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Efficacy of physiological seawater nasal irrigation for the treatment of children with SARS-CoV-2 Omicron BA.2 variant infection:a randomized controlled trial

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World Journal of Pediatrics 2024年第5期20卷 461-469页

作者： ji-lei lin Fen Zhang Yan-Bo Li Shu-Hua Yuan jin-Hong Wu jing Zhang lei Zhang Yi He jie Chen Yong Yin Department of Respiratory Medicine Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang RoadPudong DistrictShanghaiChina University of British Columbia VancouverCanada Information Technology Department Shanghai Children’s Medical Center National Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang RoadPudong DistrictShanghaiChina Department of Otorhinolaryngology Shanghai Children’s Medical CenterSchool of MedicineShanghai Jiao Tong University1678 Dongfang RoadPudong DistrictShanghaiChina Department of Respiratory Medicine Sanya Women and Children’s Hospital Affiliated to Hainan Medical CollegeHainan Branch of Shanghai Children’s Medical CenterSanyaChina Department of Respiratory Medicine Linyi Maternal and Child Healthcare HospitalLinyiChina Shanghai Children’s Medical Center Pediatric Medical Complex(Pudong) ShanghaiChina Pediatric AI Clinical Application and Research Center Shanghai Children’s Medical CenterShanghaiChina

Background Saline nasal irrigation is an effective therapy for relieving common cold *** study aimed to investigate and explore the efficacy of physiological seawater nasal irrigation(PSNI)on children with mild and asymptomatic infection with *** This randomized controlled trial was conducted in Shanghai,China,and 403 children with mild and asymptomatic infection with Omicron were *** children were allocated into the PSNI group and the control *** primary outcome was the duration of viral shedding(DVS),and the secondary outcome was the change in clinical *** The median age of all participants was 5.59(6.26)years *** DVS was significantly shorter in the PSNI group[2.40(1.13)]than in the control group[3.09(2.14)](P=0.014).The multivariable Cox regression model also showed that patients in the PSNI group had an increased probability of shorter DVS compared with patients in the control group[hazard ratio(HR),1.27;95%confidence interval(CI),1.04–1.55;P=0.017].Subgroup analysis suggested that the DVS of patients without full vaccination was significantly reduced in the PSNI *** proportions of runny nose and stuffy nose were apparently reduced in the first three days in the PSNI group or the control group,but there was no evidence showing that PSNI contributes to the benefit compared with the control *** PSNI can reduce the DVS of patients with mild and asymptomatic infection with SARS-CoV-2 Omicron BA.2 variant.

关键词： Children Duration of viral shedding Omicron Physiological seawater nasal irrigation

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基于熵值法的铝合金缸体低压铸造工艺多目标优化

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铸造 2024年第6期73卷 753-761页

作者：邓伟宋仲模雷基林罗坤徐远志张勇昆明理工大学云南省内燃机重点实验室云南昆明650500 昆明云内动力股份有限公司云南昆明650224 成都正恒动力股份有限公司四川成都610500

基于有限元软件ProCAST构建某型铝合金缸体的有限元模型,设计L16(44)正交试验方案,探究了浇注温度、模具预热温度、充型时间、保压压力四个工艺参数对凝固时间和缩松体积的影响。采用熵值法分别计算两个评价指标的权重,将凝固时间与缩... 详细信息

基于有限元软件ProCAST构建某型铝合金缸体的有限元模型,设计L16(44)正交试验方案,探究了浇注温度、模具预热温度、充型时间、保压压力四个工艺参数对凝固时间和缩松体积的影响。采用熵值法分别计算两个评价指标的权重,将凝固时间与缩松体积转化为综合评分值进行单目标优化。通过极差分析与方差分析,得到了各参数对综合评分的影响程度为:浇注温度(A)>模具预热温度(B)>保压压力(D)>充型时间(C),确定了最优的工艺参数为A1B2C1D3。对比原工艺参数方案和优选工艺参数方案发现:凝固时间缩短了20.35%,缩松体积下降了2.96%。经生产试验,缸体铸件外观质量良好,无明显铸造缺陷,验证了最佳工艺参数的合理性。

