rate and litter *** NAC to a con-ventional diet for gilts ameliorates hyperactivated ERK signaling and improves uterine receptivity,thus rescuing adverse pregnancy outcomes following ovarian stimulation.

关键词： Estradiol Gonadotropin Implantation N-acetyl-L-cysteine Ovarian stimulation Uterine receptivity

Nano high-entropy oxide cathode with enhanced stability for direct borohydride fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 309-316页

作者： lei Zhang Lingfeng Kuang Lianke Zhang Wen Chu Haiying qin Jing Zhang Junjing He Hualiang Ni Hongzhong Chi New Energy Materials Research Center College of Materials and Environmental EngineeringHangzhou Dianzi UniversityHangzhou 310018ZhejiangChina School of Materials Science and Engineering Zhejiang UniversityHangzhou 310027ZhejiangChina Key Laboratory of MEMS of Ministry of Education School of Integrated CircuitsSoutheast UniversityNanjing 210096JiangsuChina

High-entropy materials have become high-activity electrocatalysis owing to their high-entropy effect and multiple active ***,we synthesize a series of carbon-supported nano high-entropy oxides(HEOs/C),specifically (PtFeCoNiCu)O/C,using a carbothermal shock (CTS) method for application as a cathode catalyst in direct borohydride fuel cells (DBFCs).The microstructure of the prepared catalysts was characterized by X-ray photoelectron spectroscopy,X-ray absorption fine structure,and transmission electron *** prepared (PtFeCoNiCu)O/C,with particle sizes ranging from 2 to 4 nm,demonstrates 3.94 transferred electrons towards the oxygen reduction reaction in an alkaline environment,resulting in a minimal H_(2)O_(2)yield of 2.6%.Additionally,it exhibits a Tafel slope of 61 mV dec-1,surpassing that of commercial Pt/C (82 mV dec-1).Furthermore,after 40,000 cycles of cyclic voltammetry(CV) testing,the half-wave potential of (PtFeCoNiCu)O/C shows a positive shift of 3 mV,with no notable decline in the limiting current *** (PtFeCoNiCu)O/C is used as a cathode catalyst in DBFCs,the DBFC achieves a maximum power density of 441 mW cm^(-2)at 60°C and sustains a cell voltage of approximately 0.73 V after 52 h at 30°*** findings confirm that HEO/C is a promising cathode catalyst for DBFCs.

关键词： High-entropy oxides Oxygen reduction reaction Carbothermal shock Stability Direct borohydride fuel cells