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Tracy-Widom distribution, Airy2 process and its sample path properties

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Applied Mathematics(A Journal of Chinese Universities) 2021年第1期36卷 128-158页

作者： SU Zhong-gen lei yu-huan SHEN Tian School of Mathematical Sciences Zhejiang UniversityHangzhou 310027China

Tracy-Widom distribution was rst discovered in the study of largest eigenvalues of high dimensional Gaussian unitary ensembles(GUE),and since then it has appeared in a number of apparently distinct research *** is believed that Tracy-Widom distribution have a universal feature like classic normal ***2 process is de ned through nite dimensional distributions with Tracy-Widom distribution as its marginal *** this introductory survey,we will briey review some basic notions,intuitive background and fundamental properties concerning Tracy-Widom distribution and Airy2 *** sake of reading,the paper starts with some simple and well-known facts about normal distributions,Gaussian processes and their sample path properties.

关键词： Airy2 process Dyson Brownian motion Tracy-Widom distribution sample path property.

Fluorinated poly(p-triphenylene isatin) anion exchange membranes based on hydrophilic hydroxyl side chain modulation for fuel cells

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Journal of Energy Chemistry 2025年第1期100卷 702-709页

作者： Yiman Gu Yanchao Zhang Zhanyu Li Yijia lei Baozeng Sun Xiaoyu yu Zhe Wang College of Chemistry and Life Science Changchun University of Technology College of Chemical Engineering Changchun University of Technology School of Materials Science and Engineering Changchun University of Technology Key Laboratory of Advanced Functional Polymer Membrane Materials of Jilin Province

The development of alkaline fuel cells is moving forward at an accelerated pace,and the application of ether-free bonded polymers to anion exchange membranes （AEMs） has been widely ***,the question of the“trade-off”between AEM ionic conductivity and dimensional stability remains *** strategy of inducing microphase separation to improve the performance of AEM has attracted much attention recently,but the design of optimal molecular structures is still being ***,this work introduced different ratios of 3-bromo-1,1,1-trifluoroacetone （x=40,50,and 60） into the main chain of poly（p-terphenylene isatin）.Because fluorinated groups have excellent hydrophobicity,hydrophilic hydroxyl-containing side chains are introduced to jointly adjust the formation of phase separation *** results show that PTI-PTF50-NOH AEM with the appropriate fluorinated group ratio has the best ionic conductivity and alkali stability under the combined effect of *** has an ionic conductivity of 133.83 mS cm-1at 80°*** addition,the OH-conductivity remains at 89%of the initial value at 80°C and 3 M KOH for 1056 h of *** cell polarization curve based on PTI-PTF50-NOH shows a power density of 734.76 mW cm-2at a current density of 1807.7 mA cm-2.

关键词： Anion exchange membranes Poly(p-terphenylene isatin) Hydrophilic-hydrophobic phase separation Fluorinated group

护理教师对护理本科生实施创客教育认知的质性研究

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护理学杂志 2018年第15期33卷 16-19页

作者：谢伦芳王蕾宇寰安徽医科大学护理学院安徽合肥230601

目的探讨护理专业教师对护理本科生实施创客教育的认知,为开展护理专业创客教育提供参考。方法对8名护理教师采用半结构式深入访谈,对访谈资料应用内容分析法进行分析。结果护理专业教师对护理本科生实施创客教育的认知包括3个主题:护... 详细信息

目的探讨护理专业教师对护理本科生实施创客教育的认知,为开展护理专业创客教育提供参考。方法对8名护理教师采用半结构式深入访谈,对访谈资料应用内容分析法进行分析。结果护理专业教师对护理本科生实施创客教育的认知包括3个主题:护理本科生的创新素养需要进一步提升;护理本科生的创客教育应以项目为中心开展;以项目为中心实施创客教育存在条件限制,尚需多方面支持。结论护理专业教师对创客教育有一定了解,创客教育在护理本科生中开展具备可行性的同时也存在障碍。护理教育工作者应积极探索护理本科生创客教育模式,推动护理创新人才培养。