关键词：铝合金缸体低压铸造正交试验熵值法多目标优化

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Soot particle distributions inside a diesel particulate filter during soot loading in plateau environment

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Journal of Central South University 2022年第7期29卷 2201-2212页

作者： WANG Peng BI Yu-hua SHEN Li-zhong lei ji-lin YU Feng-rong Yunnan Province Key Laboratory of Internal Combustion Engines Kunming University of Science and TechnologyKunming 650500China Faculty of Metallurgical and Energy Engineering Kunming University of Science and TechnologyKunming 650500China

A three-dimensional diesel particulate filter(DPF)simulation model was developed by using AVL software FIRE to study the effects of four factors on soot particle distributions along the axial and radial directions in the DPF after the model accuracy was *** orthogonal test method was used to determine the importance and weights of the design of experiments(DoE)factors such as the expanding angle,the number of channels per square inch,and the exhaust mass flow *** effects of these factors on the uniformity of the soot particle distributions were also *** results show that when the soot loading time was 400 s,the soot particles inside the DPF along the axial direction exhibited a bowl shape,which was high on the both ends and low in the *** uniformity of the axial distribution of soot particles reduces significantly with an increase in the number of channels per square *** uniformity of the radial distribution reduced with an increase in the expanding angle of the divergent *** on the impacts on the axial uniformity,the three most influencing factors in a descending order are the number of channels per square inch,the exhaust mass flow rate,and the expanding angle of the divergent tube.

关键词： diesel particulate filter(DPF) soot particle distribution plateau environment pressure loss

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Semantic segmentation-based semantic communication system for image transmission

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Digital Communications and Networks 2024年第3期10卷 519-527页

作者： jiale Wu Celimuge Wu Yangfei lin Tsutomu Yoshinaga lei Zhong Xianfu Chen Yusheng ji The University of Electro-Communication Tokyo182-8585Japan Toyota Motor Corporation Tokyo112-8701Japan VTT Technical Research Centre of Finland OuluFinland National Institute of Informatics(NII) Tokyo101-8430Japan

With the rapid development of artificial intelligence and the widespread use of the Internet of Things, semantic communication, as an emerging communication paradigm, has been attracting great interest. Taking image transmission as an example, from the semantic communication's view, not all pixels in the images are equally important for certain receivers. The existing semantic communication systems directly perform semantic encoding and decoding on the whole image, in which the region of interest cannot be identified. In this paper, we propose a novel semantic communication system for image transmission that can distinguish between Regions Of Interest (ROI) and Regions Of Non-Interest (RONI) based on semantic segmentation, where a semantic segmentation algorithm is used to classify each pixel of the image and distinguish ROI and RONI. The system also enables high-quality transmission of ROI with lower communication overheads by transmissions through different semantic communication networks with different bandwidth requirements. An improved metric θPSNR is proposed to evaluate the transmission accuracy of the novel semantic transmission network. Experimental results show that our proposed system achieves a significant performance improvement compared with existing approaches, namely, existing semantic communication approaches and the conventional approach without semantics.

关键词： Semantic Communication Semantic segmentation Image transmission Image compression Deep learning

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Hydrogel bioadhesives harnessing nanoscale phase separation for Achilles tendon repairing

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Nano Research 2024年第2期17卷 778-787页

作者： Jun Zhang Xingmei Chen jingseng lin Pei Zhang Iek Man lei Yue Tao jiajun Zhang Tian Luo ji Liu Department of Mechanical and Energy Engineering Southern University of Science and TechnologyShenzhen 518055China Research and Innovation Center SKG Health TechnologyShenzhen 518000China SAFE(Shenzhen)Medical Technology Company Limited Shenzhen 518000China Shenzhen Key Laboratory of Biomimetic Robotics and Intelligent Systems Department of Mechanical and Energy EngineeringSouthern University of Science and TechnologyShenzhen 518055China Guangdong Provincial Key Laboratory of Human-Augmentation and Rehabilitation Robotics in Universities Southern University of Science and TechnologyShenzhen 518055China

