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Biomedical and Environmental Sciences 2019年第1期32卷 38-41页

作者： YU juan LI Hong LU Nan Nan lei you ju JIANG Shuang Ying ZHAO Sheng Cang RAO Hua Xiang Center of Hygiene Inspection Qinghai Center for Disease Control and Prevention Institute for Communicable Disease Control and Prevention Qinghai Center for Disease Control and Prevention

Human adenoviruses (HAdVs) belong to the genus Mastadenovirus, family Adenoviridae, and can cause respiratory tract and gastrointestinal tract infections, as well as ocular infections in humans[1]. Till date, a total of 84 unique genotypes of AdVs have been identified and classified as human Mastadenovirus species A to G, and specific types are often associated with certain clinical symptoms, epidemiological settings, and demographic risk groups[2]. Among these species, members of the species HAdV-B (HAdV-3, HAdV-7, HAdV-11, HAdV-16, HAdV-21, HAdV-34, HAdV-35, HAdV-50, etc), HAdV-C (HAdV-1, HAdV-2, HAdV-5, and HAdV-6), and HAdV-E (HAdV-4) have been generally associated with respiratory infections[3]. HAdV infections are mild and self-limited in healthy individuals, whereas they can result in high mortality rates in immunocompetent and immunocompromized patients[4].

关键词： Human adenoviruses (HAdVs) mammivirus Eye infection

Automatic and Rapid Throughflow-Based Optimal Design Method for Multi-Stage Axial-Flow Compressors

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Journal of Thermal Science 2025年第1期34卷 77-91页

作者： lei Fan ZHANG Xiawen ju Yaping ZHANG Chuhua Department of Fluid Machinery and Engineering School of Energy and Power EngineeringXi'an Jiaotong University Production and Environmental Department China Huaneng Group.Co.Ltd. State Key Laboratory for Strength and Vibration of Mechanical Structures Xi'an Jiaotong University

Throughflow design has the advantages of less time consumption and large optimization space,and thus is the corner stone of advanced design system of multi-stage axial-flow *** majority of relevant studies were limited to the throughflow inverse designs,and quite few works have been till now devoted to the throughflow optimal *** this work,an automatic and rapid throughflow-based optimal design method is proposed for axial-flow compressors in which a throughflow inverse design solver is embedded in optimal genetic algorithm to improve the design efficiency of axial-flow *** types of design parameters in the throughflow inverse design of axial-flow compressors,i.e.,swirl and shroud curve,are simultaneously used to optimize both the blade shape and flow *** proposed method is validated by the redesign optimization of the benchmark axial-flow compressor NASA Stage 35,and the CFD predictions show that the throughflow-based optimization leads to 1.18% efficiency benefit at design *** proposed method is then utilized to the two-dimensional throughflow optimal design of a large-scale 6.5-stage axial-flow industrial *** optimal design results are confirmed by CFD predictions,indicating that the proposed method can effectively improve the design adiabatic efficiency of the compressors by 1.09% within a few minutes on desk-top *** throughflow design implications are also obtained for advanced axial-flow industrial *** work could enhance the capability of throughflow design method and has engineering application value to explore the throughflow optimization space of multi-stage axial-flow compressors.

关键词： NASA

RepColor: deep coloring algorithm combining semantic categories

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Optoelectronics Letters 2025年

作者： lei Sun Dongjie ju School of Electrical Engineering and Automation， Tianjin University of Technology Tianjin Key Laboratory for Control Theory and Complicated Industry Systems， Tianjin University of Technology

Image coloring is an inherently uncertain and multimodal problem. By inputting a grayscale image into a coloring network， visually plausible colored photos can be generated. Conventional methods primarily rely on semantic information for image colorization. Although effective in coloring images with clear semantic information， these methods still suffer from color contamination and semantic confusion. This is largely due to the limited capacity of convolutional neural networks to effectively learn deep semantic information inherent in *** this paper， we propose a network structure that addresses these limitations by leveraging multi-level semantic information classification and fusion. Additionally， we introduce a global semantic fusion network to combat the issues of color contamination. The proposed coloring encoder accurately extracts object-level semantic information from *** further enhance visual plausibility， we employ a self-supervised adversarial training method. We train the network structure on various datasets with varying amounts of data and evaluate its performance using the ImageNet validation set and COCO validation set. Experimental results demonstrate that our proposed RepColor can generate more realistic images compared to previous approaches， showcasing its high generalization ability.

