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右美托咪定联合帕瑞昔布钠对老年腹腔镜胃癌手术患者应激反应、细胞免疫功能和认知功能的影响

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现代生物医学进展 2024年第10期24卷 1906-1910,1968页

作者：雷珊李蓉王倩茹郑娟李卫松牛晓丽西安交通大学第二附属医院麻醉科陕西西安710004 西安交通大学第二附属医院手术室陕西西安710004

目的:探讨帕瑞昔布钠和右美托咪定联合麻醉对老年腹腔镜胃癌手术患者细胞免疫功能、应激反应和认知功能的影响。方法:纳入2019年8月~2022年7月期间西安交通大学第二附属医院收治的150例老年腹腔镜胃癌手术患者。按照随机数字表法将患者... 详细信息

目的:探讨帕瑞昔布钠和右美托咪定联合麻醉对老年腹腔镜胃癌手术患者细胞免疫功能、应激反应和认知功能的影响。方法:纳入2019年8月~2022年7月期间西安交通大学第二附属医院收治的150例老年腹腔镜胃癌手术患者。按照随机数字表法将患者分为帕瑞昔布钠组(n=50,帕瑞昔布钠)、右美托咪定组(n=50,右美托咪定)和联合组(n=50,右美托咪定联合帕瑞昔布钠)。对比三组临床指标、视觉模拟评分法(VAS)、简易精神状态检查表(MMSE)评分、术后认知功能障碍(POCD)发生率、应激反应指标[皮质醇(Cor)、肾上腺素(E)、促肾上腺皮质激素(ACTH)]、细胞免疫功能变化情况。结果:联合组的术后住院天数、肛门排气时间短于右美托咪定组、帕瑞昔布钠组(P<0.05)。联合组术后12 h、术后24 h、术后48 h VAS评分低于右美托咪定组、帕瑞昔布钠组(P<0.05)。联合组术后24 h、术后72 h MMSE评分高于右美托咪定组、帕瑞昔布钠组(P<0.05)。联合组的POCD发生率低于右美托咪定组、帕瑞昔布钠组(P<0.05)。三组术后1 d Cor、E、ACTH升高,但联合组低于帕瑞昔布钠组、右美托咪定组同期(P<0.05)。三组术后1 d CD8^(+)升高,但联合组低于帕瑞昔布钠组、右美托咪定组同期;CD3^(+)、CD4^(+)、CD4^(+)CD8^(+)下降,但联合组高于帕瑞昔布钠组、右美托咪定组同期(P<0.05)。结论:右美托咪定联合帕瑞昔布钠应用于老年腹腔镜胃癌手术患者,镇痛效果显著,可减轻机体的应激反应、免疫抑制及对认知功能的损害。

关键词：右美托咪定帕瑞昔布钠老年腹腔镜手术胃癌应激反应细胞免疫功能认知功能

Research and Trial Production of X80 Pipeline Steel with High Toughness Using Acicular Ferrite

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工程科学（英文版） 2005年第3期3卷 91-94页

作者： Zheng lei Gao shan Baoshan Iron ＆ Steel Co. Ltd. Shanghai 201900

The research and trial production of X80 pipeline steel in Baosteel is briefly introduced in this paper. It is shown that the X80 pipeline steel with high toughness using acicular ferrite microstructure is designed by ultra-low carbon, micro-alloying and Mo-low-alloying in the compositions, and can be produced by combining with the clean steel-making technology and thermal-mechanical controlled processing. The pipes made from the trial producing coils meet the requirements for grade X80 line pipe of the API spec.5L, and have high Charpy V-notch impact energy and good dynamic tear-resistance ability at low temperature. The X80 pipeline steel can be applied to the high-pressure transporting gas pipeline project.

关键词： X80 管道钢针状铁素体韧性微观结构

Influence of pore structure on thermal stress distribution inside coal particles during primary fragmentation

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Particuology 2024年第2期85卷 49-61页

作者： Kai Qiao shan Zhong Siyang Tang Ke Yang Hairong Yue Kui Ma lei Song Bin Liang School of Chemical Engineering Sichuan UniversityChengdu610065China Institute of New Energy and Low-carbon Technology Chengdu610207China

Thermal stress is an important reason of coal particle primary fragmentation,during which the role of pore structure is *** stress induced fragmentation experiments were conducted with low volatile coal/char particles,and the results show that the fragmentation severity enhances with increasing *** porous thermal stress models were developed with finite element method,and the influences of the pore shape,size,position and porosity on the thermal stress were *** maximum thermal stress inside particle increases with pore curvature,the pore position affects the thermal stress more significantly at the particle center and *** expectation of the maximum tensile thermal stress linearly increases with porosity,making the particles with higher porosity easier to fragment,contrary to the conclusion deduced from the devolatilization *** obtained results are valuable for the analysis of different thermal processes concerning the thermal stresses of the solid feedstocks.