Repairing Achilles tendon has emerged as a long-standing challenge in the orthopaedic *** suture is the gold standard for re-attaching and repairing the fractured Achilles tendons in clinical surgeries,it is still subjected to numerous adverse side-effects,including chronic inflammatory,tendon tissue re-rupture,scar formation,and post-surgical peritendinous *** this work,we develop a class of hydrogel bioadhesives with tailored nanoscale phase separation for Achilles tendon *** address the existing limitations of sutures,our hydrogel bioadhesives encompass three core functionalities:(i)instant and tough adhesion to Achilles tendon tissues,(ii)extraordinary long-term adhesion robustness under wet and dynamic in vivo conditions,and(iii)anti-postsurgical peritendinous *** our hydrogel bioadhesives with sutures,such kind of integrated approach enables a conformable yet robust biointerface with the tendon tissues,and prevents the fibroblast migration and formation of connective tissues,thus facilitating the tendon *** hydrogel bioadhesives reported here open up new opportunities for the repairing of fractured Achilles tendons in diverse and complicated clinical scenarios.

关键词： hydrogels phase separation bioadhesion robustness tendon repairing

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Advances in non-invasive imaging of proteinopathies in animal models of neurodegenerative diseases

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Neural Regeneration Research 2024年第10期19卷 2115-2116页

作者： lei Cao Bin ji Ruiqing Ni Changes Technology Corporation Ltd. ShanghaiChina Fudan University ShanghaiChina School of Pharmacy Fudan UniversityShanghaiChina Institute for Biomedical Engineering University of Zurich&ETH Zurich Institute for Regenerative MedicineUniversity of ZurichZurichSwitzerland

Neurodegenerative diseases,including Alzheimer's disease(AD),frontotemporal dementia,Parkinson's disease,and dementia with Lewy bodies,represent tremendous unmet clinical needs.A common feature of these diseases is the aberrant cerebral accumulation of pathological protein aggregates,affecting selectively vulnerable circuits in a disease-specific *** studies have established a relationship between abnormal aggregation and neuronal dysfunction or loss,suggesting multifactorial pathogenesis mechanisms in these neurodegenerative disorders.

关键词： diseases degenerative clinical

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A Multiscale Model of Mass-Functionally Graded Beam-Fluid System Under Bending and Vibration Responses

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Acta Mechanica Solida Sinica 2024年第2期37卷 327-340页

作者： lei Zhang jianping lin jiaqing jiang Guannan Wang Department of Civil Engineering Zhejiang University866 Yuhangtang RoadHangzhou310058China Center for Balance Architecture Zhejiang UniversityHangzhou310007China College of Civil Engineering Huaqiao UniversityXiamen361021China Key Laboratory for Intelligent Infrastructure and Monitoring of Fujian Province Huaqiao UniversityXiamen361021China Department of Engineering Mechanics Zhejiang UniversityHangzhou310027China

In this paper,a multiscale model is developed for the mass functionally graded(FG)beam-fluid system to investigate its static and dynamic responses based on 3D printed porous beam free vibration tests,which are determined by two *** the microstructural level,the gradient variation is realized by arbitrary distribution of matrix pores,and the effective moduli under specific distribution are obtained using the micromechanics homogenization *** the meantime,at the structural level,the mechanical responses of FG porous beams subjected to mass loading are considered in a static fluid ***,the explicit expressions of local finite-element(FE)expressions corresponding to the static and dynamic responses are given in the *** present results are validated against numerical and experimental results from the literature and mechanical tests of 3D printed structures,with good agreement generally obtained,giving credence to the present *** this basis,a comprehensive parametric study is carried out,with a particular focus on the effects of boundary conditions,fluid density,and slenderness ratio on the bending and vibration of FG beams with several different gradations.

