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Synthesis strategies for disulfide bond-containing polymer- based drug delivery system for reduction-responsive controlled release

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Frontiers of Materials Science 2015年第3期9卷 211-226页

作者： lei LIU peng LIU State Key Laboratory of Applied Organic Chemistry and Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province College of Chemistry and Chemical Engineering Lanzhou University Lanzhou 730000 China

Tumor micro-environment responsive drug delivery systems （DDSs） have been developed as a potential approach to reduce the side effects of cancer chemotherapy. Glutathione （GSH） has been supposed to the most significant signal of the difference between the normal tissue and the tumor cells, besides the media pH and temperature. In recent years, the reduction-responsive DDSs have attracted more and more attention for delivery of anti-cancer drugs, based on such physiological signal. Among them, disulfide bond-containing polymers have been designed as the main tool for the purpose. The recent progress in the synthesis strategies for the disulfide bond- containing polymer-based DDS is focused in the present review.

关键词： drug delivery system (DDS) reduction-responsive disulfide bond-containing polymer tumor micro-environment responsive

Plasma Replacement Therapy for Alzheimer's Disease

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Neuroscience Bulletin 2020年第1期36卷 89-90页

作者： Xu-long Ding peng lei Department of Neurology and State Key Laboratory of Biotherapy West China HospitalSichuan UniversityChengdu 610041China West China School of Basic Medical Sciences and Forensic Medicine Sichuan UniversityChengdu 610041China Collaborative Innovation Center for Biotherapy Chengdu 610041China

Alzheimer’s disease(AD)is the most common neurode-generative disease that affects memory,thinking,behavior,and the ability to perform everyday *** has been estimated that more than 35 million people worldwide suffered from AD in 2018[1],and this figure continues to ***,no cure or treatment that slows the progression of the disease has been discovered despite extensive efforts from academics and the pharmaceutical *** drug trials for AD have targeted the 13-amyloid protein[2],which accumulates in this disease,and the failure of amyloid-based drugs to impact on cognition in people with AD has led to re-questioning of the amyloid hypothesis of AD,and has provided a fresh impetus to explore alternative therapeutic strategies.

关键词： Alzheimer drugs everyday

Ferroptosis in ischemic stroke:Animal models and mechanisms

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Zoological Research 2024年第6期45卷 1235-1248页

作者： Qing-Zhang Tuo peng lei Department of Geriatrics and State Key Laboratory of Biotherapy National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Neurology and State Key Laboratory of Biotherapy National Clinical Research Center for GeriatricsWest China HospitalSichuan UniversityChengduSichuan 610041China

Stroke is a major cause of death and disability worldwide,with the majority of cases resulting from ischemic events due to arterial *** therapeutic approaches focus on rapid reperfusion through intravenous thrombolysis and intravascular *** these interventions can mitigate long-term disability,reperfusion itself may induce neuronal *** exact mechanisms underlying neuronal damage following cerebral ischemia have yet to be *** research suggests that ferroptosis may play a significant role in post-ischemic neuronal death,which can be targeted to prevent neuronal *** review explores the three essential hallmarks of ferroptosis:the presence of redox-active iron,the peroxidation of polyunsaturated fatty acid-containing phospholipids,and the loss of lipid peroxide repair *** involvement of ferroptosis in neuronal injury following ischemic stroke is also explored,along with an overview of ferroptosis-associated changes in different ischemic stroke animal ***,recent therapeutic interventions targeting the ferroptosis pathway,as well as the opportunities,difficulties,and future directions of ferroptosis-targeted therapies in ischemic stroke,are discussed.

关键词： Ischemic stroke Ferroptosis Animal models Iron deposition Lipid peroxidation

Reaction mechanisms between molten CaF2-based slags and molten 9CrMoCoB steel

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International Journal of Minerals,Metallurgy and Materials 2020年第5期27卷 611-619页

作者： lei-zhen peng Zhou-hua Jiang Xin Geng School of Metallurgy Northeastern UniversityShenyang 110819China