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姬松茸水溶性粗多糖对镉中毒小鼠血液指标的影响

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中国兽医科学 2007年第12期37卷 1078-1081页

作者：霍俊凤汉丽梅马吉飞雷有菊沈阳农业大学畜牧兽医学院辽宁沈阳110161 天津农学院动物科学系天津300384

为观察姬松茸水溶性粗多糖对镉中毒小鼠血液系统的影响,将60只SPF级雄性健康小白鼠随机分为对照组、模型组、试验组1、试验组2和试验组3共5组,模型组与3个试验组采用同一水平镉染毒,但同时对3个试验组给予不同剂量的姬松茸水溶性粗多糖... 详细信息

为观察姬松茸水溶性粗多糖对镉中毒小鼠血液系统的影响,将60只SPF级雄性健康小白鼠随机分为对照组、模型组、试验组1、试验组2和试验组3共5组,模型组与3个试验组采用同一水平镉染毒,但同时对3个试验组给予不同剂量的姬松茸水溶性粗多糖溶液进行保护,试验日程为5周,试验结束时对各组小鼠采血,检测各项血液指标。结果显示,模型组小鼠的血液指标红细胞数(RBC)、血红蛋白浓度(HGB)、血细胞比容(HCT)、平均红细胞体积(MCV)、平均红细胞血红蛋白含量(MCH)、平均红细胞血色素浓度(MCHC)显著低于对照组的相应指标;与模型组相比,给予高剂量姬松茸水溶性粗多糖的试验组3的血液指标RBC、HGB、HCT、MCV、MCH、MCHC均显著提高,而白细胞数(WBC)、小型白细胞数(Lym)和中型白细胞数(Mid)则显著下降。证实,重金属镉能够损伤小鼠的血液系统,但高剂量姬松茸水溶性粗多糖对镉的损伤具有防止作用。

关键词：姬松茸多糖镉血液指标小鼠

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互助藏羊梭菌病病原体的分离鉴定与分析

青海畜牧兽医杂志 2019年第4期49卷 6-12,31页

作者：雷有菊王文勇张学勇青海省互助县畜牧兽医站互助810500 青海大学畜牧兽医科学院西宁810016

青海省互助县某羊场藏系绵羊患病死亡,伴有腹泻、神经症状,为快速确诊发病原因,及时防控和治疗,采集病羊样品5份,通过镜检、细菌分离培养、分子生物学试验及致病性试验进行病原鉴定分析。结果证明此次病原菌为羊致病性D型魏氏梭菌,毒素... 详细信息

青海省互助县某羊场藏系绵羊患病死亡,伴有腹泻、神经症状,为快速确诊发病原因,及时防控和治疗,采集病羊样品5份,通过镜检、细菌分离培养、分子生物学试验及致病性试验进行病原鉴定分析。结果证明此次病原菌为羊致病性D型魏氏梭菌,毒素基因分析显示该菌同时含有α和ε两种毒素基因,动物致病性试验结果表明该菌对昆明系小鼠具有较强的致病性,并从试验致死的小鼠中分离到与藏羊病原相一致的细菌。三种基因的遗传进化树显示,该菌具有较强的多样性。研究确定了本次藏羊致死的主要病原为D型魏氏梭菌,结果可为该羊场梭菌病的治疗和预防提供科学依据。

关键词：藏羊魏氏梭菌腹泻分离培养分子鉴定

H9N2禽流感病毒血凝素蛋白的主要特性及B/T细胞抗原表位预测分析

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中国病原生物学杂志 2018年第1期13卷 11-15,21页

作者：于娟李红饶华祥卢囡囡雷有菊赵生仓青海省疾病预防控制中心青海西宁810007

目的应用生物信息学方法分析人源和禽源H9N2禽流感病毒血凝素蛋白(hemagglutinin,HA)的主要特性,预测可能的B/T细胞抗原表位。方法以H9N2禽流感病毒HA蛋白的氨基酸序列一级结构为基础分析其保守性,采用ProtParam预测H9N2禽流感病毒HA蛋... 详细信息