关键词： 3D printed test Mass functionally graded beam-fluid system Multiscale model Local finite-element expressions Static bending Free vibration

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Transient features of graphitization and nitrogen-vacancy color centers in a diamond fabricated by localization femtosecond laser direct writing

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Science China(Technological Sciences) 2024年第8期67卷 2530-2536页

作者： CUI lin YIN SiYu HU ZiFan WANG lei State Key Laboratory of Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012China

Femtosecond laser direct writing provides an efficient approach to fabricating single nitrogen vacancy(NV) color centers with a relatively high yield. Different from previously reported NV color centers with a random distribution in a bulk diamond or nanocrystals, this gives an opportunity to study the photophysical properties of single NV color centers with precise numbers and positions. However, ultrafast studies on single NV color centers prepared by localization femtosecond laser direct writing are still rare, especially for the graphitization inside a diamond and its relationship with single NV color centers. Here, we report the broadband transient absorption(TA) spectroscopic features of the graphitization and NV color centers in a diamond fabricated by localization femtosecond laser direct writing at room temperature under 400 nm excitation. In comparison with the graphene oxide film, the bleaching features of the graphitization point array in a diamond are similar to reduced graphene oxide,accompanied by excited state absorption signals from local carbon atom vacancy defects in graphene-like structures induced by laser writing. On the other hand, transient features of laser processing array containing single NV color centers with a yield of~50% are different from those of the graphitization point array. Our findings suggest that for ultrashort pulse processing of diamonds, broadband TA spectral signals are sensitive to the surrounding atomic environment of processing sites, which could be applied to laser writing point defects in other materials used as solid-state single photon sources.

关键词： nitrogen-vacancy color center graphitization diamond femtosecond laser direct writing ultrafast spectroscopy

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A Novel Algorithm for Microcirculation Image Enhancement

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Chinese Journal of Biomedical Engineering(English Edition) 2010年第3期19卷 114-120页

作者： LI Hong-jun ZHAO Zhi-min ji lei ZHANG lin Nanjing University of Aeronautics and Astronautics Nanjing 210016 China

Microcirculation images often have low quality in acquisition process, which affect the following steps of process. This paper introduces enhancement algorithm based on nonsubsampled Contourlet transform (NSCT). It analyzes the characteristics of the microcirculation images generated, and separates microcirculation images to light weight and the reflection weight. It also analyzes the construction method on NSCT and proves that this method can be applied on microcirculation image enhancement algorithm. To correct light weight of microcirculation image and obtain enhancement image the enhancement microcirculation image was not only superior to the original image visually, but also improved objective data obviously. The algorithms provide a new method to microcirculation image pre-processing and guide the latter steps of the image processing.

关键词： image enhancement microcirculation image nonsubsampled Contourlet transform

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Possible Role of Cellular Polyamine Metabolism in Neuronal Apoptosis

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Current Medical Science 2024年第2期44卷 281-290页

作者： Xin-tong ji Wen-lei YU Meng-jia jiN lin-jie LU Hong-ping YIN Huan-huan WANG School of Basic Medical Sciences Affiliated Hospital of Hangzhou Normal UniversityHangzhou Normal UniversityHangzhou 311121China School of Medicine Chongqing UniversityChongqing 400030China Department of Stomatology Huzhou Wuxing District People's HospitalHuzhou Wuxing District Maternal and Child Health HospitalHuzhou 313008China School of Pharmacy Zhejiang UniversityHangzhou 310030China Department of Stomatology Haining Hospital of Traditional Chinese MedicineJiaxing 314400China

Recent studies have shown that cellular levels of polyamines(PAs)are significantly altered in neurodegenerative *** from in vivo animal and in vitro cell experiments suggests that the cellular levels of various PAs may play important roles in the central nervous system through the regulation of oxidative stress,mitochondrial metabolism,cellular immunity,and ion channel *** of PA metabolism related enzymes also contributes to neuronal injury and cognitive impairment in many neurodegenerative ***,in the current work,evidence was collected to determine the possible associations between cellular levels of PAs,and related enzymes and the development of several neurodegenerative diseases,which could provide a new idea for the treatment of neurodegenerative diseases in the future.

关键词： polyamine apoptosis mitochondria neurodegenerative disease

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