关键词： Coal particle Primary fragmentation Thermal stress Pore structure Porosity

Frequency effect on p-nitrophenol degradation under conditions of strict acoustic and electric control

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Water Science and Engineering 2011年第1期4卷 74-82页

作者： Chang-ping ZHU Bo HUANG Qing-bang HAN Cai-hua NI Guang-jun ZHU Ming-hua LIU Ming-lei shan College of Computer and lnformation Engineering Hohai University Changzhou 213022 P. R. China State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering Hohai University Nanjing 210098 P. R. China College of Information and Electrical Engineering China University of Mining and Technology Xuzhou 221008 P. R. China School of Chemical and Material Engineering Jiangnan University Wuxi 214122 P. R. China

The process of decomposing p-nitrophenol （PNP） with power ultrasound requires strict control of acoustic and electric conditions. In this study, the conditions, including acoustic power and acoustic intensity, but not ultrasonic frequency, were controlled strictly at constant levels. The absorbency and the COD concentrations of the samples were measured in order to show the variation of the sample concentration. The results show significant differences in the trend of the solution degradation rate as acoustic power increases after the PNP solution （with a concentration of ll4 mg/L and a pH value of 5.4） is irradiated for 60 min with ultrasonic frequencies of 530.8 kHz, 610.6 kHz, 855.0 kHz, and 1130.0 kHz. The degradation rate of the solution increases with time and acoustic power （acoustic intensity）. On the other hand, the degradation rate of the solution is distinctly dependent on frequency when the acoustic power and intensity are strictly controlled and maintained at constant levels, The degradation rate of the PNP solution declines with ultrasonic frequencies of 530.8 kHz, 610.6 kHz, 855.0 kHz, and 1 130.0 kHz; the COD concentration, on the contrary, increase.

关键词： ultrasonic treatment frequency effect COD concentration p-nitrophenol

Double-nylon purse-string suture in closing postoperative wounds following endoscopic resection of large(≥3 cm)gastric submucosal tumors

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World Journal of Gastroenterology 2024年第9期30卷 1143-1153页

作者： shan-shan Wang Meng-Yao Ji Xu Huang Yan-Xia Li Shi-Jie Yu Yu Zhao lei Shen Department of Gastroenterology Renmin Hospital of Wuhan UniversityWuhan 430000Hubei provinceChina

BACKGROUND Endoscopic full-thickness resection(EFTR)of gastric submucosal tumors(SMTs)is safe and effective;however,postoperative wound management is equally *** on suturing following EFTR for large(≥3 cm)SMTs is scarce and *** To evaluate the efficacy and clinical value of double-nylon purse-string suture in closing postoperative wounds following EFTR of large(≥3 cm)*** We retrospectively analyzed the data of 85 patients with gastric SMTs in the fundus of the stomach or in the lesser curvature of the gastric body whose wounds were treated with double-nylon purse-string sutures after successful tumor resection at the Endoscopy Center of Renmin Hospital of Wuhan *** operative,postoperative,and follow-up conditions of the patients were *** All tumors were completely resected using EFTR.36(42.35%)patients had tumors located in the fundus of the stomach,and 49(57.65%)had tumors located in the body of the *** patients underwent suturing with double-nylon sutures after EFTR without laparoscopic assistance or further surgical *** fever and stomach pain were reported in 13(15.29%)and 14(16.47%)patients,*** serious adverse events occurred during the intraoperative or postoperative periods.A postoperative review of all patients revealed no residual or recurrent *** Double-nylon purse-string sutures can be used to successfully close wounds that cannot be completely closed with a single nylon suture,especially for large(≥3 cm)EFTR wounds in SMTs.

关键词： Endoscopic full-thickness resection Purse-string suture Postoperative wounds Submucosal tumors

Review of Gas Transportation and Storage Facilities Construction in 2015

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China Oil & Gas 2016年第1期23卷 29-35页

作者： shan lei Sun Hui Ai Yong PetroChina Planning and Engineering Institute

By the end of 2015, total length of China＇s long-distance gas pipelines has exceeded 70,O00km. Onshore stratey, ic import paths have been formed, domestic trunk networks perfected and gas storages construction pace acceh＇rated. The Chinese section of Russia-China East Gas Pipeline was officially commenced, which marked that the northeast import path entered the stage ofconstruction. There are 13 LNG terminals in China. The National Development and Rerorm Commission （NDRC） approved China＇*** private-owned LNG terminal- the Zhoushan LNG terminal. In the *** years, the focus of institutional reform will be the independence of pipelines and networks, the focus of construction will be regional networks and branch pipelines, and joint ventures will be the mainstream for gas pipeline construction and operation.