目的应用生物信息学方法分析人源和禽源H9N2禽流感病毒血凝素蛋白(hemagglutinin,HA)的主要特性,预测可能的B/T细胞抗原表位。方法以H9N2禽流感病毒HA蛋白的氨基酸序列一级结构为基础分析其保守性,采用ProtParam预测H9N2禽流感病毒HA蛋白的理化特性,SOPMA预测其二级结构,MotifScan预测翻译后修饰位点,DNAStar分析其序列的亲水性指数、柔韧性指数、可及性参数以及抗原指数并推测B细胞抗原表位的可能位置,采用SYFPEITHI的T细胞表位预测工具分别预测CTL和Th细胞表位。结果人源和禽源H9N2禽流感病毒HA蛋白氨基酸序列分别有90和75个变异位点,其中有38个突变位点与氨基酸置换均相同,有14个突变位点相同但氨基酸置换不同。人源和禽源毒株中还各有38和23个特异性突变位点。HA蛋白存在多个糖基化、酰胺化及磷酸化等翻译后修饰位点。除了蛋白激酶C磷酸化位点外,其他类型的翻译后修饰位点在人源和禽源毒株中均有一些变化。经综合各种单参数,HA蛋白均为亲水性蛋白。人源和禽源H9N2禽流感病毒HA蛋白含有4个B细胞表位,8个CTL细胞表位和6个Th细胞表位,以人源和禽源的B细胞和Th细胞表位差异较大,而CTL细胞表位有部分序列相同。结论人源和禽源H9N2禽流感病毒HA蛋白的氨基酸序列有一定差异,其B/T细胞抗原表位的不同,可为H9N2禽流感病毒疫苗的研制提参考。

关键词： H9N2禽流感血凝素蛋白(HA) B/T细胞表位生物信息学

Synergistic effect of lithiophilic Zn nanoparticles and N-doping for stable Li metal anodes

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Journal of Energy Chemistry 2022年第2期31卷 439-447页

作者： lei you Shunlong ju Jianwen Liu Guanglin Xia Zaiping Guo Xuebin Yu Department of Materials Science Fudan UniversityShanghai 200433China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry-of-Education Key Laboratory for Synthesis and Applications of Organic Functional MoleculesCollege of Chemistry and Chemical EngineeringHubei UniversityWuhan 430062HubeiChina School of Chemical Engineering&Advanced Materials The University of AdelaideAdelaideSA 5005Australia

Li metal is the most ideal anode material for next-generation high energy lithium-ion *** uncontrollable growth of Li dendrites,however,hinders its practical ***,we propose the adoption of Zn nanoparticles uniformly embedded in N-doped carbon polyhedra homogeneously built on carbon cloth(Zn@NC@CC)to prevent the formation of Li *** on theoretical calculation and experimental observation,lithiophilic Zn nanoparticles and N-doping inside of the assynthesized Zn@NC play a synergistic role in enhancing the adsorption capacity with Li,thus resulting in uniform Li deposition and complete suppression of Li ***,the porous N-doped carbon polyhedras uniformly distributed on carbon cloth effectively relieves the volume change of Li upon repeated Li stripping/plating process,which contributes to preserving the structural integrity of the whole electrode and hence enhancing its long-term cycling *** from these synergistic effects,the Li-Zn@NC@CC electrode delivers a prolonged lifespan of over 1200 h at 1 mA cm^(-2) with an areal capacity of 1 mA h cm^(-2) in symmetric cells and high Coulombic efficiencies of 95.4%under an ultrahigh capacity of 12 mA h cm^(-2).Remarkably,Li-Zn@NC@CC//LiFePO_(4) full cells deliver a high reversible capacity of 110.2 mA h g^(-1) at 1 C over 200 cycles.

关键词： Li metal anodes Zn nanoparticles N-doping Synergistic effect

MERS-CoV棘突蛋白主要特性及B/T细胞抗原表位预测分析

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中国病原生物学杂志 2017年第7期12卷 627-630页

作者：于娟李红卢囡囡饶华祥雷有菊姜双应赵生仓青海省疾病预防控制中心青海西宁810007

目的应用生物信息学方法分析中东呼吸综合征冠状病毒(Middle East respiratory syndrome coronavirus,MERS-CoV)棘突蛋白(Spike,S)的主要特性,预测可能的B/T细胞抗原表位。结果 MERS-CoV的S蛋白氨基酸序列基本保守,具有多个糖基化、酰... 详细信息