关键词：护理教师护理本科生创客教育认知护理教育质性研究

自拟活血消肿方对桡骨远端骨折术后肢体肿胀疼痛及腕关节功能的影响

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云南中医中药杂志 2023年第5期44卷 73-76页

作者：雷环宇盛炎炎安徽中医药大学安徽合肥230038 安徽中医药大学第一附属医院安徽合肥230031

目的探讨自拟活血消肿方对桡骨远端骨折术后肢体肿胀、疼痛及腕关节功能的影响。方法回顾分析2020年9月-2022年3月在安徽中医药大学第一附属医院住院治疗行锁定钢板内固定术治疗的60例桡骨远端骨折患者,随机分为对照组和治疗组,2组各30... 详细信息

目的探讨自拟活血消肿方对桡骨远端骨折术后肢体肿胀、疼痛及腕关节功能的影响。方法回顾分析2020年9月-2022年3月在安徽中医药大学第一附属医院住院治疗行锁定钢板内固定术治疗的60例桡骨远端骨折患者,随机分为对照组和治疗组,2组各30例。对照组术后给予常规治疗和功能锻炼指导,治疗组在其基础上,加用自拟活血消肿方汤剂内服治疗。通过比较2组患者术后肢体消肿、止痛时间及治疗前后疼痛VAS评分情况,术后1月评估腕关节功能的恢复率,来判定临床疗效。结果治疗后,治疗组消肿、止痛时间及VAS评分较对照组大幅度下降(P<0.05);术后1月随访,治疗组腕关节功能恢复率为93.30%,显著高于对照组的70.00%(P<0.05)。结论自拟活血消肿方能够加快缓解桡骨远端骨折术后肢体肿胀、疼痛症状,促进腕关节功能的恢复,提高临床疗效,值得在临床上推广。

关键词：自拟活血消肿方桡骨远端骨折术后肢体肿胀疼痛腕关节功能

CNKSR2 interactome analysis indicates its association with the centrosome/microtubule system

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Neural Regeneration Research 2025年第8期20卷 2420-2432页

作者： Lin Yin Yalan Xu Jie Mu yu Leng lei Ma yu Zheng Ruizhi Li Yin Wang Peifeng Li Hai Zhu Dong Wang Jing Li Institute for Translational Medicine The Affiliated Hospital of Qingdao UniversityMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina School of Basic Medicine Qingdao UniversityQingdaoShandong ProvinceChina College of Life Sciences and School of PharmacyMedical CollegeQingdao UniversityQingdaoShandong ProvinceChina Department of Urology Qingdao Municipal Hospital Affiliated to Qingdao UniversityQingdaoShandong ProvinceChina

The protein connector enhancer of kinase suppressor of Ras 2(CNKSR2),present in both the postsynaptic density and cytoplasm of neurons,is a scaffolding protein with several protein-binding *** of the CNKSR2 gene have been implicated in neurodevelopmental disorders,particularly intellectual disability,although the precise mechanism involved has not yet been fully *** has demonstrated that CNKSR2 plays a role in facilitating the localization of postsynaptic density protein complexes to the membrane,thereby influencing synaptic signaling and the morphogenesis of dendritic ***,the function of CNKSR2 in the cytoplasm remains to be *** this study,we used immunoprecipitation and high-resolution liquid chromatography-mass spectrometry to identify the interactors of *** a combination of bioinformatic analysis and cytological experiments,we found that the CNKSR2 interactors were significantly enriched in the proteome of the *** also showed that CNKSR2 interacted with the microtubule protein DYNC1H1 and with the centrosome marker *** colocalization analysis confirmed the centrosomal localization of *** we downregulated CNKSR2 expression in mouse neuroblastoma cells(Neuro 2A),we observed significant changes in the expression of numerous centrosomal *** manipulation also affected centrosome-related functions,including cell size and shape,cell proliferation,and ***,we found that CNKSR2 interactors were highly enriched in de novo variants associated with intellectual disability and autism spectrum *** findings establish a connection between CNKSR2 and the centrosome,and offer new insights into the underlying mechanisms of neurodevelopmental disorders.

