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Journal of Environmental Sciences 2024年第3期137卷 604-614页

作者： Di Wu Xing Lu Li-Xue Dong Juan Tian Jin Deng lei Wei Hua Wen shan Zhong Ming Jiang School of Basic Medical Sciences Wuhan UniversityWuhan 430071China Key Laboratory of Freshwater Biodiversity Conservation Ministry of Agriculture and Rural AffairsYangtze River Fisheries Research InstituteChinese Academy of Fishery SciencesWuhan 430223China Hubei Province Key Laboratory of Allergy and Immunology Wuhan 430071China

Microplastics(MPs)have become a significant concern for their potential ***,the correlation between the size of plastic particles and their toxicity remains ***,we investigate the toxic effects of different sizes(80 nm,800 nm,8μm and 80μm)polystyrene MPs(PS-MPs)on the model organism Nile tilapia(Oreochromis niloticus).The results of bioluminescent imaging indicate that the 80 nm PS-MPs are more likely to invade the body.H&E staining shows severe damage on the intestinal villi and distinct hepatic steatosis in the 80 nm *** U labeling shows that the proliferation activity of intestinal and liver cells reduces significantly in the 80 nm *** gut microbiome analysis shows a severe imbalance of gut microbiota homeostasis in the 80 nm *** analysis of liver transcriptomics and metabolomics shows that the liver lipid metabolism is disordered in the 80 nm *** conclusion,this study confirms that the 80 nm PS-MPs are more likely to induce intestinal and liver *** the above lay the foundation for further study on the pathological damage of MPs to other organisms.

关键词： Microplastics(MPs) Intestinal toxicity Liver toxicity Gut microbiome Lipid metabolism

Development and Future of Natural Gas Industry in China

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China Oil & Gas 2013年第3期20卷 32-36页

作者： Sun Hui shan lei Wang Xiaolong Petro China Planning and Engineering Institute Petro China West Pipeling Company

Basic statistics of China’s natural gas industry in 2012Record-high gas reserve growth In the year of 2012,gas reserve growth maintained the momentum of the previous ***-added proven gas-in-place was 961.22 bcm(33%hi... 详细信息

关键词：天然气行业中国天然气储量统计数据储量增长立方技术

Smad8 is involvement in follicular development via the regulation of granulosa cell growth and steroidogenesis in mice

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BIOCELL 2024年第1期48卷 139-147页

作者： DAOLUN YU DEYONG SHE KAI GE lei YANG RUINA ZHAN shan LU YAFEI CAI College of Biotechnology and Pharmaceutical Engineering West Anhui UniversityLu’an237012China Lu’an Academy of Agricultural Sciences Lu’an237001China College of Life Sciences Anhui Normal UniversityWuhu241000China College of Animal Science and Technology Nanjing Agricultural UniversityNanjing210095China

Background:SMAD family proteins(SMADs)are crucial transcription factors downstream of transforming growth factor beta(TGF-ß)/SMAD signaling pathways that have been reported to play a pivotal role in mammalian ***,the role of SMAD family member 8(SMAD8,also known as SMAD9),a member of the SMAD family,in mammalian reproduction remains ***:We employed RNA interference techniques to knock down Smad8 expression in mouse granulosa cells(GCs)to investigate the effects of Smad8 on GC growth and ***:Our findings revealed a significant decrease in the proliferative capacity and a substantial increase in the apoptosis rate of GCs after transfection with Smad8-siRNA for 48 *** hormone assays demonstrated a significant decrease in estradiol(E2)levels,whereas progesterone(P4)remained *** mechanistic analysis showed that the mRNA expression of proliferating cell nuclear antigen(Pcna),Cyclin D2,cell cycle-dependent kinase 4(Cdk4),B-cell lymphoma-2(Bcl-2),estrogen receptor(Er),luteinizing hormone receptor(Lhr)and cytochrome P450 family 19 subfamily A member 1(Cyp19a1)significantly ***,the mRNA of cysteine aspartate proteinase 3(Caspase 3)significantly increased,wheras Bcl2-associated X(Bax),folliclestimulating hormone receptor(Fshr)and cytochrome P450 family 11 subfamily A member 1(Cyp11a1)remained unchanged compared to the ***:This study indicates that Smad8 knockdown inhibits cell proliferation,promotes apoptosis,reduces Er and Lhr transcription,and decreases E2 production in mouse *** findings suggest that Smad8 may serve as a novel genetic marker for mammalian reproduction.