Investigating the reaction mechanism between slag and 9CrMoCoB steel is important to develop the proper slag and produce qualified ingots in the electroslag remelting(ESR) process. Equilibrium reaction experiments between molten 9CrMoCoB steel and the slags of 55 wt%CaF2–20 wt%CaO–3 wt%MgO–22 wt%Al2O3–xwt%B2O3(x = 0.0, 0.5, 1.0, 1.5, 2.0, 3.0) were conducted. The reaction mechanisms between molten 9 CrMoCoB steel and the slags with different B2O3 contents were deduced based on the composition of the steel and slag samples at different reaction times. Results show that B content in the steel can be controlled within the target range when the B2O3 content is 0.5 wt% and the FeO content ranges from 0.18 wt% to 0.22 wt% in the slag. When the B2O3 content is ≥1 wt%, the reaction between Si and B2O3 leads to the increase of the B content of steel. The additions of SiO2 and B2O3 to the slag should accord to the mass ratio of [B]/[Si] in the electrode, and SiO2 addition inhibits the reaction between Si and Al2O3.

关键词： 9CrMoCoB electroslag remelting B2O3 thermodynamic calculation reaction mechanism

Lipidomic investigation of the protective effects of Polygonum perfoliatum against chemical liver injury in mice

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Journal of Integrative Medicine 2023年第3期21卷 289-301页

作者： lei peng Hua-guo Chen Xin Zhou Key Laboratory for Information System of Mountainous Areas and Protection of Ecological Environment Guizhou Normal UniversityGuiyang 550001Guizhou ProvinceChina Guizhou Engineering Laboratory for Quality Control&Evaluation Technology of Medicine Guizhou Normal UniversityGuiyang 550001Guizhou ProvinceChina Research Center for Quality Control of Natural Medicine Guizhou Normal UniversityGuiyang 550001Guizhou ProvinceChina

Objective:Recent investigations have demonstrated that Polygonum perfoliatum *** protect against chemical liver injury,but the mechanism behind its efficacy is still ***,we studied the pharmacological mechanism at work in *** protection against chemical liver ***:To evaluate the activity of *** against chemical liver injury,levels of alanine transaminase,lactic dehydrogenase,aspartate transaminase,superoxide dismutase,glutathione peroxidase and malondialdehyde were measured,alongside histological assessments of the liver,heart and kidney tissue.A nontargeted lipidomics strategy based on ultra-performance liquid chromatography quadrupoleorbitrap high-resolution mass spectrometry method was used to obtain the lipid profiles of mice with chemical liver injury and following treatment with ***;these profiles were used to understand the possible mechanisms behind ***'s protective ***:Lipidomic studies indicated that *** protected against chemical liver injury,and the results were consistent between histological and physiological *** comparing the profiles of liver lipids in model and control mice,we found that the levels of 89 lipids were significantly *** animals receiving *** treatment,the levels of 8 lipids were significantly improved,relative to the model *** results showed that *** extract could effectively reverse the chemical liver injury and significantly improve the abnormal liver lipid metabolism of mice with chemical liver injury,especially glycerophospholipid ***:Regulation of enzyme activity related to the glycerophospholipid metabolism pathway may be involved in the mechanism of ***'s protection against liver injury.

关键词： Lipidomics Polygonum perfoliatum L. Liver injury Mice Herbal medicine

Sequential RBF Surrogate-based Efficient Optimization Method for Engineering Design Problems with Expensive Black-Box Functions

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Chinese Journal of Mechanical Engineering 2014年第6期27卷 1099-1111页

作者： peng lei LIU Li LONG Teng GUO Xiaosong Key Laboratory of Dynamics and Control of Flight Vehicle Ministry of Education School of Aerospace Engineering Beijing Institute of Technology

As a promising technique, surrogate-based design and optimization（SBDO） has been widely used in modern engineering design optimizations. Currently, static surrogate-based optimization methods have been successfully applied to expensive optimization problems. However, due to the low efficiency and poor flexibility, static surrogate-based optimization methods are difficult to efficiently solve practical engineering cases. At the aim of enhancing efficiency, a novel surrogate-based efficient optimization method is developed by using sequential radial basis function（SEO-SRBF）. Moreover, augmented Lagrangian multiplier method is adopted to solve the problems involving expensive constraints. In order to study the performance of SEO-SRBF, several numerical benchmark functions and engineering problems are solved by SEO-SRBF and other well-known surrogate-based optimization methods including EGO, MPS, and IARSM. The optimal solutions, number of function evaluations, and algorithm execution time are recorded for comparison. The comparison results demonstrate that SEO-SRBF shows satisfactory performance in both optimization efficiency and global convergence capability. The CPU time required for running SEO-SRBF is dramatically less than that of other algorithms. In the torque arm optimization case using FEA simulation, SEO-SRBF further reduces 21% of thematerial volume compared with the solution from static-RBF subject to the stress constraint. This study provides the efficient strategy to solve expensive constrained optimization problems.