目的应用生物信息学方法分析中东呼吸综合征冠状病毒(Middle East respiratory syndrome coronavirus,MERS-CoV)棘突蛋白(Spike,S)的主要特性,预测可能的B/T细胞抗原表位。结果 MERS-CoV的S蛋白氨基酸序列基本保守,具有多个糖基化、酰胺化及磷酸化翻译后修饰位点。综合各种单参数预测MERS-CoV S蛋白可能存在4个B细胞抗原表位、7个CTL细胞表位和5个Th细胞表位。方法以MERS-CoV S蛋白的氨基酸序列一级结构为基础分析其保守性,采用ProtParam预测S蛋白的理化特性,SOPMA预测其二级结构,MotifScan预测翻译后修饰位点,DNAStar分析其序列的亲水性指数、柔韧性指数、可及性参数以及抗原指数,推测B细胞抗原表位的可能位置,采用SYFPEITHI的T细胞表位预测工具预测CTL和Th细胞表位。结论生物信息学方法预测MERS-CoV S蛋白氨基酸保守序列,该蛋白可能含有B/T细胞抗原表位,为MERS-CoV疫苗研制及其他相关研究奠定了基础。

关键词： MERS-CoV Spike蛋白 B/T细胞表位生物信息学

Preparation of mesoporous alumina with large pore size and their supported rhenium oxide catalysts in metathesis of 1-butene and 2-butene to propene

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Journal of Natural Gas Chemistry 2012年第3期21卷 352-359页

作者： lei Sang Sheng-Li Chen Guimei Yuan Zheng Zhou Rui Li Aicheng Chen Min Zheng ju you State Key Laboratory of Heavy Oil Processing College of Chemical EngineeringChina University of PetroleumBeijing 102249China

Mesoporous γ-aluminas with large pore size （up to 19 nm, denoted as MAI9） are prepared from dispersed pseudo-boehmite using pluronic P123 as template. It is found that these mesoporous alumina supported rhenium oxide catalysts were more active and have far longer working life-span in gas-phase metathesis of 1-butene and 2-butene to propene than rhenium oxide on conventional alumina with small pore size （5 nm）. At 60 ℃ and atmospheric pressure with WHSV = 1 h^-1, the similar stable conversions of butene （ca. 55%） for all the 13 wt% Re207/alumina catalysts were obtained near the chemical equilibrium, and the stable working life-spans of Re2OT/MA19 were far longer than that of Re2O7/A1203, being about 70 h and 20 h, respectively.

关键词： mesoporous alumina rhenium oxide metathesis butene propene

A Rapid and Automatic Optimal Design Method for Six-Stage Axial-Flow Industry Compressor

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Journal of Thermal Science 2021年第5期30卷 1658-1673页

作者： lei Fan ju Yaping ZHANG Chuhua School of Energy and Power Engineering Xi’an Jiaotong UniversityXi’an710049China

Existing aerodynamic design systems for multi-stage axial-flow compressor suffer from several limitations,such as experience dependent models and time costly *** attempts,however,have been devoted to the rapid and automatic optimization of aerodynamic performance at the preliminary design phase,which plays a crucial role in the final aerodynamic *** this work,a rapid and automatic aerodynamic optimal design method is developed for the multi-stage axial-flow compressor based on one-dimensional meanline design method,radial-equilibrium equation and genetic *** one-dimensional performance prediction model includes some popular empirical correlations to calculate the flow loss,incidence angle,deviation angle and flow *** radial-equilibrium equation is solved to obtain the spanwise distribution of aerodynamic and thermodynamic parameters at the inlet and outlet of each blade *** genetic algorithm is used for an automatic search of the global optimal compressor configuration aiming at maximizing the design *** developed method is illustrated with the aerodynamic optimal design of a 6-stage axial-flow industry compressor and verified by computational fluid dynamics *** results show that the developed method is capable of improving effectively the design efficiency and predicting accurately the aerodynamic performance of the 6-stage axial-flow industry compressor in a few *** work is of scientific significance to improve the axial-flow compressor design system and of engineering importance to release the designers from the heavy experience dependence especially at the preliminary design phase.

关键词： one-dimensional meanline design two-dimensional throughflow design three-dimensional CFD simulation optimal design genetic algorithm multi-stage axial-flow compressor