关键词： Mouse Smad8 RNA interference Granulosa cells Growth and steroidogenesis

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利用农村期货合作基金服务“三农”模式探讨

中国流通经济 2009年第8期23卷 44-47页

作者：单磊北京物资学院经济学院北京市101149

本文认为,现有农产品期货服务"三农"模式存在一些问题与不足,本文提出的农村期货合作基金是农产品期货服务"三农"的有效模式,该基金以县、市为单位,设立规模由当地农户的农产品种植规模确定,设立后由专业的期货经纪公司管理和运作,所有... 详细信息

本文认为,现有农产品期货服务"三农"模式存在一些问题与不足,本文提出的农村期货合作基金是农产品期货服务"三农"的有效模式,该基金以县、市为单位,设立规模由当地农户的农产品种植规模确定,设立后由专业的期货经纪公司管理和运作,所有资产全部用于当地农户生产的农产品的套期保值。与现有的"期货+订单"和"期货合作社"模式相比,其具有不存在违约风险、农民增收效果明显、管理规范等优点。

关键词：期货合作基金农产品期货套期保值期货合作社

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清代以前存见的陈旸《乐书》版本状况

中国音乐学 2008年第1期 68-72页

作者：单蕾中国艺术研究院硕士研究生北京100029

北宋陈旸所撰《乐书》,为徽宗建中靖国元年(公元1101年)"诏给笔札"、缮写进献,南宋庆元六年(公元1200年)首刊,元、明、清各朝曾多次刊刻。今有不同版本存世。本文主要是对目前已见的清代以前陈旸《乐书》版本及其版本状况进行调查和梳... 详细信息

北宋陈旸所撰《乐书》,为徽宗建中靖国元年(公元1101年)"诏给笔札"、缮写进献,南宋庆元六年(公元1200年)首刊,元、明、清各朝曾多次刊刻。今有不同版本存世。本文主要是对目前已见的清代以前陈旸《乐书》版本及其版本状况进行调查和梳理。版本状况的调查包括版印的风格特点、序跋内容和后人的题跋识语、藏书印记等。

关键词：陈旸《乐书》版本

Application of machine learning in perovskite materials and devices:A review

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Journal of Energy Chemistry 2024年第7期94卷 254-272页

作者： Ming Chen Zhenhua Yin Zhicheng shan Xiaokai Zheng lei Liu Zhonghua Dai Jun Zhang Shengzhong(Frank)Liu Zhuo Xu School of Electric Power Civil Engineering and ArchitectureCollege of Physics and Electronics EngineeringState Key Laboratory of Quantum Optics and Quantum Optics DevicesShanxiUniversityTaiyuan030006ShanxiChina Key Laboratory of Applied Surface and Colloid Chemistry National Ministry of EducationShanxi Engineering Lab for Advanced Energy TechnologySchool of Materials Science and EngineeringShaanxi Normal UniversityXi'an 710119ShaanxiChina State Key Laboratory of Catalysis Dalian National Laboratory for Clean EnergyDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023LiaoningChina

Metal-halide hybrid perovskite materials are excellent candidates for solar cells and photoelectric *** recent years,machine learning(ML)techniques have developed rapidly in many fields and provided ideas for material discovery and *** can be applied to discover new materials quickly and effectively,with significant savings in resources and time compared with traditional experiments and density functional theory(DFT)*** this review,we present the application of ML in per-ovskites and briefly review the recent works in the field of ML-assisted perovskite ***,the advantages of perovskites in solar cells and the merits of ML applied to perovskites are ***,the workflow of ML in perovskite design and some basic ML algorithms are ***,the applications of ML in predicting various properties of perovskite materials and devices are ***,we propose some prospects for the future development of this *** rapid devel-opment of ML technology will largely promote the process of materials science,and ML will become an increasingly popular method for predicting the target properties of materials and devices.