关键词： surrogate-based optimization global optimization significant sampling space adaptive surrogate radial basis function

Effect of wastewater COD/N ratio on aerobic nitrifying sludge granulation and microbial population shift

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Journal of Environmental Sciences 2012年第2期24卷 234-241页

作者： lei Wu Chengyao peng Yongzhen peng Lingyun Li Shuying Wang Yong Ma Key Laboratory of Beijing for Water Quality Science and Water Environment Recovery Engineering Beijing University of Technology Beijing 100124 China

The effect of COD/N ratio on the granulation process and microbial population succession was *** identical sequencing batch reactors,R1,R2,R3 and R4,were operated with various initial COD/N ratios ranging from 0/200 to 800/200（m/m）.Ethanol was fed as the source of *** granules were successfully cultivated in R2 and R3,operating with the COD/N ratio of 200/200 and 400/200,*** electron microscope observations indicated that short rod-shaped and spherical bacteria were dominant in R2,while granules produced in R3 were surrounded with a large amount of filamentous *** average specific nitritation rate in R2 and R3 were 0.019 and 0.008 mg N/（mg ***）,*** in situ hybridization results demonstrated that nitrifying bacteria population was enriched remarkably in *** indicated that nitrification ability and nitrifying bacteria population were enriched remarkably at low COD/N ***,no granules were formed in R1 and R4 which might attribute to either limited or excessive extracellular polymeric substances *** study contributed to a better understanding of the role of COD/N ratio in nitrifying sludge granulation.

关键词： aerobic granules COD/N ratio sequencing batch reactor nitrification performance microbial population shift

A new attenuation model of near-fault ground motions with consideration of the hanging wall effect in the Wenchuan earthquake

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Earthquake Engineering and Engineering Vibration 2011年第3期10卷 313-323页

作者： peng lei Xie Lili Hu Jinjun Wang Dong Institute of Engineering Mechanics China Earthquake Administration Harbin 150080 China School of Civil Engineering and Architecture Harbin Institute of Technology Harbin 150090 China

The hanging wall effect is an important factor that impacts the characteristics of strong ground motions in near-fault areas. Based on a residual analysis of ground motion parameters characterizing the hanging wall effect and in recognition of the nature of the effect, many models have been developed. In this study, after a comprehensive analysis of two existing models, a new model is proposed and used to model the hanging wall effect in horizontal peak ground acceleration （PGAH） and spectral acceleration （SAH） at a period of 0.1s in the Wenchuan earthquake. Finally, comparisons between the modeling results of the hanging wall effect in the Wenchuan earthquake and the results predicted by using Abrahamson and Silva＇s NGA model （AS NGA） indicate that the AS NGA model predicts a much higher hanging wall effect than the model developed in this paper. Furthermore, the AS NGA model predicts a large hanging wall effect even at great distances, while the proposed model more accurately captures the trend of the effect.

关键词： hanging wall effect Wenchuan earthquake attenuation relationship NGA model

Adaptive Multi-Bernoulli Filter Without Need of Prior Birth Multi-Bernoulli Random Finite Set

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Chinese Journal of Electronics 2018年第1期27卷 115-122页

作者： YUAN Changshun WANG Jun lei peng SUN Jinping School of Electronic and Information Engineering Beihang University

Conventional Multi-Bernoulli(MBer) filter assumes that the birth MBer Random finite set(RFS)is known a priori. However, this is not true for practical scenario. This paper proposes a novel extension of the MBer filter which eliminates the reliance of the prior birth MBer RFS and relaxes the limitation in new-born target appearance volume. The proposed filter classifies the measurements into survival measurements and birth measurements, and adaptively generates the birth MBer RFS using the birth measurements. The novel filtering equations that distinguish the persistent and new-born targets are derived. A Sequential Monte-Carlo(SMC) implementation of the proposed filter is given. Simulations are performed to verify the improvement in the performance of the proposed filter.

关键词： Random finite set Adaptive multi-Bernoulli filter Sequential Monte-Carlo Multi-target tracking