关键词： autism spectrum disorder centrosome CNKSR2 intellectual disability interactome mass spectrometry microtubule neurodevelopmental disease protein complexes protein-protein interactions

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基于K-means算法的地铁站台异物检测

计算机与现代化 2018年第6期 42-46页

作者：雷焕宇刘伟铭华南理工大学土木与交通学院广东广州510641

针对地铁屏蔽门和列车门之间的间隙会产生夹人夹物等地铁运营安全事故隐患,提出一种基于K-means的地铁站台异物面检测方法。该方法通过采用人工构造光学背景,并且采用HSV颜色空间来提高检测的效率和准确度。算法采用K-means方法对车首... 详细信息

针对地铁屏蔽门和列车门之间的间隙会产生夹人夹物等地铁运营安全事故隐患,提出一种基于K-means的地铁站台异物面检测方法。该方法通过采用人工构造光学背景,并且采用HSV颜色空间来提高检测的效率和准确度。算法采用K-means方法对车首摄像头拍摄车尾灯带图像进行目标提取,通过对目标的完整性计算来判断列车车体与屏蔽门缝隙是否存在空间异物。通过对真实视频数据进行实验,结果表明所提算法对光照变化具有很好的鲁棒性,可以准确检测出各种异物,能够辅助司机进行开车前的决策。

关键词：机器视觉 K-means 异物检测地铁自适应光线

Perilipin-2 mediates ferroptosis in oligodendrocyte progenitor cells and myelin injury after ischemic stroke

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Neural Regeneration Research 2025年第7期20卷 2015-2028页

作者： Jian Yang Jiang Wu Xueshun Xie Pengfei Xia Jinxin Lu Jiale Liu lei Bai Xiang Li Zhengquan yu Haiying Li Department of Neurosurgery&Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow UniversitySuzhouJiangsu ProvinceChina Institute of Stroke Research Soochow UniversitySuzhouJiangsu ProvinceChina

Differentiation of oligodendrocyte progenitor cells into mature myelin-forming oligodendrocytes contributes to *** of remyelination due to oligodendrocyte progenitor cell death can result in severe nerve *** is an iron-dependent form of regulated cell death caused by membrane rupture induced by lipid peroxidation,and plays an important role in the pathological process of ischemic ***,there are few studies on oligodendrocyte progenitor cell *** analyzed transcriptome sequencing data from GEO databases and identified a role of ferroptosis in oligodendrocyte progenitor cell death and myelin injury after cerebral *** analysis suggested that perilipin-2(PLIN2)was involved in oligodendrocyte progenitor cell ***2 is a lipid storage protein and a marker of hypoxia-sensitive lipid droplet *** further investigation,we established a mouse model of cerebral ischemia/*** found significant myelin damage after cerebral ischemia,as well as oligodendrocyte progenitor cell death and increased lipid peroxidation levels around the infarct *** ferroptosis inhibitor,ferrostatin-1,rescued oligodendrocyte progenitor cell death and subsequent myelin *** also found increased PLIN2 levels in the peri-infarct area that co-localized with oligodendrocyte progenitor ***2 knockdown rescued demyelination and improved neurological *** findings suggest that targeting PLIN2 to regulate oligodendrocyte progenitor cell ferroptosis may be a potential therapeutic strategy for rescuing myelin damage after cerebral ischemia.

关键词： bioinformatics bulk RNA sequencing ferroptosis ischemic stroke myelin injury oligodendrocyte progenitor cell perilipin-2 single-cell RNA sequencing

Mechanism of action of Linggui Zhugan Decoction in treating non-alcoholic fatty liver disease using untargeted metabolomics approach

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Traditional Medicine Research 2025年第2期10卷 65-76页

作者： huan Pei Ren-Lin Li Xin-Ran Song Qian-Qian Wan yu-Ming Wang Han-Zhou Li Wei-Quan Xu Jia-Bao Liao Wei-Bo Wen Jing Miao huan-Tian Cui School of Basic Medicine Yunnan University of Chinese MedicineKunming 650599China School Clinical Medical College Yunnan University of Chinese MedicineKunming 650599China First School of Clinical Medicine Yunnan University of Chinese MedicineKunming 650599China School of Integrative Chinese and Western Medicine Tianjin University of Traditional Chinese MedicineTianjin 301617China Department of Pharmacy Tianjin Second People's HospitalTianjin 300192China