关键词： Machine learning Perovskite Materials design Bandgap engineering Stability Crystal structure

Atorvastatin ameliorated myocardial fibrosis by inhibiting oxidative stress and modulating macrophage polarization in diabetic cardiomyopathy

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World Journal of Diabetes 2024年第6期15卷 1070-1073页

作者： Xiao-Tian lei Dan-Lan Pu Geng shan Qi-Nan Wu Department of Endocrinology The First Affiliated Hospital of the Third Military Medical University(Army Medical University)Chongqing 400038China Department of Endocrinology Chongqing Yubei District People's HospitalChongqing 400030China Department of Endocrinology Dazu Hospital of Chongqing Medical UniversityThe People's Hospital of DazuChongqing 402360China

In this editorial,we commented on the article published in the recent issue of the World Journal of *** cardiomyopathy(DCM)is characterized by myocardial fibrosis,ventricular hypertrophy and diastolic dysfunction in diabetic patients,which can cause heart failure and threaten the life of *** pathogenesis of DCM has not been fully clarified,and it may involve oxidative stress,inflammatory stimulation,apoptosis,and *** is lack of effective therapies for DCM in the clinical *** have been widely used in the clinical practice for years mainly to reduce cholesterol and stabilize arterial plaques,and exhibit definite cardiovascular protective *** have shown that statins also have anti-inflammatory and antioxidant *** were particularly concerned about the recent findings that atorvastatin alleviated myocardial fibrosis in db/db mice by regulating the antioxidant stress and antiinflammatory effects of macrophage polarization on diabetic myocardium,and thereby improving DCM.

关键词： Diabetic cardiomyopathy Statins Macrophage Oxidative stress

Design of steel box girder for Taizhou Yangtze River Highway Bridge

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Engineering Sciences 2011年第2期9卷 57-63页

作者： Ding lei shan Hongwei Zhou Qing Zheng Benhui Jiangsu Provincial Communications Planning and Design Institute Co. Ltd. Nanjing 210005China

Taizhou Yangtze River Highway Bridge is the first three-pylon two-span suspension bridge in China. The main girder adopts flat steamline steel closed box girder which has well wind-resistant capability and is technically mature besides beautiful appearance. Straight web plates of the steel box girder in longitudinal direction are proposed in order to ensure the integrity of the steel box girder, and to keep the stress of the steel box girder continuous in the middle pylon, as well as to reduce the gradient of the middle pylon columns. The cross section of the box girder has one box with three cells. Solid-web diaphragm plate with good integrity and high torsional stiffness is adopted. The lifting lugs are utilized in the anchors of suspender cable. In this paper, selection of the cross section of the steel box girder, the general structure design, local structure design and main structure calculation results of Taizhou Yangtze River Bridge are introduced emphatically.

关键词： Taizhou Yangtze River Highway Bridge three-pylon suspension bridge steel box girder design

Biomechanical Study of the Fixation Strength of Anteromedial Plating for Humeral Shaft Fractures

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Chinese Medical Journal 2016年第15期129卷 1850-1855页

作者： Yin-Feng Zheng Jun-Lin Zhou Xiao-Hong Wang lei shan Yang Liu Department of Orthopedics Beijing Chaoyang Hospital Capital Medical University Beijing 100020 China Technical Research Department Beijing Medical Implant Engineering Research Center Beijing 100095 China Technical Research Department Beijing Engineering Laboratory of Functional Medical Materials and Devices Beijing 100095 China Technical Research Department Beijing Naton Technology Group Co. Ltd. Beijing 100095 China