关键词： China's natural gas market Storage and transportationfiwility Pipeline LNG Gas storage

Pressure-Dependent Point-Contact Spectroscopy of Superconducting PbTaSe2 Single Crystals

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Chinese Physics Letters 2020年第9期37卷 84-88页

作者： Hai Zi Ling-Xiao Zhao Xing-Yuan Hou lei shan Zhian Ren Gen-Fu Chen Cong Ren School of Physics and Astronomy Yunnan UniversityKunming 650500China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of ScienceBeijing 100190China

We develop an experimental tool to investigate the order parameter of superconductors by combining pointcontact spectroscopy measurement with high-pressure *** is demonstrated for the first time that planar point-contact spectroscopy measurement on noncentrosymmetric superconducting PbTaSe2 single crystals is systematically subjected to hydrostatic pressures up to 12.1 *** such a high pressure,the normal-state contact resistance is sensitive to the applied pressure,reflecting the underlying variation of contact transparency upon *** a superconducting state,the pressure dependence of the energy gap△0 and the critical temperature Tc for gap opening/closing are extracted based on a generalized Blond-Tinkham-Klapwijk *** gap ratio 2△0/kB Tc indicates a crossover from weak coupling to strong coupling in electron pairing strength upon pressure for *** experimental results show the accessibility and validity of high-pressure pointcontact spectroscopy,offering rich information about high-pressure superconductivity.

关键词： technique. coupling transparency

SMAC exhibits anti-tumor effects in ECA109 cells by regulating expression of inhibitor of apoptosis protein family

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World Journal of Clinical Cases 2021年第19期9卷 5019-5027页

作者： Ning Jiang Wei-Quan Zhang Hong Dong Ying-Tao Hao Li-Ming Zhang lei shan Xiao-Dong Yang Chuan-Liang Peng Department of Thoracic Surgery The Second Hospital of Shandong UniversityJinan 250100Shandong ProvinceChina Department of Nursing The Second Hospital of Shandong UniversityJinan 250100Shandong ProvinceChina

BACKGROUND The poor prognosis and rising incidence of esophageal cancer highlight the need for improved therapeutics that are essential prior to ***161 is an SMAC(second mitochondrial activator of caspases)mimic and inhibitor of apoptosis protein(IAP)antagonist which exhibits anti-tumor effects and improves the chemical sensitivity of many *** To ascertain the effects and mechanisms of the SMAC analog LCL161 on esophageal cancer *** MTT assay and TUNEL assay were used to detect cell proliferation and apoptosis,*** blot analysis was used to study the molecular mechanisms of LCL161-induced death of ECA109 *** LCL161 decreased ECA109 cell proliferation in dose-and time-dependent manner and induced apoptosis of ECA109 cells in a dose-dependent ***,LCL161 induced a significant decrease in the expression of the XIAP and significant increase in the expression of *** addition,Bax increased significantly with increasing concentrations of LCL161,and the relative expression of Bax was significantly different between *** These findings support the hypothesis that LCL161 can inhibit proliferation and induce apoptosis in esophageal cancer cells by regulating the expression of IAP family members,suggesting that it has potential to be an effective treatment for esophageal squamous cell carcinoma.

关键词： SMAC Esophageal cancer ECA109 cell Apoptosis protein Inhibitor of apoptosis protein family

Anisotropic interfacial superconductivity induced at point contacts on topological semimetal grey arsenic

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中国科学:物理学、力学、天文学英文版 2023年第9期66卷 94-101页

作者： Meng-Di Zhang Qing Wang Xing-Yuan Hou Ling-Xiao Zhao Zong Wang Ya-Dong Gu Fan Zhang Zhi-An Ren Gen-Fu Chen Ning Hao lei shan Beijing Academy of Quantum Information Sciences Beijing 100193China Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing 100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing 100049China Anhui Province Key Laboratory of Condensed Matter Physics at Extreme Conditions High Magnetic Field LaboratoryChinese Academy of SciencesHefei 230031China Science Island Branch of Graduate School University of Science and Technology of ChinaHefei 230026China Information Materials and Intelligent Sensing Laboratory of Anhui Province Institute of Physical Science and Information TechnologyAnhui UniversityHefei 230601China Key Laboratory of Structure and Functional Regulation of Hybrid Materials(Anhui University) Ministry of EducationHefei 230601China Center of Free Electron Laser&High Magnetic Field Anhui UniversityHefei 230601China Songshan Lake Materials Laboratory Dongguan 523808China

The origin of superconductivity observed at the point contact between the normal metal tip and the topological material remains uncertain due to the potential presence of superconducting elements or allotropes *** is imperative to seek out a topological material entirely free of superconducting impurities and induce superconductivity between it and normal tips to verify the source of the induced ***,we report the observation of superconductivity up to 9 K induced at point contacts between normal metal tips and the topological material grey arsenic,which is free of *** determined temperature dependencies of superconducting gapsΔ(T)deviate from the Bardeen-Cooper-Schriefer(BCS)superconductivity law,exhibiting abnormal ***,the highly anisotropic upper critical field H_(c2)(T)suggests the anisotropy of the projected interfacial Fermi *** tuning the junction resistance,we obtained a negative correlation between the superconducting gapΔand the efective barrier height Z,which validates the interfacial coupling strength as a key factor in the observed tip-induced *** experimental results provide guidance for the relevant theory about tip-induced superconductivity on topological materials.

关键词： tip-induced superconductivity topological material interfacial superconductivity grey As