Background:Non-alcoholic fatty liver disease(NAFLD)is a liver disorder characterized by the accumulation and degeneration of fat in the liver cells,a condition that may further deteriorate and lead to cirrhosis and liver *** studies showed that metabolic dysfunction can promote NAFLD *** Zhugan Decoction(LGZGD)has therapeutic effects on *** mechanism of LGZGD still remains *** study was to examine the impact of LGZGD on the metabolic processes involved in the development of ***:A mice model of NAFLD was treated with *** therapeutic potential of LGZGD was evaluated by assessing the activity of transaminases,lipids levels of blood,and pathological changes in the liver of the mice model of ***,this study also evaluated the influence of LGZGD on liver inflammation and oxidative ***:The results of untargeted metabolomics analysis showed that LGZGD reduced the disordered lipid metabolism in NAFLD *** improved the oxidative stress and also reduced the levels of pro-inflammatory cytokines in the *** metabolomics analysis of liver samples revealed that LGZGD treatment improved metabolic disorders,including alanine,aspartate,glutamate,glycerophospholipid metabolism,and citrate *** RT-qPCR and Western blot results showed that LGZGD could regulate the expression of key enzymes in the metabolic pathway of the citrate cycle,including ATP-citrate lyase(ACLY),alanine-glyoxylate aminotransferase-2(AGXT2),phosphatidylethanolamine N-methyltransferase(PEMT),and succinate dehydrogenase(SDH).Conclusion:We found that LGZGD can treat NAFLD by reducing inflammatory responses,inhibiting oxidative stress,regulating alanine,aspartate,glutamate,and glycerophospholipid metabolism,and citrate cycle pathways.

关键词： NAFLD LGZGD untargeted metabolomics glycerophospholipid metabolism citrate cycle

茶小绿叶蝉粘样蛋白EfMLP基因的克隆、鉴定及功能分析

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昆虫学报 2024年第2期67卷 151-162页

作者：何雪怡雷雨欢宋仕月夏露霞王世宇马成文魏可欣王梦馨潘铖韩宝瑜中国计量大学生命科学学院浙江省生物计量及检验检疫技术重点实验室杭州310018

【目的】探明茶小绿叶蝉Empoasca flavescens粘样蛋白EfMLP基因的分子特征、表达模式和生物学功能。【方法】基于茶小绿叶蝉转录组数据,PCR克隆获得4条EfMLP基因的全长cDNA序列并进行生物信息学分析;qRT-PCR检测EfMLP基因在茶小绿叶蝉... 详细信息

【目的】探明茶小绿叶蝉Empoasca flavescens粘样蛋白EfMLP基因的分子特征、表达模式和生物学功能。【方法】基于茶小绿叶蝉转录组数据,PCR克隆获得4条EfMLP基因的全长cDNA序列并进行生物信息学分析;qRT-PCR检测EfMLP基因在茶小绿叶蝉不同发育阶段(卵、1-5龄若虫和初羽化雌雄成虫)及初羽化成虫不同组织(体壁、脂肪体、唾液腺、肠道、卵巢和精巢)中的表达量;通过饲喂法利用RNAi沉默茶小绿叶蝉5龄若虫EfMLP2和EfMLP4,生物测定分析EfMLP基因沉默后茶小绿叶蝉的存活率。【结果】获得4条茶小绿叶蝉EfMLP基因全长cDNA序列,分别命名为EfMLP1(GenBank登录号:OR504428),EfMLP2(GenBank登录号:OR504429),EfMLP3(GenBank登录号:OR504430)和EfMLP4(GenBank登录号:OR504431),这4条EfMLP基因编码蛋白均具有O-联糖基化位点形成粘蛋白结构域(mucin domain, MD)且该结构域包含高度重复的串联重复序列,其中EfMLP3和EfMLP4的氨基酸序列含有保守的2型几丁质结合域(chitin binding domain, CBD)。系统发育分析结果表明,EfMLP被分到两个不同的分支上,属于两种不同的MLP类型,该结果与昆虫的分类地位无相关性,猜测可能与其功能分化相关。EfMLP1和EfMLP2在茶小绿叶蝉初羽化雌雄成虫和初羽化成虫唾液腺中均特异性高表达,而EfMLP3和EfMLP4的表达在卵、若虫和成虫等不同发育阶段和初羽化成虫脂肪体等多个组织中均可被检测到。与饲喂dsGFP对照组比较,饲喂dsEfMLP2和dsEfMLP4可分别有效抑制茶小绿叶蝉体内EfMLP2和EfMLP4的表达量,并可显著降低茶小绿叶蝉的存活率。【结论】EfMLP在茶小绿叶蝉取食中扮演重要的角色,可作为开发基于RNAi的叶蝉防治技术的潜在靶标。

关键词：茶小绿叶蝉粘样蛋白基因克隆表达模式 RNA干扰