Background： Open reduction and internal fixation with plate and screws are the gold standard for the surgical treatment of humeral shaft fractures, this study was to compare the mechanical properties ofanteromedial, anterolateral, and posterior plating for humeral shaft fractures. Methods： A distal third humeral shaft fracture model was constructed using fourth-generation sawbones （#3404, composite bone）. A total of 24 sawbones with a distal third humeral shaft fracture was randomly divided into three Groups： A, B, and C （n = 8 in each group） for anteromedial, anterolateral, and posterior plating, respectively. All sawbones were subjected to horizontal torsional fatigue tests, horizontal torsional and axial compressive fatigue tests, four-point bending fatigue tests in anteroposterior （AP） and mediolateral （ML） directions and horizontal torsional destructive tests. Results： In the horizontal torsional fatigue tests, the mean torsional angle amplitude in Groups A, B, and C were 6.12°, 6.53°, and 6.81°. In horizontal torsional and axial compressive fatigue tests, the mean torsional angle amplitude in Groups A, B, and C were 5.66°, 5.67°, and 6.36°. The mean plate displacement amplitude was 0.05 mm, 0.08 mm, and 0.10 mm. Group A was smaller than Group C （P 〈 0.05）. In AP four-point bending fatigue tests, the mean plate displacement amplitude was 0.16 ram, 0.13 ram, and 0.20 mm. Group B was smaller than Group C （P 〈 0.05）. In ML lbur-point bending fatigue tests, the mean plate displacement amplitude were 0.16 mm, 0.19 ram, and 0.17 ram. In horizontal torsional destructive tests, the mean torsional rigidity in Groups A, B, and C was 0.82, 0.75, and 0.76 N·m/deg. The yielding torsional angle was 24.50°, 25.70°, and 23.86°. The mean yielding torque was 18.46, 18.05. and 16.83 N·m, respectively. Conclusions： Anteromedial plating was superior to anterolateral or posterior plating in all mechanical tests except in AP four-point bending fatigue tests compared to the anterolate

关键词： Anteromedial Plating Biomechanics Compressive Plate Fracture Model Humeral Shaft Fracture

Seismic response of a mid-story isolated structure considering SSI in mountainous areas under long-period earthquakes

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 151-161页

作者： Wan Feng Qin Shengwu Liu Dewen Zhao Tiange Zheng Yanping shan Hang Li Zhiang Peng Fusong Xu Jingran lei Min College of Construction Engineering Jilin UniversityChangchun 130015China College of Civil Engineering Southwest Forestry UniversityKunming 650024China College of civil engineering Southwest Jiaotong UniversityChengdu 610031China

At present,there is not much research on mid-story isolated structures in mountainous *** this study,a model of a mid-story isolated structure considering soil-structure interaction(SSI)in mountainous areas is established along with a model that does not consider *** long-period earthquake waves and two ordinary earthquake waves are selected as inputs for the dynamic time history analysis of the *** results show that the seismic response of a mid-story isolated structure considering SSI in mountainous areas can be amplified when compared with a structure that does not consider *** structure response under long-period earthquakes is larger than that of ordinary *** structure response under far-field harmonic-like earthquakes is larger than that of near-fault pulse-type *** structure response under near-fault pulse-type earthquakes is larger than that of far-field non-harmonic *** subjected to long-period earthquakes,the displacement of the isolated bearings exceeded the limit value,which led to instability and overturning of the *** structure with dampers in the isolated story could adequately control the nonlinear response of the structure,effectively reduce the displacement of the isolated bearings,and provide a convenient,efficient and economic method not only for new construction but also to retrofit existing structures.

关键词： SSI in mountainous areas long-period earthquakes mid-story isolated structure structural dynamic analysis